The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Environmental Cardiology: Studying Mechanistic Links Between Pollution and Heart Disease
Open accessAbstract
Environmental factors are considered key determinants of cardiovascular disease. Although lifestyle choices such as smoking, diet, and exercise are viewed as major environmental influences, the contribution of pollutants and environmental chemicals is less clear. Accumulating evidence suggests that exposure to pollutants and chemicals could elevate the risk of cardiovascular disease. Many epidemiological studies report that exposure to fine particles present in ambient air is associated with an increase in cardiovascular mortality. Statistically significant relationships between particulate air pollution and ischemic heart disease, arrhythmias, and heart failure have been reported. Animal studies show that exposure to ambient air particles increases peripheral thrombosis and atherosclerotic lesion formation. Exposures to arsenic, lead, cadmium, pollutant gases, solvents, and pesticides have also been linked to increased incidence of cardiovascular disease. Mechanistically, these effects have been attributed to changes in the synthesis or reactivity of nitric oxide that may be caused by environmental oxidants or increased endogenous production of reactive oxygen species. Additional studies are urgently needed to: identify the contribution of individual pollutants to specific aspects of cardiovascular disease; establish causality; elucidate the underlying physiological and molecular mechanisms; estimate the relative susceptibility of diseased and healthy individuals and that of specific population groups; and determine whether pollutant exposure are risk correlates, that is, whether they influence major risk factors, such as hypertension, cholesterol, or diabetes, or whether they contribute to the absolute risk of heart disease. Collectively, these investigations could contribute to the emergent field of environmental cardiology.
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Cites
Toxic potential of materials at the nanolevel
Nel, A., Xia, T., Mädler, L., & Li, N. (2006) · Science · doi:10.1126/science.1114397 · Cited by 9,324
An association between air pollution and mortality in six U.S. cities
Dockery, D. W., Pope, C. A., Xu, X., Spengler, J. D., Ware, J. H., Fay, M. E., Ferris, B. G., & Speizer, F. E. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312093292401 · Cited by 8,018
Pope, C. A., Burnett, R. T., Thurston, G. D., Thun, M. J., Calle, E. E., Krewski, D., & Godleski, J. J. (2004) · Circulation · doi:10.1161/01.cir.0000108927.80044.7f · Cited by 2,592
Passage of inhaled particles into the blood circulation in humans
Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M. F., Vanbilloen, H., Mortelmans, L., & Nemery, B. (2002) · Circulation · doi:10.1161/hc0402.104118 · Cited by 1,719
Cardiovascular Effects of Secondhand Smoke: Nearly as Large as Smoking
Barnoya, J., & Glantz, S. A. (2005) · Circulation · doi:10.1161/circulationaha.104.492215 · Cited by 939
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851
Increased plasma viscosity during an air pollution episode: a link to mortality?
Peters, A., Döring, A., Wichmann, H.-E., & Koenig, W. (1997) · The Lancet · doi:10.1016/s0140-6736(97)01211-7 · Cited by 706
Air pollution and incidence of cardiac arrhythmia
Peters, A., Liu, E., Verrier, R. L., Schwartz, J., Gold, D. R., Mittleman, M., Baliff, J., Oh, J. A., Allen, G., Monahan, K., et al. (2000) · Epidemiology · doi:10.1097/00001648-200001000-00005 · Cited by 651
Grundy, S. M., Balady, G. J., Criqui, M. H., Fletcher, G., Greenland, P., Hiratzka, L. F., Houston-Miller, N., Kris-Etherton, P., Krumholz, H. M., LaRosa, J., et al. (1998) · Circulation · doi:10.1161/01.cir.97.18.1876 · Cited by 609
Heart rate variability associated with particulate air pollution
Pope, C. A., Verrier, R. L., Lovett, E. G., Larson, A. C., Raizenne, M. E., Kanner, R. E., Schwartz, J., Villegas, G. M., Gold, D. R., & Dockery, D. W. (1999) · American Heart Journal · doi:10.1016/s0002-8703(99)70014-1 · Cited by 595
Cited by
Long-term exposure to air pollution and incidence of cardiovascular events in women
Miller, K. A., Siscovick, D. S., Sheppard, L., Shepherd, K., Sullivan, J. H., Anderson, G. L., & Kaufman, J. D. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa054409 · Cited by 1,854
Lead Exposure and Cardiovascular Disease—A Systematic Review
Navas-Acien, A., Guallar, E., Silbergeld, E. K., & Rothenberg, S. J. (2007) · Environmental Health Perspectives · doi:10.1289/ehp.9785 · Cited by 1,112
Cardiovascular effects of air pollution
Brook, R. D. (2008) · Clinical Science · doi:10.1042/cs20070444 · Cited by 657
Chowdhury, R., Ramond, A., O’Keeffe, L. M., Shahzad, S., Kunutsor, S. K., Muka, T., Gregson, J., Willeit, P., Warnakula, S., Khan, H., et al. (2018) · BMJ · doi:10.1136/bmj.k3310 · Cited by 638
Polycyclic aromatic hydrocarbon and its effects on human health: An overeview
Mallah, M. A., Changxing, L., Mallah, M. A., Noreen, S., Liu, Y., Saeed, M., Xi, H., Ahmed, B., Feng, F., Mirjat, A. A., et al. (2022) · Chemosphere · doi:10.1016/j.chemosphere.2022.133948 · Cited by 593
Metadata
- Authors
- Bhatnagar, A.
- Venue
- Circulation Research
- Published
- 2006-09-29
- Volume
- 99
- Issue
- 7
- Pages
- 692-705
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2114328455
- Cited by
- 452
- References
- 10
- FWCI
- 14.95
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
