Endothelial Function: A Critical Determinant in Atherosclerosis?

Landmesser, Ulf; Hornig, Burkhard; Drexler, Helmut

doi:10.1161/01.cir.0000129501.88485.1f

Cited by 853Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionAtherosclerosis and Cardiovascular Diseases

Endothelial Function: A Critical Determinant in Atherosclerosis?

Landmesser, Ulf, Hornig, Burkhard, Drexler, Helmut·2004·Circulation

DOI 10.1161/01.cir.0000129501.88485.1f

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Abstract

Common conditions predisposing to atherosclerosis, such as hypercholesterolemia, hypertension, diabetes, and smoking, are associated with endothelial dysfunction. Endothelial function has largely been assessed as endothelium-dependent vasomotion, at least in part based on the assumption that impaired endothelium-dependent vasodilation also reflects the alteration of other important functions of the endothelium. An important rationale for this approach has been the observation that endothelium-derived nitric oxide (NO), a major mediator of endothelium-dependent vasodilation, has important anti-inflammatory and antithrombotic properties, ie, inhibiting leukocyte adhesion, limiting platelet adhesion and aggregation, and the expression of plasminogen activator inhibitor-1 (PAI-1), a prothrombotic protein. Accumulating data suggest that the degree of impairment of endothelium-dependent vasomotion has profound and independent prognostic implications. A common mechanism underlying endothelial dysfunction relates to increased vascular production of reactive oxygen species. Recent studies also suggest that inflammation per se and C-reactive protein in particular may directly contribute to endothelial dysfunction. These findings raise the question of whether assessment of endothelial function can be used in the clinical setting to identify patients at high risk. New insights into mechanisms of endothelial dysfunction, such as a better understanding of the regulation of important vascular sources of oxygen radicals, may lead to novel therapeutic strategies with the potential to improve prognosis.

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Natriuretic Factors and Nitric Oxide Suppress Plasminogen Activator Inhibitor-1 Expression in Vascular Smooth Muscle Cells
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Oxidant Stress as a Marker for Cardiovascular Events
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Out, damned dot: studies of the NAD(P)H oxidase in atherosclerosis
Griendling, K. K., & Harrison, D. G. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14453 · Cited by 65 · see citing works
Leukocyte Recruitment Into Developing Atherosclerotic Lesions
Rosenfeld, M. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0302.104847 · Cited by 35 · see citing works
Toward Understanding of Extracellular Superoxide Dismutase Regulation in Atherosclerosis
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The Vascular Endothelium and Human Diseases
Rajendran, P., Rengarajan, T., Thangavel, J., Nishigaki, Y., Sakthisekaran, D., Sethi, G., & Nishigaki, I. (2013) · International Journal of Biological Sciences · doi:10.7150/ijbs.7502 · Cited by 1,473 · see citing works
The role of shear stress in the pathogenesis of atherosclerosis
Cunningham, K. S., & Gotlieb, A. I. (2004) · Laboratory Investigation · doi:10.1038/labinvest.3700215 · Cited by 1,155 · see citing works
Myeloperoxidase and Cardiovascular Disease
Nicholls, S. J., & Hazen, S. L. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000163262.83456.6d · Cited by 803 · see citing works
Endothelial Function and Oxidative Stress in Cardiovascular Diseases
Higashi, Y., Noma, K., Yoshizumi, M., & Kihara, Y. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1102 · Cited by 796 · see citing works
Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice
Roos, C. M., Zhang, B., Palmer, A. K., Ogrodnik, M. B., Pirtskhalava, T., Thalji, N. M., Hagler, M., Jurk, D., Smith, L. A., Casaclang‐Verzosa, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12458 · Cited by 738 · see citing works
Isoflavones
Křížová, L., Dadáková, K., Kašparovská, J., & Kašparovský, T. (2019) · Molecules · doi:10.3390/molecules24061076 · Cited by 714 · see citing works
Endothelial and Antithrombotic Actions of HDL
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Endothelial Cell Metabolism in Normal and Diseased Vasculature
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Quercetin reduces systolic blood pressure and plasma oxidised low-density lipoprotein concentrations in overweight subjects with a high-cardiovascular disease risk phenotype: a double-blinded, placebo-controlled cross-over study
Egert, S., Bosy‐Westphal, A., Seiberl, J., Kürbitz, C., Settler, U., Plachta‐Danielzik, S., Wagner, A. E., Frank, J., Schrezenmeir, J., Rimbach, G. H., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509359127 · Cited by 580 · see citing works
Pathological effects of ionizing radiation: endothelial activation and dysfunction
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Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease
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Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Sorajja, P., Gersh, B. J., Cox, D., McLaughlin, M. G., ZIMETBAUM, P. J., Costantini, C. O., Stuckey, T., Tcheng, J. E., Mehran, R., Lansky, A. J., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm184 · Cited by 536 · see citing works
An updated overview of e-cigarette impact on human health
Marqués, P., Piqueras, L., & Sanz, M. (2021) · Respiratory Research · doi:10.1186/s12931-021-01737-5 · Cited by 730 · see citing works
Environmental Cardiology
Bhatnagar, A. (2006) · Circulation Research · doi:10.1161/01.res.0000243586.99701.cf · Cited by 453 · see citing works
Deletion of LOX-1 Reduces Atherogenesis in LDLR Knockout Mice Fed High Cholesterol Diet
Mehta, J. L., Sanada, N., Hu, C. P., Chen, J., Dandapat, A., Sugawara, F., Satoh, H., Inoue, K., Kawase, Y., Jishage, K.-I., et al. (2007) · Circulation Research · doi:10.1161/circresaha.107.149724 · Cited by 444 · see citing works
Hypolipidemic, Antioxidant, and Antiinflammatory Activities of Microalgae <i>Spirulina</i>
Deng, R., & Chow, T. (2010) · Cardiovascular Therapeutics · doi:10.1111/j.1755-5922.2010.00200.x · Cited by 435 · see citing works
Simvastatin Versus Ezetimibe
Landmesser, U., Bahlmann, F. H., Mueller, M. F., Spiekermann, S., Kirchhoff, N., Schulz, S., Manes, C., Fischer, D., de Groot, K., Fliser, D., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164260.82417.3f · Cited by 425 · see citing works
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Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men
Loke, W. M., Hodgson, J. M., Proudfoot, J. M., McKinley, A. J., Puddey, I. B., & Croft, K. D. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1018 · Cited by 372 · see citing works
Kruppel-Like Factor 2 as a Novel Mediator of Statin Effects in Endothelial Cells
SenBanerjee, S., Mir, S. S., Lin, Z., Hamik, A., Atkins, G. B., Das, H., Banerjee, P., Kumar, A., & Jain, M. K. (2005) · Circulation · doi:10.1161/circulationaha.104.525774 · Cited by 348 · see citing works
Altered Activation of Endothelial Anti- and Proapoptotic Pathways by High-Density Lipoprotein from Patients with Coronary Artery Disease: Role of High-Density Lipoprotein–Proteome Remodeling
Riwanto, M., Rohrer, L., Roschitzki, B., Besler, C., Mocharla, P., Mueller, M., Perisa, D., Heinrich, K., Altwegg, L., von Eckardstein, A., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.108753 · Cited by 337 · see citing works
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The Determinants of Endothelial Dysfunction in CKD: Oxidative Stress and Asymmetric Dimethylarginine
Yılmaz, M. İ., Sağlam, M., Çağlar, K., Çakır, E., Sönmez, A., Özgürtaş, T., Aydın, A., Eyileten, T., Özcan, Ö., Açıkel, C., et al. (2005) · American Journal of Kidney Diseases · doi:10.1053/j.ajkd.2005.09.029 · Cited by 331 · see citing works
Oxidant Stress Impairs In Vivo Reendothelialization Capacity of Endothelial Progenitor Cells From Patients With Type 2 Diabetes Mellitus
Sorrentino, S. A., Bahlmann, F. H., Besler, C., Müller, M. F., Schulz, S., Kirchhoff, N., Doerries, C., Horváth, T., Limbourg, A., Limbourg, F. P., et al. (2007) · Circulation · doi:10.1161/circulationaha.106.684381 · Cited by 318 · see citing works
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Organs-on-chips: breaking the in vitro impasse
van der Meer, A. D., & van den Berg, A. (2012) · Integrative Biology · doi:10.1039/c2ib00176d · Cited by 321 · see citing works
Abnormal High-Density Lipoprotein Induces Endothelial Dysfunction via Activation of Toll-like Receptor-2
Speer, T., Rohrer, L., Blyszczuk, P., Shroff, R., Kuschnerus, K., Kränkel, N., Kania, G., Zewinger, S., Akhmedov, A., Shi, Y., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.009 · Cited by 310 · see citing works
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Osteoprotegerin, vascular calcification and atherosclerosis
Campenhout, A. V., & Golledge, J. (2008) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.09.033 · Cited by 309 · see citing works
Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients
Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298 · see citing works
Physiological Diagnostic Criteria for Vascular Failure
Tanaka, A., Tomiyama, H., Maruhashi, T., Matsuzawa, Y., Miyoshi, T., Kabutoya, T., Kario, K., Sugiyama, S., Munakata, M., Ito, H., et al. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11554 · Cited by 280 · see citing works
Prognostic Role of Flow-Mediated Dilation and Cardiac Risk Factors in Post-Menopausal Women
Rossi, R., Nuzzo, A., Origliani, G., & Modena, M. G. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.11.044 · Cited by 277 · see citing works
A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan
Mohammed, I., Hollenberg, M. D., Ding, H., & Triggle, C. R. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.718942 · Cited by 278 · see citing works
Particulate air pollution, systemic oxidative stress, inflammation, and atherosclerosis
Araujo, J. A. (2010) · Air Quality Atmosphere & Health · doi:10.1007/s11869-010-0101-8 · Cited by 269 · see citing works
Exposure to Fine Particulate Air Pollution Causes Vascular Insulin Resistance by Inducing Pulmonary Oxidative Stress
Haberzettl, P., O’Toole, T. E., Bhatnagar, A., & Conklin, D. J. (2016) · Environmental Health Perspectives · doi:10.1289/ehp212 · Cited by 263 · see citing works
Postprandial lipemia and cardiovascular disease risk: interrelationships between dietary, physiological and genetic determinants
Jackson, K. G., Poppitt, S. D., & Minihane, A. M. (2012) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2011.08.012 · Cited by 246 · see citing works
Sterol Regulatory Element Binding Protein 2 Activation of NLRP3 Inflammasome in Endothelium Mediates Hemodynamic-Induced Atherosclerosis Susceptibility
Xiao, H., Lu, M., Lin, T. Y., Chen, Z., Chen, G., Wang, W.-C., Marin, T., Shentu, T.-P., Wen, L., Gongol, B., et al. (2013) · Circulation · doi:10.1161/circulationaha.113.002714 · Cited by 257 · see citing works
Resistin is secreted from macrophages in atheromas and promotes atherosclerosis
JUNG, H., Park, K. S., CHO, Y., CHUNG, S., Cho, S., CHO, S., Kim, S. J., KIM, S., LEE, H., & Park, K. S. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2005.09.015 · Cited by 260 · see citing works
Evidence for a protective effect of polyphenols-containing foods on cardiovascular health: an update for clinicians
Habauzit, V., & Morand, C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311430006 · Cited by 260 · see citing works
Vascular Pathophysiology in Response to Increased Heart Rate
Custodis, F., Schirmer, S. H., Baumhäkel, M., Heusch, G., Böhm, M., & Laufs, U. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.09.014 · Cited by 242 · see citing works
ANGPTL4 in Metabolic and Cardiovascular Disease
Aryal, B. K., Price, N. L., Suárez, Y., & Fernandez-Hernando, C. F. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.05.010 · Cited by 237 · see citing works
Purified Anthocyanin Supplementation Improves Endothelial Function via NO-cGMP Activation in Hypercholesterolemic Individuals
Zhu, Y., Xia, M., Yang, Y., Liu, F., Li, Z., Hao, Y., Mi, M., Jin, T., & Ling, W. (2011) · Clinical Chemistry · doi:10.1373/clinchem.2011.167361 · Cited by 224 · see citing works
Molecular mechanisms of vascular effects of High‐density lipoprotein: alterations in cardiovascular disease
Besler, C., Lüscher, T. F., & Landmesser, U. (2012) · EMBO Molecular Medicine · doi:10.1002/emmm.201200224 · Cited by 219 · see citing works
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Activation of Vascular Protein Kinase C-β Inhibits Akt-Dependent Endothelial Nitric Oxide Synthase Function in Obesity-Associated Insulin Resistance
Naruse, K., Rask‐Madsen, C., Takahara, N., Ha, S. W., Suzuma, K., Way, K. J., Jacobs, J. R. C., Clermont, A. C., Ueki, K., Ohshiro, Y., et al. (2006) · Diabetes · doi:10.2337/diabetes.55.03.06.db05-0771 · Cited by 220 · see citing works
Activation of endothelial nitric oxide synthase by cilostazol via a cAMP/protein kinase A- and phosphatidylinositol 3-kinase/Akt-dependent mechanism
Hashimoto, A., Miyakoda, G., Hirose, Y., & Mori, T. (2006) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2006.01.022 · Cited by 216 · see citing works
Angiotensin II Induces Endothelial Xanthine Oxidase Activation: Role for Endothelial Dysfunction in Patients With Coronary Disease
Landmesser, U., Spiekermann, S., Preuss, C., Sorrentino, S., Fischer, D., Manes, C., Mueller, M., & Drexler, H. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000258415.32883.bf · Cited by 210 · see citing works
Self-citation
Sympathetic Nervous System Activity Is Associated With Obesity-Induced Subclinical Organ Damage in Young Adults
Lambert, E., Sari, C. I., Dawood, T., Nguyen, J., McGrane, M., Eikelis, N., Chopra, R., Wong, C., Chatzivlastou, K., Head, G., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.110.155663 · Cited by 209 · see citing works
Cilostazol: Potential mechanism of action for antithrombotic effects accompanied by a low rate of bleeding
Goto, S. (2005) · Atherosclerosis Supplements · doi:10.1016/j.atherosclerosissup.2005.09.002 · Cited by 201 · see citing works
Uric Acid Restores Endothelial Function in Patients With Type 1 Diabetes and Regular Smokers
Waring, W. S., McKnight, J. A., Webb, D. J., & Maxwell, S. R. J. (2006) · Diabetes · doi:10.2337/db06-0283 · Cited by 200 · see citing works
Impaired Endothelial Repair Capacity of Early Endothelial Progenitor Cells in Prehypertension
Giannotti, G., Doerries, C., Mocharla, P. S., Mueller, M. F., Bahlmann, F. H., Horváth, T., Jiang, H., Sorrentino, S. A., Steenken, N., Manes, C., et al. (2010) · Hypertension · doi:10.1161/hypertensionaha.109.141614 · Cited by 196 · see citing works
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Programmed Shape‐Morphing Scaffolds Enabling Facile 3D Endothelialization
Zhao, Q., Wang, J., Cui, H., Chen, H., Wang, Y., & Du, X. (2018) · Advanced Functional Materials · doi:10.1002/adfm.201801027 · Cited by 196 · see citing works
Gamma‐glutamyltransferase—friend or foe within?
Kunutsor, S. K. (2016) · Liver International · doi:10.1111/liv.13221 · Cited by 193 · see citing works
Mechanisms of endothelial dysfunction in obesity.
Avogaro, A., & de Kreutzenberg, S. V. (2005) · Clinica Chimica Acta · doi:10.1016/j.cccn.2005.04.020 · Cited by 188 · see citing works
Predictors of Endothelial Dysfunction in Young Women with Polycystic Ovary Syndrome
Kravariti, M., Naka, K. Κ., Kalantaridou, S., Kazakos, N., Katsouras, C. S., Makrigiannakis, A., Paraskevaidis, E. A., Chrousos, G. P., Tsatsoulis, A. A., & Michalis, L. K. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0151 · Cited by 188 · see citing works
Flavonoid-rich fruit and vegetables improve microvascular reactivity and inflammatory status in men at risk of cardiovascular disease—FLAVURS: a randomized controlled trial
Macready, A. L., George, T. W., Chong, M. F., Alimbetov, D., Jin, Y., Vidal‐Diez, A., Spencer, J. P. E., Kennedy, O. B., Tuohy, K. M., Minihane, A. M., et al. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.113.074237 · Cited by 192 · see citing works
The human long noncoding RNA lnc‐ IL 7 R regulates the inflammatory response
Cui, H., Xie, N., Tan, Z., Banerjee, S., Thannickal, V. J., Abraham, E. H., & Liu, G. (2014) · European Journal of Immunology · doi:10.1002/eji.201344126 · Cited by 183 · see citing works
Imaging residual inflammatory cardiovascular risk
Antoniades, C. A., Antonopoulos, A. S., & Deanfield, J. E. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz474 · Cited by 181 · see citing works
Insulin says NO to cardiovascular disease
Yu, Q., Gao, F., & Ma, X. L. (2011) · Cardiovascular Research · doi:10.1093/cvr/cvq349 · Cited by 172 · see citing works
ACE2–angiotensin-(1–7)–Mas axis and oxidative stress in cardiovascular disease
Rabelo, L. A., Alenina, N. V., & Bäder, M. (2010) · Hypertension Research · doi:10.1038/hr.2010.235 · Cited by 171 · see citing works
Advanced glycation end-products decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells
Ren, X., Ren, L., Qin, W. D., Shao, H., Chen, L., & Liu, N. (2017) · Cardiovascular Diabetology · doi:10.1186/s12933-017-0531-9 · Cited by 169 · see citing works
Endothelial progenitor cells correlate with endothelial function in patients with coronary artery disease
Werner, N., Waßmann, S., Ahlers, P., Schiegl, T., Kosiol, S., Link, A., Walenta, K. L. H., & Nickenig, G. (2007) · Basic Research in Cardiology · doi:10.1007/s00395-007-0680-1 · Cited by 169 · see citing works
High density lipoproteins and endothelial functions: mechanistic insights and alterations in cardiovascular disease
Riwanto, M., & Landmesser, U. (2013) · Journal of Lipid Research · doi:10.1194/jlr.r037762 · Cited by 169 · see citing works
Self-citation
Edaravone (3-Methyl-1-Phenyl-2-Pyrazolin-5-one), A Novel Free Radical Scavenger, for Treatment of Cardiovascular Diseases
Higashi, Y., Jitsuiki, D., Chayama, K., & Yoshizumi, M. (2006) · Recent Advances in Cardiovascular Drug Discovery (Formerly Recent Patents on Cardiovascular Drug Discovery) · doi:10.2174/157489006775244191 · Cited by 165 · see citing works
The forgotten face of regular physical exercise: a ‘natural’ anti-atherogenic activity
Szostak, J., & Laurant, P. (2011) · Clinical Science · doi:10.1042/cs20100520 · Cited by 163 · see citing works
Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis
Lara, J., Ashor, A. W., Oggioni, C., Ahluwalia, A., Mathers, J. C., & Siervo, M. (2016) · European Journal of Nutrition · doi:10.1007/s00394-015-0872-7 · Cited by 163 · see citing works
Menopause and Ovariectomy Cause a Low Grade of Systemic Inflammation that May Be Prevented by Chronic Treatment with Low Doses of Estrogen or Losartan
Abu-Taha, M. I., Rius, C., Hermenegildo, C., Noguera, I., Cerdá‐Nicolás, M., Issekutz, A. C., Jose, P. J., Cortijo, J., Morcillo, E. J., & Sanz, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803157 · Cited by 161 · see citing works
Vascular adaptation to deconditioning and the effect of an exercise countermeasure: results of the Berlin Bed Rest study
Bleeker, M. W. P., de Groot, P. C. E., Rongen, G. A. P. J. M., Rittweger, J., Felsenberg, D., Smits, P., & Hopman, M. T. E. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00118.2005 · Cited by 160 · see citing works
Inflammation and Atherosclerosis
Kaperonis, E. A., Liapis, C. D., Kakisis, J. D., Dimitroulis, D., & Papavassiliou, V. G. (2005) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2005.11.001 · Cited by 152 · see citing works
Astaxanthin from Haematococcus pluvialis Prevents Oxidative Stress on Human Endothelial Cells without Toxicity
Régnier, P., Bastias, J., Rodriguez‐Ruiz, V., Caballero‐Casero, N., Caballo, C., Sicilia, M. D., Fuentes, A., Maire, M., Crépin, M., Letourneur, D., et al. (2015) · Marine Drugs · doi:10.3390/md13052857 · Cited by 152 · see citing works
Endothelial function and hypertension
Landmesser, U., & Drexler, H. (2007) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3281ca710d · Cited by 152 · see citing works
Self-citation
Thrombospondin-1 supports blood pressure by limiting eNOS activation and endothelial-dependent vasorelaxation
Bauer, E. M., Yan, Q., Miller, T. W., Bandle, R., Csányi, G., Pagano, P. J., Bauer, P. M., Schnermann, J. B., Roberts, D. D., & Isenberg, J. S. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq218 · Cited by 152 · see citing works
Neuronal nitric oxide synthase and human vascular regulation
Melikian, N., Seddon, M. D., Casadei, B., Chowienczyk, P. J., & Shah, A. M. (2009) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2010.02.007 · Cited by 151 · see citing works
Green tea (Camellia sinensis) catechins and vascular function
Moore, R. J., Jackson, K. G., & Minihane, A. M. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991218 · Cited by 149 · see citing works
Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis
Herman, A. G., & Moncada, S. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi333 · Cited by 150 · see citing works
Small Concentrations of oxLDL Induce Capillary Tube Formation From Endothelial Cells via LOX-1–Dependent Redox-Sensitive Pathway
Dandapat, A., Hu, C., Sun, L., & Mehta, J. L. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.152272 · Cited by 148 · see citing works
Aged garlic extract supplemented with B vitamins, folic acid and l-arginine retards the progression of subclinical atherosclerosis: A randomized clinical trial
Budoff, M. J., Ahmadi, N., Gul, K. M., Liu, S. T., Flores, F. R., Tiano, J., Takasu, J., Miller, E. R., & Tsimikas, S. (2009) · Preventive Medicine · doi:10.1016/j.ypmed.2009.06.018 · Cited by 147 · see citing works
Statins as Regulators of Redox State in the Vascular Endothelium: Beyond Lipid Lowering
Margaritis, M., Channon, K. M., & Antoniades, C. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5430 · Cited by 144 · see citing works
Circulating Progenitor Cells Are Reduced in Patients with Severe Lung Disease
Fadini, G. P., Schiavon, M., Cantini, M., Baesso, I., Facco, M., Miorin, M., Tassinato, M., de Kreutzenberg, S. V., Avogaro, A., & Agostini, C. (2006) · Stem Cells · doi:10.1634/stemcells.2005-0440 · Cited by 144 · see citing works
Mathematical modelling of atheroma plaque formation and development in coronary arteries
Cilla, M., Peña, E., & Martínez, M. Á. (2013) · Journal of The Royal Society Interface · doi:10.1098/rsif.2013.0866 · Cited by 144 · see citing works
Adiponectin Blocks Interleukin-18-mediated Endothelial Cell Death via APPL1-dependent AMP-activated Protein Kinase (AMPK) Activation and IKK/NF-κB/PTEN Suppression
Chandrasekar, B., Boylston, W. H., Venkatachalam, K., Webster, N. J. G., Prabhu, S. D., & Valente, A. J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804236200 · Cited by 143 · see citing works
The vasa vasorum in diseased and nondiseased arteries
Mulligan‐Kehoe, M. J. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00884.2009 · Cited by 143 · see citing works
Cardiovascular diseases related to ionizing radiation: The risk of low-dose exposure (Review)
Baselet, B., Rombouts, C., Benotmane, M. A., Baatout, S., & Aerts, A. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2777 · Cited by 144 · see citing works
An Increased Osteoprotegerin Serum Release Characterizes the Early Onset of Diabetes Mellitus and May Contribute to Endothelial Cell Dysfunction
Secchiero, P., Corallini, F., Pandolfi, A., Consoli, A., Candido, R., Fabris, B., Celeghini, C., Capitani, S., & Zauli, G. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.060398 · Cited by 144 · see citing works
The clinical significance of endothelial dysfunction
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Authors: Landmesser, U., Hornig, B., & Drexler, H.
Affiliations: Medizinische Hochschule Hannover (DE)
ORCID: Landmesser, Ulf
Venue: Circulation
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2004-06
Volume: 109
Issue: 21_suppl_1
Pages: II27-33
ISSN: 0009-7322 (ISSN-L)
1524-4539
DOI: 10.1161/01.cir.0000129501.88485.1f
OpenAlex: W2163221788
Cited by: 851
References: 78
Citations by year: 2026: 10 · 2025: 10 · 2024: 10 · 2023: 16 · 2022: 11 · 2021: 29 · 2020: 27 · 2019: 20 · 2018: 38 · 2017: 42 · 2016: 47 · 2015: 44 · 2014: 47 · 2013: 59 · 2012: 42
FWCI: 35.77
Type: journal article
Language: en
Open access: closed
Locations: Circulation (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Keywords: endothelial dysfunction, endothelial function, atherosclerosis, endothelium-dependent vasodilation, nitric oxide, reactive oxygen species, inflammation, C-reactive protein, plasminogen activator inhibitor-1, hypertension, hypercholesterolemia, diabetes mellitus, smoking, cardiovascular risk prediction
MeSH terms: Animals, Arteriosclerosis, Endothelium, Vascular, Humans, Inflammation, Models, Cardiovascular, Nitric Oxide, Prognosis, Thrombosis, Reactive Oxygen Species, Mice

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Endothelial Function: A Critical Determinant in Atherosclerosis?

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