The DOI matches its Crossref record.
Effects of Autonomic Blockade on the Baroreflex in Man at Rest and During Exercise
Abstract
The reflex bradycardia produced by a transient phenylephrine-induced rise of arterial pressure was investigated in man during rest and supine exercise, before and after autonomic blockade of the heart. Reflex bradycardia diminished proportionally to the tachycardia of exercise. Propranolol slowed the heart at rest and during exercise, but increased the reflex response only at rest, having no effect during exercise. Atropine, or atropine with propranolol, blocked the reflex during rest and exercise. The tachycardia following hypotension induced by amyl nitrite was similarly affected by the two drugs. Tachycardia induced by standing up and by isoprenaline also diminished the reflex bradycardia. It is concluded that reflex heart rate changes following sudden changes of arterial pressure are predominantly parasympathetic, and diminish during exercise in parallel with the decrease of parasympathetic tone. The reflex response is determined partly by the interaction of parasympathetic and sympathetic impulses at the sinoatrial node, shown by the effects of peripheral sympathetic stimulation and blockade at rest. During exercise central depression of the reflex may also occur.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Imai, K., Sato, H., Hori, M., Kusuoka, H., Ozaki, H., Yokoyama, H., Takeda, H., Inoue, M., & Kamada, T. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90150-3 · Cited by 991
Hemodynamic fluctuations and baroreflex sensitivity in humans: a beat-to-beat model
deBoer, R. W., Karemaker, J. M., & Strackee, J. (1987) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1987.253.3.h680 · Cited by 851
Arterial Baroreflexes in Humans
Mancia, G., & Mark, A. L. (1983) · Comprehensive Physiology · doi:10.1002/cphy.cp020320 · Cited by 292
GROSSMAN, P., & KOLLAI, M. (1993) · Psychophysiology · doi:10.1111/j.1469-8986.1993.tb02072.x · Cited by 250
Autonomic Control of the Aging Heart
Kaye, D. M., & Esler, M. D. (2008) · NeuroMolecular Medicine · doi:10.1007/s12017-008-8034-1 · Cited by 92
Metadata
- Authors
- PICKERING, T. G., GRIBBIN, B., PETERSEN, E. S., CUNNINGHAM, D. J. C., & SLEIGHT, P.
- Venue
- Circulation Research
- Published
- 1972-02
- Volume
- 30
- Issue
- 2
- Pages
- 177-185
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2159666046
- Cited by
- 230
- References
- 0
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effects of Autonomic Blockade on the Baroreflex in Man at Rest and During Exercise. https://app.cochat.ai/papers/10.1161/01.res.30.2.177
- The paper
- PICKERING, T. G., GRIBBIN, B., PETERSEN, E. S., CUNNINGHAM, D. J. C., & SLEIGHT, P. (1972). Effects of Autonomic Blockade on the Baroreflex in Man at Rest and During Exercise. Circulation Research. https://doi.org/10.1161/01.res.30.2.177
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
