Cited by 593Heart Rate Variability and Autonomic ControlCardiovascular Syncope and Autonomic DisordersBlood Pressure and Hypertension Studies

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Role of the Baroreceptor Reflex in Daily Control of Arterial Blood Pressure and Other Variables in Dogs

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COWLEY, ALLEN W., LIARD, JEAN FRANCOIS, GUYTON, ARTHUR C.·1973·Circulation Research

DOI 10.1161/01.res.32.5.564

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Abstract

Normal and sinoaortic baroreceptor-denervated dogs were monitored continuously (24 hours a day) to quantify the role of the baroreceptors in determining the average level and the variability of arterial blood pressure, heart rate, cardiac output, and total peripheral resistance. The frequency of occurrence over 24-hour periods was obtained for each variable using a fiber optic curve-scanning system to read the variables from continuously recorded charts and a digital computer system to plot curves. The results indicate that the degree of hypertension previously reported for this preparation has been highly exaggerated, presumably due to the methods of study. The average 24-hour mean arterial blood pressure was 101.6 mm Hg in normal dogs and only 112.7 mm Hg in baroreceptor-denervated dogs. The normal dogs exhibited narrowly distributed 24-hour frequency distribution curves for blood pressure; in contrast the denervated dogs exhibited curves with twice the 24-hour standard deviation. Similar analysis indicated that the baroreceptors exerted less influence on the daily stabilization of heart rate than they did on arterial blood pressure and that they had very little if any influence on the daily stabilization of cardiac output and total peripheral resistance. Hemodynamic variables during postural changes were studied along with diurnal rhythms. We concluded that the primary function of the baroreceptor reflex is not to set the chronic level of arterial blood pressure but, instead, to minimize variations in systemic arterial blood pressure, whether these variations are caused by postural changes of the animal, excitement, diurnal rhythm, or even spontaneous fluctuations of unknown origin.

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Authors: COWLEY, A. W., LIARD, J. F., & GUYTON, A. C.
Affiliations: University of Mississippi Medical Center (US)
ORCID: COWLEY, ALLEN W.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 1973-05
Volume: 32
Issue: 5
Pages: 564-576
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/01.res.32.5.564
OpenAlex: W2163685664
Cited by: 593
References: 34
Citations by year: 2026: 3 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 15 · 2012: 17
FWCI: 9.81
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: baroreflex, sinoaortic denervation, blood pressure regulation, blood pressure variability, heart rate, cardiac output, systemic vascular resistance, diurnal cycle, postural changes, hypertension, dogs
MeSH terms: Analog-Digital Conversion, Animals, Aorta, Blood Flow Velocity, Blood Pressure, Cardiac Output, Carotid Sinus, Circadian Rhythm, Computers, Denervation, Dogs, Heart Rate, Posture, Potassium, Pressoreceptors, Pulse, Radioimmunoassay, Renin, Sodium, Time Factors, Vagotomy, Vascular Resistance

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Role of the Baroreceptor Reflex in Daily Control of Arterial Blood Pressure and Other Variables in Dogs

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