The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Role of the Baroreceptor Reflex in Daily Control of Arterial Blood Pressure and Other Variables in Dogs
Open accessAbstract
Normal and sinoaortic baroreceptor-denervated dogs were monitored continuously (24 hours a day) to quantify the role of the baroreceptors in determining the average level and the variability of arterial blood pressure, heart rate, cardiac output, and total peripheral resistance. The frequency of occurrence over 24-hour periods was obtained for each variable using a fiber optic curve-scanning system to read the variables from continuously recorded charts and a digital computer system to plot curves. The results indicate that the degree of hypertension previously reported for this preparation has been highly exaggerated, presumably due to the methods of study. The average 24-hour mean arterial blood pressure was 101.6 mm Hg in normal dogs and only 112.7 mm Hg in baroreceptor-denervated dogs. The normal dogs exhibited narrowly distributed 24-hour frequency distribution curves for blood pressure; in contrast the denervated dogs exhibited curves with twice the 24-hour standard deviation. Similar analysis indicated that the baroreceptors exerted less influence on the daily stabilization of heart rate than they did on arterial blood pressure and that they had very little if any influence on the daily stabilization of cardiac output and total peripheral resistance. Hemodynamic variables during postural changes were studied along with diurnal rhythms. We concluded that the primary function of the baroreceptor reflex is not to set the chronic level of arterial blood pressure but, instead, to minimize variations in systemic arterial blood pressure, whether these variations are caused by postural changes of the animal, excitement, diurnal rhythm, or even spontaneous fluctuations of unknown origin.
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“we confirm that either acute nitrate supplementation or chronic citrulline supplementation decreased mean arterial pressure and diastolic pressure, implying a decrease in total peripheral resistance (Cowley et al. 1973).”
From Oral nitrate and citrulline decrease blood pressure and increase vascular conductance in young adults: a potential therapy for heart failure (2016) · cites this paper as Cowley et al. 1973
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Haber, E., KOERNER, T., Page, L. B., Kliman, B., & PURNODE, A. (1969) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-29-10-1349 · Cited by 2,222
Guyton, A., Coleman, T. G., Cowley, A. W., Scheel, K., Manning, R., & Norman, R. A. (1972) · American Journal of Medicine · doi:10.1016/0002-9343(72)90050-2 · Cited by 1,110
Self-citationReflexogenic Areas of the Cardiovascular System
Heymans, C. (1960) · Perspectives in biology and medicine · doi:10.1353/pbm.1960.0038 · Cited by 703
Folkow, B., GRIYBY, G., & Thulesius, O. (1958) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1958.tb01626.x · Cited by 507
Wolinsky, H. (1972) · Circulation Research · doi:10.1161/01.res.30.3.301 · Cited by 322
VARIATION IN ARTERIAL PRESSURE THROUGHOUT THE DAY AND NIGHT.
Richardson, D. C., Honour, A. J., Fenton, G., Stott, F. H., & Pickering, G. W. (1964) · PubMed · Cited by 241
Servoanalysis of Carotid Sinus Reflex Effects on Peripheral Resistance
Scher, A. M., & Young, A. C. (1963) · Circulation Research · doi:10.1161/01.res.12.2.152 · Cited by 169
Cushing, H. (1903) · The American Journal of the Medical Sciences · doi:10.1097/00000441-190306000-00006 · Cited by 139
Comparison of Afferent Activity of Canine Aortic and Sinus Nerves
Pelletier, C. L., Clement, D. L., & Shepherd, J. T. (1972) · Circulation Research · doi:10.1161/01.res.31.4.557 · Cited by 90
Granger, H. J., & Guyton, A. C. (1969) · Circulation Research · doi:10.1161/01.res.25.4.379 · Cited by 83
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Research works printed but not linked: 1
- SACAWA, K.: Analysis of the CNS ischemic feedback regulation of the circulation. In Physical Bases of Circulatory Transport Regulation and Exchange edited by A. C. Guyton and A. A. Reeves. Philadelphia, W. B. Saunders Company, 1967, p 129.
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Pickering, T. G., Hall, J. E., Appel, L. J., Falkner, B. E., Graves, J., Hill, M. N., Jones, D. W., Kurtz, T., Sheps, S. G., & Roccella, E. J. (2005) · Hypertension · doi:10.1161/01.hyp.0000150859.47929.8e · Cited by 2,051
Parati, G., Saul, J. P., Di Rienzo, M., & Mancia, G. (1995) · Hypertension · doi:10.1161/01.hyp.25.6.1276 · Cited by 849
Blood pressure and heart rate variabilities in normotensive and hypertensive human beings.
Mancia, G., Ferrari, A. U., Gregorini, L., Parati, G., Pomidossi, G. A., Bertinieri, G., Grassi, G. M., Rienzo, M. D., Pedotti, A., & Zanchetti, A. (1983) · Circulation Research · doi:10.1161/01.res.53.1.96 · Cited by 770
Baroreflex Sensitivity: Measurement and Clinical Implications
Rovere, M. T. L., Pinna, G. D., & Raczak, G. (2008) · Annals of Noninvasive Electrocardiology · doi:10.1111/j.1542-474x.2008.00219.x · Cited by 663
Human responses to upright tilt: a window on central autonomic integration
Cooke, W. H., Hoag, J. B., Crossman, A. A., Kuusela, T., Tahvanainen, K. U. O., & Eckberg, D. L. (1999) · The Journal of Physiology · doi:10.1111/j.1469-7793.1999.0617t.x · Cited by 501
Metadata
- Authors
- COWLEY, A. W., LIARD, J. F., & GUYTON, A. C.
- Affiliations
- University of Mississippi Medical Center (US)
- ORCID
- COWLEY, ALLEN W.
- Venue
- Circulation Research
- Published
- 1973-05
- Volume
- 32
- Issue
- 5
- Pages
- 564-576
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2163685664
- Cited by
- 593
- References
- 34
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 8 · 2023: 3 · 2022: 9 · 2021: 15 · 2020: 6 · 2019: 11 · 2018: 10 · 2017: 12 · 2016: 15 · 2015: 13 · 2014: 18 · 2013: 15 · 2012: 17
- FWCI
- 9.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- baroreflex, sinoaortic denervation, blood pressure regulation, blood pressure variability, heart rate, cardiac output, systemic vascular resistance, diurnal cycle, postural changes, hypertension, dogs
- MeSH terms
- Analog-Digital Conversion, Animals, Aorta, Blood Flow Velocity, Blood Pressure, Cardiac Output, Carotid Sinus, Circadian Rhythm, Computers, Denervation, Dogs, Heart Rate, Posture, Potassium, Pressoreceptors, Pulse, Radioimmunoassay, Renin, Sodium, Time Factors, Vagotomy, Vascular Resistance
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