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Assessment of Passive Elastic Stiffness for Isolated Heart Muscle and the Intact Heart
Open accessAbstract
A sensitive method was developed for detecting stiffness changes in the left ventricle. Stress-strain relationships (σ--ε) were obtained in the form dσ/dε = kσ + c from published studies on eight normal canine hearts, five infarcted canine hearts, and seven isolated cat papillary muscles. Utilizing pressure-volume relationships, the elastic stiffness (dσ/dε) and the stiffness constant ( k ) were also evaluated in patients with normal ventricles, inappropriate hypertrophy, and congestive cardiomyopathy. The k values were 35.0 ± 1.7 (isolated muscle, 30°C), 37.3 ± 1.9 (normal canine, 23°C), and 23.9 (infarcted). For the patient groups, k and the passive elastic stiffness were 15.8 ± 0.3 and 249 ± 22.4 g/cm 2 for 13 normal patients, 26.4 ± 1.7 and 286 ± 32.0 g/cm 2 for 7 patients with inappropriate hypertrophy, and 20.1 ± 1.2 and 1360 ± 209 g/cm 2 for 6 patients with congestive cardiomyopathy. The results indicate that (1) k is sensitive to stiffness changes due to infarction, (2) hypertrophy causes an increase in the value of k although elastic stiffness remains within normal limits, and (3) k for the intact human heart is lower than it is for isolated muscle.
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Cited by
Black, L. D., Meyers, J. D., Weinbaum, J. S., Shvelidze, Y. A., & Tranquillo, R. T. (2009) · Tissue Engineering Part A · doi:10.1089/ten.tea.2008.0502 · Cited by 161
Image-Based Predictive Modeling of Heart Mechanics
Wang, V. Y., Nielsen, P. M. F., & Nash, M. P. (2015) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-071114-040609 · Cited by 63
Metadata
- Authors
- MIRSKY, I., & PARMLEY, W. W.
- Venue
- Circulation Research
- Published
- 1973-08
- Volume
- 33
- Issue
- 2
- Pages
- 233-243
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2131576310
- Cited by
- 400
- References
- 0
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- bronze
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- MIRSKY, I., & PARMLEY, W. W. (1973). Assessment of Passive Elastic Stiffness for Isolated Heart Muscle and the Intact Heart. Circulation Research. https://doi.org/10.1161/01.res.33.2.233
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