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Cited by 340Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlCardiovascular and exercise physiology

The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.

Human Splanchnic and Forearm Vasoconstrictor Responses to Reductions of Right Atrial and Aortic Pressures

JOHNSON, JOHN M., ROWELL, LORING B., NIEDERBERGER, MANFRED, EISMAN, MARTIN M.·1974·Circulation Research
DOI 10.1161/01.res.34.4.515
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Abstract

Regional vascular responses to gradual reductions in right atrial pressure and aortic pressure were investigated in nine men. In each study, lower body negative pressure was applied in a ramp of -1 mm Hg/min for 40-50 minutes. During the range from control to -20 mm Hg, right atrial pressure (4 studies) fell from 4.2 mm Hg to -0.6 mm Hg; heart rate was slightly reduced (2 beats/min), and aortic mean pressure and pulse pressure (6 studies) were unchanged. The maximal rate of rise of aortic pressure showed no consistent trends. Forearm blood flow (30 studies) fell with the onset of lower body negative pressure and reached 67% of the control value by -20 mm Hg. Splanchnic blood flow (14 studies) was significantly reduced by -7 mm Hg and fell to 89% of control by -20 mm Hg. During the range from -20 to -50 mm Hg, right atrial pressure continued to fall. Aortic mean pressure fell slightly or was unchanged in four subjects and fell dramatically at -35 mm Hg in two subjects. Aortic pulse pressure began to fall at about -20 mm Hg and fell linearly thereafter. Heart rate paralleled aortic pulse pressure ( r = -0.86 to -0.93). Forearm blood flow fell to 55% and splanchnic blood flow fell to 65% of control at -50 mm Hg. Thus, significant vasoconstriction occurred without measurable change in arterial blood pressure. We concluded that low-pressure baroreceptors, presumably in the cardiopulmonary region, initiate splanchnic and forearm vasoconstriction with more pronounced vasoconstrictio…

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Crossref · 10.1161/01.res.34.4.515

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Metadata

Authors
JOHNSON, J. M., ROWELL, L. B., NIEDERBERGER, M., & EISMAN, M. M.
Affiliations
University of Washington (US)
Venue
Circulation Research
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1974-04
Volume
34
Issue
4
Pages
515-524
ISSN
  • 0009-7330 (ISSN-L)
  • 1524-4571
DOI
10.1161/01.res.34.4.515
OpenAlex
W2044267482
Cited by
340
References
28
Citations by year
2026: 1 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 6 · 2019: 2 · 2018: 8 · 2017: 2 · 2016: 3 · 2015: 9 · 2014: 6 · 2013: 6 · 2012: 1
FWCI
5.43
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
splanchnic vasoconstriction, right atrial pressure, aortic pressure, lower body negative pressure, baroreceptors, cardiopulmonary baroreflex, regional blood flow, aortic pulse pressure, heart rate, hypotension
MeSH terms
Abdomen, Adult, Aorta, Thoracic, Blood Pressure, Forearm, Heart Rate, Homeostasis, Humans, Male, Pressoreceptors, Pulse, Regional Blood Flow, Vasomotor System, Atrial Function

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