The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Mechanisms of glycolytic inhibition in ischemic rat hearts.
Open accessAbstract
The mechanisms of glycolytic inhibition in ischemic myocardium were investigated in the isolated, perfused rat heart. Glycolysis was inhibited at the level of glyceraldehyde-3-phosphate dehydrogenase. The major factors that accounted for the glycolytic inhibition in the ischemic heart compared with the anoxic heart appeared to be higher tissue levels of lactate and H+ in the ischemic tissue. Increased extracellular pH inhibited glycolysis in anoxic and hypoxic hearts much more readily than it did in aerobic hearts. However, maintenance of both extracellular and intracellular pH caused only a modest acceleration of glycolysis in ischemic hearts. Accumulation of tissue lactate and inhibition of glycolysis were directly proportional to the reduction in coronary bloow flow in both anoxic and ischemic hearts. At intracellular lactate concentrations between 15 and 20 mM, glycolysis was inhibited under both conditions. Addition of either 10, 20, or 40 mM lactate to the perfusate inhibited glycolysis in aerobic, anoxic, and ischemic hearts. The effect of lactate did not appear to be mediated through changes in intracellular pH. It is concluded that accumulation of lactate represents a major factor in the inhibition of glycolysis that develops in ischemic hearts.
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Cites
Merritt, A. J. (1964) · Microchemical Journal · doi:10.1016/0026-265x(64)90139-0 · Cited by 5,166
Williamson, D., Lund, P., & Krebs, H. (1967) · Biochemical Journal · doi:10.1042/bj1030514 · Cited by 1,871
Relationship Between Carbohydrate and Lipid Metabolism and the Energy Balance of Heart Muscle
Neely, J. R., & Morgan, H. E. (1974) · Annual Review of Physiology · doi:10.1146/annurev.ph.36.030174.002213 · Cited by 1,261
Self-citationEffect of pressure development on oxygen consumption by isolated rat heart
Neely, Liebermeister, H., Battersby, E., & Morgan, H. (1967) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1967.212.4.804 · Cited by 1,094
Regulation of Glucose Uptake in Muscle
Morgan, H. E., Henderson, M. J., Regen, D. M., & Park, C. R. (1961) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)64348-0 · Cited by 597
Myocardial utilization of carbohydrate and lipids
Neely, J. R., Rovetto, M. J., & Oram, J. F. (1972) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(72)90029-1 · Cited by 511
Self-citationFatty Acid and Glucose Metabolism in the Perfused Heart
SHIPP, J. C., OPIE, L. H., & CHALLONER, D. (1961) · Nature · doi:10.1038/1891018a0 · Cited by 381
Effects of ischemia on function and metabolism of the isolated working rat heart
Neely, Rovetto, M., Whitmer, J., & Morgan, H. (1973) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1973.225.3.651 · Cited by 346
Self-citationRegulation of glycolysis in the ischemic and the anoxic myocardium
Kübler, W. (1970) · Journal of Molecular and Cellular Cardiology · doi:10.1016/0022-2828(70)90034-9 · Cited by 305
Williamson, J. R. (1966) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)99666-3 · Cited by 260
Cited by
Sheline, C. T., Behrens, M. M., & Choi, D. W. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-09-03139.2000 · Cited by 366
Energy Metabolism in the Normal and Failing Heart: Potential for Therapeutic Interventions
Stanley, W. C., & Chandler, M. P. (2002) · Heart Failure Reviews · doi:10.1023/a:1015320423577 · Cited by 271
Wiesner, R. J., Rösen, P., & Grieshaber, M. K. (1988) · Biochemical Medicine and Metabolic Biology · doi:10.1016/0885-4505(88)90100-4 · Cited by 42
Metadata
- Authors
- Rovetto, M. J., Lamberton, W. F., & Neely, J. R.
- Venue
- Circulation Research
- Published
- 1975-12
- Volume
- 37
- Issue
- 6
- Pages
- 742-751
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2105694339
- Cited by
- 375
- References
- 25
- FWCI
- 8.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Rovetto, M. J., Lamberton, W. F., & Neely, J. R. (1975). Mechanisms of glycolytic inhibition in ischemic rat hearts. Circulation Research. https://doi.org/10.1161/01.res.37.6.742
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
