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The Cardiac Renin-Angiotensin System: Conceptual, or a Regulator of Cardiac Function?
Open accessAbstract
Abstract—Angiotensin II, the effector peptide of the renin-angiotensin system, regulates cellular growth in response to developmental, physiological, and pathological processes. The identification of renin-angiotensin system components and angiotensin II receptors in cardiac tissue suggests the existence of an autocrine/paracrine system that has effects independent of angiotensin II derived from the circulatory system. To be functional, a local renin-angiotensin system should produce sufficient amounts of the autocrine and/or paracrine factor to elicit biological responses, contain the final effector (angiotensin II receptor), and respond to humoral, neural, and/or mechanical stimuli. In this review, we discuss evidence for a functional cardiac renin-angiotensin system.
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Citations
Cited by
Brutsaert, D. L. (2003) · Physiological Reviews · doi:10.1152/physrev.00017.2002 · Cited by 697
Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance
Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00522.2007 · Cited by 317
Localization and function of angiotensin AT1 receptors.
ALLEN, A. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(99)00249-6 · Cited by 278
Expression of Renin-Angiotensin System Components in the Taste Organ of Mice
Shigemura, N., Takai, S., Hirose, F., Yoshida, R., Sanematsu, K., & Ninomiya, Y. (2019) · Nutrients · doi:10.3390/nu11092251 · Cited by 65
Sansoè, G., Aragno, M., & Wong, F. (2020) · Liver International · doi:10.1111/liv.14272 · Cited by 61
Chen, P., Yang, F., Wang, W., Li, X., Liu, D., Zhang, Y., Yin, G., Lv, F., Guo, Z., Mehta, J. L., et al. (2021) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248420942007 · Cited by 31
Metadata
- Authors
- Dostal, D. E., & Baker, K. M.
- Venue
- Circulation Research
- Published
- 1999-10
- Volume
- 85
- Issue
- 7
- Pages
- 643-650
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2082110280
- Cited by
- 398
- References
- 0
- FWCI
- 21.28
- Type
- journal article
- Language
- en
- Open access
- bronze
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