Cited by 317Renin-Angiotensin System StudiesNitric Oxide and Endothelin EffectsEicosanoids and Hypertension Pharmacology

Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

Cooper, Shawna A., Whaley-Connell, Adam, Habibi, Javad, Wei, Yongzhong, Lastra, Guido, Manrique, Camila, Stas, Sameer, Sowers, James R.·2007·American Journal of Physiology-Heart and Circulatory Physiology

Abstract

Hypertension commonly occurs in conjunction with insulin resistance and other components of the cardiometabolic syndrome. Insulin resistance plays a significant role in the relationship between hypertension, Type 2 diabetes mellitus, chronic kidney disease, and cardiovascular disease. There is accumulating evidence that insulin resistance occurs in cardiovascular and renal tissue as well as in classical metabolic tissues (i.e., skeletal muscle, liver, and adipose tissue). Activation of the renin-angiotensin-aldosterone system and subsequent elevations in angiotensin II and aldosterone, as seen in cardiometabolic syndrome, contribute to altered insulin/IGF-1 signaling pathways and reactive oxygen species formation to induce endothelial dysfunction and cardiovascular disease. This review examines currently understood mechanisms underlying the development of resistance to the metabolic actions of insulin in cardiovascular as well as skeletal muscle tissue.

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Registry

Crossref · 10.1152/ajpheart.00522.2007

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247 of 247 references verified0 citation errors · 0 not checkable

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Authors
Cooper, S. A., Whaley-Connell, A., Habibi, J., Wei, Y., Lastra, G., Manrique, C., Stas, S., & Sowers, J. R.
Affiliations
University of Missouri (US)
Venue
American Journal of Physiology-Heart and Circulatory Physiology
Published
2007-10
Volume
293
Issue
4
Pages
H2009-H2023
ISSN
  • 0363-6135 (ISSN-L)
  • 1522-1539
OpenAlex
W2132975480
Cited by
317
References
247
Citations by year
2026: 6 · 2025: 13 · 2024: 14 · 2023: 13 · 2022: 9 · 2021: 13 · 2020: 8 · 2019: 17 · 2018: 12 · 2017: 15 · 2016: 11 · 2015: 18 · 2014: 17 · 2013: 21 · 2012: 25
FWCI
3.95
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Physiology-Heart and Circulatory Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Renin-Angiotensin System Studies
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
renin-angiotensin-aldosterone system, oxidative stress, insulin resistance, cardiometabolic syndrome, hypertension, type 2 diabetes, chronic kidney disease, cardiovascular disease, angiotensin II, aldosterone, IGF-1 signaling, reactive oxygen species, endothelial dysfunction, skeletal muscle insulin signaling
MeSH terms
Angiotensin II, Animals, Cardiovascular Diseases, Chronic Disease, Diabetes Mellitus, Type 2, Endothelium, Vascular, Humans, Hypertension, Insulin, Insulin Resistance, Insulin-Like Growth Factor I, Kidney Diseases, Mineralocorticoids, Myocardium, Renin-Angiotensin System, Risk Factors, Signal Transduction, Reactive Oxygen Species, Oxidative Stress, Muscle, Skeletal, Metabolic Syndrome, Receptor, Angiotensin, Type 1

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