The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat
Open accessAbstract
Abstract —We investigated the role of heme oxygenase (HO)–1 in the development of hypoxia-induced pulmonary hypertension. HO catalyzes the breakdown of heme to the antioxidant bilirubin and the vasodilator carbon monoxide. Hypoxia is a potent but transient inducer of HO-1 in vascular smooth muscle cells in vitro and in the lung in vivo. By using agonists of HO-1, we sustained a high expression of HO-1 in the lungs of rats for 1 week. We report that this in vivo enhancement of HO-1 in the lung prevented the development of hypoxic pulmonary hypertension and inhibited the structural remodeling of the pulmonary vessels. The mechanism(s) underlying this effect may involve a direct vasodilating and antiproliferative action of endogenous carbon monoxide, as well as an indirect effect of carbon monoxide on the production of vasoconstrictors. These results provide evidence that enhancement of endogenous adaptive responses may be used to prevent hypoxia-induced pulmonary hypertension.
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Citations
Cites
Inhibition of hypoxia-inducible factor 1 activity by nitric oxide donors in hypoxia
Sogawa, K., Numayama-Tsuruta, K., Ema, M., Abe, M., Abe, H., & Fujii-Kuriyama, Y. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.13.7368 · Cited by 224
Cited by
Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications
Wu, L., & Wang, R. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.4.3 · Cited by 962
Transcription Factor NRF2 as a Therapeutic Target for Chronic Diseases: A Systems Medicine Approach
Cuadrado, A., Manda, G., Hassan, A., Alcaraz, M. J., Barbas, C., Daiber, A., Ghezzi, P., León, R., López, M. G., Oliva, B., et al. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014753 · Cited by 632
Redox regulation of mitochondrial function
Handy, D. E., & Loscalzo, J. (2012) · Antioxidants & Redox Signaling · doi:10.1089/ars.2011.4123 · Cited by 588
Heme Oxygenase-1: The “Emerging Molecule” Has Arrived
Morse, D., & Choi, A. M. K. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.27.1.4862 · Cited by 532
Heme oxygenase/carbon monoxide signaling pathways: Regulation and functional significance
Ryter, S. W., Otterbein, L. E., Morse, D., & Choi, A. M. K. (2002) · Molecular and Cellular Biochemistry · doi:10.1023/a:1015957026924 · Cited by 497
Metadata
- Authors
- Christou, H., Morita, T., Hsieh, C.-M., Koike, H., Arkonac, B., Perrella, M. A., & Kourembanas, S.
- Venue
- Circulation Research
- Published
- 2000-06-23
- Volume
- 86
- Issue
- 12
- Pages
- 1224-1229
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2101035566
- Cited by
- 204
- References
- 1
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Christou, H., Morita, T., Hsieh, C.-M., Koike, H., Arkonac, B., Perrella, M. A., & Kourembanas, S. (2000). Prevention of Hypoxia-Induced Pulmonary Hypertension by Enhancement of Endogenous Heme Oxygenase-1 in the Rat. Circulation Research. https://doi.org/10.1161/01.res.86.12.1224
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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