The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca 2+ Channels in Native Vascular Smooth Muscle Cells
Abstract
Abstract —Mammalian counterparts of the Drosophila trp gene have been suggested to encode store-operated Ca 2+ channels. These specialized channels are widely distributed and may have a general function to reload Ca 2+ into sarcoplasmic reticulum as well as specific functions, including the control of cell proliferation and muscle contraction. Heterologous expression of mammalian trp genes enhances or generates Ca 2+ channel activity, but the crucial question of whether any of the genes encode native subunits of store-operated channels remains unanswered. We have investigated if TrpC1 protein (encoded by trp1 gene) is a store-operated channel in freshly isolated smooth muscle cells of resistance arterioles, arteries, and veins from human, mouse, or rabbit. Messenger RNA encoding TrpC1 was broadly expressed. TrpC1-specific antibody targeted to peptide predicted to contribute to the outer vestibule of TrpC1 channels revealed that TrpC1 is localized to the plasma membrane and has an extracellular domain. Peptide-specific binding of the antibody had a functional effect, selectively blocking store-operated Ca 2+ channel activity. The antibody is a powerful new tool for the study of mammalian trp1 gene product. The study shows that TrpC1 is a novel physiological Ca 2+ channel subunit in arterial smooth muscle cells.
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Citations
Cites
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From worm to man: three subfamilies of TRP channels
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Receptor-mediated Regulation of the Nonselective Cation Channels TRPC4 and TRPC5
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On the molecular basis and regulation of cellular capacitative calcium entry: Roles for Trp proteins
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Coassembly of TRP and TRPL Produces a Distinct Store-Operated Conductance
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Coassembly of Trp1 and Trp3 Proteins Generates Diacylglycerol- and Ca2+-sensitive Cation Channels
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Trp1, a Candidate Protein for the Store-operated Ca2+Influx Mechanism in Salivary Gland Cells
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Cited by
The Role of the Funny Current in Pacemaker Activity
DiFrancesco, D. (2010) · Circulation Research · doi:10.1161/circresaha.109.208041 · Cited by 587
Transient Receptor Potential Channels in the Vasculature
Earley, S., & Brayden, J. E. (2015) · Physiological Reviews · doi:10.1152/physrev.00026.2014 · Cited by 420
Regulation of HCN channel surface expression by a novel C-terminal protein-protein interaction
Santoro, B., Wainger, B. J., & Siegelbaum, S. A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3300-04.2004 · Cited by 210
Metadata
- Authors
- Xu, S.-Z., & Beech, D. J.
- Venue
- Circulation Research
- Published
- 2001-01-19
- Volume
- 88
- Issue
- 1
- Pages
- 84-87
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2154275119
- Cited by
- 361
- References
- 26
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Xu, S.-Z., & Beech, D. J. (2001). TrpC1 Is a Membrane-Spanning Subunit of Store-Operated Ca 2+ Channels in Native Vascular Smooth Muscle Cells. Circulation Research. https://doi.org/10.1161/01.res.88.1.84
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