The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Requirement of the Inositol Trisphosphate Receptor for Activation of Store-Operated Ca 2+ Channels
Abstract
The coupling mechanism between endoplasmic reticulum (ER) calcium ion (Ca 2+ ) stores and plasma membrane (PM) store-operated channels (SOCs) is crucial to Ca 2+ signaling but has eluded detection. SOCs may be functionally related to the TRP family of receptor-operated channels. Direct comparison of endogenous SOCs with stably expressed TRP3 channels in human embryonic kidney (HEK293) cells revealed that TRP3 channels differ in being store independent. However, condensed cortical F-actin prevented activation of both SOC and TRP3 channels, which suggests that ER-PM interactions underlie coupling of both channels. A cell-permeant inhibitor of inositol trisphosphate receptor (InsP 3 R) function, 2-aminoethoxydiphenyl borate, prevented both receptor-induced TRP3 activation and store-induced SOC activation. It is concluded that InsP 3 Rs mediate both SOC and TRP channel opening and that the InsP 3 R is essential for maintaining coupling between store emptying and physiological activation of SOCs.
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Cites
Activation of a TRPC3-Dependent Cation Current through the Neurotrophin BDNF
Li, H.-S., Xu, X.-Z. S., & Montell, C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80838-7 · Cited by 345
Cited by
Store-Operated Calcium Channels
Parekh, A. B., & Putney, J. W. (2005) · Physiological Reviews · doi:10.1152/physrev.00057.2003 · Cited by 2,089
Calcium signaling mechanisms in T lymphocytes.
Lewis, R. S. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.497 · Cited by 860
Orai1 and STIM Reconstitute Store-operated Calcium Channel Function
Soboloff, J., Spassova, M. A., Tang, X. D., Hewavitharana, T., Xu, W., & Gill, D. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.c600126200 · Cited by 549
Self-citation2-Aminoethoxydiphenyl Borate Is a Common Activator of TRPV1, TRPV2, and TRPV3
Hu, H.-Z., Gu, Q., Wang, C., Colton, C. K., Tang, J., Kinoshita-Kawada, M., Lee, L.-Y., Wood, J. D., & Zhu, M. X. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404164200 · Cited by 517
Xu, S.-Z., & Beech, D. J. (2001) · Circulation Research · doi:10.1161/01.res.88.1.84 · Cited by 361
Metadata
- Authors
- Ma, H.-T., Patterson, R. L., van, D. B., Rossum, Birnbaumer, L., Mikoshiba, K., & Gill, D. L.
- Venue
- Science
- Published
- 2000-03-03
- Volume
- 287
- Issue
- 5458
- Pages
- 1647-1651
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1974342767
- Cited by
- 577
- References
- 1
- FWCI
- 33.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ma, H.-T., Patterson, R. L., van, D. B., Rossum, Birnbaumer, L., Mikoshiba, K., & Gill, D. L. (2000). Requirement of the Inositol Trisphosphate Receptor for Activation of Store-Operated Ca 2+ Channels. Science. https://doi.org/10.1126/science.287.5458.1647
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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