Cited by 157Healthcare Systems and Public HealthCardiovascular Health and Risk FactorsAcute Ischemic Stroke Management

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Trends in Stroke and Coronary Heart Disease in the WHO MONICA Project

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Truelsen, Thomas, Mähönen, Markku, Tolonen, Hanna, Asplund, Kjell, Bonita, Ruth, Vanuzzo, Diego·2003·Stroke

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Abstract

Background and Purpose— Coronary heart disease (CHD) and stroke are leading causes of death and disability. Because they share major common risk factors, it would be expected that trends in mortality and incidence of these 2 major cardiovascular diseases would be similar. Methods— Data from the World Health Organization (WHO) Multinational Monitoring of Trends and Determinants in Cardiovascular Disease (MONICA) Project were used to compare 10-year trends in mortality, event rates, and case fatality from both CHD and stroke. Fifteen populations in the WHO MONICA Project provided data on both CHD (60 763 events) and stroke (10 442 events) in men and women aged 35 to 64 years (23.4 million person-years of observation in total). Results— Trends for the 2 cardiovascular diseases varied within and between populations, and when data from all populations were combined, trends in CHD and stroke mortality differed in men ( P =0.001) but not in women, whereas trends in event rates differed significantly in both men and women ( P <0.001 and P =0.011, respectively). The differences in trends for CHD and stroke case fatality were not statistically significant in either men or women. In sensitivity analyses, differences in trends in event rates remained statistically significant in men ( P <0.001) but not in women. Conclusions— Trends for CHD and stroke mortality rates, event rates, and case fatality differ substantially between and within the study populations.

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Authors: Truelsen, T., Mähönen, M., Tolonen, H., Asplund, K., Bonita, R., & Vanuzzo, D.
Affiliations: University Hospital of Umeå (SE)
From the World Health Organization Noncommunicable Diseases and Mental Health/Cross Cluster Surveillance (NMH/CCS), Geneva, Switzerland (T.T., R.B.); Department of Epidemiology and Health Promotion, National Public Health Institute (KTL), Helsinki, Finland (M.M., H.T.); Department of Medicine, University Hospital, Umeå, Sweden (K.A.); and Centro Malattie Cardiovascolari, A.S.S.4 “Medico Friuli,” Udine, Italy (D.V.).
ORCID: Tolonen, Hanna
Asplund, Kjell
Bonita, Ruth
Vanuzzo, Diego
Venue: Stroke
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2003-06
Volume: 34
Issue: 6
Pages: 1346-1352
ISSN: 0039-2499 (ISSN-L)
1524-4628
DOI: 10.1161/01.str.0000069724.36173.4d
OpenAlex: W2012820125
Cited by: 157
References: 25
Citations by year: 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 8 · 2018: 7 · 2017: 2 · 2016: 6 · 2015: 11 · 2014: 7 · 2013: 10 · 2012: 8
FWCI: 6.55
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Stroke (publishedVersion)
PubMed (publishedVersion)
Funders: Servier
National Institutes of Health
Institut de Recherches Servier
National Heart, Lung, and Blood Institute
Topics: Health Sciences › Medicine › Epidemiology › Healthcare Systems and Public Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
Keywords: coronary artery disease, cardiovascular disease trends, mortality trends, incidence, case fatality, sex differences, MONICA project, cardiovascular risk factors
MeSH terms: Adult, Coronary Disease, Female, Humans, Male, Middle Aged, Mortality, Sensitivity and Specificity, Sex Factors, Global Health, World Health Organization, Incidence, Sex Distribution, Stroke

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Trends in Stroke and Coronary Heart Disease in the WHO MONICA Project

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