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Cited by 298Acute Ischemic Stroke ManagementCerebrovascular and Carotid Artery DiseasesIntracerebral and Subarachnoid Hemorrhage Research

The DOI matches its Crossref record; 23 of the 24 references it cites were found in a registry or an index.

Cause of Stroke Recurrence Is Multifactorial: Patterns, Risk Factors, and Outcomes of Stroke Recurrence in the South London Stroke Register

Hillen, Thomas, Coshall, Catherine, Tilling, Kate, Rudd, Anthony G., McGovern, Rory, Wolfe, Charles D.A.·2003·Stroke
DOI 10.1161/01.str.0000072985.24967.7f
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Abstract

Background and Purpose— This article examines stroke recurrence and whether the subtype of the initial stroke influences the risk and subtypes of further strokes. The proportion of recurrences attributable to conventional risk factors is quantified. Methods— From January 1995 to August 2000, all first-in-a-lifetime strokes (n=1626) were identified and prospectively followed up in a defined multiethnic inner city population of 234 533. Twelve overlapping referral sources and face-to-face follow-up at 3 months and 1 and 3 years were used to attain complete registration of stroke recurrence. Index and recurrent stroke were classified according to the Oxford Community Stroke Project classification. Results— In 2744 person-years of follow-up, 153 recurrences were observed. At 5 years, the cumulative risk of first stroke recurrence was 16.6% (95% CI, 13.5 to 20.4), and the combined risk of death or stroke recurrence was 65.3% (95% CI, 61.9 to 68.6). Ethnicity and subtype of index stroke were not associated with stroke recurrence. A change in subtype between index and recurrent stroke occurred in 45.5% (95% CI, 35.8 to 55.2) of cases and was most frequent among index lacunar strokes and primary intracerebral hemorrhages. In multivariable analyses, diabetes mellitus and atrial fibrillation were associated with both stroke recurrence and recurrence-free survival. In the stroke population, 9.1% (95% CI, −2.0 to 20.2) of recurrences were attributable to diabetes and 4.9% (95% CI, −7.3 to 17.2) to atrial fibrillation during the first year after the index stroke. Conclusions— The cause of stroke recurrence is multifactorial, and the subtypes of index and recurrent strokes are often not identical. Most recurrences remain unexplained by conventional risk factors.

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Crossref · 10.1161/01.str.0000072985.24967.7f

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Research works printed but not linked: 12

  1. 10.1161/str.22.2.2003278 · DOI
  2. 10.1161/str.29.1.126 · DOI
  3. 10.1161/str.25.2.8303740 · DOI
  4. 10.1161/str.29.10.2114 · DOI
  5. 10.1161/str.31.5.1062 · DOI
  6. 10.1161/str.29.12.2491 · DOI
  7. 10.1161/str.25.5.8165690 · DOI
  8. 10.1161/str.20.10.2799873 · DOI
  9. 10.1161/str.32.1.37 · DOI
  10. 10.1161/str.21.6.2349586 · DOI
  11. 10.1161/str.31.2.469 · DOI
  12. 10.1161/str.28.7.1507 · DOI

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Metadata

Authors
Hillen, T., Coshall, C., Tilling, K., Rudd, A. G., McGovern, R., & Wolfe, C. D. A.
Affiliations
St Thomas' Hospital (GB)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2003-06
Volume
34
Issue
6
Pages
1457-1463
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.0000072985.24967.7f
OpenAlex
W2095596783
Cited by
298
References
24
Citations by year
2026: 8 · 2025: 9 · 2024: 11 · 2023: 9 · 2022: 15 · 2021: 21 · 2020: 18 · 2019: 18 · 2018: 15 · 2017: 13 · 2016: 12 · 2015: 17 · 2014: 17 · 2013: 14 · 2012: 13
FWCI
6.78
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
  • Research Portal (King's College London) (submittedVersion)
Topics
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cerebrovascular and Carotid Artery Diseases
  • Health Sciences › Medicine › Clinical Neurology › Intracerebral and Subarachnoid Hemorrhage Research
Keywords
stroke recurrence, stroke subtypes, lacunar stroke, intracerebral hemorrhage, diabetes mellitus, atrial fibrillation, stroke risk factors, recurrence-free survival, ethnic differences, multifactorial etiology
MeSH terms
Aged, Atrial Fibrillation, Diabetes Mellitus, Female, Follow-Up Studies, Humans, London, Male, Prospective Studies, Recurrence, Registries, Risk Factors, Comorbidity, Causality, Life Tables, Incidence, Multivariate Analysis, Survival Analysis, Treatment Outcome, Risk Assessment, Disease-Free Survival, Stroke

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