The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke
Abstract
Background and Purpose— Therapies that transiently prevent ischemic neuronal death can potentially extend therapeutic time windows for stroke thrombolysis. We conducted a pilot study to investigate the effects of high-flow oxygen in acute ischemic stroke. Methods— We randomized patients with acute stroke (<12 hours) and perfusion-diffusion “mismatch” on magnetic resonance imaging (MRI) to high-flow oxygen therapy via facemask for 8 hours (n=9) or room air (controls, n=7). Stroke scale scores and MRI scans were obtained at baseline, 4 hours, 24 hours, 1 week, and 3 months. Clinical deficits and MR abnormalities were compared between groups. Results— Stroke scale scores were similar at baseline, tended to improve at 4 hours (during therapy) and 1 week, and significantly improved at 24 hours in hyperoxia-treated patients. There was no significant difference at 3 months. Mean (±SD) relative diffusion MRI lesion volumes were significantly reduced in hyperoxia-treated patients at 4 hours (87.8±22% versus 149.1±41%; P =0.004) but not subsequent time points. The percentage of MRI voxels improving from baseline “ischemic” to 4-hour “non-ischemic” values tended to be higher in hyperoxia-treated patients. Cerebral blood volume and blood flow within ischemic regions improved with hyperoxia. These “during-therapy” benefits occurred without arterial recanalization. By 24 hours, MRI showed reperfusion and asymptomatic petechial hemorrhages in 50% of hyperoxia-treated patients versus 17% of controls ( P =0.6). Conclusions— High-flow oxygen therapy is associated with a transient improvement of clinical deficits and MRI abnormalities in select patients with acute ischemic stroke. Further studies are warranted to investigate the safety and efficacy of hyperoxia as a stroke therapy.
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Cites
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 6,872
Mechanisms, challenges and opportunities in stroke
Lo, E. H., Dalkara, T., & Moskowitz, M. A. (2003) · Nature Reviews Neuroscience · doi:10.1038/nrn1106 · Cited by 1,781
Self-citationReactive Oxygen Radicals in Signaling and Damage in the Ischemic Brain
Chan, P. H. (2001) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200101000-00002 · Cited by 1,581
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Hacke, W., Albers, G., Al-Rawi, Y., Bogousslavsky, J., Davalos, A., Eliasziw, M., Fischer, M., Furlan, A., Kaste, M., Lees, K. R., et al. (2005) · Stroke · doi:10.1161/01.str.0000149938.08731.2c · Cited by 1,015
Kidwell, C. S., Saver, J. L., Mattiello, J., Starkman, S., Vinuela, F., Duckwiler, G., Gobin, Y. P., Jahan, R., Vespa, P., Kalafut, M., et al. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200004)47:4<462::aid-ana9>3.0.co;2-y · Cited by 692
Diffusion‐ and perfusion‐weighted MRI response to thrombolysis in stroke
Parsons, M. W., Barber, P. A., Chalk, J., Darby, D. G., Rose, S., Desmond, P. M., Gerraty, R. P., Tress, B. M., Wright, P. M., Donnan, G. A., et al. (2002) · Annals of Neurology · doi:10.1002/ana.10067 · Cited by 355
Should Stroke Victims Routinely Receive Supplemental Oxygen?: A Quasi-Randomized Controlled Trial
Rønning, O. M., & Guldvog, B. (1999) · Stroke · doi:10.1161/01.str.30.10.2033 · Cited by 313
Menzel, M., Doppenberg, E. M. R., Zauner, A., Soukup, J., Reinert, M. M., & Bullock, R. (1999) · Journal of Neurosurgery · doi:10.3171/jns.1999.91.1.0001 · Cited by 303
Cited by
Medical Complications After Stroke: A Multicenter Study
Langhorne, P., Stott, D. J., Robertson, L., MacDonald, J., Jones, L., McAlpine, C., Dick, F., Taylor, G. S., & Murray, G. (2000) · Stroke · doi:10.1161/01.str.31.6.1223 · Cited by 1,196
Inflammatory mechanisms in ischemic stroke: therapeutic approaches
Lakhan, S. E., Kirchgessner, A., & Hofer, M. (2009) · Journal of Translational Medicine · doi:10.1186/1479-5876-7-97 · Cited by 1,072
Adams, H. P., del Zoppo, G., Alberts, M. J., Bhatt, D. L., Brass, L., Furlan, A., Grubb, R. L., Higashida, R. T., Jauch, E. C., Kidwell, C., et al. (2007) · Circulation · doi:10.1161/circulationaha.107.181486 · Cited by 904
Chu, D. K., Kim, L. H.-Y., Young, P. J., Zamiri, N., Almenawer, S. A., Jaeschke, R., Szczeklik, W., Schünemann, H. J., Neary, J. D., & Alhazzani, W. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30479-3 · Cited by 778
Girardis, M., Busani, S., Damiani, E., Donati, A., Rinaldi, L., Marudi, A., Morelli, A., Antonelli, M., & Singer, M. (2016) · JAMA · doi:10.1001/jama.2016.11993 · Cited by 723
Metadata
- Authors
- Singhal, A. B., Benner, T., Roccatagliata, L., Koroshetz, W. J., Schaefer, P. W., Lo, E. H., Buonanno, F. S., Gonzalez, R. G., & Sorensen, A. G.
- Venue
- Stroke
- Published
- 2005-04
- Volume
- 36
- Issue
- 4
- Pages
- 797-802
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2044308941
- Cited by
- 280
- References
- 27
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- closed
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- Singhal, A. B., Benner, T., Roccatagliata, L., Koroshetz, W. J., Schaefer, P. W., Lo, E. H., Buonanno, F. S., Gonzalez, R. G., & Sorensen, A. G. (2005). A Pilot Study of Normobaric Oxygen Therapy in Acute Ischemic Stroke. Stroke. https://doi.org/10.1161/01.str.0000158914.66827.2e
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