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Uric Acid Is a Risk Factor for Myocardial Infarction and Stroke: The Rotterdam Study
Open accessAbstract
Background and Purpose— The role of uric acid as a risk factor for myocardial infarction is controversial, and little is known about its role as a risk factor for stroke. Recent evidence suggests that uric acid may be an important causal agent in cardiovascular disease, for example, by inducing renal disease and hence hypertension. We investigated the association between serum uric acid and coronary heart disease and stroke in a large prospective population-based study. Methods— The study was based on 4385 participants of the Rotterdam Study who, at baseline (1990 to 1993), were ≥55 years of age, free from stroke and coronary heart disease, and had blood taken. Follow-up for incident stroke and myocardial infarction was complete until January 1, 2002. Data were analyzed with Cox proportional hazards models with adjustment for relevant confounders. Results— Average follow-up was 8.4 years. High serum uric acid levels were associated with risk of myocardial infarction and stroke; age- and sex-adjusted hazard ratios (95% CIs) for highest versus lowest quintile of uric acid were 1.68 (1.24 to 2.27) for cardiovascular disease (515 cases), 1.87 (1.12 to 3.13) for myocardial infarction (194 cases), 1.57 (1.11 to 2.22) for stroke (381 cases), 1.77 (1.10 to 2.83) for ischemic stroke (205 cases), and 1.68 (0.68 to 4.15) for hemorrhagic stroke (46 cases). Adjustment for other vascular risk factors only slightly attenuated these associations. Associations were stronger in persons without hypertension than in those with hypertension. Conclusions— Uric acid is a strong risk factor for myocardial infarction and stroke.
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Serum Uric Acid and Cardiovascular Mortality: The NHANES I Epidemiologic Follow-up Study, 1971-1992
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Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
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Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart Study
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Uric Acid, Hominoid Evolution, and the Pathogenesis of Salt-Sensitivity
Watanabe, S., Kang, D.-H., Feng, L., Nakagawa, T., Kanellis, J., Lan, H., Mazzali, M., & Johnson, R. J. (2002) · Hypertension · doi:10.1161/01.hyp.0000028589.66335.aa · Cited by 563
Significance of hyperuricemia as a risk factor for developing ESRD in a screened cohort
Iseki, K., Ikemiya, Y., Inoue, T., Iseki, C., Kinjo, K., & Takishita, S. (2004) · American Journal of Kidney Diseases · doi:10.1016/s0272-6386(04)00934-5 · Cited by 526
Relations of Serum Uric Acid to Longitudinal Blood Pressure Tracking and Hypertension Incidence
Sundström, J., Sullivan, L., D’Agostino, R. B., Levy, D., Kannel, W. B., & Vasan, R. S. (2005) · Hypertension · doi:10.1161/01.hyp.0000150784.92944.9a · Cited by 491
Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham Study
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Relation of Serum Uric Acid to Mortality and Ischemic Heart Disease
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Self-citationHyperuricemia and coronary heart disease: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2010) · Arthritis Care & Research · doi:10.1002/acr.20065 · Cited by 671
Hyperuricemia and risk of stroke: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2009) · Arthritis Care & Research · doi:10.1002/art.24612 · Cited by 484
Hyperuricaemia and gout in cardiovascular, metabolic and kidney disease
Borghi, C., Agabiti-Rosei, E., Johnson, R. J., Kielstein, J. T., Lurbe, E., Mancia, G., Redon, J., Stack, A. G., & Tsioufis, K. P. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.07.006 · Cited by 435
Uric acid: A marker of increased cardiovascular risk
Gagliardi, A. C. M., Miname, M. H., & Santos, R. D. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.022 · Cited by 384
Metadata
- Authors
- Bos, M. J., Koudstaal, P. J., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B.
- Venue
- Stroke
- Published
- 2006-06
- Volume
- 37
- Issue
- 6
- Pages
- 1503-1507
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2056045638
- Cited by
- 615
- References
- 25
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bos, M. J., Koudstaal, P. J., Hofman, A., Witteman, J. C. M., & Breteler, M. M. B. (2006). Uric Acid Is a Risk Factor for Myocardial Infarction and Stroke: The Rotterdam Study. Stroke. https://doi.org/10.1161/01.str.0000221716.55088.d4
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