The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease?
Abstract
Hyperuricemia is associated with hypertension, vascular disease, renal disease, and cardiovascular events. In this report, we review the epidemiologic evidence and potential mechanisms for this association. We also summarize experimental studies that demonstrate that uric acid is not inert but may have both beneficial functions (acting as an antioxidant) as well as detrimental actions (to stimulate vascular smooth muscle cell proliferation and induce endothelial dysfunction). A recently developed experimental model of mild hyperuricemia also provides the first provocative evidence that uric acid may have a pathogenic role in the development of hypertension, vascular disease, and renal disease. Thus, it is time to reevaluate the role of uric acid as a risk factor for cardiovascular disease and hypertension and to design human studies to address this controversy.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504
Uric acid-iron ion complexes. A new aspect of the antioxidant functions of uric acid
Davies, K. J. A., Sevanian, A., Muakkassah-Kelly, S. F., & Hochstein, P. (1986) · Biochemical Journal · doi:10.1042/bj2350747 · Cited by 558
Allopurinol Improves Myocardial Efficiency in Patients With Idiopathic Dilated Cardiomyopathy
Cappola, T. P., Kass, D. A., Nelson, G. S., Berger, R. D., Rosas, G. O., Kobeissi, Z. A., Marbán, E., & Hare, J. M. (2001) · Circulation · doi:10.1161/hc4501.098928 · Cited by 436
Hyperuricemia and xanthine oxidase in preeclampsia, revisited
Many, A., Hubel, C. A., & Roberts, J. M. (1996) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(96)70410-6 · Cited by 187
Cited by
Richette, P., & Bardin, T. (2010) · The Lancet · doi:10.1016/s0140-6736(09)60883-7 · Cited by 915
Hyperuricemia and coronary heart disease: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2010) · Arthritis Care & Research · doi:10.1002/acr.20065 · Cited by 671
Yu, M.-A., Sánchez-Lozada, L. G., Johnson, R. J., & Kang, D.-H. (2010) · Journal of Hypertension · doi:10.1097/hjh.0b013e328337da1d · Cited by 626
Self-citationFructose metabolism and metabolic disease
Hannou, S. A., Haslam, D. E., McKeown, N. M., & Herman, M. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96702 · Cited by 561
Hyperuricemia and risk of stroke: A systematic review and meta‐analysis
Kim, S. Y., Guevara, J. P., Kim, K. M., Choi, H. K., Heitjan, D. F., & Albert, D. A. (2009) · Arthritis Care & Research · doi:10.1002/art.24612 · Cited by 484
Metadata
- Authors
- Johnson, R. J., Kang, D.-H., Feig, D., Kivlighn, S., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodriguez-Iturbe, B., Herrera-Acosta, J., & Mazzali, M.
- Venue
- Hypertension
- Published
- 2003-06
- Volume
- 41
- Issue
- 6
- Pages
- 1183-1190
- ISSN
- 0194-911X (ISSN-L)
- 1524-4563
- OpenAlex
- W2106362601
- Cited by
- 1,361
- References
- 4
- FWCI
- 29.42
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? https://app.cochat.ai/papers/10.1161/01.hyp.0000069700.62727.c5
- The paper
- Johnson, R. J., Kang, D.-H., Feig, D., Kivlighn, S., Kanellis, J., Watanabe, S., Tuttle, K. R., Rodriguez-Iturbe, B., Herrera-Acosta, J., & Mazzali, M. (2003). Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension. https://doi.org/10.1161/01.hyp.0000069700.62727.c5
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
