Regional cerebral blood flow decreases during chronic and acute hyperglycemia.
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The presence of hyperglycemia prior to stroke or cardiac arrest can increase neuronal damage caused by brain ischemia. Acute hyperglycemia shows this effect in animal models of stroke. However, chronic hyperglycemia and chronic hyperglycemia with additional acute elevation of blood glucose are more common premorbid states for stroke patients. The effect of chronic hyperglycemia on regional cerebral blood flow (rCBF) is unclear but blood flow changes may play a role in this ischemic cell damage. We measured rCBF in awake restrained rats that had chronic hyperglycemia induced by treatment with streptozotocin. This was compared to that measured in rats made acutely hyperglycemic by injecting glucose into the peritoneal space. rCBF was measured in 17 brain regions using [14C]iodoantipyrine. During chronic hyperglycemia, when plasma glucose was 29 microns/ml, rCBF was decreased and a regional distribution of this effect was noted; 9 hindbrain regions showed a mean flow decrease of 14% while forebrain regions demonstrated less flow reduction. Acute elevation of plasma glucose during normoglycemia or superimposed on chronic hyperglycemia produced flow reductions of 7% for each 10 microns/ml increment in plasma glucose up to 60 microns/ml. Both chronic and acute hyperglycemia are associated with decreased rCBF and the mechanism for this effect does not appear to adapt to chronic hyperglycemia.
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Brain glucose transport is significantly reduced in diabetic animals.
“We know that brain glucose transport is significantly reduced in diabetic animals (34, 35).”
From Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly (2003) · cites this paper as [34]
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References 34 · Cited by 158
Research works printed but not linked: 5
- Levy DE, Pulsinelli WA, SchererPB, Plum F: Effect of admis- sion glucose level on recovery from acute stroke. Ann Neurol 1985;18:122
- Brint S, Kraig R, Kiessling M, Pulsinelli WA: Hyperglycemia augments infarct size in focal experimental brain ischemia. Ann Neurol 1985;18:127
- Ginsberg MD, Welsh FA, Budd WW: Deleterious effect of glucose pretreatment on recovery from diffuse cerebral ische- mia in the cat. Stroke 1980; 11:347-354
- Kassell NF, Bauman KW, Hitchon PW, Gerk MK, Hill TR, Sokoll MD: The effect of high dose mannitol on cerebral blood flow in dogs with normal intracranial pressure. Stroke 1982; 13:59-61
- Crabtree HG: Observation on the carbohydrate metabolism of tumors. Biochem J 1929;23:536-545
- Authors
- Duckrow, R. B., Beard, D. C., & Brennan, R. W.
- Venue
- Stroke
- Published
- 1987-01
- Volume
- 18
- Issue
- 1
- Pages
- 52-58
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2010011292
- Cited by
- 158
- References
- 34
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 10 · 2023: 4 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 3 · 2016: 5 · 2015: 4 · 2014: 3 · 2013: 6 · 2012: 3
- FWCI
- 5.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Stroke (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- Topics
- Health Sciences › Medicine › Epidemiology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Neurology › Traumatic Brain Injury and Neurovascular Disturbances
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Neurological and metabolic disorders
- Keywords
- regional cerebral blood flow, hyperglycemia, chronic hyperglycemia, acute hyperglycemia, streptozotocin-induced diabetes, cerebral ischemia, hindbrain, forebrain, plasma glucose, cerebral autoregulation
- MeSH terms
- Acute Disease, Alloxan, Animals, Cerebrovascular Circulation, Chronic Disease, Glucose, Hyperglycemia, Male, Rats, Inbred Strains, Streptozocin, Rats
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