The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study.
Abstract
We sought to modify existing sex-specific health risk appraisal functions (profile functions) for the prediction of first stroke that better assess the effects of the use of antihypertensive medication. Health risk appraisal functions were previously developed from the Framingham Study cohort. These functions were Cox proportional hazards regression models relating age, systolic blood pressure, diabetes mellitus, cigarette smoking, prior cardiovascular disease, atrial fibrillation, left ventricular hypertrophy by electrocardiogram, and the use of antihypertensive medication to the occurrence of stroke. Closer examination of the data indicated that antihypertensive therapy effect is present only for systolic blood pressures between 110 and 200 mm Hg. Adjustments to the regressions to better fit the observed data were developed and tested for statistical significance and goodness-of-fit of the model residuals. Modified functions more consistent with the data were developed, and, from these, tables to evaluate 10-year risk of first stroke were computed. The stroke profile can be used for evaluation of the risk of stroke and suggestion of risk factor modification to reduce risk. The effect of antihypertensive therapy in the evaluation of stroke risk can now be better evaluated.
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Citations
Cites
Probability of stroke: a risk profile from the Framingham Study.
Wolf, P. A., D'Agostino, R. B., Belanger, A. J., & Kannel, W. B. (1991) · Stroke · doi:10.1161/01.str.22.3.312 · Cited by 1,782 · cited 2×
“Subjects and Methods The data used were the same as those used to develop the first functions.(1) Health risk appraisal functions were developed using subjects aged 55 to 84 years, free of stroke at the time of two examination cycles (examinations 9 and 14), and followed for 10 years from each of these examinations.”
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Cited by
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Heart Disease and Stroke Statistics—2010 Update: A Report From the American Heart Association
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R. J., Brown, T. M., Carnethon, M., Dai, S., De Simone, G., Ferguson, T. B., Ford, E., Furie, K., et al. (2010) · Circulation · doi:10.1161/circulationaha.109.192667 · Cited by 5,700
Gage, B. F., Waterman, A. D., Shannon, W., Boechler, M., Rich, M. W., & Radford, M. J. (2001) · JAMA · doi:10.1001/jama.285.22.2864 · Cited by 4,832
Cosentino, F., Grant, P. J., Aboyans, V., Bailey, C. J., Ceriello, A., Delgado, V., Federici, M., Filippatos, G., Grobbee, D. E., Hansen, T. B., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz486 · Cited by 4,763
WRITING GROUP MEMBERS, Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T. B., Flegal, K., Ford, E., Furie, K., Go, A., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.191261 · Cited by 3,140
Metadata
- Authors
- D'Agostino, R. B., Wolf, P. A., Belanger, A. J., & Kannel, W. B.
- Venue
- Stroke
- Published
- 1994-01
- Volume
- 25
- Issue
- 1
- Pages
- 40-43
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2135954257
- Cited by
- 712
- References
- 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- closed
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- D'Agostino, R. B., Wolf, P. A., Belanger, A. J., & Kannel, W. B. (1994). Stroke risk profile: adjustment for antihypertensive medication. The Framingham Study. Stroke. https://doi.org/10.1161/01.str.25.1.40
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