The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid Angiopathy
Abstract
Background and Purpose Cerebral amyloid angiopathy is an important cause of intracerebral hemorrhage in the elderly. The ε4 allele of the apolipoprotein E gene, recently established as a genetic risk for Alzheimer's disease, has also been suggested as a possible risk factor for cerebral amyloid angiopathy. We sought to determine whether this allele is specifically associated with hemorrhages related to amyloid angiopathy and whether it correlates with the age at which first amyloid angiopathy-related hemorrhage occurs. Methods Forty-five consecutive patients presenting with lobar hemorrhage were prospectively classified according to clinical, radiological, and when available, pathological features and evaluated for apolipoprotein E genotype. They were compared with 1899 elderly patients from a population-based sample and with 18 consecutive patients with hemorrhages in deep regions typical of a hypertensive mechanism. Results Patients with multiple hemorrhages confined to the lobar territory demonstrated a greater than twofold overrepresentation ( P <.001) in frequency of the apolipoprotein E ε4 allele compared with the population-based sample. Apolipoprotein E genotypes of patients with hemorrhages in deep territories resembled the population sample. Among patients with strictly lobar hemorrhages, carriers of the ε4 allele had their first hemorrhage more than 5 years earlier than noncarriers (mean age at first hemorrhage, 73.4±8.0 versus 78.9±7.4 years; P =.033). These effects were independent of the accompanying presence of Alzheimer's disease. Conclusions The data support a specific role for apolipoprotein E ε4 in accelerating the process that leads to amyloid angiopathy-related hemorrhage.
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Cites
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Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology
Mahley, R. W. (1988) · Science · doi:10.1126/science.3283935 · Cited by 4,028
Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease
Saunders, A. M., Strittmatter, W. J., Schmechel, D., St. George-Hyslop, P. H., Pericak-Vance, M. A., Joo, S. H., Rosi, B. L., Gusella, J. F., Crapper-MacLachlan, D. R., Alberts, M. J., et al. (1993) · Neurology · doi:10.1212/wnl.43.8.1467 · Cited by 3,786
Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease
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Cerebral amyloid angiopathy without and with cerebral hemorrhages: A comparative histological study
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Apolipoprotein E, Dementia, and Cortical Deposition of β-Amyloid Protein
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Apolipoprotein E alleles, dyslipidemia, and coronary heart disease. The Framingham Offspring Study
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Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
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Self-citationProtection against Alzheimer's disease with apoE ∈2
Talbot, C., Lendon, C., Craddock, N., Shears, S., Morris, J., & Goate, A. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92557-7 · Cited by 225
Cited by
Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy
Liu, C.-C., Kanekiyo, T., Xu, H., & Bu, G. (2013) · Nature Reviews Neurology · doi:10.1038/nrneurol.2012.263 · Cited by 3,459
Soluble Amyloid β Peptide Concentration as a Predictor of Synaptic Change in Alzheimer's Disease
Lue, L.-F., Kuo, Y.-M., Roher, A. E., Brachova, L., Shen, Y., Sue, L., Beach, T., Kurth, J. H., Rydel, R. E., & Rogers, J. (1999) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65184-x · Cited by 1,530
Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria
Knudsen, K. A., Rosand, J., Karluk, D., & Greenberg, S. M. (2001) · Neurology · doi:10.1212/wnl.56.4.537 · Cited by 1,015
Self-citationCerebral amyloid angiopathy in the elderly
Viswanathan, A., & Greenberg, S. M. (2011) · Annals of Neurology · doi:10.1002/ana.22516 · Cited by 643
Self-citationCharidimou, A., Gang, Q., & Werring, D. J. (2012) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301308 · Cited by 611
Metadata
- Authors
- Greenberg, S. M., Briggs, M. E., Hyman, B. T., Kokoris, G. J., Takis, C., Kanter, D. S., Kase, C. S., & Pessin, M. S.
- Venue
- Stroke
- Published
- 1996-08
- Volume
- 27
- Issue
- 8
- Pages
- 1333-1337
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W2169851819
- Cited by
- 259
- References
- 9
- FWCI
- 6.87
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenberg, S. M., Briggs, M. E., Hyman, B. T., Kokoris, G. J., Takis, C., Kanter, D. S., Kase, C. S., & Pessin, M. S. (1996). Apolipoprotein E ε4 Is Associated With the Presence and Earlier Onset of Hemorrhage in Cerebral Amyloid Angiopathy. Stroke. https://doi.org/10.1161/01.str.27.8.1333
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