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Cited by 643Intracerebral and Subarachnoid Hemorrhage ResearchCerebrovascular and genetic disordersAlzheimer's disease research and treatments

Cerebral amyloid angiopathy in the elderly

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Viswanathan, Anand, Greenberg, Steven M.·2011·Annals of Neurology
DOI 10.1002/ana.22516PMC PMC4004372
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Abstract

Cerebral amyloid angiopathy (CAA) results from deposition of β‐amyloid in the media and adventitia of small arteries and capillaries of the leptomeninges and cerebral cortex and is a major cause of lobar intracerebral hemorrhage and cognitive impairment in the elderly. CAA is associated with a high prevalence of magnetic resonance imaging markers of small vessel disease, including cerebral microbleeds and white matter hyperintensities. Although advanced CAA is present in approximately ¼ of brains with Alzheimer disease (AD), fewer than half of CAA cases meet pathologic criteria for AD. This review will discuss the pathophysiology of CAA and focus on new imaging modalities and laboratory biomarkers that may aid in the clinical diagnosis of individuals with the disease. Ann Neurol 2011;70:871–880

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  • Microbleeds are red blood cell-derived iron-containing perivascular hemosiderin deposits that can be visualized as small hypointense regions on T2*- and/or susceptibility-weighted imaging MRI sequences.

    “Microbleeds are RBC-derived iron-containing perivascular hemosiderin deposits that can be visualized as small hypointense regions on T2*- and/or susceptibility-weighted imaging (SWI) MRI sequences (620).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [620]

    The 'Cerebral Microbleeds and Significance in Sporadic CAA' section says that hemosiderin, a blood breakdown product, causes the hypointense T2* signal and that susceptibility-weighted imaging improves microbleed detection. It does not specifically describe microbleeds as RBC-derived, iron-containing perivascular hemosiderin deposits. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

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  1. [1]Smith EE Greenberg SM Beta-amyloid, blood vessels, and brain function Stroke 2009 40 2601 2606 19443808 PMC2704252
  2. [2]Viswanathan A Greenberg SM Chapter 38: Intracerebral hemorrhage Handb Clin Neurol 2008 93 767 790 18804679
  3. [3]Vinters HV Cerebral amyloid angiopathy. A critical review Stroke 1987 18 311 324 3551211
  4. [4]Jellinger KA Alzheimer disease and cerebrovascular pathology: an update J Neural Transm 2002 109 813 836 12111471
  5. [9]Herzig MC Van Nostrand WE Jucker M Mechanism of cerebral beta-amyloid angiopathy: murine and cellular models Brain Pathol 2006 16 40 54 16612981 PMC8095938
  6. [10]Davis J Xu F Deane R Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch/Iowa mutant form of amyloid beta-protein precursor J Biol Chem 2004 279 20296 20306 14985348
  7. [11]Deane R Wu Z Sagare A LRP/amyloid beta-peptide interaction mediates differential brain efflux of Abeta isoforms Neuron 2004 43 333 344 15294142
  8. [12]Monro OR Mackic JB Yamada S Substitution at codon 22 reduces clearance of Alzheimer’s amyloid-beta peptide from the cerebrospinal fluid and prevents its transport from the central nervous system into blood Neurobiol Aging 2002 23 405 412 11959403
  9. [13]Deane R Du Yan S Submamaryan RK RAGE mediates amyloid-beta peptide transport across the blood-brain barrier and accumulation in brain Nat Med 2003 9 907 913 12808450
  10. [14]Eisele YS Obermuller U Heilbronner G Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis Science 2010 330 980 982 20966215 PMC3233904
  11. [15]Sutcliffe JG Hedlund PB Thomas EA Peripheral reduction of beta-amyloid is sufficient to reduce brain beta-amyloid: implications for Alzheimer’s disease J Neurosci Res 2011 89 808 814 21374699
  12. [16]Ujiie M Dickstein DL Carlow DA Jefferies WA Blood-brain barrier permeability precedes senile plaque formation in an Alzheimer disease model Microcirculation 2003 10 463 470 14745459
  13. [17]Mackic JB Bading J Ghiso J Circulating amyloid-beta peptide crosses the blood-brain barrier in aged monkeys and contributes to Alzheimer’s disease lesions Vascul Pharmacol 2002 38 303 313 12529925
  14. [18]Mackic JB Weiss MH Miao W Cerebrovascular accumulation and increased blood-brain barrier permeability to circulating Alzheimer’s amyloid beta peptide in aged squirrel monkey with cerebral amyloid angiopathy J Neurochem 1998 70 210 215 9422364
  15. [19]Poduslo JF Curran GL Haggard JJ Permeability and residual plasma volume of human, Dutch variant, and rat amyloid beta-protein 1–40 at the blood-brain barrier Neurobiol Dis 1997 4 27 34 9258909
  16. [20]Martel CL Mackic JB McComb JG Blood-brain barrier uptake of the 40 and 42 amino acid sequences of circulating Alzheimer’s amyloid beta in guinea pigs Neurosci Lett 1996 206 157 160 8710175
  17. [21]Ghilardi JR Catton M Stimson ER Intra-arterial infusion of [125I]A beta 1–40 labels amyloid deposits in the aged primate brain in vivo Neuroreport 1996 7 2607 2611 8981432
  18. [22]Zlokovic BV Ghiso J Mackic JB Blood-brain barrier transport of circulating Alzheimer’s amyloid beta Biochem Biophys Res Commun 1993 197 1034 1040 8280117
  19. [23]Grabowski TJ Cho HS Vonsattel JP Novel amyloid precursor protein mutation in an Iowa family with dementia and severe cerebral amyloid angiopathy Ann Neurol 2001 49 697 705 11409420
  20. [24]Mandybur TI Cerebral amyloid angiopathy: the vascular pathology and complications J Neuropathol Exp Neurol 1986 45 79 90 3941328
  21. [25]Vinters HV Natte R Maat-Schieman ML Secondary microvascular degeneration in amyloid angiopathy of patients with hereditary cerebral hemorrhage with amyloidosis, Dutch type (HCHWA-D) Acta Neuropathol 1998 95 235 244 9542588
  22. [27]Zekry D Duyckaerts C Belmin J Cerebral amyloid angiopathy in the elderly: vessel walls changes and relationship with dementia Acta Neuropathol 2003 106 367 373 12898153
  23. [28]Vinters HV Secor DL Read SL Microvasculature in brain biopsy specimens from patients with Alzheimer’s disease: an immunohistochemical and ultrastructural study Ultrastruct Pathol 1994 18 333 348 8066824
  24. [29]Calhoun ME Burgermeister P Phinney AL Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid Proc Natl Acad Sci U S A 1999 96 14088 14093 10570203 PMC24195
  25. [30]Christie R Yamada M Moskowitz M Hyman B Structural and functional disruption of vascular smooth muscle cells in a transgenic mouse model of amyloid angiopathy Am J Pathol 2001 158 1065 1071 11238054 PMC1850363
  26. [31]Fryer JD Taylor JW DeMattos RB Apolipoprotein E markedly facilitates age-dependent cerebral amyloid angiopathy and spontaneous hemorrhage in amyloid precursor protein transgenic mice J Neurosci 2003 23 7889 7896 12944519 PMC6740607
  27. [32]Van Dorpe J Smeijers L Dewachter I Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the London mutant of human APP in neurons Am J Pathol 2000 157 1283 1298 11021833 PMC1850171
  28. [33]Winkler DT Bondolfi L Herzig MC Spontaneous hemorrhagic stroke in a mouse model of cerebral amyloid angiopathy J Neurosci 2001 21 1619 1627 11222652 PMC6762950
  29. [34]Kimchi EY Kajdasz S Bacskai BJ Hyman BT Analysis of cerebral amyloid angiopathy in a transgenic mouse model of Alzheimer disease using in vivo multiphoton microscopy J Neuropathol Exp Neurol 2001 60 274 279 11245211
  30. [35]Niwa K Carlson GA Iadecola C Exogenous A beta1–40 reproduces cerebrovascular alterations resulting from amyloid precursor protein overexpression in mice J Cereb Blood Flow Metab 2000 20 1659 1668 11129782
  31. [36]Niwa K Younkin L Ebeling C Abeta 1–40-related reduction in functional hyperemia in mouse neocortex during somatosensory activation Proc Natl Acad Sci U S A 2000 97 9735 9740 10944232 PMC16934
  32. [38]Shin HK Jones PB Garcia-Alloza M Age-dependent cerebrovascular dysfunction in a transgenic mouse model of cerebral amyloid angiopathy Brain 2007 130 2310 2319 17638859
  33. [41]Smith EE Vijayappa M Lima F Impaired visual evoked flow velocity response in cerebral amyloid angiopathy Neurology 2008 71 1424 1430 18955685 PMC2676960
  34. [42]Viswanathan A Patel P Rahman R Tissue microstructural changes are independently associated with cognitive impairment in cerebral amyloid angiopathy Stroke 2008 39 1988 1992 18436874 PMC2698787
  35. [43]Smith EE Gurol ME Eng JA White matter lesions, cognition, and recurrent hemorrhage in lobar intracerebral hemorrhage Neurology 2004 63 1606 1612 15534243
  36. [44]Holland CM Smith EE Csapo I Spatial distribution of white-matter hyperintensities in Alzheimer disease, cerebral amyloid angiopathy, and healthy aging Stroke 2008 39 1127 1133 18292383 PMC2754400
  37. [46]Smith EE Nandigam KR Chen YW MRI markers of small vessel disease in lobar and deep hemispheric intracerebral hemorrhage Stroke 2010 41 1933 1938 20689084 PMC4084787
  38. [47]Zhu Y Chabriat H Godin O Distribution of white matter hyperintensity in patients with intracerebral hemorrhage and healthy aging Paper presented at: Second International CAA Conference: Cerebral Amyloid Angiopathy and Related Microangiopathies May 13–15, 2010 Los Angeles, CA
  39. [48]Olichney JM Hansen LA Hofstetter CR Association between severe cerebral amyloid angiopathy and cerebrovascular lesions in Alzheimer disease is not a spurious one attributable to apolipoprotein E4 Arch Neurol 2000 57 869 874 10867785
  40. [49]Haglund M Passant U Sjobeck M Cerebral amyloid angiopathy and cortical microinfarcts as putative substrates of vascular dementia Int J Geriatr Psychiatry 2006 21 681 687 16802283
  41. [50]Suter OC Sunthorn T Kraftsik R Cerebral hypoperfusion generates cortical watershed microinfarcts in Alzheimer disease Stroke 2002 33 1986 1992 12154250
  42. [51]Okamoto Y Ihara M Fujita Y Cortical microinfarcts in Alzheimer’s disease and subcortical vascular dementia Neuroreport 2009 20 990 996 19483658
  43. [52]Okazaki H Reagan TJ Campbell RJ Clinicopathologic studies of primary cerebral amyloid angiopathy Mayo Clin Proc 1979 54 22 31 759733
  44. [53]Soontornniyomkij V Lynch MD Mermash S Cerebral microinfarcts associated with severe cerebral beta-amyloid angiopathy Brain Pathol 2010 20 459 467 19725828 PMC3127860
  45. [54]Kimberly WT Gilson A Rost NS Silent ischemic infarcts are associated with hemorrhage burden in cerebral amyloid angiopathy Neurology 2009 72 1230 1235 19349602 PMC2677484
  46. [55]Menon RS Kidwell CS Neuroimaging demonstration of evolving small vessel ischemic injury in cerebral amyloid angiopathy Stroke 2009 40 e675 e677 19850897
  47. [56]Lansberg MG Thijs VN O’Brien MW Evolution of apparent diffusion coefficient, diffusion-weighted, and T2-weighted signal intensity of acute stroke AJNR Am J Neuroradiol 2001 22 637 644 11290470 PMC7976036
  48. [57]Greenberg SM Eng JA Ning M Hemorrhage burden predicts recurrent intracerebral hemorrhage after lobar hemorrhage Stroke 2004 35 1415 1420 15073385
  49. [58]Zhang-Nunes SX Maat-Schieman ML van Duinen SG The cerebral beta-amyloid angiopathies: hereditary and sporadic Brain Pathol 2006 16 30 39 16612980 PMC8095991
  50. [59]Woo D Sauerbeck LR Kissela BM Genetic and environmental risk factors for intracerebral hemorrhage: preliminary results of a population-based study Stroke 2002 33 1190 1195 11988589
  51. [60]Biffi A Ayres AM Sonni A APOE Genotype Predicts Hematoma Volume and Expansion in Intracerebral Hemorrhage Paper presented at: International Stroke Conference February 9– 11, 2011 Los Angeles, CA
  52. [61]Biffi A Sonni A Anderson CD Variants at APOE influence risk of deep and lobar intracerebral hemorrhage Ann Neurol 2010 68 934 943 21061402 PMC3058266
  53. [62]O’Donnell HC Rosand J Knudsen KA Apolipoprotein E genotype and the risk of recurrent lobar intracerebral hemorrhage N Engl J Med 2000 342 240 245 10648765
  54. [64]Greenberg SM Briggs ME Hyman BT Apolipoprotein E epsilon 4 is associated with the presence and earlier onset of hemorrhage in cerebral amyloid angiopathy Stroke 1996 27 1333 1337 8711797
  55. [66]Schmechel DE Saunders AM Strittmatter WJ Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease Proc Natl Acad Sci U S A 1993 90 9649 9653 8415756 PMC47627
  56. [67]Premkumar DR Cohen DL Hedera P Apolipoprotein E-epsilon4 alleles in cerebral amyloid angiopathy and cerebrovascular pathology associated with Alzheimer’s disease Am J Pathol 1996 148 2083 2095 8669492 PMC1861657
  57. [68]Greenberg SM Rebeck GW Vonsattel JP Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy Ann Neurol 1995 38 254 259 7654074
  58. [69]Corder EH Lannfelt L Bogdanovic N The role of APOE polymorphisms in late-onset dementias Cell Mol Life Sci 1998 54 928 934 9791536 PMC11147178
  59. [70]Saunders AM Hulette O Welsh-Bohmer KA Specificity, sensitivity, and predictive value of apolipoprotein-E genotyping for sporadic Alzheimer’s disease Lancet 1996 348 90 93 8676723
  60. [72]Scharf J Brauherr E Forsting M Sartor K Significance of haemorrhagic lacunes on MRI in patients with hypertensive cerebrovascular disease and intracerebral haemorrhage Neuroradiology 1994 36 504 508 7845571
  61. [73]Offenbacher H Fazekas F Schmidt R MR of cerebral abnormalities concomitant with primary intracerebral hematomas AJNR Am J Neuroradiol 1996 17 573 578 8881257 PMC8337976
  62. [74]Fazekas F Kleinert R Roob G Histopathologic analysis of foci of signal loss on gradient-echo T2*-weighted MR images in patients with spontaneous intracerebral hemorrhage: evidence of microangiopathy-related microbleeds AJNR Am J Neuroradiol 1999 20 637 642 10319975 PMC7056037
  63. [75]Ripoll MA Siosteen B Hartman M Raininko R MR detectability and appearance of small experimental intracranial hematomas at 1.5 T and 0.5 T. A 6–7-month follow-up study Acta Radiol 2003 44 199 205 12694108
  64. [76]Alemany Ripoll M Stenborg A Sonninen P Detection and appearance of intraparenchymal haematomas of the brain at 1. 5 T with spin-echo, FLAIR and GE sequences: poor relationship to the age of the haematoma Neuroradiology 2004 46 435 443 15138744
  65. [77]Atlas SW Mark AS Grossman RI Gomori JM Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T. Comparison with spinecho imaging and clinical applications Radiology 1988 168 803 807 3406410
  66. [78]Greenberg SM Finklestein SP Schaefer PW Petechial hemorrhages accompanying lobar hemorrhage: detection by gradient-echo MRI Neurology 1996 46 1751 1754 8649586
  67. [79]Roob G Fazekas F Magnetic resonance imaging of cerebral microbleeds Curr Opin Neurol 2000 13 69 73 10719653
  68. [80]Haacke EM DelProposto ZS Chaturvedi S Imaging cerebral amyloid angiopathy with susceptibility-weighted imaging AJNR Am J Neuroradiol 2007 28 316 317 17297004 PMC7977403
  69. [81]Nandigam K Viswanathan A Skehan ME Newer susceptibility-weighted MRI to detect cerebral microbleeds: examining the effect of field strength, sequence parameters, and slice thickness A JNR Am J Neuroractology 2009 30 338 343 PMC2760298 19001544
  70. [82]Vernooij MW van der Lugt A Ikram MA Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study Neurology 2008 70 1208 1214 18378884
  71. [84]Knudsen KA Rosand J Karluk D Greenberg SM Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria Neurology 2001 56 537 539 11222803
  72. [85]Greenberg SM O’Donnell HC Schaefer PW Kraft E MRI detection of new hemorrhages: potential marker of progression in cerebral amyloid angiopathy Neurology 1999 53 1135 1138 10496283
  73. [86]Vinters HV Gilbert JJ Cerebral amyloid angiopathy: incidence and complications in the aging brain. II. The distribution of amyloid vascular changes Stroke 1983 14 924 928 6658996
  74. [87]Ropper AH Davis KR Lobar cerebral hemorrhages: acute clinical syndromes in 26 cases Ann Neurol 1980 8 141 147 7425568
  75. [89]Rosand J Muzikansky A Kumar A Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy Ann Neurol 2005 58 459 462 16130107
  76. [90]Greenberg SM Nandigam RN Delgado P Microbleeds versus macrobleeds: evidence for distinct entities Stroke 2009 40 2382 2386 19443797 PMC2758289
  77. [91]Okoye MI Watanabe I Ultrastructural features of cerebral amyloid angiopathy Hum Pathol 1982 13 1127 1132 6757100
  78. [92]Atri A Locascio JJ Lin JM Prevalence and effects of lobar microhemorrhages in early-stage dementia Neurodegener Dis 2005 2 305 312 16909013
  79. [93]Cordonnier C van der Flier WM Sluimer JD Prevalence and severity of microbleeds in a memory clinic setting Neurology 2006 66 1356 1360 16682667
  80. [94]Hanyu H Tanaka Y Shimizu S Cerebral microbleeds in Alzheimer’s disease J Neurol 2003 250 1496 1497 14673587
  81. [95]Nakata Y Shiga K Yoshikawa K Subclinical brain hemorrhages in Alzheimer’s disease: evaluation by magnetic resonance T2*-weighted images Ann N Y Acad Sci 2002 977 169 172 12480748
  82. [96]Pettersen JA Sathiyamoorthy G Gao F-Q Microbleed topography, leukoaraiosis, and cognition in probable Alzheimer disease from the Sunnybrook dementia study Arch Neurol 2008 65 790 795 18541799
  83. [97]Cordonnier C Al-Shahi Salman R Wardlaw J Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting Brain 2007 130 1988 2003 17322562
  84. [98]Viswanathan A Chabriat H Cerebral microhemorrhage Stroke 2006 37 550 555 16397165
  85. [100]Snowdon DA Greiner LH Mortimer JA Brain infarction and the clinical expression of Alzheimer disease The Nun Study JAMA 1997 277 813 817 9052711
  86. [101]Neuropathology Group of the Medical Research Council Cognitive Function and Ageing Study (MRC CFAS). Pathological correlates of late-onset dementia in a multicentre, community-based population in England and Wales Lancet 2001 357 169 175 11213093
  87. [103]Esiri MM Nagy Z Smith MZ Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer’s disease Lancet 1999 354 919 920 10489957
  88. [104]Heyman A Fillenbaum GG Welsh-Bohmer KA Cerebral infarcts in patients with autopsy-proven Alzheimer’s disease: CERAD, part XVIII. Consortium to Establish a Registry for Alzheimer’s Disease Neurology 1998 51 159 162 9674796
  89. [106]Lee JH Olichney JM Hansen LA Small concomitant vascular lesions do not influence rates of cognitive decline in patients with Alzheimer disease Arch Neurol 2000 57 1474 1479 11030800
  90. [107]Zekry D Duyckaerts C Moulias R Degenerative and vascular lesions of the brain have synergistic effects in dementia of the elderly Acta Neuropathol 2002 103 481 487 11935264
  91. [108]Vermeer SE Prins ND den Heijer T Silent brain infarcts and the risk of dementia and cognitive decline N Engl J Med 2003 348 1215 1222 12660385
  92. [109]Longstreth WT Jr Dulberg C Manolio TA Incidence, manifestations, and predictors of brain infarcts defined by serial cranial magnetic resonance imaging in the elderly: the Cardiovascular Health Study Stroke 2002 33 2376 2382 12364724
  93. [110]Orgogozo JM Gilman S Dartigues JF Subacute meningoencephalitis in a subset of patients with AD after Abeta42 immunization Neurology 2003 61 46 54 12847155
  94. [111]Ferrer I Boada Rovira M Sanchez Guerra ML Neuropathology and pathogenesis of encephalitis following amyloid-beta immunization in Alzheimer’s disease Brain Pathol 2004 14 11 20 14997933 PMC8095815
  95. [115]Black RS Sperling R Kirby L A single ascending dose study of bapinezumab, a humanized monoclonal antibody to A″ AD 006 Paper presented at: Ninth Annual Geneva Spring-field Symposium on Advances in Alzheimer’s Therapy April 19–22, 2006 Geneva, Switzerland
  96. [116]Sveinbjornsdottir S Sigurdsson S Aspelund T Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location J Neurol Neurosurg Psychiatry 2008 79 1002 1006 18270235 PMC11090473
  97. [117]Arvanitakis Z Leurgans S Wang Z Cerebral amyloid angiopathy pathology and cognitive domains in older persons Ann Neurol 2011 69 320 327 21387377 PMC3228518
  98. [118]Klunk WE Engler H Nordberg A Imaging brain amyloid in Alzheimer’s disease with Pittsburgh compound-B Ann Neurol 2004 55 306 319 14991808
  99. [119]Bacskai BJ Hickey GA Skoch J Four-dimensional multiphoton imaging of brain entry, amyloid binding, and clearance of an amyloid-beta ligand in transgenic mice Proc Natl Acad Sci U S A 2003 100 12462 12467 14517353 PMC218780
  100. [120]Bacskai BJ Frosch MP Freeman SH Molecular imaging with Pittsburgh compound B confirmed at autopsy: a case report Arch Neurol 2007 64 431 434 17353389
  101. [121]Johnson KA Gregas M Becker JA Imaging of amyloid burden and distribution in cerebral amyloid angiopathy Ann Neurol 2007 62 229 234 17683091
  102. [123]Greenberg SM Grabowski T Gurol ME Detection of isolated cerebrovascular beta-amyloid with Pittsburgh compound B Ann Neurol 2008 64 587 591 19067370 PMC2605158
  103. [126]Vemuri P Wiste HJ Weigand SD Serial MRI and CSF biomarkers in normal aging, MCI, and AD Neurology 2010 75 143 151 20625167 PMC2905929
  104. [127]Dubois B Feldman HH Jacova C Research criteria for the diagnosis of Alzheimer’s disease: revising the NINCDS-ADRDA criteria Lancet Neurol 2007 6 734 746 17616482
  105. [128]de Jong D Kremer BP Olde Rikkert MG Verbeek MM Current state and future directions of neurochemical biomarkers for Alzheimer’s disease Clin Chem Lab Med 2007 45 1421 1434 17970699
  106. [129]Hulstaert F Blennow K Ivanoiu A Improved discrimination of AD patients using beta-amyloid(1–42) and tau levels in CSF Neurology 1999 52 1555 1562 10331678
  107. [130]Verbeek MM De Jong D Kremer HP Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases Ann Clin Biochem 2003 40 25 40 12542908
  108. [131]Sunderland T Linker G Mirza N Decreased beta-amyloid1– 42 and increased tau levels in cerebrospinal fluid of patients with Alzheimer disease JAMA 2003 289 2094 2103 12709467
  109. [132]Verbeek MM Kremer BP Rikkert MO Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy Ann Neurol 2009 66 245 249 19743453 PMC3697750
  110. [133]Salat DH Smith EE Tuch DS White matter alterations in cerebral amyloid angiopathy measured by diffusion tensor imaging Stroke 2006 37 1759 1764 16763176
  111. [134]Arima H Tzourio C Anderson C Effects of perindopril-based lowering of blood pressure on intracerebral hemorrhage related to amyloid angiopathy: the PROGRESS trial Stroke 2010 41 394 396 20044530
  112. [135]Eckman MH Rosand J Knudsen KA Can patients be anti-coagulated after intracerebral hemorrhage? A decision analysis Stroke 2003 34 1710 1716 12805495
  113. [136]Lee SH Ryu WS Roh JK Cerebral microbleeds are a risk factor for warfarin-related intracerebral hemorrhage Neurology 2009 72 171 176 19139370
  114. [137]Soo YO Yang SR Lam WW Risk vs benefit of anti-thrombotic therapy in ischaemic stroke patients with cerebral microbleeds J Neurol 2008 255 1679 1686 19156486
  115. [138]Biffi A Halpin A Towfighi A Aspirin and recurrent intracerebral hemorrhage in cerebral amyloid angiopathy Neurology 2010 75 693 698 20733144 PMC2931649
  116. [139]Prada CM Garcia-Alloza M Betensky RA Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging J Neurosci 2007 27 1973 1980 17314293 PMC6673561
  117. [141]Thakker DR Weatherspoon MR Harrison J Intracerebroventricular amyloid-beta antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice Proc Natl Acad Sci U S A 2009 106 4501 4506 19246392 PMC2647980

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Authors
Viswanathan, A., & Greenberg, S. M.
Affiliations
Harvard University (US)
Corresponding author
Viswanathan, Anand
ORCID
Venue
Annals of Neurology
Publisher
Wiley
Published
2011-12
Volume
70
Issue
6
Pages
871-880
ISSN
  • 0364-5134 (ISSN-L)
  • 1531-8249
DOI
10.1002/ana.22516
PMC
PMC4004372
OpenAlex
W1981666590
Cited by
643
References
24
Citations by year
2026: 31 · 2025: 44 · 2024: 50 · 2023: 42 · 2022: 58 · 2021: 74 · 2020: 49 · 2019: 35 · 2018: 28 · 2017: 31 · 2016: 53 · 2015: 47 · 2014: 43 · 2013: 30 · 2012: 26
FWCI
3.97
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 20 d)
Locations
  • Annals of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Aging (K23AG028726, P50AG005134)
Topics
  • Health Sciences › Medicine › Neurology › Intracerebral and Subarachnoid Hemorrhage Research
  • Health Sciences › Medicine › Neurology › Cerebrovascular and genetic disorders
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
cerebral amyloid angiopathy, amyloid-beta deposition, lobar intracerebral hemorrhage, cognitive impairment, cerebral small vessel disease, cerebral microbleeds, white matter hyperintensities, Alzheimer's disease, pathophysiology, imaging biomarkers, laboratory biomarkers, older adults
MeSH terms
Aged, Aged, 80 and over, Alzheimer Disease, Amyloid, Blood Vessels, Brain, Brain Injuries, Cerebral Hemorrhage, Cognition Disorders, Humans, Magnetic Resonance Imaging, Cerebral Amyloid Angiopathy, Plaque, Amyloid

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