Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 406

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke: Feasibility, Safety, and Efficacy in the First Year of Clinical Practice

Chiu, David, Krieger, Derk, Villar-Cordova, Carlos, Kasner, Scott E., Morgenstern, Lewis B., Bratina, Patti L., Yatsu, Frank M., Grotta, James C.·1998·Stroke
DOI 10.1161/01.str.29.1.18
Open this paper in CoChat — free account

Abstract

Background and Purpose —The feasibility, safety, and efficacy of intravenous tissue plasminogen activator (t-PA) for patients with acute ischemic stroke in clinical practice need to be assessed. Methods —We initiated a prospective open-label study at a university hospital and two community hospitals in Houston, Tex, immediately after the publication of the National Institute of Neurological Disorders and Stroke (NINDS) t-PA study. A total of 30 patients, age 32 to 90 years, were treated with 0.9 mg/kg of intravenous t-PA (maximum dose, 90 mg) within 3 hours of acute ischemic stroke between December 1995 and December 1996. Results —Six percent (6%) of all patients hospitalized with ischemic stroke received intravenous t-PA at the university hospital and 1.1% at the community hospitals. The rates of total, symptomatic, and fatal intracerebral hemorrhage were 10%, 7%, and 3%. Thirty-seven percent (37%) of patients recovered to fully independent function. The average time from stroke onset to emergency department arrival was 57 minutes; emergency department arrival to computed tomography scan 41 minutes; and computed tomography scan to administration of treatment 59 minutes. Conclusions —When treatment guidelines are carefully followed in an urban hospital setting, intravenous t-PA for acute ischemic stroke is feasible and shows safety and efficacy comparable to the results of the NINDS study.

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1161/01.str.29.1.18

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 13 references

Cited by

See all 406

Metadata

Authors
Chiu, D., Krieger, D., Villar-Cordova, C., Kasner, S. E., Morgenstern, L. B., Bratina, P. L., Yatsu, F. M., & Grotta, J. C.
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-01
Volume
29
Issue
1
Pages
18-22
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.29.1.18
OpenAlex
W2148750186
Cited by
406
References
13
FWCI
26.84
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke: Feasibility, Safety, and Efficacy in the First Year of Clinical Practice. https://app.cochat.ai/papers/10.1161/01.str.29.1.18
The paper
Chiu, D., Krieger, D., Villar-Cordova, C., Kasner, S. E., Morgenstern, L. B., Bratina, P. L., Yatsu, F. M., & Grotta, J. C. (1998). Intravenous Tissue Plasminogen Activator for Acute Ischemic Stroke: Feasibility, Safety, and Efficacy in the First Year of Clinical Practice. Stroke. https://doi.org/10.1161/01.str.29.1.18

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.