CoChat
Sign Up
Cited by 111Systemic Lupus Erythematosus ResearchAcute Ischemic Stroke ManagementCerebral Venous Sinus Thrombosis

The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.

Cerebrovascular Ischemic Events With High Positive Anticardiolipin Antibodies

Verro, Piero, Levine, Steven R., Tietjen, Gretchen E.·1998·Stroke
DOI 10.1161/01.str.29.11.2245
Open this paper in CoChat — free account

Abstract

Background and purpose The aim of our study was to characterize the patient profile and prognostic value associated with high positive IgG (>100 GPL) anticardiolipin antibodies (aCL). Methods We studied the clinical, laboratory, radiological, and prospective historical features of ischemic cerebrovascular disease in patients with >100 GPL titers. From our neurology department, 27 consecutive patients were prospectively identified and followed up (mean follow-up time, 34 months). Results The mean age of our cohort was 41 years. Lupuslike illness occurred in 3; 23 had primary antiphospholipid syndrome, including 3 who met criteria for Sneddon's syndrome; 1 patient had progressive systemic sclerosis. Cerebral infarcts occurred in 74% and were recurrent in 37%. Systemic ischemic events, most commonly deep vein thrombosis, occurred in 37%. Tobacco use was documented in 85%, hyperlipidemia in 74%, hypertension in 44%, and diabetes mellitus in 7% of patients. A prominent headache history was present in 67%. Lupus anticoagulant (LA) was present in 72%, approximately one half had positive antinuclear antibodies and thrombocytopenia, and one quarter had a false-positive VDRL. We compared mean GPL levels in patients testing positive for specific laboratory features of antiphospholipid syndrome with those testing negative for these parameters. Only the LA(+) group had a significantly higher mean GPL than the LA(-) group (P=0.006). Brain imaging showed nonlacunar infarcts in 73% and lacun…

Overview

Integrity signals

Registry

Crossref · 10.1161/01.str.29.11.2245

Cites

50 of 50 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 8

  1. 10.1161/str.21.9.2396261 · DOI
  2. 10.1161/str.29.9.1755 · DOI
  3. Spinazzi A Noseda A Paloscia L Caputo M Maselli A Bonomo L. Association of levels of anticardiolipin (aCL) antibodies with peripheral atherosclerotic disease (PAD) documented by angiography. In: Proceedings of the Fifth International Symposium on Antiphospholipid Antibodies; September 9–12 1992; San Antonio Tex.
  4. 10.1161/str.19.5.3363593 · DOI
  5. 10.1161/str.23.2.1561646 · DOI
  6. 10.1161/str.22.6.2057974 · DOI
  7. Turhim S, Rand JH, Goldbold JH, Weinberger J, Horowitz DR, Goldman M. Elevated antiphosphatidyl serine antibodies are a risk factor for ischemic stroke. Neurology. 1998;50:A246. Abstract.
  8. 10.1161/str.29.9.1759 · DOI

Cited by

Sorted by citations

See all 111

Related

See all

Metadata

Authors
Verro, P., Levine, S. R., & Tietjen, G. E.
Affiliations
Henry Ford Health (US)
ORCID
Venue
Stroke
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1998-11
Volume
29
Issue
11
Pages
2245-2253
ISSN
  • 0039-2499 (ISSN-L)
  • 1524-4628
DOI
10.1161/01.str.29.11.2245
OpenAlex
W2132099411
Cited by
111
References
51
Citations by year
2025: 4 · 2024: 3 · 2023: 3 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 3 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
FWCI
4.30
Type
journal article
Language
en
Open access
closed
Locations
  • Stroke (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS-30896, R01NS030896, NS-23393)
Topics
  • Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
  • Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
  • Health Sciences › Medicine › Clinical Neurology › Cerebral Venous Sinus Thrombosis
Keywords
anticardiolipin antibodies, antiphospholipid syndrome, lupus anticoagulant, cerebral ischemia, cerebral infarction, recurrent ischemic events, deep vein thrombosis, prognosis, IgG antibody titers, neurological deficit, thrombocytopenia, antinuclear antibodies, VDRL test
MeSH terms
Adult, Aged, Intracranial Embolism and Thrombosis, Ischemic Attack, Transient, Cerebrovascular Disorders, Disability Evaluation, Echocardiography, Follow-Up Studies, Humans, Immunoglobulin G, Magnetic Resonance Imaging, Middle Aged, Prospective Studies, Risk Factors, Tomography, X-Ray Computed, Lupus Coagulation Inhibitor, Antibodies, Anticardiolipin

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review