Anticardiolipin antibodies: detection by radioimmunoassay and association with thrombosis in systemic lupus erythematosus
Abstract
A new solid-phase radioimmunoassay for the detection of anticardiolipin antibodies is 200-400 times more sensitive than the precipitation method used in the Venereal Disease Reference Laboratory test. 61% of serum samples from patients with systemic lupus erythematosus (SLE) had high levels of anticardiolipin antibodies of at least one immunoglobulin class. There were strong correlations between raised anticardiolipin levels and the lupus anticoagulant, venous and arterial thrombosis, and thrombocytopenia, but no correlation with anti-DNA antibody levels. Of the 15 patients with the highest anticardiolipin titres, 6 had a history of venous thrombosis, 5 cerebral thrombosis, 5 thrombocytopenia, and 2 each pulmonary hypertension and multiple abortions. This simple immunoassay appears to have predictive value for thrombosis in SLE and related disorders.
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aPL were first described in patients with SLE.
“aPL were first described in patients with SLE [2, 3].”
From Antiphospholipid patterns predict risk of thrombosis in systemic lupus erythematosus (2021) · cites this paper as [3]
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- Authors
- Harris, E. N., Boey, M. L., Mackworth-Young, C. G., Gharavi, A. E., Patel, B. M., Loizou, S., & Hughes, G. R. V.
- Affiliations
- Hammersmith Hospital (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1983-11
- Volume
- 322
- Issue
- 8361
- Pages
- 1211-1214
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2000055469
- Cited by
- 1,383
- References
- 20
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 9 · 2023: 9 · 2022: 7 · 2021: 12 · 2020: 10 · 2019: 11 · 2018: 15 · 2017: 10 · 2016: 15 · 2015: 10 · 2014: 17 · 2013: 17 · 2012: 23
- FWCI
- 43.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Hematology › Blood Coagulation and Thrombosis Mechanisms
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Vasculitis and related conditions
- Keywords
- anticardiolipin antibodies, systemic lupus erythematosus, thrombosis, lupus anticoagulant, venous thrombosis, arterial thrombosis, thrombocytopenia, cerebral thrombosis, pulmonary hypertension, multiple abortion, anti-DNA antibodies, solid-phase radioimmunoassay, autoantibody detection
- MeSH terms
- Adolescent, Adult, Autoantibodies, Cardiolipins, DNA, Female, Humans, Immunoglobulins, Lupus Erythematosus, Systemic, Male, Middle Aged, Radioimmunoassay, Thrombosis
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