The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Cooling for Acute Ischemic Brain Damage (COOL AID): An Open Pilot Study of Induced Hypothermia in Acute Ischemic Stroke
Abstract
Background and Purpose — Hypothermia is effective in improving outcome in experimental models of brain infarction. We studied the feasibility and safety of hypothermia in patients with acute ischemic stroke treated with thrombolysis. Methods — An open study design was used. All patients presented with major ischemic stroke (National Institutes of Health Stroke Scale [NIHSS] score >15) within 6 hours of onset. After informed consent, patients with a persistent NIHSS score of >8 were treated with hypothermia to 32±1°C for 12 to 72 hours depending on vessel patency. All patients were monitored in the neurocritical care unit for complications. A modified Rankin Scale was measured at 90 days and compared with concurrent controls. Results — Ten patients with a mean age of 71.1±14.3 years and an NIHSS score of 19.8±3.3 were treated with hypothermia. Nine patients served as concurrent controls. The mean time from symptom onset to thrombolysis was 3.1±1.4 hours and from symptom onset to initiation of hypothermia was 6.2±1.3 hours. The mean duration of hypothermia was 47.4±20.4 hours. Target temperature was achieved in 3.5±1.5 hours. Noncritical complications in hypothermia patients included bradycardia (n=5), ventricular ectopy (n=3), hypotension (n=3), melena (n=2), fever after rewarming (n=3), and infections (n=4). Four patients with chronic atrial fibrillation developed rapid ventricular rate, which was noncritical in 2 and critical in 2 patients. Three patients had myocardial infarctions without sequelae. There were 3 deaths in patients undergoing hypothermia. The mean modified Rankin Scale score at 3 months in hypothermia patients was 3.1±2.3. Conclusion — Induced hypothermia appears feasible and safe in patients with acute ischemic stroke even after thrombolysis. Refinements of the cooling process, optimal target temperature, duration of therapy, and, most important, clinical efficacy, require further study.
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Cites
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Lack of Effect of Induction of Hypothermia after Acute Brain Injury
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Treatment of Traumatic Brain Injury with Moderate Hypothermia
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Early stroke treatment associated with better outcome: The NINDS rt-PA Stroke Study
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Moderate Hypothermia in the Treatment of Patients With Severe Middle Cerebral Artery Infarction
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Cited by
Medical Complications After Stroke: A Multicenter Study
Langhorne, P., Stott, D. J., Robertson, L., MacDonald, J., Jones, L., McAlpine, C., Dick, F., Taylor, G. S., & Murray, G. (2000) · Stroke · doi:10.1161/01.str.31.6.1223 · Cited by 1,196
Medical complications after stroke
Kumar, S., Selim, M. H., & Caplan, L. R. (2010) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70266-2 · Cited by 601
Polderman, K. H. (2004) · Intensive Care Medicine · doi:10.1007/s00134-003-2152-x · Cited by 435
Myocardial Protection at a Crossroads: The Need for Translation Into Clinical Therapy
Bolli, R., Becker, L., Gross, G., Mentzer, R., Balshaw, D., & Lathrop, D. A. (2004) · Circulation Research · doi:10.1161/01.res.0000137171.97172.d7 · Cited by 428
Adams, H., Adams, R., Del Zoppo, G., & Goldstein, L. B. (2005) · Stroke · doi:10.1161/01.str.0000163257.66207.2d · Cited by 423
Metadata
- Authors
- Krieger, D. W., De Georgia, M. A., Abou-Chebl, A., Andrefsky, J. C., Sila, C. A., Katzan, I. L., Mayberg, M. R., & Furlan, A. J.
- Venue
- Stroke
- Published
- 2001-08
- Volume
- 32
- Issue
- 8
- Pages
- 1847-1854
- ISSN
- 0039-2499 (ISSN-L)
- 1524-4628
- OpenAlex
- W1964349082
- Cited by
- 403
- References
- 27
- FWCI
- 21.22
- Type
- journal article
- Language
- en
- Open access
- closed
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- Krieger, D. W., De Georgia, M. A., Abou-Chebl, A., Andrefsky, J. C., Sila, C. A., Katzan, I. L., Mayberg, M. R., & Furlan, A. J. (2001). Cooling for Acute Ischemic Brain Damage (COOL AID): An Open Pilot Study of Induced Hypothermia in Acute Ischemic Stroke. Stroke. https://doi.org/10.1161/01.str.32.8.1847
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