The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Chemokines in Vascular Dysfunction and Remodeling
Open accessAbstract
Vascular remodeling stands for structural changes of the vessel wall in response to various noxious stimuli, which results in reorganization of the vessel wall architecture. Luminal narrowing because of neointima formation and constrictive remodeling leading to hypoperfusion is the most relevant clinical effect. Smooth muscle cell (SMC) accumulation, inflammatory cell recruitment, and endothelial regeneration are the critical parts in obstructive vascular remodeling. Chemokines and chemokine receptors have a great impact on initiating and progressing neointimal formation by controlling each step of the remodeling process. SDF-1α regulates vascular repair by CXCR4-dependent smooth muscle progenitor cell recruitment, which contributes to the maladaptive response to injury. The three distinct chemokine-chemokine receptor pairs MCP-1/CCR2, RANTES/CCR5, and Fractalkine/CX 3 CR1 direct lesional leukocyte infiltration. In addition MCP-1/CCR2 and Fractalkine/CX 3 CR1 increase neointimal SMC expansion. In contrast, KC/Gro-α supports endothelial recovery through CXCR2, which attenuates neointima formation. These findings highlight the importance to characterize specific functions of the chemokine network to enable therapeutic intervention.
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Cites
Inflammation, Atherosclerosis, and Coronary Artery Disease
Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773
The many roles of chemokines and chemokine receptors in inflammation
Charo, I. F., & Ransohoff, R. M. (2006) · New England Journal of Medicine · doi:10.1056/nejmra052723 · Cited by 2,523
A new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1101 · Cited by 1,482
Huo, Y., Weber, C., Forlow, S. B., Sperandio, M., Thatte, J., Mack, M., Jung, S., Littman, D. R., & Ley, K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12877 · Cited by 266
Cited by
Metformin inhibits inflammatory response via AMPK-PTEN pathway in vascular smooth muscle cells
Kim, S. A., & Choi, H. C. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.165 · Cited by 149
Bernstein, D. L., Zuluaga-Ramirez, V., Gajghate, S., Reichenbach, N. L., Polyak, B., Persidsky, Y., & Rom, S. (2020) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x19882264 · Cited by 120
miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions
Rom, S., Dykstra, H., Zuluaga-Ramirez, V., Reichenbach, N. L., & Persidsky, Y. (2015) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2015.154 · Cited by 118
Medicinal Plants with Antiplatelet Activity
El Haouari, M., & Rosado, J. A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5619 · Cited by 54
Song, R., Ao, L., Zhao, K.-S., Zheng, D., Venardos, N., Fullerton, D. A., & Meng, X. (2014) · Inflammation Research · doi:10.1007/s00011-014-0743-3 · Cited by 37
Metadata
- Authors
- Schober, A.
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2008-11
- Volume
- 28
- Issue
- 11
- Pages
- 1950-1959
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- OpenAlex
- W2146840987
- Cited by
- 257
- References
- 5
- FWCI
- 10.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
