Medicinal Plants with Antiplatelet Activity
Abstract
Blood platelets play an essential role in the hemostasis and wound-healing processes. However, platelet hyperactivity is associated to the development and the complications of several cardiovascular diseases. In this sense, the search for potent and safer antiplatelet agents is of great interest. This article provides an overview of experimental studies performed on medicinal plants with antiplatelet activity available through literature with particular emphasis on the bioactive constituents, the parts used, and the various platelet signaling pathways modulated by medicinal plants. From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, and Zingiberaceae. The antiplatelet effect is attributed to the presence of bioactive compounds such as polyphenols, flavonoids, coumarins, terpenoids, and other substances which correct platelet abnormalities by interfering with different platelet signalization pathways including inhibition of the ADP pathway, suppression of TXA2 formation, reduction of intracellular Ca(2+) mobilization, and phosphoinositide breakdown, among others. The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic-related disorders by inhibiting platelet aggregation. Copyright © 2016 John Wiley & Sons, Ltd.
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Polyphenols have antiplatelet activity.
“These molecules have also antiplatelet activity [56,57].”
From Mediterranean Diet as an Antioxidant: The Impact on Metabolic Health and Overall Wellbeing (2021) · cites this paper as [57]
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Anisuzzman, M., Mou, S. Z., Mollah, A., Akter, F., Islam, M. M., Zilani, M. N. H., & Khan, T. E. (2024) · Khulna University Studies · doi:10.53808/kus.2024.21.02.1219-ls · Cited by 1 · see citing works
Therapeutic Potentials of Girinimbine, A Carbazole Alkaloid: A Review
Abdel-dayem, S. I. A., Fahim, S. A., El‐Dessouki, A. M., El‐Shiekh, R. A., Attallah, K. A., Abdou, K., & Rabie, M. A. (2026) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-025-00736-7 · Cited by 1 · see citing works
Yılmaz, B., & Yılmaz, S. (2023) · Cumhuriyet Science Journal · doi:10.17776/csj.1282586 · Cited by 1 · see citing works
Nath, P., & Thakur, R. (2025) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496475.2025.2512372 · Cited by 1 · see citing works
Гречана, О. В., & Сербін, А. Г. (2019) · Journal of Chemistry and Technologies · doi:10.15421/0817260205 · Cited by 1 · see citing works
Influência da adesão ao Padrão Alimentar Mediterrânico na saúde ao longo do Ciclo de Vida
João, D. R., Mateus, M. P., & Braz, N. M. D. A. R. (2022) · Acta Portuguesa de Nutrição · doi:10.21011/apn.2022.2808 · Cited by 1 · see citing works
Gut microbiota and their effects on atherosclerosis, platelet function, and hypertension
Duttaroy, A. K. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-822405-2.00022-0
Mishra, P. K., Verma, R. G., Solanki, M. S., Ashok, V., Krishna, V. L. S., Soni, A., Choubey, V., & Rajput, M. (2005) · Environment Conservation Journal · doi:10.36953/ecj.2005.0612318
BIOANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF ANTIPLATELET DRUG IN HUMAN PLASMA BY HPLC
(2023) · International Research Journal of Modernization in Engineering Technology and Science · doi:10.56726/irjmets40579
- Authors
- El Haouari, M., & Rosado, J. A.
- Affiliations
- Centre Régional des Métiers de l'Education et de la Formation de Taza (CRMEF - Taza); B.P. 1178 Taza Gare Morocco
- Universidad de Extremadura (ES)
- ORCID
- Rosado, Juan A.
- Venue
- Phytotherapy Research
- Publisher
- Wiley
- Published
- 2016-04-06
- Volume
- 30
- Issue
- 7
- Pages
- 1059-1071
- ISSN
- 0951-418X (ISSN-L)
- OpenAlex
- W2342221617
- Cited by
- 54
- References
- 152
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 1
- FWCI
- 0.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Phytotherapy Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- MINECO (BFU2013-45564-C2-1-P)
- Junta de Extremadura-FEDER (GR15029)
- Topics
- Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Keywords
- medicinal plants, antiplatelet activity, platelet aggregation, bioactive compounds, polyphenols, flavonoids, coumarins, terpenoids, thromboxane A2, calcium mobilization, phosphoinositide breakdown, cardiovascular disease, thromboprophylaxis, Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, Zingiberaceae
- MeSH terms
- Blood Platelets, Humans, Plant Extracts, Plants, Medicinal, Platelet Aggregation, Platelet Aggregation Inhibitors, Signal Transduction
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