Cited by 55Platelet Disorders and TreatmentsMedicinal Plant ResearchPhytochemistry and Biological Activities

Medicinal Plants with Antiplatelet Activity

El Haouari, Mohammed, Rosado, Juan A.·2016·Phytotherapy Research

Abstract

Blood platelets play an essential role in the hemostasis and wound-healing processes. However, platelet hyperactivity is associated to the development and the complications of several cardiovascular diseases. In this sense, the search for potent and safer antiplatelet agents is of great interest. This article provides an overview of experimental studies performed on medicinal plants with antiplatelet activity available through literature with particular emphasis on the bioactive constituents, the parts used, and the various platelet signaling pathways modulated by medicinal plants. From this review, it was suggested that medicinal plants with antiplatelet activity mainly belong to the family of Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, and Zingiberaceae. The antiplatelet effect is attributed to the presence of bioactive compounds such as polyphenols, flavonoids, coumarins, terpenoids, and other substances which correct platelet abnormalities by interfering with different platelet signalization pathways including inhibition of the ADP pathway, suppression of TXA2 formation, reduction of intracellular Ca(2+) mobilization, and phosphoinositide breakdown, among others. The identification and/or structure modification of the plant constituents and the understanding of their action mechanisms will be helpful in the development of new antiplatelet agents based on medicinal plants which could contribute to the prevention of thromboembolic-related disorders by inhibiting platelet aggregation. Copyright © 2016 John Wiley & Sons, Ltd.

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Crossref · 10.1002/ptr.5619

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Authors
El Haouari, M., & Rosado, J. A.
Affiliations
  • Centre Régional des Métiers de l'Education et de la Formation de Taza (CRMEF - Taza); B.P. 1178 Taza Gare Morocco
  • Universidad de Extremadura (ES)
Venue
Phytotherapy Research
Publisher
Wiley
Published
2016-04-06
Volume
30
Issue
7
Pages
1059-1071
ISSN
0951-418X (ISSN-L)
OpenAlex
W2342221617
Cited by
54
References
152
Citations by year
2026: 1 · 2025: 1 · 2024: 5 · 2023: 5 · 2022: 7 · 2021: 8 · 2020: 7 · 2019: 5 · 2018: 5 · 2017: 7 · 2016: 1
FWCI
0.85
Type
journal article
Language
en
Open access
closed
Locations
  • Phytotherapy Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • MINECO (BFU2013-45564-C2-1-P)
  • Junta de Extremadura-FEDER (GR15029)
Topics
  • Health Sciences › Medicine › Hematology › Platelet Disorders and Treatments
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
medicinal plants, antiplatelet activity, platelet aggregation, bioactive compounds, polyphenols, flavonoids, coumarins, terpenoids, thromboxane A2, calcium mobilization, phosphoinositide breakdown, cardiovascular disease, thromboprophylaxis, Asteraceae, Rutaceae, Fabaceae, Lamiaceae, Zygophyllaceae, Rhamnaceae, Liliaceae, Zingiberaceae
MeSH terms
Blood Platelets, Humans, Plant Extracts, Plants, Medicinal, Platelet Aggregation, Platelet Aggregation Inhibitors, Signal Transduction

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