The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.
Chemokines as Mediators of Neovascularization
Open accessAbstract
Chemokines are a superfamily of homologous heparin-binding proteins, first described for their role in recruiting leukocytes to sites of inflammation. Chemokines have since been recognized as key factors mediating both physiological and pathological neovascularization in such diverse clinical settings as malignancy, wound repair, chronic fibroproliferative disorders, myocardial ischemia, and atherosclerosis. Members of the CXC chemokine family, structurally defined as containing the ELR amino acid motif, are potent inducers of angiogenesis, whereas another subset of the CXC chemokines inhibits angiogenesis. In addition, CCL2, a CC chemokine ligand, has been implicated in arteriogenesis. In this article, we review the current literature on the role of chemokines as mediators of neovascularization.
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“CXCL9 also inhibits neovascularization (83) and has anti-tumor and anti-metastatic effects (74).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [83]
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“CXCL10, or interferon gamma-induced protein 10, is secreted not only by monocytes and macrophages, but also by fibroblasts and endothelial cells (83).”
From Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014) · cites this paper as [83]
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Cites
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Involvement of chemokine receptors in breast cancer metastasis
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Chemokines — Chemotactic Cytokines That Mediate Inflammation
Luster, A. D. (1998) · New England Journal of Medicine · doi:10.1056/nejm199802123380706 · Cited by 3,633
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Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
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Cited by
Sorted by citations
Macrophage Cytokines: Involvement in Immunity and Infectious Diseases
Arango Duque, G., & Descoteaux, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00491 · Cited by 2,708
“CXCL10 (IP-10) CXCL10, or interferon gamma-induced protein 10, is secreted not only by monocytes and macrophages, but also by fibroblasts and endothelial cells (83).”
BackgroundChemokines in health and disease
Raman, D., Sobolik-Delmaire, T., & Richmond, A. J. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.01.005 · Cited by 387
Comprehensive Analysis of Inflammatory Immune Mediators in Vitreoretinal Diseases
Yoshimura, T., Sonoda, K., Sugahara, M., Mochizuki, Y., Enaida, H., Oshima, Y., Ueno, A., Hata, Y., Yoshida, H., & Ishibashi, T. (2009) · PLoS ONE · doi:10.1371/journal.pone.0008158 · Cited by 349
Extracellular matrix, inflammation, and the angiogenic response
Arroyo, A. G., & Iruela‐Arispe, M. L. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq049 · Cited by 353
CXC Chemokines in Cancer Angiogenesis and Metastases
Keeley, E. C., Mehrad, B., & Strieter, R. M. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)06003-3 · Cited by 263
Self-citation
Metadata
- Authors
- Keeley, E. C., Mehrad, B., & Strieter, R. M.
- Affiliations
- University of Virginia (US)
- Venue
- Arteriosclerosis, Thrombosis, and Vascular Biology
- Published
- 2008-11
- Volume
- 28
- Issue
- 11
- Pages
- 1928-1936
- ISSN
- 1079-5642 (ISSN-L)
- 1524-4636
- PMC
- PMC2735456
- OpenAlex
- W2125050685
- Cited by
- 192
- References
- 142
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 10 · 2021: 17 · 2020: 7 · 2019: 6 · 2018: 12 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 12 · 2013: 15 · 2012: 19
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL66027, HL-73848, R01HL066027, R01HL073848)
- National Cancer Institute (CA-87879, R01CA087879)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Connective Tissue Growth Factor Research
- Keywords
- chemokines, neovascularization, angiogenesis, arteriogenesis, CXC chemokines, CC chemokines, MCP-1, inflammation, wound healing, atherosclerosis, myocardial ischemia, fibroproliferative disorders, cancer
- MeSH terms
- Animals, Humans, Neovascularization, Pathologic, Neovascularization, Physiologic, Chemokines, Angiogenic Proteins, Endothelial Cells, Angiostatic Proteins
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