Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1
Abstract
The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly understood. The chemokine stromal cell-derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marrow by binding to CXCR4 on circulating cells. SDF-1 and CXCR4 are expressed in complementary patterns during embryonic organogenesis and guide primordial stem cells to sites of rapid vascular expansion. However, the regulation of SDF-1 and its physiological role in peripheral tissue repair remain incompletely understood. Here we show that SDF-1 gene expression is regulated by the transcription factor hypoxia-inducible factor-1 (HIF-1) in endothelial cells, resulting in selective in vivo expression of SDF-1 in ischemic tissue in direct proportion to reduced oxygen tension. HIF-1-induced SDF-1 expression increases the adhesion, migration and homing of circulating CXCR4-positive progenitor cells to ischemic tissue. Blockade of SDF-1 in ischemic tissue or CXCR4 on circulating cells prevents progenitor cell recruitment to sites of injury. Discrete regions of hypoxia in the bone marrow compartment also show increased SDF-1 expression and progenitor cell tropism. These data show that the recruitment of CXCR4-positive progenitor cells to regenerating tissues is mediated by hypoxic gradients via HIF-1-induced expression of SDF-1.
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Other hypoxia-induced pro-angiogenic factors include PDGF-β, ANGPT2, and SDF-1α, all of which promote neoangiogenesis.
“Other hypoxia-induced pro-angiogenic factors include platelet-derived growth factor-β (PDGF-β) (Kelly et al., 2003), angiopoietin-2 (ANGPT2) (Kelly et al., 2003), and stromal-derived factor 1α (SDF-1α) (Ceradini et al., 2004), all of which promote neoangiogenesis.”
From Therapeutic targeting of hypoxia and hypoxia-inducible factors in cancer (2016) · cites this paper as Ceradini et al., 2004
Activation of HIF-1α and formation of the HIF complex induce angiogenic growth factor genes including VEGF and SDF-1/CXCL12.
“The activation of HIF-1α and the formation of the HIF complex induce several angiogenic growth factor genes, including VEGF and stromal cell-derived factor-1 (SDF-1)/C-X-C motif chemokine 12 (CXCL12) [82,83,84].”
From The Pathogenesis of Adenomyosis vis-à-vis Endometriosis (2020) · cites this paper as [83]
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- Authors
- Ceradini, D. J., Kulkarni, A. R., Callaghan, M. J., Tepper, O. M., Bastidas, N., Kleinman, M. E., Capla, J. M., Galiano, R. D., Levine, J. P., & Gurtner, G. C.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Gurtner, Geoffrey C
- ORCID
- Venue
- Nature Medicine
- Published
- 2004-07-04
- Volume
- 10
- Issue
- 8
- Pages
- 858-864
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- OpenAlex
- W1982861439
- Cited by
- 2,600
- References
- 31
- Citations by year
- 2026: 35 · 2025: 52 · 2024: 59 · 2023: 68 · 2022: 65 · 2021: 78 · 2020: 83 · 2019: 106 · 2018: 122 · 2017: 124 · 2016: 131 · 2015: 154 · 2014: 163 · 2013: 169 · 2012: 182
- FWCI
- 55.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sarnoff Cardiovascular Research Foundation
- National Institutes of Health
- National Institute of Biomedical Imaging and Bioengineering (EB002265, R21EB002265)
- Topics
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- HIF-1, CXCL12, CXCR4, ischemic tissue repair, stem cell homing, endothelial cells, bone marrow, tissue regeneration
- MeSH terms
- Analysis of Variance, Animals, Bone Marrow, Cell Adhesion, Cell Movement, Disease Models, Animal, DNA-Binding Proteins, Enzyme-Linked Immunosorbent Assay, Gene Expression Regulation, Ischemia, Mice, Nude, Nuclear Proteins, Precipitin Tests, Stem Cells, Transcription Factors, Cell Hypoxia, In Situ Hybridization, Receptors, CXCR4, Chemokines, CXC, Reverse Transcriptase Polymerase Chain Reaction, Endothelial Cells, Mice, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit, Chemokine CXCL12
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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