Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta—Brief Report

Sawada, Hisashi, Rateri, Debra L., Moorleghen, Jessica J., Majesky, Mark W., Daugherty, Alan·2017·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.117.309599

Cited by (181)

Items 101–181 of 181

  1. Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins
    Ares D. Pasipoularides · 2019 · Journal of Molecular and Cellular Cardiology
  2. Review of the Essential Roles of SMCs in ATAA Biomechanics
    Claudie Petit, S. Jamaleddin Mousavi, Stéphane Avril · 2019 · Elsevier eBooks
  3. Region-specific gene expression and sex inform about disease susceptibility in the aorta
    Milagros C. Romay, Feiyang Ma, Ana Mompeón, Michele Silvestro, Gloria E. Hernandez, Jocelynda Salvador, Andrew L. Wang, Marie Vandestienne, Nathalie Bardin, Marcel Blot‐Chabaud et al. · 2025 · Nature Cardiovascular Research
  4. Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
    Sohei Ito, Hong S. Lu, Alan Daugherty, Hisashi Sawada · 2022 · Genes
  5. The impact of genetic factors and testing on operative indications and extent of surgery for aortopathy
    Elizabeth L. Norton, Bo Yang · 2021 · JTCVS Open
  6. Nuclear Control of Vascular Smooth Muscle Cell Plasticity during Vascular Remodeling
    Ibrahim A. Ahmed, Mingjun Liu, Delphine A Gomez · 2023 · American Journal Of Pathology
  7. Selective mural cell recruitment of pericytes to networks of assembling endothelial cell-lined tubes
    Ksenia Yrigoin, George E. Davis · 2024 · Frontiers in Cell and Developmental Biology
  8. Transcriptional regulation of postnatal aortic development
    Dar Weiss, N. Yeung, Abhay B. Ramachandra, J. D. Humphrey · 2024 · Cells and Development
  9. SMAD4 : A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development
    Brianna E. Alexander, Huaning Zhao, Sophie Astrof · 2023 · Developmental Dynamics
  10. Mst1/2 Kinases Inhibitor, XMU-MP-1, Attenuates Angiotensin II-Induced Ascending Aortic Expansion in Hypercholesterolemic Mice
    Michihiro Okuyama, Weihua Jiang, Lihua Yang, Venkateswaran Subramanian · 2021 · Circulation Reports
  11. Progesterone Receptor Modulates Extraembryonic Mesoderm and Cardiac Progenitor Specification during Mouse Gastrulation
    Anna Maria Drozd, Luca Mariani, Xiaogang Guo, Victor E. Goitea, Niels Alvaro Menezes, Elisabetta Ferretti · 2022 · International Journal of Molecular Sciences
  12. Smooth muscle cells and fibroblasts in the ascending aorta exhibit minor differences between embryonic origins in angiotensin II-driven transcriptional alterations
    Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J. Moorleghen, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen, Hong S. Lu, Alan Daugherty et al. · 2025 · Scientific Reports
  13. Epigenomic landscape of single vascular cells reflects developmental origin and disease risk loci
    Chad S. Weldy, Soumya Kundu, João P. Monteiro, Wenduo Gu, Albert J Pedroza, Alex R. Dalal, Matthew D. Worssam, Daniel Yuhang Li, Brian T. Palmisano, Quanyi Zhao et al. · 2025 · Molecular Systems Biology
  14. Human Cardiac Development
    Jill P. J. M. Hikspoors, Nutmethee Kruepunga, Greet M. C. Mommen, Eleonore S Köhler, Robert Henry Anderson, Wouter H. Lamers · 2024 · Advances in experimental medicine and biology
  15. Angiotensin I Infusion Reveals Differential Effects of Angiotensin-Converting Enzyme in Aortic Resident Cells on Aneurysm Formation
    Hisashi Sawada, Masayoshi Kukida, Xiaofeng Chen, Deborah A. Howatt, Jessica J. Moorleghen, Anju Balakrishnan, Congqing Wu, Alan Daugherty, Hong S. Lu · 2020 · Circulation Journal
  16. Aortic Valve Embryology, Mechanobiology, and Second Messenger Pathways: Implications for Clinical Practice
    Maximiliaan L. Notenboom, Lucas Van Hoof, Art Schuermans, Johanna J.M. Takkenberg, Filip Rega, Yannick J.H.J. Taverne · 2024 · Journal of Cardiovascular Development and Disease
  17. Milestone Papers on Signal Transduction Mechanisms of Hypertension and Its Complications
    Satoru Eguchi, Keiichi Torimoto, Adebowale Adebiyi, Praghalathan Kanthakumar, Gisele Facholi Bomfim, Camilla Ferreira Wenceslau, Shelby A. Dahlen, Patrick Osei‐Owusu · 2024 · Hypertension
  18. Extracellular Determinants of Arterial Morphogenesis, Growth, and Homeostasis
    Robert P. Mecham, Francesco Ramirez · 2018 · Current topics in developmental biology/Current Topics in Developmental Biology
  19. Transcription Factor TBX18 Reprograms Vascular Smooth Muscle Cells of Ascending Aorta to Pacemaker-Like Cells
    Fengyuan Wang, Hongyi Zhao, Lin Yin, Yanhong Tang, Xi Wang, Qingyan Zhao, Teng Wang, Congxin Huang · 2019 · DNA and Cell Biology
  20. Primary Mouse Aortic Smooth Muscle Cells Exhibit Region- and Sex-Dependent Biological Responses In Vitro
    Niyousha Karbasion, Yujun Xu, J. Caleb Snider, Matthew R. Bersi · 2024 · Journal of Biomechanical Engineering
  21. Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 1: Pluridisciplinary perspective on their hemodynamics and morphomechanics
    Ares D. Pasipoularides · 2019 · Journal of Molecular and Cellular Cardiology
  22. Application of genetic cell-lineage tracing technology to study cardiovascular diseases
    Xiaotong Sun, Lingxia Lyu, Xingxing Zhong, Zhichao Ni, Qingbo Xu · 2021 · Journal of Molecular and Cellular Cardiology
  23. Phenotypic Switching of VSMCs in the Development of CVDs: Focus on miRs
    Ulyana Khovantseva, Yuliya V. Markina, Tatiana Vladimirovna Kirichenko, Karina Goncharova, Diana G. Kiseleva, Vadim R. Cherednichenko, Alexander M. Markin · 2025 · International Journal of Molecular Sciences
  24. A Comprehensive Review of Epigenetic Regulation of Vascular Smooth Muscle Cells During Development and Disease
    Lautaro Natalí, Benjamin de la Cruz-Thea, Andrea Godino, Cecilia B. Conde, Víctor I. Peinado, Melina Mara Musri · 2026 · Biomolecules
  25. Deletion of PDK1 Caused Cardiac Malmorphogenesis and Heart Defects Due to Profound Protein Phosphorylation Changes Mediated by SHP2
    Luo HongMei, Zhongzhou Yang, Jie Li, Hengwei Jin, Mingyang Jiang, Congjia Shan · 2023 · Journal of Cardiovascular Translational Research
  26. The Dichotomy of Vascular Smooth Muscle Differentiation/De- Differentiation in Health and Disease
    Mariana Di Luca, Roya Hakimjavadi, Denise Burtenshaw, Emma Fitzpatrick, Pattie Mathiue, Caitríona Lally, Eileen M. Redmond, Paul Aidan Cahill · 2018 · InTech eBooks
  27. Developmental heterogeneity of vascular cells: Insights into cellular plasticity in atherosclerosis?
    Alexander Lin, Yogambha Ramaswamy, Ashish Misra · 2023 · Seminars in Cell and Developmental Biology
  28. A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives
    Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Henry Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A. Hanley, Magnus Rattray, Simon D. Bamforth et al. · 2025 · eLife
  29. Structure of comorbidity in ascending aortic aneurysm
    Irina A. Goncharova, Д. С. Панфилов, S. A. Belyaeva, Boris N. Kozlov, Maria S. Nazarenko · 2023 · Russian Journal of Cardiology
  30. Presenilin-1 in smooth muscle cells facilitates hypermuscularization in elastin aortopathy
    Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif · 2023 · iScience
  31. MFG ‐ E8 Accelerates Abdominal Aortic Aneurysm Formation by Enhancing ERK MAPK / NOX4 Axis‐Associated Oxidative Stress
    Jie Xiao, Hai Hu, Minghui Zou, Chenhao Li, Dawei Deng, Xing Chen, Jinping Liu · 2025 · Cell Proliferation
  32. Out to the tissues
    Jui M. Dave, Junichi Saito, Giorgio Mottola, Daniel M. Greif · 2022 · Elsevier eBooks
  33. Positive Correlation Between Thoracic Aortic Diameter and Intracranial Aneurysm Size–An Observational Cohort Study
    Ville Rantasalo, Jarmo M. Gunn, Emily Pan, Tuomas Kiviniemi, Jussi Hirvonen, Melissa Rahi, Terhi Fordell, Jaakko K. Rinne, Dan Laukka · 2024 · World Neurosurgery
  34. Inositol 1,4,5-trisphosphate receptor 2 as a novel marker of vasculature to delineate processes of cardiopulmonary development
    Reina Ishizaki, Keiko Uchida, Takatoshi Tsuchihashi, Akimichi Shibata, Kazuki Kodo, Katsura Emoto, Katsuhiko Mikoshiba, Takao Takahashi, Hiroyuki Yamagishi · 2019 · Developmental Biology
  35. A Novel Human Biospecimen Repository for Clinical and Molecular Investigation of Thoracic Aortopathy
    Courtney E. Vujakovich, Benjamin J. Landis · 2021 · Cardiogenetics
  36. Aortic Neointimal Formation: The Role of Elastin in Conjunction With Vascular Smooth Muscle Cell Origin
    Kimberly R. Rebello, Scott A. LeMaire, Ying H. Shen · 2021 · Arteriosclerosis Thrombosis and Vascular Biology
  37. The epigenomic landscape of single vascular cells reflects developmental origin and identifies disease risk loci
    Chad S. Weldy, Soumya Kundu, João P. Monteiro, Wenduo Gu, Albert J Pedroza, Alex R. Dalal, Matthew D. Worssam, Daniel Yuhang Li, Brian T. Palmisano, Quanyi Zhao et al. · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
  38. Unraveling Cardiovascular Development and Function: Insights From Single-Cell Omics
    Rebecca L. Harper, Patrick M. Lelliott, Shawn B. Bender, Alexander Ruvantha Pinto · 2026 · Circulation Research
  39. Thoracic aortic aneurysm and dissection: Similarities, differences and pharmacotherapy
    Yan-Ni Hu, Mi Wang, Zheng Zhang · 2026 · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
  40. Current opinion: Underreported cell populations in the aortic valve influence tissue development and homeostasis
    Daniel Chaparro, Joshua D. Hutcheson · 2023 · Current Opinion in Biomedical Engineering
  41. A novel pathogenic variant located just upstream of the C ‐terminal Ser423‐X‐Ser425 phosphorylation motif in SMAD3 causing Loeys–Dietz syndrome
    Satoshi Ishii, Takayuki Fujiwara, Hiroki Yagi, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Ryo Inuzuka, Yuki Taniguchi, Masaru Hatano, Issei Komuro · 2023 · Molecular Genetics & Genomic Medicine
  42. Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies
    Hisashi Sawada, Yuriko Katsumata, Hideyuki Higashi, Chen Zhang, Yanming Li, Stephanie Morgan, Lang Ho Lee, Sasha A. Singh, Jeff Zheying Chen, Michael Franklin et al. · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
  43. Annexin A1: a promising target for preventing aortic dissections
    Hisashi Sawada, Hong S. Lu, Alan Daugherty · 2022 · Cardiovascular Research
  44. Intrinsic Mechanics of Human Stem Cell Derived Aortic Smooth Muscle Cells Support a Developmental Basis for Aneurysm Localization in Marfan Syndrome
    Robert J. Wiener, Helen Orins, Kevin D. Costa · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  45. Angiotensin II Induces Abdominal Aortic Branch Aneurysms in Fibrillin-1 C1041G/+ Mice
    Michael Franklin, Deborah A. Howatt, Jessica J. Moorleghen, Mary Burchett Sheppard, Yuriko Katsumata, Hisashi Sawada, Hong S. Lu, Alan Daugherty · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Origins of Aortic Coarctation: A Vascular Smooth Muscle Compartment Boundary Model
    Christina L. Greene, Geoffrey R. Traeger, Akshay Venkatesh, David K. M. Han, Mark W. Majesky · 2025 · Journal of Developmental Biology
  47. Transforming growth factor-beta (TGF-β) in the pathogenesis of hereditary thoracic aneurysm disorders
    Wendy A. Espinoza Camejo, Emily E. Bramel, Elena Gallo MacFarlane · 2025 · Cardiovascular Pathology
  48. Structural and Signaling Mechanisms of Aortic Wall Failure in Heritable Thoracic Aortic Disease
    Norifumi Takeda, Hiroki Yagi, Takayuki Fujiwara, Hitomi Aono‐Setoguchi, Ryo Inuzuka, Issei Komuro · 2026 · Cells
  49. Aortic Valve Disease - Recent Advances
    P. Syamasundar Rao · 2023 · Cardiology and cardiovascular medicine.
  50. The remarkable diversity of vascular smooth muscle in development and disease
    Mark W. Majesky · 2022 · Elsevier eBooks
  51. Ascending Aortic Aneurysm in Relation to Aortic Valve Phenotype
    David Freiholtz, Per Olof Eriksson, Hanna M. Björck · 2024 · Cardiology and cardiovascular medicine.
  52. Drebrin: a new player in angiotensin II-induced aortopathies
    Hisashi Sawada, Bradley C. Wright, Jeff Zheying Chen, Hong S. Lu, Alan Daugherty · 2018 · Cardiovascular Research
  53. REPLY FROM THE AUTHOR: RESPECT MOTHER NATURE—AORTIC ROOT REPAIR IN ACUTE TYPE A AORTIC DISSECTION
    Bo Yang · 2020 · Journal of Thoracic and Cardiovascular Surgery
  54. Positional transcriptomics shed light on site-specific pathologies of the aorta
    Milagros C. Romay, Feiyang Ma, Gloria E. Hernandez, Marie Vandestienne, Todd Haswell Kimball, Michele Silvestro, Tarik Hadi, Andrew de los Reyes, Margaret Ramirez, Nathalie Bardin et al. · 2021 · Research Square
  55. Heterogeneous Cardiac- and Neural Crest-Derived Aortic Smooth Muscle Cells have Similar Transcriptional Changes after TGFβ Signaling Disruption
    Pengwei Ren, Bo Jiang, Abdulrahman H. M. Hassab, Guangxin Li, Wei Li, Roland Assi, George Tellides · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Smooth Muscle Cells and Fibroblasts in the Proximal Thoracic Aorta Exhibit Minor Differences Between Embryonic Origins in Angiotensin II-driven Transcriptional Alterations
    Sohei Ito, David B Graf, Yuriko Katsumata, Jessica J. Moorleghen, Chen Zhang, Yanming Li, Scott A. LeMaire, Ying H. Shen, Hong S. Lu, Alan Daugherty et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  57. New Tools for Precision Targeting of Origin-Specific Vascular Smooth Muscle Cells Using Intersectional Genetics
    Mark W. Majesky · 2025 · Circulation
  58. A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives
    Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Henry Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A. Hanley, Magnus Rattray, Simon D. Bamforth et al. · 2025 · eLife
  59. Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal development
    Xuanyu Liu, Wen Chen, Wenke Li, Ziyi Zeng, James Rush Priest, Zhou Zhou · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  60. References
    2022 · Elsevier eBooks
  61. Loss of presenilin-1 in smooth muscle cells ameliorates elastin aortopathy
    Junichi Saito, Jui M. Dave, Freddy Duarte Lau, Daniel M. Greif · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  62. Plaque stabilizing and destabilizing effects in atherosclerosis
    Renée J. H. A. Tillie · 2024 · Research Publications (Maastricht University)
  63. Mechanobiology of aortic cells and extracellular matrix
    Keshav A. Kailash, Maria Thea Rane Dela Cruz Clarin, Md Al Amin Sheikh, Hiromi Yanagisawa, Jessica E. Wagenseil · 2024 · Elsevier eBooks
  64. Aortic and arterial diseases (Aortopathies)
    Ilse Van Gucht, Aline Verstraeten, Bart Loeys · 2024 · Elsevier eBooks
  65. Management of an elderly patient with nonsyndromic TGFBR1‐related aortopathy: A case report
    Hitomi Aono‐Setoguchi, Hiroki Yagi, Nana Akiyama, Norifumi Takeda, Masahiko Ando, Haruo Yamauchi, Issei Komuro, Norihiko Takeda · 2024 · Clinical Case Reports
  66. The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis
    Yuesheng Zhang, Ziyin Guan, Hui Gong, Zhichao Ni, Qingzhong Xiao, Xiaogang Guo, Qingbo Xu · 2024 · Cardiology Discovery
  67. Assessing the gene expression networks regulated by TBX18 in vascular smooth muscle cells to maintain aortic homeostasis
    Mukherjee, Debanjan · 2024
  68. Embryologie des Blut- und Lymphgefäßsystems: Allgemeiner Fahrplan und Mechanismen der embryonalen Gefäßbildung
    Jörg Männer · 2025 · Springer eBooks
  69. A cell atlas of the developing human outflow tract of the heart and its adult derivatives
    Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, John Henry Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A. Hanley, Magnus Rattray, Simon D. Bamforth et al. · 2025 · eLife
  70. Focal adhesion proteins confer smooth muscle anoikis resistance and protection against aortic aneurysm and dissection
    Zhenyuan Zhu, Mingjun Liu, Jianxin Wei, Deepa Suryanarayan, Parya Behzadi, Robert Edgar, Julie A. Phillippi, Cynthia St. Hilaire, Cristina Espinosa‐Díez, Delphine A Gomez · 2026 · JCI Insight
  71. Identification of portal mesenchymal stem cells and derived myofibroblasts in liver fibrosis
    Lin Lei · 2020 · theses.fr (ABES)
  72. Étude des mécanismes physiopathologiques impliqués dans la dysplasie géléophysique associée au gène FBN1 et dans le syndrome de Myhre associé au gène SMAD4
    Zakaria Mougin · 2023 · theses.fr (ABES)
  73. Genomic depiction of human iPSC differentiation into smooth muscle cells and application to assess the functional regulation at LRP1, a pleiotropic genetic risk locus for several cardiovascular diseases
    Lu Liu · 2022 · theses.fr (ABES)
  74. A cell atlas of the developing human outflow tract of the heart and its adult aortic valve derivatives
    Rotem Leshem, Syed Murtuza Baker, Joshua Mallen, Lu Wang, J H Dark, Andrew D Sharrocks, Karen Piper Hanley, Neil A. Hanley, Magnus Rattray, Simon D. Bamforth et al. · 2026 · eLife
  75. S100A4-lineage cells contribute modestly to angiotensin II-mediated thoracic aortic aneurysms through angiotensin II type 1a receptor in mice
    Sohei Ito, Jeff Zheying Chen, Deborah A. Howatt, Jessica J. Moorleghen, Hong S. Lu, Alan Daugherty, Hisashi Sawada · 2026 · PLoS ONE
  76. Increased medial collagen enhances aortic resilience against mural delamination from hydraulic fracturing
    Alan Chou, Kristina Wang, Dustin K. Lieu, Prashanth Vallabhajosyula, Jay D. Humphrey, George Tellides, Roland Assi · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  77. Elastin Regulates Vascular Smooth Muscle Cell Behavior During Development and in Diseases
    Junichi Saito, Irusha Dahal, Christine Sanderson, Md Mahbubur Rahman Khan · 2026 · Pediatrics International
  78. Microregional RNA sequencing reveals layer-specific smooth muscle cell heterogeneity in human bicuspid aortic valve-associated aortic dilatation
    Shigeki Koizumi, Chiho Tokunaga, Keiichi Asano, Kenichi Kimura, Hiroko Matsunaga, Eri Motoyama, Hnin Htet Htet Aung, Kaori Sugiyama, Haruko Takeyama, Yuji Hiramatsu et al. · 2026 · JVS Vascular Science
  79. Smooth Muscle Cell Plasticity as a Central Determinant of Plaque Stability
    Pei-Yu Chen, Michael Simons · 2026 · Current Atherosclerosis Reports
  80. Matrix metalloproteinase imaging and survival prospects with aging in murine aortic aneurysm
    Mean Ghim, Onur Varli, Azmi A. Ahmad, Afarin Neishabouri, Gunjan Kukreja, ZhengXing Zhang, Saalar Zarnegar, Nicholas T. Gangemi, Keshvad Hedayatyanfard, Jakub Toczek et al. · 2026 · EJNMMI Research
  81. In utero barcoding of mouse mesoderm reveals the clonal architecture of organ mesenchyme
    Jingyan He, Johan Lorentz, Agustín Andrés Corbat, Sergey V. Isaev, Raphaël Mauron, Sandra de Haan, Lenka Belicová, Jia Sun, Bettina Semsch, Noémi Van Hul et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)