Smooth Muscle Cells Derived From Second Heart Field and Cardiac Neural Crest Reside in Spatially Distinct Domains in the Media of the Ascending Aorta—Brief Report

2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and Management of Patients With Thoracic Aortic Disease

WRITING GROUP MEMBERS, Hiratzka, L. F., Bakris, G. L., Beckman, J. A., Bersin, R. M., Carr, V. F., Casey, D. E., Eagle, K. A., Hermann, L. K., Isselbacher, E. M., et al. (2010) · Circulation · doi:10.1161/cir.0b013e3181d4739e · Cited by 2,323 · see citing works

Fate of the mammalian cardiac neural crest

Jiang, X., Rowitch, D. H., Soriano, P. M., McMahon, A. P., & Sucov, H. M. (2000) · Development · doi:10.1242/dev.127.8.1607 · Cited by 1,163 · see citing works

Mesenchymal derivatives of the neural crest: analysis of chimaeric quail and chick embryos

Lièvre, C. S. L., & Douarin, N. M. L. (1975) · Development · doi:10.1242/dev.34.1.125 · Cited by 1,006 · see citing works

Developmental Basis of Vascular Smooth Muscle Diversity

Majesky, M. W. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.141069 · Cited by 737 · see citing works

Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart

Waldo, K. L., Hutson, M. R., Ward, C., Zdanowicz, M., Stadt, H. A., Kumiski, D. H., Abu‐Issa, R., & Kirby, M. L. (2005) · Developmental Biology · doi:10.1016/j.ydbio.2005.02.012 · Cited by 358 · see citing works

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1 + smooth muscle progenitor cells

Regan, J. N., Dong, X. R., Wu, S., Maguire, C. T., Hogan, K. A., Bautch, V. L., & Majesky, M. W. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711382105 · Cited by 308 · see citing works

Tgfbr2 disruption in postnatal smooth muscle impairs aortic wall homeostasis

Li, W., Li, Q., Jiao, Y., Qin, L., Ali, R., Zhou, J., Ferruzzi, J., Kim, R. W., Geirsson, A., Dietz, H. C., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci69942 · Cited by 284 · see citing works

Hand2 function in second heart field progenitors is essential for cardiogenesis

Tsuchihashi, T., Maeda, J., Shin, C. H., Ivey, K. N., Black, B. L., Olson, E. N., Yamagishi, H., & Srivastava, D. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.023 · Cited by 129 · see citing works

Angiotensin II Induces Region-Specific Medial Disruption during Evolution of Ascending Aortic Aneurysms

Rateri, D. L., Davis, F. M., Balakrishnan, A., Howatt, D. A., Moorleghen, J. J., O’Connor, W. N., Charnigo, R. J., Cassis, L. A., & Daugherty, A. (2014) · American Journal Of Pathology · doi:10.1016/j.ajpath.2014.05.014 · Cited by 115 · see citing works

Aortopathy in a Mouse Model of Marfan Syndrome Is Not Mediated by Altered Transforming Growth Factor β Signaling

Hao, W., Hu, J. H., Angelov, S. N., Fox, K., Yan, J., Enstrom, R., Smith, A. C. H., & Dichek, D. A. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.004968 · Cited by 113 · see citing works

Pathologic calcification of adult vascular smooth muscle cells differs on their crest or mesodermal embryonic origin

Leroux‐Berger, M., Quéguiner, I., Maciel, T. T., Ho, A. T. V., Relaix, F., & Kempf, H. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.382 · Cited by 110 · see citing works

Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm

Zhang, P., Hou, S., Chen, J., Zhang, J., Lin, F., Ju, R., Cheng, X., Ma, X., Song, Y., Zhang, Y., et al. (2016) · Circulation Research · doi:10.1161/circresaha.115.308040 · Cited by 101 · see citing works

Ascending Aortic Aneurysm in Angiotensin II–Infused Mice

Trachet, B., Piersigilli, A., Fraga‐Silva, R. A., Aslanidou, L., Sordet‐Dessimoz, J., Astolfo, A., Stampanoni, M., Segers, P., & Stergiopulos, N. (2016) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.116.307211 · Cited by 94 · see citing works

Embryonic domains of the aorta derived from diverse origins exhibit distinct properties that converge into a common phenotype in the adult

Pfaltzgraff, E. R., Shelton, E. L., Galindo, C. L., Nelms, B. L., Hooper, C. W., Poole, S. D., Labosky, P. A., Bader, D. M., & Reese, J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.016 · Cited by 72 · see citing works

Smooth muscle cell-specific Tgfbr1 deficiency promotes aortic aneurysm formation by stimulating multiple signaling events

Yang, P., Schmit, B. M., Fu, C., DeSart, K. M., Oh, S. P., Berceli, S. A., & Jiang, Z. (2016) · Scientific Reports · doi:10.1038/srep35444 · Cited by 69 · see citing works

Aortic dissection in the outer third of the media: what is the role of the vasa vasorum in the triggering process?

Osada, H., Kyogoku, M., Ishidou, M., Morishima, M., & Nakajima, H. (2012) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezs640 · Cited by 64 · see citing works

Nkx2‐5 lineage tracing visualizes the distribution of second heart field‐derived aortic smooth muscle

Harmon, A. W., & Nakano, A. (2013) · genesis · doi:10.1002/dvg.22721 · Cited by 62 · see citing works

A Decade of Advances in the Molecular Embryology and Genetics Underlying Congenital Heart Defects

Kodo, K., & Yamagishi, H. (2011) · Circulation Journal · doi:10.1253/circj.cj-11-0636 · Cited by 34 · see citing works

Solitary aortic arch artery. A result of surgical ablation of cardiac neural crest and nodose placode in the avian embryo.

Rosenquist, T. H., Kirby, M. L., & Mierop, L. H. V. (1989) · Circulation · doi:10.1161/01.cir.80.5.1469 · Cited by 29 · see citing works

Smooth Muscle LDL Receptor-Related Protein-1 Deletion Induces Aortic Insufficiency and Promotes Vascular Cardiomyopathy in Mice

Basford, J. E., Koch, S. E., Anjak, A., Singh, V., Krause, E. G., Robbins, N., Weintraub, N. L., Hui, D. Y., & Rubinstein, J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0082026 · Cited by 16 · see citing works

Vascular smooth muscle cells in atherosclerosis

Basatemur, G. L., Jørgensen, H. F., Clarke, M. C. H., Bennett, M. R., & Mallat, Z. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-019-0227-9 · Cited by 1,099 · see citing works

Single-cell and spatial transcriptomics enables probabilistic inference of cell type topography

Andersson, A., Bergenstråhle, J., Asp, M., Bergenstråhle, L., Jurek, A., Navarro, J. F., & Lundeberg, J. (2020) · Communications Biology · doi:10.1038/s42003-020-01247-y · Cited by 463 · see citing works

Disease-relevant transcriptional signatures identified in individual smooth muscle cells from healthy mouse vessels

Dobnikar, L., Taylor, A. L., Chappell, J., Oldach, P., Harman, J. J., Oerton, E., Dzierzak, E. A., Bennett, M. R., Spivakov, M., & Jørgensen, H. F. (2018) · Nature Communications · doi:10.1038/s41467-018-06891-x · Cited by 303 · see citing works

The mechanism and therapy of aortic aneurysms

Gao, J., Cao, H., Hu, G., Wu, Y., Xu, Y., Cui, H., Lu, H. S., & Zheng, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01325-7 · Cited by 231 · see citing works

Renin-Angiotensin System and Cardiovascular Functions

Wu, C.-H., Mohammadmoradi, S., Chen, J. Z., Sawada, H., Daugherty, A., & Lu, H. S. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311282 · Cited by 176 · see citing works

Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration

Tang, J., Wang, H., Huang, X., Li, F., Zhu, H., Li, Y., He, L., Zhang, H., Pu, W., Liu, K., et al. (2019) · Cell stem cell · doi:10.1016/j.stem.2019.11.010 · Cited by 151 · see citing works

The changing face of Turner syndrome

Gravholt, C. H., Viuff, M., Just, J., Sandahl, K., Brun, S., van der Velden, J., Andersen, N. H., & Skakkebaek, A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnac016 · Cited by 149 · see citing works

Role of Resident Stem Cells in Vessel Formation and Arteriosclerosis

Zhang, L., Bhaloo, S. I., Chen, T., Zhou, B., & Xu, Q. (2018) · Circulation Research · doi:10.1161/circresaha.118.313058 · Cited by 132 · see citing works

Lineage-specific events underlie aortic root aneurysm pathogenesis in Loeys-Dietz syndrome

MacFarlane, E. G., Parker, S. J., Shin, J. Y., Ziegler, S. G., Creamer, T. J., Bagirzadeh, R., Bedja, D., Chen, Y., Calderón, J. F., Weissler, K. A., et al. (2019) · Journal of Clinical Investigation · doi:10.1172/jci123547 · Cited by 117 · see citing works

A single-cell transcriptomic inventory of murine smooth muscle cells

Muhl, L., Mocci, G., Pietilä, R. S., Liu, J., He, L., Genové, G., Leptidis, S., Gustafsson, S., Buyandelger, B., Raschperger, E., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.09.015 · Cited by 103 · see citing works

Vascular Development

Majesky, M. W. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.310223 · Cited by 98 · see citing works

Pathogenic Mechanisms of Bicuspid Aortic Valve Aortopathy

Yassine, N. M., Shahram, J. T., & Body, S. C. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00687 · Cited by 85 · see citing works

Cell Phenotype Transitions in Cardiovascular Calcification

Hortells, L., Sur, S., & Hilaire, C. S. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2018.00027 · Cited by 84 · see citing works

A pictorial account of the human embryonic heart between 3.5 and 8 weeks of development

Hikspoors, J. P. J. M., Kruepunga, N., Mommen, G. M. C., Köhler, E. S., Anderson, R. H., & Lamers, W. H. (2022) · Communications Biology · doi:10.1038/s42003-022-03153-x · Cited by 82 · see citing works

On vasa vasorum: A history of advances in understanding the vessels of vessels

Phillippi, J. A. (2022) · Science Advances · doi:10.1126/sciadv.abl6364 · Cited by 81 · see citing works

A comprehensive comparison on cell-type composition inference for spatial transcriptomics data

Chen, J., Liu, W., Luo, T., Yu, Z., Jiang, M.-Z., Wen, J., Gupta, G. P., Giusti‐Rodríguez, P., Hongtu Zhu, B., Yang, Y., et al. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac245 · Cited by 76 · see citing works

Generation of Vascular Smooth Muscle Cells From Induced Pluripotent Stem Cells

Shen, M., Quertermous, T., Fischbein, M. P., & Wu, J. C. (2021) · Circulation Research · doi:10.1161/circresaha.120.318049 · Cited by 77 · see citing works

Lineage tracking of origin and fate of smooth muscle cells in atherosclerosis

Bentzon, J. F., & Majesky, M. W. (2017) · Cardiovascular Research · doi:10.1093/cvr/cvx251 · Cited by 72 · see citing works

The Role of Vascular Smooth Muscle Cells in the Physiology and Pathophysiology of Blood Vessels

Bačáková, L., Trávníčková, M., Filová, E., Matějka, R., Štěpanovská, J., Musı́lková, J., Zárubová, J., & Molitor, M. (2018) · InTech eBooks · doi:10.5772/intechopen.77115 · Cited by 71 · see citing works

Cell-Specific Functions of ADAM17 Regulate the Progression of Thoracic Aortic Aneurysm

Shen, M., Hu, M., Fedak, P. W. M., Oudit, G. Y., & Kassiri, Z. (2018) · Circulation Research · doi:10.1161/circresaha.118.313181 · Cited by 70 · see citing works

Central artery stiffness and thoracic aortopathy

Humphrey, J. D., & Tellides, G. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00205.2018 · Cited by 68 · see citing works

Notch1 haploinsufficiency causes ascending aortic aneurysms in mice

Koenig, S. N., LaHaye, S., Feller, J. D., Rowland, P., Hor, K. N., Trask, A. J., Janssen, P. M. L., Radtke, F., Lilly, B., & Garg, V. (2017) · JCI Insight · doi:10.1172/jci.insight.91353 · Cited by 63 · see citing works

Unveiling cellular and molecular aspects of ascending thoracic aortic aneurysms and dissections

Ganizada, B., Veltrop, R. J. A., Akbulut, A. C., Koenen, R. R., Accord, R. E., Lorusso, R., Maessen, J. G., Reesink, K. D., Bidar, E., & Schurgers, L. J. (2024) · Basic Research in Cardiology · doi:10.1007/s00395-024-01053-1 · Cited by 59 · see citing works

The origin and mechanisms of smooth muscle cell development in vertebrates

Donadon, M., & Santoro, M. M. (2021) · Development · doi:10.1242/dev.197384 · Cited by 58 · see citing works

Second Heart Field–Derived Cells Contribute to Angiotensin II–Mediated Ascending Aortopathies

Sawada, H., Katsumata, Y., Higashi, H., Zhang, C., Li, Y., Morgan, S., Lee, L. H., Singh, S. A., Chen, J. Z., Franklin, M., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.058173 · Cited by 55 · see citing works

hiPSC Modeling of Lineage-Specific Smooth Muscle Cell Defects Caused by TGFBR1 A230T Variant, and Its Therapeutic Implications for Loeys-Dietz Syndrome

Zhou, D. F., Feng, H., Yang, Y., Huang, T., Qiu, P., Zhang, C., Olsen, T. R., Zhang, J., Chen, Y. E., Mizrak, D., et al. (2021) · Circulation · doi:10.1161/circulationaha.121.054744 · Cited by 53 · see citing works

In Vitro Lineage-Specific Differentiation of Vascular Smooth Muscle Cells in Response to SMAD3 Deficiency

Gong, J. P., Zhou, D. F., Jiang, L., Qiu, P., Milewicz, D. M., Chen, Y. E., & Yang, B. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.313033 · Cited by 49 · see citing works

Insights on the Pathogenesis of Aneurysm through the Study of Hereditary Aortopathies

Creamer, T. J., Bramel, E. E., & MacFarlane, E. G. (2021) · Genes · doi:10.3390/genes12020183 · Cited by 50 · see citing works

Sex Chromosome Complement Defines Diffuse Versus Focal Angiotensin II–Induced Aortic Pathology

Alsiraj, Y., Thatcher, S. E., Blalock, E. M., Fleenor, B. S., Daugherty, A., & Cassis, L. A. (2017) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.117.310035 · Cited by 48 · see citing works

Small GTP-Binding Protein GDP Dissociation Stimulator Prevents Thoracic Aortic Aneurysm Formation and Rupture by Phenotypic Preservation of Aortic Smooth Muscle Cells

Nogi, M., Satoh, K., Sunamura, S., Kikuchi, N., Satoh, T., Kurosawa, R., Omura, J., Al-Mamun, M. E., Siddique, M. A. H., Numano, K., et al. (2018) · Circulation · doi:10.1161/circulationaha.118.035648 · Cited by 48 · see citing works

Elastin, arterial mechanics, and stenosis

Lin, C.-J., Cocciolone, A. J., & Wagenseil, J. E. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00448.2021 · Cited by 45 · see citing works

Embryologic Origin Influences Smooth Muscle Cell Phenotypic Modulation Signatures in Murine Marfan Syndrome Aortic Aneurysm

Pedroza, A. J., Dalal, A. R., Shad, R., Yokoyama, N., Nakamura, K., Cheng, P. P., Wirka, R. C., Mitchel, O. R., Baiocchi, M., Hiesinger, W., et al. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317381 · Cited by 44 · see citing works

Human and murine fibroblast single-cell transcriptomics reveals fibroblast clusters are differentially affected by ageing and serum cholesterol

van Kuijk, K., McCracken, I. R., Tillie, R. J. H. A., Asselberghs, S., Kheder, D. A., Muitjens, S., Jin, H., Taylor, R. S., Schreur, R. W., Kuppe, C., et al. (2023) · Cardiovascular Research · doi:10.1093/cvr/cvad016 · Cited by 43 · see citing works

Smooth Muscle Heterogeneity and Plasticity in Health and Aortic Aneurysmal Disease

Hu, Y., Cai, Z., & He, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241411701 · Cited by 42 · see citing works

Biology of vascular mural cells

Siekmann, A. F. (2023) · Development · doi:10.1242/dev.200271 · Cited by 42 · see citing works

Progressive Microstructural Deterioration Dictates Evolving Biomechanical Dysfunction in the Marfan Aorta

Cavinato, C., Chen, M., Weiss, D., Ruiz-Rodríguez, M. J., Schwartz, M. A., & Humphrey, J. D. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.800730 · Cited by 41 · see citing works

Thoracic Aortic Aneurysm Development in Patients with Bicuspid Aortic Valve: What Is the Role of Endothelial Cells?

van de Pol, V., Kurakula, K., DeRuiter, M. C., & Goumans, M. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00938 · Cited by 41 · see citing works

Neural Crest Cells Differentiate Into Brown Adipocytes and Contribute to Periaortic Arch Adipose Tissue Formation

Fu, M., Xu, L., Chen, X., Han, W., Ruan, C., Li, J., Cai, C., Ye, M., & Gao, P. (2019) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.119.312838 · Cited by 40 · see citing works

Normal and abnormal development of the aortic valve and ascending aortic wall: a comprehensive overview of the embryology and pathology of the bicuspid aortic valve

Grewal, N., Groot, A. C. G., Lindeman, J. H. N., Klautz, A., Driessen, A. H. G., Klautz, R. J. M., & Poelmann, R. E. (2022) · Annals of Cardiothoracic Surgery · doi:10.21037/acs-2021-bav-14 · Cited by 39 · see citing works

Organ Abnormalities Caused by Turner Syndrome

Yoon, S. H., Kim, G. Y., Choi, G. T., & Tae, J. (2023) · Cells · doi:10.3390/cells12101365 · Cited by 41 · see citing works

Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency

Lin, C.-J., Brengle, B. M., Roth, R. A., Lin, C., Wagenseil, J. E., & Mecham, R. P. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315681 · Cited by 38 · see citing works

β-Aminopropionitrile Induces Distinct Pathologies in the Ascending and Descending Thoracic Aortic Regions of Mice

Franklin, M., Sawada, H., Ito, S., Howatt, D. A., Amioka, N., Liang, C.-L., Zhang, N., Graf, D. B., Moorleghen, J. J., Katsumata, Y., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320402 · Cited by 37 · see citing works

Arterial smooth muscle dynamics in development and repair

Roostalu, U., & Wong, J. K. F. (2018) · Developmental Biology · doi:10.1016/j.ydbio.2018.01.018 · Cited by 36 · see citing works

VSMCs in atherosclerosis: Implications on the role of inflammation and extracellular matrix remodelling

Jarad, S., Gill, G. S., Amadi, P. U., Gu, H.-M., & Zhang, D. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107833 · Cited by 40 · see citing works

Age and sex dependency of thoracic aortopathy in a mouse model of Marfan syndrome

Gharraee, N., Sun, Y., Swisher, J. A., & Lessner, S. M. (2021) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00255.2021 · Cited by 34 · see citing works

Comparative analysis of thoracic and abdominal aortic aneurysms across the segment and species at the single-cell level

Wu, H., Xie, C., Wang, R., Cheng, J., Xu, Q., & Zhao, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1095757 · Cited by 34 · see citing works

Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during development

Chen, W., Liu, X., Li, W., Shen, H., Zeng, Z., Yin, K., Priest, J. R., & Zhou, Z. (2021) · EMBO Reports · doi:10.15252/embr.202152389 · Cited by 32 · see citing works

Irradiation abolishes smooth muscle investment into vascular lesions in specific vascular beds

Newman, A. A. C., Baylis, R. A., Hess, D. L., Griffith, S. D., Shankman, L. S., Cherepanova, O. A., & Owens, G. K. (2018) · JCI Insight · doi:10.1172/jci.insight.121017 · Cited by 29 · see citing works

Endothelial/Epithelial Mesenchymal Transition in Ascending Aortas of Patients With Bicuspid Aortic Valve

Maleki, S., Poujade, F.-A., Bergman, O., Gådin, J. R., Simon, N. L., Lång, K., Franco‐Cereceda, A., Body, S. C., Björck, H. M., & Eriksson, P. O. (2019) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2019.00182 · Cited by 28 · see citing works

Dissecting the Heterogeneity of Human Thoracic Aortic Aneurysms Using Single-Cell Transcriptomics

Mizrak, D., Feng, H., & Yang, B. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.122.317484 · Cited by 28 · see citing works

Cardiac Neural Crest Cells: Their Rhombomeric Specification, Migration, and Association with Heart and Great Vessel Anomalies

Schussler, O., Gharibeh, L., Mootoosamy, P., Mürith, N., Tien, V., Rougemont, A., Sologashvili, T., Suuronen, E. J., Lecarpentier, Y., & Ruel, M. (2020) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-020-00863-w · Cited by 27 · see citing works

An update on clonality: what smooth muscle cell type makes up the atherosclerotic plaque?

Schwartz, S. M., Virmani, R., & Majesky, M. W. (2018) · F1000Research · doi:10.12688/f1000research.15994.1 · Cited by 27 · see citing works

Single-Molecule Spatial Transcriptomics of Human Thoracic Aortic Aneurysms Uncovers Calcification-Related CARTPT -Expressing Smooth Muscle Cells

Mizrak, D., Zhao, Y., Feng, H., MacAulay, J., Tang, Y., Sultan, Z., Zhao, G., Guo, Y., Zhang, J., Yang, B., et al. (2023) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319329 · Cited by 26 · see citing works

The adventitia in arterial development, remodeling, and hypertension

Majesky, M. W., & Weiser‐Evans, M. C. M. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.115259 · Cited by 26 · see citing works

Heterogeneity of aortic smooth muscle cells: A determinant for regional characteristics of thoracic aortic aneurysms?

Sawada, H., Chen, J. Z., Wright, B. C., Sheppard, M. B., Lu, H. S., & Daugherty, A. (2018) · Journal of Translational Internal Medicine · doi:10.2478/jtim-2018-0023 · Cited by 26 · see citing works

GFAP (Glial Fibrillary Acidic Protein)-Positive Progenitor Cells Contribute to the Development of Vascular Smooth Muscle Cells and Endothelial Cells—Brief Report

Osman, I., Wang, L., Hu, G., Zheng, Z., & Zhou, J. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314078 · Cited by 25 · see citing works

Aortic “Disease-in-a-Dish”: Mechanistic Insights and Drug Development Using iPSC-Based Disease Modeling

Davaapil, H., Shetty, D. K., & Sinha, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.550504 · Cited by 27 · see citing works

Novel Myh11 Dual Reporter Mouse Model Provides Definitive Labeling and Identification of Smooth Muscle Cells—Brief Report

Ruan, J., Zhang, L., Hu, D., Qu, X., Yang, F., Chen, F., He, X., Shen, J., Dong, K., Sweet, M. L., et al. (2020) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.315107 · Cited by 24 · see citing works

Enlightening the Association between Bicuspid Aortic Valve and Aortopathy

Sophocleous, F., Milano, E. G., Pontecorboli, G., Chivasso, P., Caputo, M., Rajakaruna, C., Bucciarelli‐Ducci, C., Emanueli, C., & Biglino, G. (2018) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd5020021 · Cited by 24 · see citing works

PIEZO1 attenuates Marfan syndrome aneurysm development through TGF-β signaling pathway inhibition via TGFBR2

Yang, P., Liu, H., Wang, S.-G., Xiao, X., Jiang, L., Le, S., Chen, S., Ye, P., & Xia, J. (2024) · European Heart Journal · doi:10.1093/eurheartj/ehae786 · Cited by 23 · see citing works

Emerging Concepts of Vascular Cell Clonal Expansion in Atherosclerosis

Misra, A., Rehan, R., Lin, A., Patel, S., & Fisher, E. A. (2022) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.316093 · Cited by 23 · see citing works

Quantitative proteomics reveal lineage-specific protein profiles in iPSC-derived Marfan syndrome smooth muscle cells

Iosef, C., Pedroza, A. J., Cui, J. Z., Dalal, A. R., Arakawa, M., Tashima, Y., Koyano, T. K., Burdon, G., Churovich, S., Orrick, J. O., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-77274-w · Cited by 22 · see citing works

Bio-chemo-mechanics of thoracic aortic aneurysms

Wagenseil, J. E. (2018) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2018.01.002 · Cited by 22 · see citing works

Vascular elastic fiber heterogeneity in health and disease

Halabi, C. M., & Kozel, B. A. (2020) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000578 · Cited by 22 · see citing works

Latent TGFβ-binding proteins 1 and 3 protect the larval zebrafish outflow tract from aneurysmal dilatation

Abrial, M., Basu, S., Huang, M., Butty, V. L., Schwertner, A., Jeffrey, S., Jordan, D., Burns, C. E., & Burns, C. G. (2022) · Disease Models & Mechanisms · doi:10.1242/dmm.046979 · Cited by 21 · see citing works

Reporting Sex and Sex Differences in Preclinical Studies

Lu, H. S., Schmidt, A. M., Hegele, R. A., Mackman, N., Rader, D. J., Weber, C., & Daugherty, A. (2018) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.118.311717 · Cited by 21 · see citing works

Intracellular signaling control of mechanical homeostasis in the aorta

Irons, L., Estrada, A. C., & Humphrey, J. D. (2022) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-022-01593-2 · Cited by 21 · see citing works

HDAC1-mediated repression of the retinoic acid-responsive gene ripply3 promotes second heart field development

Song, Y. C., Dohn, T. E., Rydeen, A. B., Nechiporuk, A. V., & Waxman, J. S. (2019) · PLoS Genetics · doi:10.1371/journal.pgen.1008165 · Cited by 20 · see citing works

Structural abnormalities in the non-dilated ascending aortic wall of bicuspid aortic valve patients

Grewal, N., Girdauskas, E., Mohammed Idhrees, A., Velayudhan, B. V., Klautz, R. J. M., Driessen, A. H. G., & Poelmann, R. E. (2022) · Cardiovascular Pathology · doi:10.1016/j.carpath.2022.107478 · Cited by 19 · see citing works

Bioengineered vascular grafts with a pathogenic TGFBR1 variant model aneurysm formation in vivo and reveal underlying collagen defects

Yang, Y., Feng, H., Tang, Y., Wang, Z., Qiu, P., Huang, X., Chang, L., Zhang, J., Chen, Y. E., Mizrak, D., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adg6298 · Cited by 19 · see citing works

Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease

Teekakirikul, P., Zhu, W., Gabriel, G. C., Young, C. B., Williams, K., Martin, L. J., Hill, J. C., Richards, T. D., Billaud, M., Phillippi, J. A., et al. (2021) · Human Genetics and Genomics Advances · doi:10.1016/j.xhgg.2021.100037 · Cited by 18 · see citing works

Generation of Embryonic Origin-Specific Vascular Smooth Muscle Cells from Human Induced Pluripotent Stem Cells

Shen, M., Liu, C., & Wu, J. C. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1979-7_15 · Cited by 18 · see citing works

SpatialcoGCN: deconvolution and spatial information–aware simulation of spatial transcriptomics data via deep graph co-embedding

Yin, W., Wan, Y., & Zhou, Y. (2024) · Briefings in Bioinformatics · doi:10.1093/bib/bbae130 · Cited by 18 · see citing works

Role of vascular smooth muscle cell clonality in atherosclerosis

Luo, L., Fu, C., Bell, C., Wang, Y., & Leeper, N. J. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1273596 · Cited by 17 · see citing works

Exploring Origin-Dependent Susceptibility of Smooth Muscle Cells to Aortic Diseases Through Intersectional Genetics

Han, X., Li, Y., Wang, E., Zhu, H., Huang, X., Pu, W., Zhang, M., Liu, K., Zhao, H., Liu, Z., et al. (2025) · Circulation · doi:10.1161/circulationaha.124.070782 · Cited by 17 · see citing works

GTAD: a graph-based approach for cell spatial composition inference from integrated scRNA-seq and ST-seq data

Zhang, T., Zhang, Z., Li, L., Dong, B., Wang, G., & Zhang, D. (2023) · Briefings in Bioinformatics · doi:10.1093/bib/bbad469 · Cited by 16 · see citing works

Multiple Arterial Dissections and Connective Tissue Abnormalities

Erhart, P., Körfer, D., Dihlmann, S., Qiao, J.-L., Haußer, I., Ringleb, P. A., Männer, J., Dikow, N., Schaaf, C. P., Grond‐Ginsbach, C., et al. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11123264 · Cited by 15 · see citing works

Bio-chemo-mechanics of the thoracic aorta

Iddawela, S., Ravendren, A., & Harky, A. (2021) · Vascular Biology · doi:10.1530/vb-20-0015 · Cited by 15 · see citing works

Postnatal Smad3 Inactivation in Murine Smooth Muscle Cells Elicits a Temporally and Regionally Distinct Transcriptional Response

Bramel, E. E., Creamer, T. J., Saqib, M., Nunez, W. A. C., Bagirzadeh, R., Roker, L. A., Goff, L. A., & MacFarlane, E. G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.826495 · Cited by 15 · see citing works

Differential contribution of the two waves of cardiac progenitors and their derivatives to aorta and pulmonary artery

Jin, H., Wang, H., Li, J., Yu, S. L., Xu, M., Qiu, Z., Meng, X., Zhu, J., Feng, Q., Xie, J., et al. (2019) · Developmental Biology · doi:10.1016/j.ydbio.2019.03.019 · Cited by 15 · see citing works

Discovering New Progenitor Cell Populations through Lineage Tracing and In Vivo ImagingPreprint

Das, R. N., & Yaniv, K. (2020) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a035618 · Cited by 15 · see citing works

Use of iPSC-Derived Smooth Muscle Cells to Model Physiology and Pathology

Kwartler, C. S., & Pinelo, J. E. E. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.319703 · Cited by 15 · see citing works

A SOX17-PDGFB signaling axis regulates aortic root development

Lu, P., WANG, P. H., Wu, B., Wang, Y., Liu, Y., Cheng, W., Feng, X., Yuan, X., Atteya, M. M., Ferro, H., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-31815-1 · Cited by 14 · see citing works

Transcriptome Analysis Reveals Differential Gene Expression between the Closing Ductus Arteriosus and the Patent Ductus Arteriosus in Humans

Saito, J., Kojima, T., Tanifuji, S., Kato, Y., Oka, S., Ichikawa, Y., Miyagi, E., Tachibana, T., Asou, T., & Yokoyama, U. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8040045 · Cited by 13 · see citing works

Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice

Shukla, S., Jana, S., Sanford, N., Lee, C. Y., Liu, L., Cheng, P. P., Quertermous, T., & Dichek, D. A. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321482 · Cited by 13 · see citing works

Distinct Contribution of Global and Regional Angiotensin II Type 1a Receptor Inactivation to Amelioration of Aortopathy in Tgfbr1M318R/+ Mice

Bramel, E. E., Bagirzadeh, R., Saqib, M., Creamer, T. J., Camejo, W. A. E., Roker, L. A., Habashi, J. P., Dietz, H. C., & MacFarlane, E. G. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.936142 · Cited by 13 · see citing works

Ventricular Septation and Outflow Tract Development in Crocodilians Result in Two Aortas with Bicuspid Semilunar Valves

Poelmann, R. E., Groot, A. C. G., Goerdajal, C., Grewal, N., Bakker, M., & Richardson, M. K. (2021) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd8100132 · Cited by 13 · see citing works

Spatial mapping of cell types by integration of transcriptomics dataPreprint

Andersson, A., Bergenstråhle, J., Asp, M., Bergenstråhle, L., Jurek, A., Navarro, J. F., & Lundeberg, J. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2019.12.13.874495 · Cited by 13 · see citing works

Heterogeneous Cardiac-Derived and Neural Crest–Derived Aortic Smooth Muscle Cells Exhibit Similar Transcriptional Changes After TGFβ Signaling Disruption

Ren, P., Jiang, B., Hassab, A. H. M., Guangxin, L., Li, W., Assi, R., & Tellides, G. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321706 · Cited by 12 · see citing works

Implications of Bicuspid Aortic Valve Disease and Aortic Stenosis/Insufficiency as Risk Factors for Thoracic Aortic Aneurysm

Jabagi, H., Levine, D., Gharibeh, L., Camillo, C., Castillero, E., Ferrari, G. M., Takayama, H., & Grau, J. B. (2023) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2406178 · Cited by 11 · see citing works

Densified collagen tubular grafts for human tissue replacement and disease modelling applications

Justin, A. W., Cammarata, F., Guy, A. A., Estévez, S. R., Burgess, S., Davaapil, H., Tatla, A. S., Ong, J., Jacob, A. G., Saeb‐Parsy, K., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.213245 · Cited by 11 · see citing works

Nicotine Exacerbates TAAD Formation Induced by Smooth Muscle-Specific Deletion of the TGF-β Receptor 2

Chun, C., Qi, X., Wang, F., Madrid, K., Saldarriaga, L. A., Fisch, M. R., Brantly, M., Upchurch, G. R., & Jiang, Z. (2021) · Journal of Immunology Research · doi:10.1155/2021/6880036 · Cited by 11 · see citing works

Recent Advances in Understanding the Molecular Pathophysiology of Angiotensin II Receptors: Lessons From Cell-Selective Receptor Deletion in Mice

Eguchi, S., Sparks, M. A., Sawada, H., Lu, H. S., Daugherty, A., & Zhuo, J. L. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.06.421 · Cited by 10 · see citing works

Global research status analysis of the association between aortic aneurysm and inflammation: a bibliometric analysis from 1999 to 2023

Wang, Q., Chen, G., Qi, Z., Zeng, Y., Tan, L., & Tang, H. (2023) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2023.1260935 · Cited by 10 · see citing works

TRPV1 inhibits smooth muscle cell phenotype switching in a mouse model of abdominal aortic aneurysm

Wang, S., & Jia, C. (2020) · Channels · doi:10.1080/19336950.2020.1730020 · Cited by 10 · see citing works

Site-specific genetic and functional signatures of aortic endothelial cells at aneurysm predilection sites in healthy and AngII ApoE−/− mice

Brückner, A., Brandtner, A. T., Rieck, S., Matthey, M., Geisen, C., Fels, B., Stei, M., Kusche‐Vihrog, K., Fleischmann, B. K., & Wenzel, D. (2024) · Angiogenesis · doi:10.1007/s10456-024-09933-9 · Cited by 9 · see citing works

Zebrafish arterial valve development occurs through direct differentiation of second heart field progenitors

Derrick, C. J., Eley, L., Alqahtani, A., Henderson, D. J., & Chaudhry, B. (2024) · Cardiovascular Research · doi:10.1093/cvr/cvae230 · Cited by 9 · see citing works

Recommendations for Design, Execution, and Reporting of Studies on Experimental Thoracic Aortopathy in Preclinical Models

Daugherty, A., Milewicz, D. M., Dichek, D. A., Ghaghada, K. B., Humphrey, J. D., LeMaire, S. A., Li, Y., Mallat, Z., Saeys, Y., Sawada, H., et al. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.320259 · Cited by 11 · see citing works

Cellular Heterogeneity in Aortic Aneurysm and Dissection: Molecular Mechanisms and Therapeutic Opportunities

Song, T., Han, Y., Xie, L. P., & Ji, Y. (2026) · Circulation Research · doi:10.1161/circresaha.125.327197 · Cited by 9 · see citing works

Is Transposition of the Great Arteries Associated With Shortening of the Intrapericardial Portions of the Great Arterial Trunks? An Echocardiographic Analysis on Newborn Infants With Simple Transposition of the Great Arteries to Explore an Animal Model‐Based Hypothesis on Human Beings

Omer, S. O. B., Alhabshan, F., Jijeh, A. M. Z., Caimbon, N. C., Enriquez, C. C., Männer, J., & Yelbuz, T. M. (2021) · Journal of the American Heart Association · doi:10.1161/jaha.120.019334 · Cited by 9 · see citing works

Abstract 17810: Second Heart Field-Derived Smooth Muscle Cells Contribute to Angiotensin II-Induced Medial Thickness in the Ascending Aorta

Sawada, H., Moorleghen, J. J., Rateri, D. L., Majesky, M. W., & Daugherty, A. (2016) · Circulation

Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Ito, S., Lu, H. S., Daugherty, A., & Sawada, H. (2022) · Genes · doi:10.3390/genes13091618 · Cited by 8 · see citing works

Developmental origin of smooth muscle cells in the descending aorta in mice

Wasteson, P., Johansson, B. R., Jukkola, T., Breuer, S., Akyürek, L. M., Partanen, J. M., & Lindahl, P. (2008) · Development · doi:10.1242/dev.020958 · Cited by 204 · see citing works

Nkx2‐5 lineage tracing visualizes the distribution of second heart field‐derived aortic smooth muscle

Harmon, A. W., & Nakano, A. (2013) · genesis · doi:10.1002/dvg.22721 · Cited by 62 · see citing works

Single-Cell Transcriptomics Identifies Selective Lineage-Specific Regulation of Genes in Aortic Smooth Muscle Cells in Mice

Shukla, S., Jana, S., Sanford, N., Lee, C. Y., Liu, L., Cheng, P. P., Quertermous, T., & Dichek, D. A. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.124.321482 · Cited by 13 · see citing works