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Cited by 18Aortic aneurysm repair treatmentsConnective tissue disorders researchGenetic Associations and Epidemiology

Proteomics Analysis of Genetic Liability of Abdominal Aortic Aneurysm Identifies Plasma Neogenin and Kit Ligand: The ARIC Study

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Steffen, Brian T., Pankow, James S., Norby, Faye L., Lutsey, Pamela L., Demmer, Ryan T., Guan, Weihua, Pankratz, Nathan, Li, Aixin +4 more·2023·Arteriosclerosis, Thrombosis, and Vascular Biology
DOI 10.1161/atvbaha.122.317984PMC PMC9995137
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Abstract

Background: Genome-wide association studies have reported 23 gene loci related to abdominal aortic aneurysm (AAA)—a potentially lethal condition characterized by a weakened dilated vessel wall. This study aimed to identify proteomic signatures and pathways related to these risk loci to better characterize AAA genetic susceptibility. Methods: Plasma concentrations of 4870 proteins were determined using a DNA aptamer-based array. Linear regression analysis estimated the associations between the 23 risk alleles and plasma protein levels with adjustments for potential confounders in a race-stratified analysis of 1671 Black and 7241 White participants. Significant proteins were then evaluated for their prediction of clinical AAA (454 AAA events in 11 064 individuals), and those significantly associated with AAA were further interrogated using Mendelian randomization analysis. Results: Risk variants proximal to PSRC1-CELSR2-SORT1 , PCIF1-ZNF335-MMP9, RP11-136O12.2/TRIB1 , ZNF259/APOA5, IL6R , PCSK9 , LPA , and APOE were associated with 118 plasma proteins in Whites and 59 were replicated in Black participants. Novel associations with clinical AAA incidence were observed for kit ligand (HR, 0.59 [95% CI, 0.42–0.82] for top versus first quintiles) and neogenin (HR, 0.64 [95% CI, 0.46–0.88]) over a median 21.2-year follow-up; neogenin was also associated with ultrasound-detected asymptomatic AAA (N=4295; 57 asymptomatic AAA cases). Mendelian randomization inverse variance weighted estimates suggested that AAA risk is promoted by lower levels of kit ligand (OR per SD=0.67; P =1.4×10 −5 ) and neogenin (OR per SD=0.50; P =0.03). Conclusions: Low levels of neogenin and kit ligand may be novel risk factors for AAA development in potentially causal pathways. These findings provide insights and potential targets to reduce AAA susceptibility.

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  • ZPR1/rs964184 has been implicated in the LXR/RXR activation pathway that affected the expression and plasma level of ApoE, along with ApoA1, ApoA5, and ApoC3.

    “Since the submission of our manuscript, ZPR1/rs964184 has been implicated in the LXR/RXR activation pathway that affected the expression and plasma level of ApoE, along with ApoA1, ApoA5 and ApoC3 [41].”

    From Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk (2023) · cites this paper as [41]

    The Results (Pathway analysis; page unavailable) link rs964184, labeled ZNF259/APOA5, to LXR/RXR activation. The Results (Associations of proteins and AAA-related SNPs; page unavailable) also report an association with plasma apolipoprotein A-V. Our copy does not establish effects on gene expression or specifically link rs964184 to plasma ApoE, ApoA1, or ApoC3. (LLM, conf=0.87)

    Experimental — accuracy not yet measured

  • rs964184 has been associated with triglycerides, type 2 diabetes, and abdominal aortic aneurysm.

    “has been associated with triglycerides [39, 40], type 2 diabetes [39] and abdominal aortic aneurysm (AAA) [41].”

    From Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk (2023) · cites this paper as [41]

  • The cited finding provides confirmation to our independent observation and affirms the association of ZPR1/rs964184 with ApoE level being genuine.

    “This provides confirmation to our independent observation and affirms the association of ZPR1/rs964184 with ApoE level being genuine.”

    From Genome-wide analysis identifies novel loci influencing plasma apolipoprotein E concentration and Alzheimer’s disease risk (2023) · cites this paper as [41]

    The Results section, “Associations of proteins and AAA-related SNPs” (page unavailable), reports that rs964184 was associated with 33 plasma proteins, highlighting apolipoprotein A-V and protein phosphatase inhibitor 2. Neither that passage nor the additional passages searched for rs964184 and apolipoprotein E establish an association with ApoE levels; the paper discusses an APOE-linked variant, rs429358, separately. (LLM, conf=0.70)

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Cited by

Sorted by citations

Authors
Steffen, B. T., Pankow, J. S., Norby, F. L., Lutsey, P. L., Demmer, R. T., Guan, W., Pankratz, N., Li, A., Liu, G., Matsushita, K., Tin, A., & Tang, W.
Affiliations
  • University of Minnesota (US)
  • Cedars-Sinai Medical Center (US)
  • The University of Texas Health Science Center at Houston (US)
  • Johns Hopkins University (US)
  • University of Mississippi Medical Center (US)
ORCID
Venue
Arteriosclerosis, Thrombosis, and Vascular Biology
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2023-02
Volume
43
Issue
2
Pages
367-378
ISSN
  • 1079-5642 (ISSN-L)
  • 1524-4636
DOI
10.1161/atvbaha.122.317984
PMC
PMC9995137
OpenAlex
W4313279978
Cited by
18
References
2
Citations by year
2026: 9 · 2025: 3 · 2024: 4 · 2023: 2
FWCI
1.45
Type
journal article
Language
en
Open access
Locations
  • Arteriosclerosis Thrombosis and Vascular Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Heart, Lung, and Blood Institute (HHSN268201700004I, R01HL103695, R01HL155209, HHSN268201700001I, HHSN268201700003I, R01HL087641, R01HL059367, R01HL134320, HHSN268201700001C, HHSN268201700002I, HHSN268201700003C, HHSN268201700002C, HHSN268201700004C, K24HL159246, K01HL164764, T32HL007779, R01HL086694)
  • National Human Genome Research Institute (U01HG004402)
  • National Center for Research Resources (UL1RR025005)
Topics
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Aortic aneurysm repair treatments
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Connective tissue disorders research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Keywords
abdominal aortic aneurysm, genetic susceptibility, plasma proteomics, neogenin, stem cell factor, genetic susceptibility loci, asymptomatic aneurysm, Mendelian randomization, aneurysm risk factors
MeSH terms
Proprotein Convertase 9, Humans, Membrane Proteins, Nuclear Proteins, Risk Factors, Transcription Factors, Protein Serine-Threonine Kinases, Aortic Aneurysm, Abdominal, Stem Cell Factor, Proteomics, Intracellular Signaling Peptides and Proteins, Adaptor Proteins, Signal Transducing, Genome-Wide Association Study

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