Elovanoids are a novel class of homeostatic lipid mediators that protect neural cell integrity upon injury
Open accessAbstract
-methyl-d-aspartate receptor-mediated excitotoxicity, as well as in experimental ischemic stroke. The methyl ester or sodium salt of ELV-N32 and ELV-N34 resulted in reduced infarct volumes, promoted cell survival, and diminished neurovascular unit disruption when administered 1 hour following 2 hours of ischemia by middle cerebral artery occlusion. Together, our data reveal a novel prohomeostatic and neuroprotective lipid-signaling mechanism aiming to sustain neural cell integrity.
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DHA is enriched in the CNS, including the retina, and serves as the precursor for neuroprotective and prohomeostatic 22-carbon docosanoids and 32- or 34-carbon elovanoids.
“DHA is enriched in the CNS, which includes the retina (Bazan, 2009, 2007, 2006; Gordon and Bazan, 1990), and serves as the precursor for neuroprotective and prohomeostatic 22-carbon docosanoids (Bazan, 2009, 2007; Bazan et al., 2010; Mukherjee et al., 2004) and of 32- or 34-carbon ELVs (Bhattacharjee et al., 2017; Jun et al., 2017).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Bhattacharjee et al., 2017
These ≥ 28 carbons VLC fatty acids are critical to brain function.
“These ≥ 28 carbons VLC fatty acids are critical to brain function (Bhattacharjee et al., 2017; Demaerschalk et al., 2016; Jun et al., 2017; Poulin et al., 2016; Rau et al., 2012; Tasca et al., 2015; Tasic et al., 2016; Zeisel et al., 2015; Zhang et al., 2014).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Bhattacharjee et al., 2017
The structure and stereochemistry of ELV-N32 and ELV-N34 was established.
“The structure and stereochemistry of ELVs with 32 and 34 carbons (ELV-N32, ELV-N34) was established (Bhattacharjee et al., 2017; Jun et al., 2017).”
From Docosanoids and elovanoids from omega-3 fatty acids are pro-homeostatic modulators of inflammatory responses, cell damage and neuroprotection (2018) · cites this paper as Bhattacharjee et al., 2017
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- Authors
- Bhattacharjee, S., Jun, B., Belayev, L., Heap, J., Kautzmann, M.-A., Obenaus, A., Menghani, H., Marcell, S. J., Khoutorova, L., Yang, R., Petasis, N. A., & Bazan, N. G.
- Affiliations
- Louisiana State University Health Sciences Center New Orleans (US)
- Department of Pediatrics, University of California, Irvine, Irvine, CA 92697, USA.
- Louisiana State University (US)
- University of Southern California (US)
- Corresponding author
- Bazan, Nicolas G.
- ORCID
- Venue
- Science Advances
- Published
- 2017-09
- Volume
- 3
- Issue
- 9
- Pages
- e1700735-e1700735
- ISSN
- 2375-2548 (ISSN-L)
- PMC
- PMC5617374
- OpenAlex
- W2760405290
- Cited by
- 57
- References
- 35
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 15 · 2022: 6 · 2021: 9 · 2020: 6 · 2019: 5 · 2018: 4
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by-nc
- Locations
- Science Advances (publishedVersion, cc-by-nc)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute of General Medical Sciences (award321576, GM103340)
- National Institute of Neurological Disorders and Stroke (award321577, NS046741)
- American Chemical Society (award349154, The Arthur C. Cope Scholar Fund)
- Topics
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sphingolipid Metabolism and Signaling
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- neuroprotection, ischemic stroke, excitotoxicity, NMDA receptor, middle cerebral artery occlusion, infarct size, neurovascular unit, lipid signaling
- MeSH terms
- Animals, Astrocytes, Blood-Brain Barrier, Cell Survival, Cells, Cultured, Female, Homeostasis, Magnetic Resonance Imaging, Neurons, Pregnancy, Stereoisomerism, Molecular Structure, Biomarkers, Receptors, N-Methyl-D-Aspartate, Pyramidal Cells, Neuroprotective Agents, Stroke, Rats
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