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2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy: Executive Summary: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines
Abstract
Aim: This executive summary of the hypertrophic cardiomyopathy clinical practice guideline provides recommendations and algorithms for clinicians to diagnose and manage hypertrophic cardiomyopathy in adult and pediatric patients as well as supporting documentation to encourage their use. Methods: A comprehensive literature search was conducted from January 1, 2010, to April 30, 2020, encompassing studies, reviews, and other evidence conducted on human subjects that were published in English from PubMed, EMBASE, the Cochrane Collaboration, Agency for Healthcare Research and Quality reports, and other relevant databases. Structure: Many recommendations from the earlier hypertrophic cardiomyopathy guidelines have been updated with new evidence or a better understanding of earlier evidence. This summary operationalizes the recommendations from the full guideline and presents a combination of diagnostic work-up, genetic and family screening, risk stratification approaches, lifestyle modifications, surgical and catheter interventions, and medications that constitute components of guideline directed medical therapy. For both guideline-directed medical therapy and other recommended drug treatment regimens, the reader is advised to follow dosing, contraindications and drug-drug interactions based on product insert materials.
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“Current guidelines from the European Society of Cardiology (ESC) and the American College of Cardiology (ACC) recommend anti-obstructive therapy, i.e., beta-blockers or verapamil to reduce gradient and symptoms (6–8).”
From Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (2024) · cites this paper as [6]
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“Therefore, current guidelines do not recommend these three classes of drugs for HOCM (6, 7).”
From Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy (2024) · cites this paper as [6]
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Metadata
- Authors
- Writing Committee Members, Ommen, S. R., Mital, S., Burke, M. A., Day, S. M., Deswal, A., Elliott, P., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P., Kimmelstiel, C., Kittleson, M., Link, M. S., Maron, M. S., Martinez, M. W., Miyake, C. Y., Schaff, H. V., Semsarian, C., & Sorajja, P.
- Affiliations
- ACC/AHA Representative.
- American Hospital Association (US)
- ASE Representative.
- HRS Representative.
- SCMR Representative.
- AATS Representative.
- SCAI Representative.
- ORCID
- Venue
- Circulation
- Published
- 2020-12-22
- Volume
- 142
- Issue
- 25
- Pages
- e533-e557
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W3113392623
- Cited by
- 336
- References
- 317
- Citations by year
- 2026: 38 · 2025: 46 · 2024: 64 · 2023: 77 · 2022: 70 · 2021: 39 · 2020: 1
- FWCI
- 30.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Effects of Exercise
- Health Sciences › Medicine › Infectious Diseases › Viral Infections and Immunology Research
- Keywords
- hypertrophic cardiomyopathy, diagnosis, treatment, guideline-directed medical therapy, risk stratification, genetic screening, family screening, lifestyle modification, surgical treatment, interventional catheterization, medication, pediatric patients, adult patients
- MeSH terms
- Algorithms, American Heart Association, Cardiology, Cardiomyopathy, Hypertrophic, Decision Support Techniques, Humans, Predictive Value of Tests, United States, Treatment Outcome, Evidence-Based Medicine, Consensus, Cardiac Imaging Techniques
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