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Cited by 257Atherosclerosis and Cardiovascular DiseasesAdipokines, Inflammation, and Metabolic DiseasesInflammatory Biomarkers in Disease Prognosis

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

Elevated CD14 ++ CD16 − Monocytes Predict Cardiovascular Events

Berg, Katarina E., Ljungcrantz, Irena, Andersson, Linda, Bryngelsson, Carl, Hedblad, Bo, Fredrikson, Gunilla N., Nilsson, Jan, Björkbacka, Harry·2012·Circulation: Cardiovascular Genetics
DOI 10.1161/circgenetics.111.960385
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Abstract

Background—: Although monocytes in peripheral blood are no longer considered to be a homogeneous population, associations between distinct monocyte subsets and cardiovascular disease have not been highlighted in large epidemiological studies. Methods and Results—: The study included 700 randomly selected subjects from the cardiovascular arm of the Malmö Diet and Cancer study. Among these, 123 subjects experienced ischemic cardiovascular events during the follow-up until December 2008. Mononuclear leukocytes frozen at the baseline investigation in 1991 to 1994 were thawed and analyzed with flow cytometry to enumerate monocyte subsets, based on CD14 and CD16 expression. The percentage and number of classical CD14 ++ CD16 − monocytes were increased in the cardiovascular-event group compared with the event-free subjects (median, 69% [interquartile range, 62% to 76%] versus 67% [59% to 72%], P =0.017; 344 [251 to 419] cells/μL versus 297 [212 to 384] cells/μL, P =0.003). The hazard ratio was 1.66 for suffering a cardiovascular event in the highest tertile of the number of CD14 ++ CD16 − monocytes compared with the lowest tertile, even after adjustment for common risk factors (HR, 1.66; 95% CI: 1.02 to 2.72). CD14 ++ CD16 − monocytes did not, however, associate with the extent of atherosclerosis at baseline. In contrast, the percentage of monocytes expressing CD16 was negatively associated to the extent of carotid atherosclerosis measured as intima-media thickness at baseline. The chemokine receptors CCR2, CX3CR1, and CCR5 were not differentially expressed between cases and controls on any of the monocyte subsets, but CCR5 expression on CD14 + CD16 ++ monocytes was negatively associated to carotid intima-media thickness. Conclusions—: This study shows that classical CD14 ++ CD16 − monocytes can predict future cardiovascular risk independently of other risk factors in a randomly selected population.

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Crossref · 10.1161/circgenetics.111.960385

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  1. Welfare. TNBoHa. Evaluation of quality of diagnosis of acute myocardial infarction, inpatient register 1997 and 1995 Stockholm, Sweden: Socialstyrelsen; 2000.

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Metadata

Authors
Berg, K. E., Ljungcrantz, I., Andersson, L., Bryngelsson, C., Hedblad, B., Fredrikson, G. N., Nilsson, J., & Björkbacka, H.
Affiliations
Malmö University (SE)
ORCID
Venue
Circulation: Cardiovascular Genetics
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-02
Volume
5
Issue
1
Pages
122-131
ISSN
  • 1942-325X (ISSN-L)
  • 1942-3268
DOI
10.1161/circgenetics.111.960385
OpenAlex
W2165073428
Cited by
257
References
42
Citations by year
2026: 10 · 2025: 16 · 2024: 16 · 2023: 18 · 2022: 12 · 2021: 20 · 2020: 23 · 2019: 22 · 2018: 19 · 2017: 16 · 2016: 24 · 2015: 14 · 2014: 18 · 2013: 18 · 2012: 11
FWCI
8.50
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Cardiovascular Genetics (publishedVersion)
  • PubMed (publishedVersion)
  • Lund University Publications (Lund University) (submittedVersion)
  • Malmö University Publications (Malmö University) (submittedVersion)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
  • Health Sciences › Medicine › Oncology › Inflammatory Biomarkers in Disease Prognosis
Keywords
CD14+CD16+ monocytes, classical monocytes, monocyte subsets, cardiovascular risk prediction, ischemic cardiovascular events, carotid intima-media thickness, atherosclerosis, CCR5, CCR2, CX3CR1, chemokine receptors, Malmö Diet and Cancer Study
MeSH terms
CX3C Chemokine Receptor 1, Aged, Cardiovascular Diseases, Female, Follow-Up Studies, Humans, Male, Middle Aged, Monocytes, Phenotype, Predictive Value of Tests, Risk Factors, Proportional Hazards Models, Receptors, IgG, Disease-Free Survival, Lipopolysaccharide Receptors, Receptors, Chemokine, Receptors, CCR5, Receptors, CCR2

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