Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior
Abstract
The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX 3 CR1 and was required for rapid tissue invasion at the site of an infection by this “resident” monocyte population, which initiated an early immune response and differentiated into macrophages.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The CCL2-CCR2 and CX3CL1-CX3CR1 chemotactic axes are two ligand-receptor signaling pathways that recruit monocytes to sites of inflammation, including the brain.
“the CCL2-CCR2 and CX3CL1-CX3CR1 chemotactic axis are two ligand-receptor signaling pathways that recruit monocytes to sites of inflammation (Auffray et al, 2007;Tsou et al, 2007), including the brain (D' Mello et al, 2009).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Auffray et al, 2007
Cites
Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009 · see citing works
Blood Monocytes Consist of Two Principal Subsets with Distinct Migratory Properties
Geissmann, F., Jung, S., & Littman, D. R. (2003) · Immunity · doi:10.1016/s1074-7613(03)00174-2 · Cited by 3,366 · see citing works
Self-citationA new class of membrane-bound chemokine with a CX3C motif
Bazan, J. F., Bacon, K. B., Hardiman, G., Wang, W., Soo, K., Rossi, D., Greaves, D. R., Zlotnik, A., & Schall, T. J. (1997) · Nature · doi:10.1038/385640a0 · Cited by 2,013 · see citing works
Imai, T., Hieshima, K., Haskell, C. A., Baba, M., Nagira, M., Nishimura, M., Kakizaki, M., Takagi, S., Nomiyama, H., Schall, T. J., et al. (1997) · Cell · doi:10.1016/s0092-8674(00)80438-9 · Cited by 1,446 · see citing works
TNF/iNOS-Producing Dendritic Cells Mediate Innate Immune Defense against Bacterial Infection
Serbina, N. V., Salazar‐Mather, T. P., Biron, C. A., Kuziel, W. A., & Pamer, E. G. (2003) · Immunity · doi:10.1016/s1074-7613(03)00171-7 · Cited by 1,174 · see citing works
Subpopulations of Mouse Blood Monocytes Differ in Maturation Stage and Inflammatory Response
Sunderkötter, C., Nikolic, T., Dillon, M. J., van Rooijen, N., Stehling, M., Drevets, D. A., & Leenen, P. J. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.7.4410 · Cited by 1,124 · see citing works
A Clonogenic Bone Marrow Progenitor Specific for Macrophages and Dendritic Cells
Fogg, D. K., Sibon, C., Miled, C., Jung, S., Aucouturier, P., Littman, D. R., Cumano, A., & Geissmann, F. (2005) · Science · doi:10.1126/science.1117729 · Cited by 1,050 · see citing works
Self-citationIdentification and characterization of a novel monocyte subpopulation in human peripheral blood
Passlick, B., Flieger, D., & Ziegler‐Heitbrock, H. W. L. (1989) · Blood · doi:10.1182/blood.v74.7.2527.2527 · Cited by 1,032 · see citing works
Langerhans cells arise from monocytes in vivo
Ginhoux, F., Tacke, F., Angeli, V., Bogunovic, M., Loubeau, M., Dai, X.-M., Stanley, E. R., Randolph, G. J., & Mérad, M. (2006) · Nature Immunology · doi:10.1038/ni1307 · Cited by 741 · see citing works
Phillipson, M., Heit, B., Colarusso, P., Liu, L., Ballantyne, C. M., & Kubes, P. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060925 · Cited by 713 · see citing works
Fong, A. M., Robinson, L. A., Steeber, D. A., Tedder, T. F., Yoshie, O., Imai, T., & Patel, D. D. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.8.1413 · Cited by 682 · see citing works
Monocytes give rise to mucosal, but not splenic, conventional dendritic cells
Varol, C., Landsman, L., Fogg, D. K., Greenshtein, L., Gildor, B., Margalit, R., Kalchenko, V., Geissmann, F., & Jung, S. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061011 · Cited by 627 · see citing works
Self-citationIntrasplenic steady-state dendritic cell precursors that are distinct from monocytes
Naik, S. H., Metcalf, D., van Nieuwenhuijze, A. E. M., Wicks, I. P., Wu, L., O’Keeffe, M. A., & Shortman, K. (2006) · Nature Immunology · doi:10.1038/ni1340 · Cited by 598 · see citing works
Inflammatory Chemokine Transport and Presentation in HEV
Palframan, R. T., Jung, S., Cheng, G., Weninger, W., Luo, Y., Dorf, M. E., Littman, D. R., Rollins, B. J., Zweerink, H. J., Rot, A., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.9.1361 · Cited by 551 · see citing works
Chemokines Trigger Immediate β2 Integrin Affinity and Mobility Changes
Constantin, G., Majeed, M., Giagulli, C., Piccio, L. M., Kim, J. Y., Butcher, E. C., & Laudanna, C. (2000) · Immunity · doi:10.1016/s1074-7613(00)00074-1 · Cited by 519 · see citing works
Decreased atherosclerosis in CX3CR1–/– mice reveals a role for fractalkine in atherogenesis
Lesnik, P., Haskell, C. A., & Charo, I. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci15555 · Cited by 487 · see citing works
Locomotion of monocytes on endothelium is a critical step during extravasation
Schenkel, A. R., Mamdouh, Z., & Müller, W. A. (2004) · Nature Immunology · doi:10.1038/ni1051 · Cited by 441 · see citing works
Fractalkine in Vascular Biology
Umehara, H., Bloom, E. T., Okazaki, T., Nagano, Y., Yoshie, O., & Imai, T. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000095360.62479.1f · Cited by 320 · see citing works
CD14+CD16+ monocytes in coronary artery disease and their relationship to serum TNF-α levels
Blankenberg, S., Espinola–Klein, C., Dopheide, J. F., Bickel, C., Lackner, K. J., Iz, M., Meyer, J., Darius, H., Rupprecht, H. J., Schlitt, A., et al. (2004) · Thrombosis and Haemostasis · doi:10.1160/th04-02-0095 · Cited by 301 · see citing works
Iwahashi, M., Yamamura, M., Aita, T., Okamoto, A., Ueno, A., Ogawa, N., Akashi, S., Miyake, K., Godowski, P. J., & Makino, H. (2004) · Arthritis & Rheumatism · doi:10.1002/art.20219 · Cited by 267 · see citing works
Goda, S., Imai, T., Yoshie, O., Yoneda, O., Inoue, H., Nagano, Y., Okazaki, T., Imai, H., Bloom, E. T., Domae, N., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.8.4313 · Cited by 225 · see citing works
Near-Wall μ-PIV Reveals a Hydrodynamically Relevant Endothelial Surface Layer in Venules In Vivo
Smith, M. L., Long, D. S., Damiano, E. R., et al. (2003) · Biophysical Journal · doi:10.1016/s0006-3495(03)74507-x · Cited by 214 · see citing works
Selective mobilization of CD14+CD16+ monocytes by exercise
Steppich, B., Dayyani, F., Gruber, R., Lorenz, R. L., Mack, M., & Ziegler‐Heitbrock, H. W. L. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c578 · Cited by 193 · see citing works
Leukocyte adhesion deficiency: molecular basis and functional consequences.
Fischer, A., Lisowska‐Grospierre, B., Anderson, D. C., et al. (1988) · PubMed · Cited by 190 · see citing works
Balance of MafB and PU. 1 specifies alternative macrophage or dendritic cell fate
Bakri, Y., Sarrazin, S., Mayer, U. P., Tillmanns, S., Nerlov, C., Boned, A., & Sieweke, M. H. (2005) · Blood · doi:10.1182/blood-2004-04-1448 · Cited by 187 · see citing works
Ghassabeh, G. H., BAETSELIER, P. D., Brys, L., Noël, W., Ginderachter, J. A. V., Meerschaut, S., Beschin, A., Brombacher, F., & Raes, G. (2006) · Blood · doi:10.1182/blood-2005-04-1485 · Cited by 175 · see citing works
Unique Role of the Chemokine Domain of Fractalkine in Cell Capture
Haskell, C. A., Cleary, M. D., & Charo, I. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m005731200 · Cited by 124 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144 · see citing works
Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm
Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840 · see citing works
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Development of Monocytes, Macrophages, and Dendritic Cells
Geissmann, F., Manz, M. G., Jung, S., Sieweke, M. H., Merad, M., & Ley, K. (2010) · Science · doi:10.1126/science.1178331 · Cited by 3,049 · see citing works
Self-citationMonocyte recruitment during infection and inflammation
Shi, C., & Pamer, E. G. (2011) · Nature Reviews Immunology · doi:10.1038/nri3070 · Cited by 3,015 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Self-citationMacrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384 · see citing works
Nahrendorf, M., Swirski, F. K., Aikawa, E., Stangenberg, L., Wurdinger, T., Figueiredo, J.-L., Libby, P., Weissleder, R., & Pittet, M. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070885 · Cited by 2,300 · see citing works
Identification of splenic reservoir monocytes and their deployment to inflammatory sites
Swirski, F. K., Nahrendorf, M., Etzrodt, M., Wildgruber, M., Cortez-Retamozo, V., Panizzi, P., Figueiredo, J.-L., Kohler, R. H., Chudnovskiy, A., Waterman, P., et al. (2009) · Science · doi:10.1126/science.1175202 · Cited by 2,221 · see citing works
Kigerl, K. A., Gensel, J. C., Ankeny, D. P., Alexander, J. K., Donnelly, D. J., & Popovich, P. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.3257-09.2009 · Cited by 2,130 · see citing works
From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation
Italiani, P., & Boraschi, D. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00514 · Cited by 2,067 · see citing works
Microglial <scp>M1/M2</scp> polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070 · see citing works
Inflammation in obesity, diabetes, and related disorders
Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works
Monocytes and macrophages: developmental pathways and tissue homeostasis
Ginhoux, F., & Jung, S. (2014) · Nature Reviews Immunology · doi:10.1038/nri3671 · Cited by 1,840 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
The far-reaching scope of neuroinflammation after traumatic brain injury
Simon, D. W., McGeachy, M. J., Bayır, H., Clark, R. S. B., Loane, D. J., & Kochanek, P. M. (2017) · Nature Reviews Neurology · doi:10.1038/nrneurol.2017.13 · Cited by 1,190 · see citing works
Yang, J., Zhang, L., Yu, C., Yang, X.-F., & Wang, H. (2014) · Biomarker Research · doi:10.1186/2050-7771-2-1 · Cited by 1,099 · see citing works
Phagocyte partnership during the onset and resolution of inflammation
Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
Patel, A. A., Zhang, Y., Fullerton, J. N., Boelen, L., Rongvaux, A., Maini, A. A., Bigley, V., Flavell, R. A., Gilroy, D. W., Asquith, B., et al. (2017) · Journal of Experimental Medicine · doi:10.1084/jem.20170355 · Cited by 946 · see citing works
Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · see citing works
Kubes, P., & Jenne, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052415 · Cited by 923 · see citing works
Monocytes in atherosclerosis: subsets and functions
Woollard, K. J., & Geissmann, F. (2010) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2009.228 · Cited by 890 · see citing works
Self-citationFlow Cytometric Analysis of Macrophages and Dendritic Cell Subsets in the Mouse Lung
Misharin, A. V., Morales-Nebreda, L., Mutlu, G. M., Budinger, G. R. S., & Perlman, H. (2013) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2013-0086ma · Cited by 838 · see citing works
Promoting tissue regeneration by modulating the immune system
Julier, Z., Park, A. J., Briquez, P. S., & Martino, M. M. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.056 · Cited by 766 · see citing works
Satellite Cells and Skeletal Muscle Regeneration
Dumont, N. A., Bentzinger, C. F., Sincennes, M., & Rudnicki, M. A. (2015) · Comprehensive Physiology · doi:10.1002/cphy.c140068 · Cited by 719 · see citing works
Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
Ghosn, E. E. B., Cassado, A. A., Govoni, G. R., Fukuhara, T., Yang, Y., Monack, D. M., Bortoluci, K. R., Almeida, S. R., Herzenberg, L. A., & Herzenberg, L. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0915000107 · Cited by 689 · see citing works
Trompette, A., Gollwitzer, E. S., Pattaroni, C., Lopez-Mejia, I. C., Riva, E., Pernot, J., Ubags, N., Fajas, L., Nicod, L. P., & Marsland, B. J. (2018) · Immunity · doi:10.1016/j.immuni.2018.04.022 · Cited by 678 · see citing works
Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions.
Bartholomäus, I., Kawakami, N., Odoardi, F., Schläger, C., Miljkovic, D., Ellwart, J. W., Klinkert, W. E. F., Flügel-Koch, C., Issekutz, T. B., Wekerle, H., et al. (2009) · Nature · doi:10.1038/nature08478 · Cited by 685 · see citing works
Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works
Sterile inflammation in the liver
Kubes, P., & Mehal, W. Z. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.09.008 · Cited by 666 · see citing works
Hanna, R. N., Carlin, L. M., Hubbeling, H. G., Nackiewicz, D., Green, A. M., Punt, J. A., Geissmann, F., & Hedrick, C. C. (2011) · Nature Immunology · doi:10.1038/ni.2063 · Cited by 639 · see citing works
Self-citationSaederup, N., Cardona, A. E., Croft, K., Mizutani, M., Cotleur, A. C., Tsou, C.-L., Ransohoff, R. M., & Charo, I. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013693 · Cited by 599 · see citing works
Wohleb, E. S., Powell, N. D., Godbout, J. P., & Sheridan, J. F. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.1671-13.2013 · Cited by 563 · see citing works
Tumor-associated macrophages: Functional diversity, clinical significance, and open questions
Biswas, S. K., Allavena, P., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0367-7 · Cited by 551 · see citing works
CCR2 recruits an inflammatory macrophage subpopulation critical for angiogenesis in tissue repair
Willenborg, S., Lucas, T., van Loo, G., Knipper, J. A., Krieg, T., Haase, I., Brachvogel, B., Hammerschmidt, M., Nagy, A., Ferrara, N., et al. (2012) · Blood · doi:10.1182/blood-2012-01-403386 · Cited by 534 · see citing works
Beyond stem cells: self-renewal of differentiated macrophages
Sieweke, M. H., & Allen, J. E. (2013) · Science · doi:10.1126/science.1242974 · Cited by 503 · see citing works
Blériot, C., Dupuis, T., Jouvion, G., Eberl, G., Disson, O., & Lecuit, M. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.020 · Cited by 471 · see citing works
Pittet, M. J., & Weissleder, R. (2011) · Cell · doi:10.1016/j.cell.2011.11.004 · Cited by 466 · see citing works
Auffray, C., Fogg, D. K., Narni-Mancinelli, E., Senechal, B., Trouillet, C., Saederup, N., Leemput, J., Bigot, K., Campisi, L., Abitbol, M., et al. (2009) · Journal of Experimental Medicine · doi:10.1084/jem.20081385 · Cited by 422 · see citing works
Self-citationSeidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-30 · Cited by 390 · see citing works
Cellular dynamics in the muscle satellite cell niche
Bentzinger, C. F., Wang, Y. X., Dumont, N. A., & Rudnicki, M. A. (2013) · The EMBO Reports · doi:10.1038/embor.2013.182 · Cited by 398 · see citing works
Monocytes and macrophages in tissue repair: Implications for immunoregenerative biomaterial design
Ogle, M. E., Segar, C. E., Sridhar, S., & Botchwey, E. A. (2016) · Experimental Biology and Medicine · doi:10.1177/1535370216650293 · Cited by 378 · see citing works
Mizutani, M., Pino, P. A., Saederup, N., Charo, I. F., Ransohoff, R. M., & Cardona, A. E. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1100421 · Cited by 346 · see citing works
Pinto, A. R., Paolicelli, R., Salimova, E., Gospocic, J., Slonimsky, E., Bilbao-Cortes, D., Godwin, J. W., & Rosenthal, N. A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036814 · Cited by 318 · see citing works
Identification of an atypical monocyte and committed progenitor involved in fibrosis
Satoh, T., Nakagawa, K., Sugihara, F., Kuwahara, R., Ashihara, M., Yamane, F., Minowa, Y., Fukushima, K., Ebina, I., Yoshioka, Y., et al. (2017) · Nature · doi:10.1038/nature20611 · Cited by 302 · see citing works
Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal
Weber, M. D., Godbout, J. P., & Sheridan, J. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.102 · Cited by 283 · see citing works
Elevated CD14 <sup>++</sup> CD16 <sup>−</sup> Monocytes Predict Cardiovascular Events
Berg, K. E., Ljungcrantz, I., Andersson, L., Bryngelsson, C., Hedblad, B., Fredrikson, G. N., Nilsson, J., & Björkbacka, H. (2012) · Circulation: Cardiovascular Genetics · doi:10.1161/circgenetics.111.960385 · Cited by 257 · see citing works
Intravascular immunity: the host–pathogen encounter in blood vessels
Hickey, M. J., & Kubes, P. (2009) · Nature Reviews Immunology · doi:10.1038/nri2532 · Cited by 251 · see citing works
Impaired functions of peripheral blood monocyte subpopulations in aged humans
Nyugen, J., Agrawal, S., Gollapudi, S., & Gupta, S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9448-8 · Cited by 249 · see citing works
Gautier, E. L., Jakubzick, C., & Randolph, G. J. (2009) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.108.180505 · Cited by 216 · see citing works
Aoyama, T., Inokuchi, S., Brenner, D. A., & Seki, E. (2010) · Hepatology · doi:10.1002/hep.23795 · Cited by 211 · see citing works
Complement receptors and their role in leukocyte recruitment and phagocytosis
Vandendriessche, S., Cambier, S., Proost, P., & Marques, P. E. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.624025 · Cited by 178 · see citing works
Development and homeostasis of “resident” myeloid cells: the case of the microglia
Gomez Perdiguero, E., Schulz, C., & Geissmann, F. (2013) · Glia · doi:10.1002/glia.22393 · Cited by 182 · see citing works
Self-citationLy6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy
Jung, K., Heishi, T., Khan, O. F., Kowalski, P. S., Incio, J., Rahbari, N. N., Chung, E., Clark, J. W., Willett, C. G., Luster, A. D., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci93182 · Cited by 164 · see citing works
The effects of monocytes on tumor cell extravasation in a 3D vascularized microfluidic model
Boussommier-Calleja, A., Atiyas, Y., Haase, K., Headley, M., Lewis, C., & Kamm, R. D. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2018.03.005 · Cited by 158 · see citing works
Myeloid cell heterogeneity in cancer: not a single cell alike
Kiss, M., Van Gassen, S., Movahedi, K., Saeys, Y., & Laoui, D. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.02.008 · Cited by 159 · see citing works
Targeting vascular and leukocyte communication in angiogenesis, inflammation and fibrosis
Kreuger, J., & Phillipson, M. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2015.2 · Cited by 160 · see citing works
Chong, S. Z., Evrard, M., Devi, S., Chen, J., Lim, J. Y., See, P., Zhang, Y., Adrover, J. M., Lee, B., Tan, L., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20160800 · Cited by 142 · see citing works
Xue, Q., Lu, Y., Eisele, M. R., Sulistijo, E. S., Khan, N., Fan, R., & Miller-Jensen, K. (2015) · Science Signaling · doi:10.1126/scisignal.aaa2155 · Cited by 143 · see citing works
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8–mediated TGFβ activation
Kelly, A., Gunaltay, S., McEntee, C. P., Shuttleworth, E. E., Smedley, C., Houston, S. A., Fenton, T. M., Levison, S., Mann, E. R., & Travis, M. A. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171491 · Cited by 124 · see citing works
Microglia: unique and common features with other tissue macrophages
Prinz, M., Tay, T. L., Wolf, Y., & Jung, S. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1267-1 · Cited by 126 · see citing works
Innate Immune Cell Trafficking and Function During Sterile Inflammation of the Liver
McDonald, B., & Kubes, P. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.09.048 · Cited by 123 · see citing works
Mechanisms of Mononuclear Phagocyte Recruitment in Alzheimers Disease
Hickman, S. E., & Khoury, J. E. (2010) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152710791011982 · Cited by 120 · see citing works
Quintar, A., McArdle, S., Wolf, D., Marki, A., Ehinger, E., Vassallo, M., Miller, J., Mikulski, Z., Ley, K., & Buscher, K. (2017) · Circulation Research · doi:10.1161/circresaha.117.310739 · Cited by 109 · see citing works
In vivo dynamics of innate immune sentinels in the CNS
Nayak, D., Zinselmeyer, B. H., Corps, K. N., & McGavern, D. B. (2012) · IntraVital · doi:10.4161/intv.22823 · Cited by 109 · see citing works
Myeloid cell dysfunction and the pathogenesis of the diabetic chronic wound
Wicks, K., Torbica, T., & Mace, K. A. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2014.04.006 · Cited by 93 · see citing works
A role for spleen monocytes in post-ischemic brain inflammation and injury
Bao, Y., Kim, E., Bhosle, S., Mehta, H., & Cho, S. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-92 · Cited by 94 · see citing works
The Translational Potential of Microglia and Monocyte-Derived Macrophages in Ischemic Stroke
Wicks, E. E., Ran, K. R., Kim, J. E., Xu, R., Lee, R. P., & Jackson, C. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.897022 · Cited by 92 · see citing works
Protective features of peripheral monocytes/macrophages in stroke
Gliem, M., Schwaninger, M., & Jander, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.11.004 · Cited by 88 · see citing works
Monocyte and macrophage biology: an overview
Rees, A. J. (2010) · Seminars in Nephrology · doi:10.1016/j.semnephrol.2010.03.002 · Cited by 84 · see citing works
Sindrilaru, A., Peters, T., Schymeinsky, J., Oreshkova, T., Wang, H., Gompf, A., Mannella, F., Wlaschek, M., Sunderkötter, C., Rudolph, K. L., et al. (2009) · Blood · doi:10.1182/blood-2008-07-166702 · Cited by 73 · see citing works
Lessard, A.-J., LeBel, M., Egarnes, B., Préfontaine, P., Thériault, P., Droit, A., Brunet, A., Rivest, S., & Gosselin, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.08.009 · Cited by 70 · see citing works
Hardt, O., Wild, S., Oerlecke, I., Hofmann, K., Luo, S., Wiencek, Y., Kantelhardt, E., Vess, C., Smith, G. P., Schroth, G. P., et al. (2012) · Cancer Letters · doi:10.1016/j.canlet.2012.06.010 · Cited by 64 · see citing works
Nagenborg, J., Goossens, P., Biessen, E. A. L., & Donners, M. M. P. C. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.10.005 · Cited by 50 · see citing works
The role of macrophages in protective and pathological responses to <i>Toxoplasma gondii</i>
Park, J., & Hunter, C. A. (2020) · Parasite Immunology · doi:10.1111/pim.12712 · Cited by 54 · see citing works
Reprint of: Monocyte subsets in man and other species
Ziegler-Heitbrock, L. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.06.008 · Cited by 40 · see citing works
Sun, D., Zhang, M., Sun, P., Liu, G., Strickland, A. B., Chen, Y., Fu, Y., Yosri, M., & Shi, M. (2020) · PLOS Pathogens · doi:10.1371/journal.ppat.1008361 · Cited by 34 · see citing works
Fungal Infection in the Brain: What We Learned from Intravital Imaging
Shi, M., & Mody, C. H. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00292 · Cited by 33 · see citing works
Imaging macrophage development and fate in atherosclerosis and myocardial infarction
Swirski, F. K., & Nahrendorf, M. (2013) · Immunology & Cell Biology · doi:10.1038/icb.2012.72 · Cited by 23 · see citing works
Li, C., Chen, Y.-H., & Zhang, K. (2020) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317520927169 · Cited by 17 · see citing works
Wnt Signaling Regulates Macrophage Mediated Immune Response to Pathogens
Jati, S., & Sen, M. (2020) · Macrophage Activation - Biology and Disease · doi:10.5772/intechopen.86433 · Cited by 4 · see citing works
- Authors
- Auffray, C., Fogg, D., Garfa, M., Elain, G., Join-Lambert, O., Kayal, S., Sarnacki, S., Cumano, A., Lauvau, G., & Geissmann, F.
- Affiliations
- Institut Nationale de la Santé et de la Recherche Médicale (INSERM) U838, Laboratory of Biology of the Mononuclear Phagocyte System, and Cellular and Molecular imaging core facility, Institut Fédératif de Recherche Necker-Enfants Malades, Paris, France.
- Hôpital Necker-Enfants Malades (FR)
- Venue
- Science
- Published
- 2007-08-03
- Volume
- 317
- Issue
- 5838
- Pages
- 666-670
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1985502949
- Cited by
- 1,973
- References
- 27
- Citations by year
- 2026: 52 · 2025: 55 · 2024: 113 · 2023: 110 · 2022: 97 · 2021: 122 · 2020: 112 · 2019: 122 · 2018: 105 · 2017: 132 · 2016: 140 · 2015: 131 · 2014: 125 · 2013: 105 · 2012: 115
- FWCI
- 54.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- LFA-1 integrin, CX3CR1, monocyte recruitment, tissue invasion, infection, macrophage differentiation, leukocyte rolling, endothelium, inflammation, tissue damage
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Blood Vessels, Cell Adhesion, Cell Differentiation, Cell Movement, Endothelium, Vascular, Gene Expression Regulation, Immunity, Innate, Inflammation, Listeriosis, Listeria monocytogenes, Macrophages, Mesenteric Arteries, Mesenteric Veins, Monocytes, Lymphocyte Function-Associated Antigen-1, Microscopy, Confocal, Receptors, Chemokine, Dermis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
