The Impact of Mechanical Forces in Heart Morphogenesis

Notch Signaling: Cell Fate Control and Signal Integration in Development

Artavanis-Tsakonas, S., Rand, M. D., & Lake, R. J. (1999) · Science · doi:10.1126/science.284.5415.770 · Cited by 5,909 · see citing works

A mechanosensory complex that mediates the endothelial cell response to fluid shear stress

Tzima, E., Irani-Tehrani, M., Kiosses, W. B., Dejana, E., Schultz, D., Engelhardt, B., Cao, G., DeLisser, H. M., & Schwartz, M. A. (2005) · Nature · doi:10.1038/nature03952 · Cited by 1,738 · see citing works

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein

Nonaka, S., Tanaka, Y., Okada, Y., Takeda, S., Harada, A., Kanai, Y., Kido, M. A., & Hirokawa, N. (1998) · Cell · doi:10.1016/s0092-8674(00)81705-5 · Cited by 1,619 · see citing works

Mutations in NOTCH1 cause aortic valve disease

Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509 · see citing works

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

Carmeliet, P., Lampugnani, M. G., Moons, L., Breviario, F., Compernolle, V., Bono, F., Balconi, G., Spagnuolo, R., Oosthuyse, B., Dewerchin, M. A., et al. (1999) · Cell · doi:10.1016/s0092-8674(00)81010-7 · Cited by 1,284 · see citing works

Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1

Li, L., Krantz, I. D., Deng, Y., Genin, A., Banta, A. B., Collins, C. C., Qi, M., Trask, B. J., Kuo, W. L., Cochran, J., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-243 · Cited by 1,277 · see citing works

Cardiac Malformation in Neonatal Mice Lacking Connexin43

Reaume, A. G., Sousa, P. A. D., Kulkarni, S., Langille, B. L., Zhu, D., Davies, T. C., Juneja, S. C., Kidder, G. M., & Rossant, J. (1995) · Science · doi:10.1126/science.7892609 · Cited by 1,243 · see citing works

Mutations in the human Jagged1 gene are responsible for Alagille syndrome

Oda, T., ELKAHLOUN, A. G., Pike, B. L., Okajima, K., Krantz, I. D., Genin, A., Piccoli, D. A., Meltzer, P. S., Spinner, N. B., Collins, F. S., et al. (1997) · Nature Genetics · doi:10.1038/ng0797-235 · Cited by 1,150 · see citing works

Notch signaling is essential for vascular morphogenesis in micePreprint

Krebs, L. T., Xue, Y., Norton, C. R., Shutter, J. R., Maguire, M., Sundberg, J. P., Gallahan, D., Closson, V., Kitajewski, J., Callahan, R., et al. (2000) · Genes & Development · doi:10.1101/gad.14.11.1343 · Cited by 1,060 · see citing works

Intracardiac fluid forces are an essential epigenetic factor for embryonic cardiogenesis

Hove, J. R., Köster, R. W., Forouhar, A. S., Acevedo‐Bolton, G., Fraser, S. E., & Gharib, M. (2003) · Nature · doi:10.1038/nature01282 · Cited by 1,000 · see citing works

Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformationPreprint

Timmerman, L., Grego‐Bessa, J., Raya, Á., Bertrán, E., Pérez-Pomares, J. M., Díez, J., Aranda, S., Palomo‐Ponce, S., McCormick, F., Izpisúa‐Belmonte, J. C., et al. (2003) · Genes & Development · doi:10.1101/gad.276304 · Cited by 986 · see citing works

<i>Chlamydomonas</i> Kinesin-II–dependent Intraflagellar Transport (IFT): IFT Particles Contain Proteins Required for Ciliary Assembly in <i>Caenorhabditis elegans</i> Sensory Neurons

Cole, D. G., Diener, D. R., Himelblau, A. L., Beech, P. L., Fuster, J. C., & Rosenbaum, J. L. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.141.4.993 · Cited by 898 · see citing works

Two Populations of Node Monocilia Initiate Left-Right Asymmetry in the Mouse

McGrath, J. M., Somlo, S., Makova, S. Z., Tian, X., & Brueckner, M. K. (2003) · Cell · doi:10.1016/s0092-8674(03)00511-7 · Cited by 797 · see citing works

NOTCH2 Mutations Cause Alagille Syndrome, a Heterogeneous Disorder of the Notch Signaling Pathway

McDaniell, R. M., Warthen, D. M., Sanchez-Lara, P. A., Pai, A. A., Krantz, I. D., Piccoli, D. A., & Spinner, N. B. (2006) · The American Journal of Human Genetics · doi:10.1086/505332 · Cited by 747 · see citing works

Notch Signaling: The Core Pathway and Its Posttranslational Regulation

Fortini, M. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.03.010 · Cited by 745 · see citing works

Determination of left–right patterning of the mouse embryo by artificial nodal flow

Nonaka, S., Shiratori, H., Saijoh, Y., & Hamada, H. (2002) · Nature · doi:10.1038/nature00849 · Cited by 683 · see citing works

Cranial and cardiac neural crest defects in endothelin-A receptor-deficient mice

Clouthier, D. E., Hosoda, K., Richardson, J. A., Williams, S. C., Yanagisawa, H., Kuwaki, T., Kumada, M., Hammer, R. E., & Yanagisawa, M. (1998) · Development · doi:10.1242/dev.125.5.813 · Cited by 651 · see citing works

Cis-interactions between Notch and Delta generate mutually exclusive signalling states

Sprinzak, D., Lakhanpal, A., LeBon, L., Santat, L. A., Fontes, M. E., Anderson, G. A., García‐Ojalvo, J., & Elowitz, M. B. (2010) · Nature · doi:10.1038/nature08959 · Cited by 636 · see citing works

The suppressor of hairless protein participates in notch receptor signaling

Fortini, M. (1994) · Cell · doi:10.1016/0092-8674(94)90196-1 · Cited by 541 · see citing works

Situs inversus and embryonic ciliary morphogenesis defects in mouse mutants lacking the KIF3A subunit of kinesin-II

Marszalek, J. R., Ruiz‐Lozano, P., Roberts, E. A., Chien, K. R., & Goldstein, L. S. B. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.9.5043 · Cited by 530 · see citing works

Notch Signaling Is Essential for Ventricular Chamber Development

Grego‐Bessa, J., Luna‐Zurita, L., del Monte‐Nieto, G., Bolós, V., Melgar, P., Arandilla, A., Garratt, A. N., Zang, H., Mukouyama, Y., Chen, H., et al. (2007) · Developmental Cell · doi:10.1016/j.devcel.2006.12.011 · Cited by 522 · see citing works

Dual genetic pathways of endothelin-mediated intercellular signaling revealed by targeted disruption of endothelin converting enzyme-1 gene

Yanagisawa, H., Yanagisawa, M., Kapur, R. P., Richardson, J. A., Williams, S. C., Clouthier, D. E., de Wit, D., Emoto, N., & Hammer, R. E. (1998) · Development · doi:10.1242/dev.125.5.825 · Cited by 490 · see citing works

Structural development of endocardial cushions

Markwald, R. R., Fitzharris, T. P., & Manasek, F. J. (1977) · American Journal of Anatomy · doi:10.1002/aja.1001480108 · Cited by 489 · see citing works

Left-Right Asymmetry and Kinesin Superfamily Protein KIF3A: New Insights in Determination of Laterality and Mesoderm Induction by kif3A−/− Mice Analysis

Takeda, S., YONEKAWA, Y., Tanaka, Y., Okada, Y., Nonaka, S., & Hirokawa, N. (1999) · The Journal of Cell Biology · doi:10.1083/jcb.145.4.825 · Cited by 438 · see citing works

The Ion Channel Polycystin-2 Is Required for Left-Right Axis Determination in Mice

Pennekamp, P., Karcher, C., Fischer, A., Schweickert, A., Skryabin, B. V., Horst, J., Blum, M., & Dworniczak, B. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00869-2 · Cited by 426 · see citing works

EndoCAM: a novel endothelial cell-cell adhesion molecule.

Albelda, S. M., Oliver, P., Romer, L. H., & Buck, C. A. (1990) · The Journal of Cell Biology · doi:10.1083/jcb.110.4.1227 · Cited by 402 · see citing works

Cardiac defects and renal failure in mice with targeted mutations in Pkd2

Wu, G., Markowitz, G. S., Li, L., D’Agati, V. D., Factor, S. M., Geng, L., Tibara, S., Tuchman, J. B., Cai, Y., Park, J. H., et al. (2000) · Nature Genetics · doi:10.1038/71724 · Cited by 399 · see citing works

DNA microarray reveals changes in gene expression of shear stressed human umbilical vein endothelial cells

McCormick, S. M., Eskin, S. G., McIntire, L. V., Teng, C. L., Lu, C., Russell, C. G., & Chittur, K. K. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.171259298 · Cited by 385 · see citing works

Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1.

Kurihara, Y., Kurihara, H., Oda, H., Maemura, K., Nagai, R., Ishikawa, T., & Yazaki, Y. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118033 · Cited by 384 · see citing works

Mutations in the JARID1C Gene, Which Is Involved in Transcriptional Regulation and Chromatin Remodeling, Cause X-Linked Mental Retardation

Jensen, L. R., Amende, M., Gurok, U., Moser, B., Gimmel, V., Tzschach, A., Janecke, A. R., Tariverdian, G., Chelly, J., Fryns, J.-P., et al. (2005) · The American Journal of Human Genetics · doi:10.1086/427563 · Cited by 373 · see citing works

Modulation of GTPase activity of G proteins by fluid shear stress and phospholipid composition

Gudi, S., Nolan, J. P., & Frangos, J. A. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2515 · Cited by 343 · see citing works

Abnormal Aortic Valve Development in Mice Lacking Endothelial Nitric Oxide Synthase

Lee, T. C., Zhao, Y. D., Courtman, D. W., & Stewart, D. J. (2000) · Circulation · doi:10.1161/01.cir.101.20.2345 · Cited by 328 · see citing works

Ciliary Polycystin-2 Is a Mechanosensitive Calcium Channel Involved in Nitric Oxide Signaling Cascades

AbouAlaiwi, W. A., Takahashi, M., Mell, B., Jones, T. J., Ratnam, S., Kolb, R. J., & Nauli, S. M. (2009) · Circulation Research · doi:10.1161/circresaha.108.192765 · Cited by 327 · see citing works

Evidence for a role of platelet endothelial cell adhesion molecule-1 in endothelial cell mechanosignal transduction

Osawa, M., Masuda, M., Kusano, K.-I., & Fujiwara, K. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200205049 · Cited by 307 · see citing works

Klf2 Is an Essential Regulator of Vascular Hemodynamic Forces In Vivo

Lee, J. S., Yu, Q., Shin, J. T., Sebzda, E., Bertozzi, C. C., Chen, M., Mericko, P., Stadtfeld, M., Zhou, D. D., Cheng, L., et al. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.09.006 · Cited by 304 · see citing works

Familial Tetralogy of Fallot caused by mutation in the jagged1 gene

Eldadah, Z. A. (2001) · Human Molecular Genetics · doi:10.1093/hmg/10.2.163 · Cited by 296 · see citing works

Disruption of Hemoglobin Oxygen Transport Does Not Impact Oxygen-Dependent Physiological Processes in Developing Embryos of Zebra Fish ( Danio rerio )

Pelster, B., & Burggren, W. W. (1996) · Circulation Research · doi:10.1161/01.res.79.2.358 · Cited by 293 · see citing works

Mutation in myosin heavy chain 6 causes atrial septal defect

Ching, Y., Ghosh, T. K., Cross, S. J., Packham, E. A., Honeyman, L., Loughna, S., Robinson, T. E., Dearlove, A., Ribas, G., Bonser, A. J., et al. (2005) · Nature Genetics · doi:10.1038/ng1526 · Cited by 280 · see citing works

Novel NOTCH1 mutations in patients with bicuspid aortic valve disease and thoracic aortic aneurysms

McKellar, S. H., Tester, D. J., Yagubyan, M., Majumdar, R., Ackerman, M. J., & Sundt, T. M. (2007) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.02.041 · Cited by 276 · see citing works

Fluid Flow Rapidly Activates G Proteins in Human Endothelial Cells

Gudi, S. R. P., Clark, C. B., & Frangos, J. A. (1996) · Circulation Research · doi:10.1161/01.res.79.4.834 · Cited by 270 · see citing works

An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation

High, F. A., Zhang, M., Proweller, A., Tu, L., Parmacek, M. S., Pear, W. S., & Epstein, J. A. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30070 · Cited by 267 · see citing works

Mutation in the alpha-cardiac actin gene associated with apical hypertrophic cardiomyopathy, left ventricular non-compaction, and septal defects

Monserrat, L., Hermida‐Prieto, M., Fernández, X., Rodrı́guez, I., Dumont, C. A., Cazón, L., Cuesta, M. G., González‐Juanatey, C., Peteiro, J., Alvarez, N., et al. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm239 · Cited by 264 · see citing works

Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish

Berdougo, E., Coleman, H., Lee, D. H., Stainier, D. Y. R., & Yelon, D. L. (2003) · Development · doi:10.1242/dev.00838 · Cited by 261 · see citing works

The shear stress of it all: the cell membrane and mechanochemical transduction

White, C. R., & Frangos, J. A. (2007) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2007.2128 · Cited by 255 · see citing works

Remodeling of chick embryonic ventricular myoarchitecture under experimentally changed loading conditions

Sedmera, D., Pexieder, T., Rychterová, V., Hu, N., & Clark, E. B. (1999) · The Anatomical Record · doi:10.1002/(sici)1097-0185(19990201)254:2 · Cited by 252 · see citing works

Expression pattern of Motch , a mouse homolog of Drosophila Notch , suggests an important role in early postimplantation mouse development

del Amo, F. F., Smith, D. E., Swiatek, P. J., Gendron‐Maguire, M., Greenspan, R. J., McMahon, A. P., & Gridley, T. (1992) · Development · doi:10.1242/dev.115.3.737 · Cited by 249 · see citing works

Embryonic cardiomyocyte hypoplasia and craniofacial defects in Gαq. Gα11‐mutant mice

Offermanns, S., Zhao, L., Gohla, A., Sarosi, I., Simon, M. I., & Wilkie, T. M. (1998) · The EMBO Journal · doi:10.1093/emboj/17.15.4304 · Cited by 236 · see citing works

Unilateral Vitelline Vein Ligation Alters Intracardiac Blood Flow Patterns and Morphogenesis in the Chick Embryo

Hogers, B., DeRuiter, M. C., Gittenberger-de Groot, A. C., & Poelmann, R. E. (1997) · Circulation Research · doi:10.1161/01.res.80.4.473 · Cited by 232 · see citing works

Expression analysis of a Notch homologue in the mouse embryo

Reaume, A. G., Conlon, R. A., Zirngibl, R. A., Yamaguchi, T. P., & Rossant, J. (1992) · Developmental Biology · doi:10.1016/0012-1606(92)90076-s · Cited by 228 · see citing works

Development of Heart Failure and Congenital Septal Defects in Mice Lacking Endothelial Nitric Oxide Synthase

Feng, Q., Song, W., Lu, X., Hamilton, J. A., Lei, M., Peng, T., & Yee, S. (2002) · Circulation · doi:10.1161/01.cir.0000024114.82981.ea · Cited by 226 · see citing works

Notch: a membrane-bound transcription factor

Kopan, R. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.6.1095 · Cited by 225 · see citing works

Novel missense mutations (p.T596M and p.P1797H) in NOTCH1 in patients with bicuspid aortic valve

Mohamed, S. A., Aherrahrou, Z., Liptau, H., Erasmi, A. W., Hagemann, C., Wróbel, S., Borzym, K., Schunkert, H., Sievers, H. H., & Erdmann, J. (2006) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2006.05.046 · Cited by 225 · see citing works

Early Myocardial Function Affects Endocardial Cushion Development in Zebrafish

Bartman, T., Walsh, E. C., Wen, K., McKane, M., Ren, J., Alexander, J. S., Rubenstein, P. A., & Stainier, D. Y. R. (2004) · PLoS Biology · doi:10.1371/journal.pbio.0020129 · Cited by 224 · see citing works

Optical approaches to ontogeny of electrical activity and related functional organization during early heart development

Kamino, K. (1991) · Physiological Reviews · doi:10.1152/physrev.1991.71.1.53 · Cited by 216 · see citing works

Loss of connexin45 causes a cushion defect in early cardiogenesis

Kumai, M., Nishii, K., Nakamura, K., Takeda, N., Suzuki, M., & Shibata, Y. (2000) · Development · doi:10.1242/dev.127.16.3501 · Cited by 206 · see citing works

The Development of the Atrioventricular Junction in the Human Heart

Wessels, A., Markman, M. W. M., Vermeulen, J. L. M., Anderson, R. H., Moorman, A. F. M., & Lamers, W. H. (1996) · Circulation Research · doi:10.1161/01.res.78.1.110 · Cited by 205 · see citing works

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development

High, F. A., Jain, R., Stoller, J. Z., Antonucci, N. B., Lu, M. M., Loomes, K. M., Kaestner, K. H., Pear, W. S., & Epstein, J. A. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38922 · Cited by 201 · see citing works

Loss of connexin45 causes a cushion defect in early cardiogenesis

熊井, ま. (2000) · Medical Entomology and Zoology · doi:10.11501/3175008 · Cited by 199 · see citing works

Shear Stress Increases Expression of the Arterial Endothelial Marker EphrinB2 in Murine ES Cells via the VEGF-Notch Signaling Pathways

Masumura, T., Yamamoto, K., Shimizu, N., Obi, S., & Ando, J. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.193185 · Cited by 187 · see citing works

Elementary Mechanics of the Endothelium of Blood Vessels

Fung, Y. C., & Liu, S. Q. (1993) · Journal of Biomechanical Engineering · doi:10.1115/1.2895465 · Cited by 185 · see citing works

Spatial distribution of Na+-K+-ATPase in dendritic spines dissected by nanoscale superresolution STED microscopy

Blom, H., Rönnlund, D., Scott, L., Špicarová, Z., Widengren, J., Bondar, A. A., Aperia, A. C., & Brismar, H. (2011) · BMC Neuroscience · doi:10.1186/1471-2202-12-16 · Cited by 158 · see citing works

Extraembryonic venous obstructions lead to cardiovascular malformations and can be embryolethal

Hogers, B. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00218-1 · Cited by 155 · see citing works

Endothelial Barrier Function under Laminar Fluid Shear Stress

Seebach, J., Dieterich, P., Luo, F., Schillers, H., Vestweber, D., Oberleithner, H., Galla, H., & Schnittler, H. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780193 · Cited by 152 · see citing works

Alpha-cardiac actin mutations produce atrial septal defects

Matsson, H., Eason, J., Bookwalter, C. S., Klar, J., Gustavsson, P., Sunnegårdh, J. T., Enell, H., Jonzon, A., Vikkula, M., Gutierrez, I., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm302 · Cited by 152 · see citing works

α-Cardiac myosin heavy chain (MYH6) mutations affecting myofibril formation are associated with congenital heart defects

Granados-Riveron, J. T., Ghosh, T. K., Pope, M., Bu'Lock, F. A., Thornborough, C., Eason, J., Kirk, E. P., Fatkin, D., Feneley, M. P., Harvey, R. P., et al. (2010) · Human Molecular Genetics · doi:10.1093/hmg/ddq315 · Cited by 152 · see citing works

Heart Defects in Connexin43-Deficient Mice

Ya, J., Ernste, E. B. H. W., de Boer, P. A. J., van Kempen, M. J. A., Jongsma, H. J., Gros, D. B., Moorman, A. F. M., & Lamers, W. H. (1998) · Circulation Research · doi:10.1161/01.res.82.3.360 · Cited by 146 · see citing works

Long mutant dystrophins and variable phenotypes: evasion of nonsense-mediated decay?

Kerr, T. P., Sewry, C. A., Robb, S. A., & Roberts, R. G. (2001) · Human Genetics · doi:10.1007/s004390100598 · Cited by 138 · see citing works

Monocilia on chicken embryonic endocardium in low shear stress areas

der Heiden, K. V., Groenendijk, B. C. W., Hierck, B. P., Hogers, B., Koerten, H. K., Mommaas, A. M., Groot, A. C. G., & Poelmann, R. E. (2005) · Developmental Dynamics · doi:10.1002/dvdy.20557 · Cited by 137 · see citing works

Embryonic atrial function is essential for mouse embryogenesis, cardiac morphogenesis and angiogenesis

Huang, C., Sheikh, F., Hollander, M. S., Cai, C.-L., Becker, D. L., Chu, P., Evans, S. Μ., & Chen, J. (2003) · Development · doi:10.1242/dev.00831 · Cited by 134 · see citing works

Noncompaction of the Ventricular Myocardium Is Associated with a De Novo Mutation in the β-Myosin Heavy Chain Gene

Budde, B. S., Binner, P., Waldmüller, S., Höhne, W. E., Blankenfeldt, W., Haßfeld, S., Brömsen, J., Dermintzoglou, A., Wieczorek, M., May, E., et al. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001362 · Cited by 133 · see citing works

Development‐related changes in the expression of shear stress responsive genes KLF‐2, ET‐1, and NOS‐3 in the developing cardiovascular system of chicken embryos

Groenendijk, B. C. W., Hierck, B. P., Groot, A. C. G., & Poelmann, R. E. (2004) · Developmental Dynamics · doi:10.1002/dvdy.20029 · Cited by 126 · see citing works

Jagged1 (JAG1) mutations in patients with tetralogy of fallot or pulmonic stenosis

Bauer, R. C., Laney, A. O., Smith, R., Gerfen, J., Morrissette, J. J. D., Woyciechowski, S., Garbarini, J. L., Loomes, K. M., Krantz, I. D., Urbán, Z., et al. (2010) · Human Mutation · doi:10.1002/humu.21231 · Cited by 124 · see citing works

High Incidence of Cardiac Malformations in Connexin40-Deficient Mice

Gu, H., Smith, F. C., Taffet, S. M., & Delmar, M. (2003) · Circulation Research · doi:10.1161/01.res.0000084852.65396.70 · Cited by 124 · see citing works

Gene expression in cardiac tissues from infants with idiopathic conotruncal defects

Bittel, D. C., Butler, M. G., Kibiryeva, N., Marshall, J. A., Chen, J., Lofland, G. K., & O’Brien, J. E. (2011) · BMC Medical Genomics · doi:10.1186/1755-8794-4-1 · Cited by 117 · see citing works

Spatial distribution of “Tissue‐Specific” antigens in the developing human heart and skeletal muscle. II. An immunohistochemical analysis of myosin heavy chain isoform expression patterns in the embryonic heart

Wessels, A., Vermeulen, J. L. M., Virágh, S., Kálmán, F., Lamers, W. H., & Moorman, A. F. M. (1991) · The Anatomical Record · doi:10.1002/ar.1092290309 · Cited by 113 · see citing works

Cardiac conduction is required to preserve cardiac chamber morphology

Chi, N. C., Bussen, M., Brand‐Arzamendi, K., Ding, C., Olgin, J. E., Shaw, R. M., Martin, G. R., & Stainier, D. Y. R. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0909432107 · Cited by 104 · see citing works

Monocilia in the embryonic mouse heart suggest a direct role for cilia in cardiac morphogenesis

Slough, J., Cooney, L., & Brueckner, M. K. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21669 · Cited by 103 · see citing works

Spectrum of heart malformations in mice with situs solitus, situs inversus, and associated visceral heterotaxy.

Icardo, J. M., & de Vega, M. J. S. (1991) · Circulation · doi:10.1161/01.cir.84.6.2547 · Cited by 99 · see citing works

Combined Mutation Screening of NKX2-5, GATA4, and TBX5 in Congenital Heart Disease: Multiple Heterozygosity and Novel Mutations

Granados-Riveron, J. T., Pope, M., Bu'Lock, F. A., Thornborough, C., Eason, J., Setchfield, K., Ketley, A., Kirk, E. P., Fatkin, D., Feneley, M. P., et al. (2011) · Congenital Heart Disease · doi:10.1111/j.1747-0803.2011.00573.x · Cited by 96 · see citing works

The ubiquitin-proteasome system and nonsense-mediated mRNA decay in hypertrophic cardiomyopathy

Carrier, L., Schlossarek, S., Willis, M. S., & Thomas Eschenhagen, A. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp247 · Cited by 85 · see citing works

Comparison of connexin expression patterns in the developing mouse heart and human foetal heart

Coppen, S. R., Kaba, R. A., Halliday, D., Dupont, E., Skepper, J. N., Elneil, S., & Severs, N. J. (2003) · Springer eBooks · doi:10.1007/978-1-4757-4712-6_16 · Cited by 85 · see citing works

Intracardiac Blood Flow Patterns Related to the Yolk Sac Circulation of the Chick Embryo

Hogers, B., DeRuiter, M. C., Baasten, A. M. J., Groot, A. C. G., & Poelmann, R. E. (1995) · Circulation Research · doi:10.1161/01.res.76.5.871 · Cited by 83 · see citing works

Molecular cloning and characterization of human cardiac alpha- and beta-form myosin heavy chain complementary DNA clones. Regulation of expression during development and pressure overload in human atrium.

Kurabayashi, M., Tsuchimochi, H., Komuro, I., Takaku, F., & Yazaki, Y. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113627 · Cited by 81 · see citing works

Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo

Nishii, K., Morimoto, S., Minakami, R., Miyano, Y., Hashizume, K., Ohta, M., Zhan, D., Lu, Q.-W., & Shibata, Y. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.07.007 · Cited by 79 · see citing works

VEGF signaling has distinct spatiotemporal roles during heart valve development

Stankunas, K., Ma, G. K., Kuhnert, F., Kuo, C. J., & Chang, C. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.08.030 · Cited by 78 · see citing works

The Na+-Ca2+ Exchanger Is Essential for Embryonic Heart Development in Mice

Cho, C.-H., Kim, S. S., Jeong, M.-J., Lee, C. O., & Shin, H. (2000) · Molecules and Cells · doi:10.1007/s10059-000-0712-2 · Cited by 77 · see citing works

Risks of human conotruncal heart defects associated with 32 single nucleotide polymorphisms of selected cardiovascular disease-related genes

Shaw, G. M., Iovannisci, D. M., Yang, W., Finnell, R. H., Carmichael, S. L., Cheng, S., & Lammer, E. J. (2005) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.30924 · Cited by 72 · see citing works

Early events in development of electrical activity and contraction in embryonic rat heart assessed by optical recording.

Hirota, A., Kamino, K., Komuro, H., Sakai, T., & Yada, T. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015897 · Cited by 70 · see citing works

Comparison of connexin expression patterns in the developing mouse heart and human foetal heart

Coppen, S. R., Kaba, R. A., Halliday, D., Dupont, E., Skepper, J. N., Elneil, S., & Severs, N. J. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/a:1021150014764 · Cited by 70 · see citing works

GPx3: The plasma-type glutathione peroxidase is expressed under androgenic control in the mouse epididymis and vas deferens

Schwaab, V., Faure, J., Dufaure, J., & Drevet, J. R. (1998) · Molecular Reproduction and Development · doi:10.1002/(sici)1098-2795(199812)51:4 · Cited by 64 · see citing works

Cyclic Strain Regulates the Notch/CBF-1 Signaling Pathway in Endothelial Cells

Morrow, D. J., Cullen, J. P., Cahill, P. A., & Redmond, E. M. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.142778 · Cited by 63 · see citing works

Cardio-Respiratory Ontogeny During Chronic Carbon Monoxide Exposure in the Clawed Frog Xenopus Laevis

Territo, P. R., & Burggren, W. W. (1998) · Journal of Experimental Biology · doi:10.1242/jeb.201.9.1461 · Cited by 63 · see citing works

Interruption of Cardiac Output Does Not Affect Short-Term Growth and Metabolic Rate in day 3 And 4 Chick Embryos

Burggren, W. W., Warburton, S. J., & Slivkoff, M. D. (2000) · Journal of Experimental Biology · doi:10.1242/jeb.203.24.3831 · Cited by 62 · see citing works

Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6

Abu‐Daya, A., Sater, A. K., Wells, D. E., Mohun, T. J., & Zimmerman, L. B. (2009) · Developmental Biology · doi:10.1016/j.ydbio.2009.09.019 · Cited by 53 · see citing works

Mode and determination of the initial contraction stage in the mouse embryo heart

Nishii, K., & Shibata, Y. (2005) · Anatomy and Embryology · doi:10.1007/s00429-005-0065-x · Cited by 50 · see citing works

Optical indications of pace‐maker potential and rhythm generation in early embryonic chick heart.

Fujii, S., Hirota, A., & Kamino, K. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013627 · Cited by 49 · see citing works

Rapid changes in shear stress induce dissociation of a Gαq/11–platelet endothelial cell adhesion molecule‐1 complex

Otte, L. A., Bell, K. S., Loufrani, L., Yeh, J., Melchior, B., Dao, D. N., Stevens, H. Y., White, C. R., & Frangos, J. A. (2009) · The Journal of Physiology · doi:10.1113/jphysiol.2009.172643 · Cited by 43 · see citing works

Common 894G>T single nucleotide polymorphism in the gene coding for endothelial nitric oxide synthase (eNOS) and risk of congenital heart defects

van Beynum, I. M., Mooij, C. F., Kapusta, L., Heil, S. G., den Heijer, M., & Blom, H. J. (2008) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm.2008.271 · Cited by 37 · see citing works

Body, eye, and chorioallantoic vessel growth are not dependent on cardiac output level in day 3–4 chicken embryos

Burggren, W. W., Khorrami, S., Pinder, A. W., & Sun, T. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00086.2004 · Cited by 32 · see citing works

How do avian embryos breathe? oxygen transport in the blood of early chick embryos

Cirotto, C., & Arangi, I. (1989) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(89)90602-6 · Cited by 31 · see citing works

Recent progress in the genetics of cardiomyopathy and its role in the clinical evaluation of patients with cardiomyopathy

Ghosh, N., & Haddad, H. A. (2011) · Current Opinion in Cardiology · doi:10.1097/hco.0b013e3283439797 · Cited by 29 · see citing works

Myosin-based contraction is not necessary for cardiac c-looping in the chick embryo

Rémond, M. C., Fee, J. A., Elson, E. L., & Taber, L. A. (2006) · Anatomy and Embryology · doi:10.1007/s00429-006-0094-0 · Cited by 27 · see citing works

Knockdown of alpha myosin heavy chain disrupts the cytoskeleton and leads to multiple defects during chick cardiogenesis

Rutland, C. S., Warner, L. A., Thorpe, A., Alibhai, A. A., Robinson, T. E., Shaw, B., Layfield, R., Brook, J. D., & Loughna, S. (2009) · Journal of Anatomy · doi:10.1111/j.1469-7580.2009.01079.x · Cited by 27 · see citing works

Normal Development of the Muscular Region of the Interventricular Septum – I. The Significance of the Ventricular Trabeculations

Contreras‐Ramos, A., Sánchez‐Gómez, C., García‐Romero, H. L., & Cimarosti, L. O. (2008) · Anatomia Histologia Embryologia · doi:10.1111/j.1439-0264.2008.00852.x · Cited by 19 · see citing works

Endocardium, Cardiac Cushions, and Valve Development

Kirby, M. L. (2007) · doi:10.1093/oso/9780195178197.003.0009 · Cited by 7 · see citing works

Mechanobiology and Developmental Control

Mammoto, T., Mammoto, A., & Ingber, D. E. (2013) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122340 · Cited by 436 · see citing works

Cadherin Adhesion and Mechanotransduction

Leckband, D. E., & de Rooij, J. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013212 · Cited by 394 · see citing works

Electrical and mechanical stimulation of cardiac cells and tissue constructs

Stoppel, W. L., Kaplan, D. L., & Black, L. D. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.07.009 · Cited by 290 · see citing works

Naturally Engineered Maturation of Cardiomyocytes

Scuderi, G. J., & Butcher, J. T. (2017) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2017.00050 · Cited by 200 · see citing works

Embryonic cardiac chamber maturation: Trabeculation, conduction, and cardiomyocyte proliferation

Samsa, L. A., Yang, B., & Liu, J. (2013) · American Journal of Medical Genetics Part C Seminars in Medical Genetics · doi:10.1002/ajmg.c.31366 · Cited by 173 · see citing works

Mechanical regulation of cardiac development

Lindsey, S. E. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2014.00318 · Cited by 159 · see citing works

Interplay between cardiac function and heart development

Andrés‐Delgado, L., & Mercader, N. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.004 · Cited by 128 · see citing works

Advances in the Study of Heart Development and Disease Using Zebrafish

Brown, D., Samsa, L. A., Li, Q., & Liu, J. (2016) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd3020013 · Cited by 129 · see citing works

Calcium handling precedes cardiac differentiation to initiate the first heartbeat

Tyser, R. C. V., Miranda, A. M. A., Chen, C. M., Davidson, S. M., Srinivas, S., & Riley, P. R. (2016) · eLife · doi:10.7554/elife.17113 · Cited by 117 · see citing works

The force within: endocardial development, mechanotransduction and signalling during cardiac morphogenesis

Haack, T., & Abdelilah‐Seyfried, S. (2016) · Development · doi:10.1242/dev.131425 · Cited by 95 · see citing works

Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

de Lima, J. E., Bonnin, M.-A., Birchmeier, C., & Duprez, D. (2016) · eLife · doi:10.7554/elife.15593 · Cited by 89 · see citing works

Piezo1 is required for outflow tract and aortic valve development

Faucherre, A., Maati, H. M. O., Nasr, N., Pinard, A., Théron, A., Odelin, G., Desvignes, J., Salgado, D., Collod‐Béroud, G., Aviérinos, J.-F., et al. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.03.013 · Cited by 87 · see citing works

Ethanol exposure alters early cardiac function in the looping heart: a mechanism for congenital heart defects?

Karunamuni, G. H., Gu, S., Doughman, Y. Q., Peterson, L. M., Mai, K., McHale, Q., Jenkins, M. W., Linask, K. K., Rollins, A. M., & Watanabe, M. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00600.2013 · Cited by 66 · see citing works

A Decade of Discovery in the Genetic Understanding of Thoracic Aortic Disease

Andelfinger, G., Loeys, B., & Dietz, H. (2015) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2015.10.017 · Cited by 62 · see citing works

The LINC Between Mechanical Forces and Chromatin

Lityagina, O., & Dobreva, G. D. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.710809 · Cited by 62 · see citing works

Bioengineering methods for myocardial regeneration

Parsa, H., Ronaldson, K., & Vunjak‐Novakovic, G. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2015.06.012 · Cited by 62 · see citing works

Learn from Your Elders: Developmental Biology Lessons to Guide Maturation of Stem Cell-Derived Cardiomyocytes

Marchianò, S., Bertero, A., & Murry, C. E. (2019) · Pediatric Cardiology · doi:10.1007/s00246-019-02165-5 · Cited by 56 · see citing works

Tropomyosin 1: Multiple roles in the developing heart and in the formation of congenital heart defects

England, J. C., Granados-Riveron, J. T., Polo‐Parada, L., Kuriakose, D., Moore, C., Brook, J. D., Rutland, C. S., Setchfield, K., Gell, C., Ghosh, T. K., et al. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.03.006 · Cited by 55 · see citing works

Influence of blood flow on cardiac development

Courchaine, K., Rykiel, G., & Rugonyi, S. (2018) · Progress in Biophysics and Molecular Biology · doi:10.1016/j.pbiomolbio.2018.05.005 · Cited by 46 · see citing works

The intercalated disc: a mechanosensing signalling node in cardiomyopathy

Pruna, M., & Ehler, E. (2020) · Biophysical Reviews · doi:10.1007/s12551-020-00737-x · Cited by 40 · see citing works

Morphomechanics: transforming tubes into organs

Taber, L. A. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.03.004 · Cited by 39 · see citing works

Quantitative analysis of polarity in 3D reveals local cell coordination in the embryonic mouse heart

Garrec, J. L., Ragni, C. V., Pop, S., Dufour, A., Olivo‐Marín, J., BUCKINGHAM, M. E., & Meilhac, S. M. (2012) · Development · doi:10.1242/dev.087940 · Cited by 38 · see citing works

Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish

Benslimane, F. M., Alser, M., Zakaria, Z. Z., Sharma, A., Abdelrahman, H. A., & Yalcin, H. C. (2019) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2019.00096 · Cited by 37 · see citing works

From cytoskeletal dynamics to organ asymmetry: a nonlinear, regulative pathway underlies left–right patterning

McDowell, G. S., Rajadurai, S., & Levin, M. G. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0409 · Cited by 36 · see citing works

Cardiac Mechanoperception: A Life-Long Story from Early Beats to Aging and Failure

Pesce, M., Messina, E., Chimenti, I., & Beltrami, A. P. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0206 · Cited by 33 · see citing works

Functional Morphology of the Cardiac Jelly in the Tubular Heart of Vertebrate Embryos

Männer, J., & Yelbuz, T. M. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6010012 · Cited by 32 · see citing works

The First Heartbeat—Origin of Cardiac Contractile ActivityPreprint

Tyser, R. C. V., & Srinivas, S. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a037135 · Cited by 31 · see citing works

HCN4 ion channel function is required for early events that regulate anatomical left-right patterning in a Nodal- and Lefty asymmetric gene expression-independent manner

Pai, V. P., Willocq, V., Pitcairn, E. J., Lemire, J. M., Paré, J., Shi, N., McLaughlin, K. A., & Levin, M. G. (2017) · Biology Open · doi:10.1242/bio.025957 · Cited by 30 · see citing works

Cardiac forces regulate zebrafish heart valve delamination by modulating Nfat signaling

Chow, R., Fukui, H., Chan, W. X., Tan, J. K. S., Roth, S., Duchemin, A., Messaddeq, N., Nakajima, H., Liu, F., Faggianelli, N., et al. (2022) · PLoS Biology · doi:10.1371/journal.pbio.3001505 · Cited by 28 · see citing works

Fluid dynamics in heart development: effects of hematocrit and trabeculation

Battista, N., Lane, A. N., Liu, J., & Miller, L. A. (2017) · Mathematical Medicine and Biology A Journal of the IMA · doi:10.1093/imammb/dqx018 · Cited by 27 · see citing works

4D subject-specific inverse modeling of the chick embryonic heart outflow tract hemodynamics

Goenezen, S., Chivukula, V. K., Midgett, M., Phan, L., & Rugonyi, S. (2015) · Biomechanics and Modeling in Mechanobiology · doi:10.1007/s10237-015-0720-y · Cited by 25 · see citing works

Recent progress of organ-on-a-chip towards cardiovascular diseases: advanced design, fabrication, and applications

Wu, H., Shi, S., Liu, Y., Zhang, Q., Lam, R. H. W., Lim, C. T., & Hu, J. (2023) · Biofabrication · doi:10.1088/1758-5090/acdaf9 · Cited by 23 · see citing works

The EMT transcription factor Snai1 maintains myocardial wall integrity by repressing intermediate filament gene expression

Gentile, A., Bensimon‐Brito, A., Priya, R., Maischein, H., Piesker, J., Günther, S., Gunawan, F., & Stainier, D. Y. R. (2021) · eLife · doi:10.7554/elife.66143 · Cited by 23 · see citing works

Optical stimulation enables paced electrophysiological studies in embryonic hearts

Wang, Y. T., Gu, S., Ma, P., Watanabe, M., Rollins, A. M., & Jenkins, M. W. (2014) · Biomedical Optics Express · doi:10.1364/boe.5.001000 · Cited by 22 · see citing works

Cardiac troponin T is necessary for normal development in the embryonic chick heart

England, J. C., Pang, K. L., Parnall, M., Haig, M. I., & Loughna, S. (2016) · Journal of Anatomy · doi:10.1111/joa.12486 · Cited by 21 · see citing works

Engineering Heart Morphogenesis

Mandrycky, C., Williams, N. P., Batalov, I., El‐Nachef, D., de Bakker, B. S., Davis, J., Kim, D., DeForest, C. A., Zheng, Y. Y., Stevens, K. R., et al. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.01.006 · Cited by 19 · see citing works

The Cardiac Sarcomere and Cell Cycle

Pettinato, A. M., Ladha, F. A., & Hinson, J. T. (2022) · Current Cardiology Reports · doi:10.1007/s11886-022-01682-9 · Cited by 16 · see citing works

Cardiomyocyte stretching for regenerative medicine and hypertrophy study

Shradhanjali, A., Riehl, B. D., Kwon, I. K., & Lim, J. Y. (2015) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-015-0010-x · Cited by 18 · see citing works

Cessation of contraction induces cardiomyocyte remodeling during zebrafish cardiogenesis

Yang, J., Hartjes, K. A., Nelson, T. J., & Xu, X. (2013) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00721.2013 · Cited by 18 · see citing works

Mechanotransduction in Blood and Lymphatic Vascular Development and Disease

Urner, S., Kelly‐Goss, M. R., Peirce, S. M., & Lammert, E. (2017) · Advances in pharmacology · doi:10.1016/bs.apha.2017.08.009 · Cited by 17 · see citing works

Vortex Dynamics in Trabeculated Embryonic Ventricles

Battista, N., Douglas, D. R., Lane, A., Samsa, L. A., Liu, J., & Miller, L. A. (2019) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd6010006 · Cited by 16 · see citing works

Human pluripotent stem cell-based models of heart development and disease

Velichkova, G., & Dobreva, G. D. (2023) · Cells and Development · doi:10.1016/j.cdev.2023.203857 · Cited by 15 · see citing works

Gap junctional regulation of pressure, fluid force, and electrical fields in the epigenetics of cardiac morphogenesis and remodeling

Seki, A., Nishii, K., & Hagiwara, N. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.10.022 · Cited by 15 · see citing works

Cell diversity and plasticity during atrioventricular heart valve EMTs

Lotto, J., Cullum, R., Drissler, S., Arostegui, M., Garside, V. C., Fuglerud, B. M., Clement-Ranney, M., Thakur, A., Underhill, T. M., & Hoodless, P. A. (2023) · Nature Communications · doi:10.1038/s41467-023-41279-6 · Cited by 13 · see citing works

Genetic and flow anomalies in congenital heart disease

Rugonyi, S. (2016) · Global Medical Genetics · doi:10.3934/genet.2016.3.157 · Cited by 13 · see citing works

Enhanced cardiomyogenic induction of mouse pluripotent cells by cyclic mechanical stretch

Shradhanjali, A., Riehl, B. D., Lee, J. S., Ha, L., & Lim, J. Y. (2017) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2017.05.092 · Cited by 13 · see citing works

Recapitulating Cardiac Structure and Function In Vitro from Simple to Complex Engineering

Santos, A. C., Jang, Y., Son, I., Kim, J., & Park, Y. (2021) · Micromachines · doi:10.3390/mi12040386 · Cited by 12 · see citing works

From Stem Cells to Cardiomyocytes

Kaushik, G. N., & Engler, A. J. (2014) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-394624-9.00009-9 · Cited by 11 · see citing works

The Hypothesis of “Embryonic Recall”: Mechanotransduction as Common Denominator Linking Normal Cardiogenesis to Recovery in Adult Failing Hearts

Möhl, W., Milašinović, D., Aschacher, T., Jusić, A., Maimaitiaili, A., & Rattay, F. (2014) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd1010073 · Cited by 10 · see citing works

Role of tissue biomechanics in the formation and function of myocardial trabeculae in zebrafish embryos

Cairelli, A. G., Gendernalik, A., Chan, W. X., Nguyen, P., Vermot, J., Lee, J., Bark, D. L., & Yap, C. H. (2024) · The Journal of Physiology · doi:10.1113/jp285490 · Cited by 9 · see citing works

Cardiac trabeculation in vertebrates: Convergent evolution or evolutionary adaptations associated with heart complexity?

Tran, T. H. Y., Saha, D., & del Monte‐Nieto, G. (2025) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2025.103622 · Cited by 9 · see citing works

The Hemodynamically-Regulated Vascular Microenvironment Promotes Migration of the Steroidogenic Tissue during Its Interaction with Chromaffin Cells in the Zebrafish Embryo

Chou, C.-W., Zhuo, Y.-L., Jiang, Z.-Y., & Liu, Y. (2014) · PLoS ONE · doi:10.1371/journal.pone.0107997 · Cited by 8 · see citing works

Rare and Common Variants Uncover the Role of the Atria in Coarctation of the Aorta

Zhu, W., Williams, K., Young, C. B., Lin, J.-H. I., Teekakirikul, P., & Lo, C. W. Y. (2022) · Genes · doi:10.3390/genes13040636 · Cited by 7 · see citing works

Examples of Weak, If Not Absent, Form-Function Relations in the Vertebrate Heart

Jensen, B. K., & Smit, T. H. (2018) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd5030046 · Cited by 7 · see citing works

Developmental and Evolutionary Heart Adaptations Through Structure–Function Relationships

Phillips, M., Nimmo, M., & Rugonyi, S. (2025) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd12030083 · Cited by 6 · see citing works

Advancing Cardiac Organoid Engineering Through Application of Biophysical Forces

Blazeski, A., García‐Cardeña, G., & Kamm, R. D. (2024) · IEEE Reviews in Biomedical Engineering · doi:10.1109/rbme.2024.3514378 · Cited by 7 · see citing works

A Developmental Approach to Induced Pluripotent Stem cells-based Tissue Engineered Heart Valves

Roest, M. V., & Merryman, W. D. (2016) · Future Cardiology · doi:10.2217/fca-2016-0071 · Cited by 6 · see citing works

In vitro approaches to mimic cardiac mechanical load dynamics for enhancing maturation and disease modelling

Cano-Jorge, M., Gómez, S., den Toonder, J. M. J., Wang, Y., & Passier, R. C. (2025) · Cardiovascular Research · doi:10.1093/cvr/cvaf247 · Cited by 6 · see citing works

Fluid Flow Control of Stem Cells With Investigation of Mechanotransduction Pathways

Riehl, B. D., Donahue, H. J., & Lim, J. Y. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-802734-9.00017-2 · Cited by 5 · see citing works

Following the Beat: Imaging the Valveless Pumping Function in the Early Embryonic Heart

Wang, S., & Larina, I. V. (2022) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd9080267 · Cited by 5 · see citing works

Human Genetics of Atrial Septal Defect

Khan, R. S., & Jay, P. Y. (2015) · Springer eBooks · doi:10.1007/978-3-7091-1883-2_20 · Cited by 4 · see citing works

Cardiac Tissue Engineering

Hortensius, R. A., Lin, W., & Ogle, B. M. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813068-1.00001-4 · Cited by 4 · see citing works

The cardiac 4D nucleome: nuclear and chromatin dynamics across development, disease and ageing

Wang, Y., & Dobreva, G. D. (2026) · Nature Reviews Cardiology · doi:10.1038/s41569-026-01322-7 · Cited by 2 · see citing works

Studies of Genes Involved in Congenital Heart Disease

Ghosh, T., Granados-Riveron, J. T., Buxton, S., Setchfield, K., Loughna, S., & Brook, J. (2014) · Journal of Cardiovascular Development and Disease · doi:10.3390/jcdd1010134 · Cited by 2 · see citing works

Mechanical Mediation of Signaling Pathways in Heart Valve Development and Disease

Tandon, I., Lam, N. T., & Balachandran, K. (2018) · Springer eBooks · doi:10.1007/978-3-030-01993-8_10 · Cited by 2 · see citing works

Quantitative Imaging Analysis of Internal Structural Complexity in Mouse Heart Organoids; Comparison to Mouse Embryonic Hearts

Kaneko, R., Ishino, F., & Lee, J. (2025) · Genes to Cells · doi:10.1111/gtc.70055 · Cited by 1 · see citing works

Propisochlor disrupts cardiovascular and neural development through apoptotic and oxidative pathways in zebrafish

Kweon, J., Lee, H., Kim, S., Song, J., Bae, S.-M., Song, G., Lim, W., & Jeong, W. (2025) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2025.181180 · Cited by 1 · see citing works

Mechanobiological Control of Cell Fate for Applications in Cardiovascular Regenerative Medicine

Putnam, A. J. (2016) · Springer eBooks · doi:10.1007/978-1-4939-5617-3_11 · Cited by 1 · see citing works

Mechanical Determinants of Tissue Development

Liaudanskaya, V., Sood, D., & Kaplan, D. L. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-809880-6.00024-2 · Cited by 1 · see citing works

Cardiac Tissue Engineering: A Pathway for Repair

Hortensius, R. A., Lin, W., Fontenot, J. F., Ogle, B. M., & Jung, J. P. (2024) · Springer eBooks · doi:10.1007/978-3-031-71067-4_15 · Cited by 1 · see citing works

Endocardial primary cilia and blood flow are required for regulation of EndoMT during endocardial cushion developmentPreprint

Berg, K., Gorham, J., Lundt, F., Seidman, J. G., & Brueckner, M. K. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.05.15.594405 · Cited by 1 · see citing works

Maturation of functional cardiac tissue patches

Engelmayr, G. C., Zhang, D., & Bursac, N. (2014) · Elsevier eBooks · doi:10.1533/9780857096715.2.248

Gli2 Accelerates Cardiac Progenitor Gene Expression During Mouse Embryonic Stem Cell Differentiation

Fair, J. (2014) · uO Research (University of Ottawa) · doi:10.20381/ruor-4281

Cadherins in Mechanotransduction

Leckband, D. E. (2016) · Springer eBooks · doi:10.1007/978-1-4939-5617-3_3

OPTICAL IMAGING OF EMBRYONIC CARDIAC CONDUCTION

Ma, P. (2016) · OhioLink ETD Center (Ohio Library and Information Network)

Maturation of Human Pluripotent Stem Cell-Derived Engineered Cardiac Tissues

Ruan, J.-L. (2014) · ResearchWorks at the University of Washington (University of Washington)

The Interplay of Biomechanics, Tissue Polarity and Collective Migration as it Contributes to Early Heart Organogenesis

Jackson, T. R. (2017) · D-Scholarship@Pitt (University of Pittsburgh)

Cardiovascular Effects of Aerobic Exercise Training in Hypoxic-induced Intrauterine Growth Restriction

Martínez, R. (2017) · ERA: Education and Research Archive (University of Alberta) · doi:10.7939/r34b2xj8h

Cardiac looping and laterality

Campione, M., Aránega, A. E., & Franco, D. (2018) · Oxford University Press eBooks · doi:10.1093/med/9780198757269.003.0014

Vortex dynamics in trabeculated embryonic ventriclesPreprint

Battista, N., Douglas, D. R., Lane, A., Samsa, L. A., Liu, J., & Miller, L. A. (2015) · arXiv (Cornell University) · doi:10.48550/arxiv.1601.07917

Molecular Regulation of Zebrafish Cardiac Maturation

Samsa, L. A. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/mqfe-zh72

Author response: Muscle contraction is required to maintain the pool of muscle progenitors via YAP and NOTCH during fetal myogenesis

de Lima, J. E., Bonnin, M.-A., Birchmeier, C., & Duprez, D. (2016) · eLife · doi:10.7554/elife.15593.020

Effect of cyclic tensile force on the expression of bone morphogenetic protein 9 and interleukin 6 in human periodontal ligament cells

Tantilertanant, Y., & Sanchavanakit, N. (2018) · doi:10.58837/chula.the.2018.385

Coordination of focal adhesion nanostructure and mechano-signaling drives cardiomyocyte differentiationPreprint

Xiao, J., Zhong, X., Ang, J. W., Wong, D. C. P., Lee, C. J. M., Foo, R., Kanchanawong, P., & Low, B. C. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.13.566796

Hypoplastic Left Heart Syndrome Cardiomyocytes Exhibit Intrinsic Stress Vulnerabilities and Augmented Stress Responses in vitro

Varela, M., Ampuja, M., Broberg, M. E., Ranta, A., Talman, V., & Helle, E. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11127-3

Physiopathologie et génétique de la bicuspidie aortique non syndromique

Théron, A. (2017) · doi:10.70675/d2ed234az9f17z4c64zb848z26b032abab67

Study of Hippo effectors, Yap1 et Wwrt1, during proepicardium formation

López, L. O. (2021) · theses.fr (ABES) · doi:10.70675/1f82aeecze5a2z448ez9083z3281f86c7be0

Prenatal Diagnosis of Conotruncal Anomalies Before 16 Weeks: Longitudinal Evolution, Genetic Findings and Early Prognostic Markers

Volpe, P., Bosco, M., Robertis, V. D., Ramezzana, I. G., Olivieri, C., Fantasia, I., Gentile, Á., Giudicepietro, A., & Persico, N. (2026) · Prenatal Diagnosis · doi:10.1002/pd.70179

N-cadherin orientational order decreases with mechanical load at cardiomyocyte adherens junctionsPreprint

Tran, Y. T. B., Dean, W. F., Han, Y., Karpov, K. I., Ainslie, C. M., Mattheyses, A. L., & Kwiatkowski, A. V. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.17.739172

Notch Signaling Pathway and Congenital Heart Disease

Kunling, T., & 陈川宁 (2024) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.12290/xhyxzz.2023-0594

Endocardial Notch Signaling in Cardiac Development and Disease

Luxán, G., D’Amato, G., MacGrogan, D., & de la Pompa, J. L. (2015) · Circulation Research · doi:10.1161/circresaha.115.305350 · Cited by 249 · see citing works

Regulating NOTCH ligands: The role of Mind bomb1 during cardiac development and disease

García, L., & de, G. (2013) · Dialnet (Universidad de la Rioja)

Formation, Contraction, and Mechanotransduction of Myofribrils in Cardiac Development: Clues from Genetics

Granados-Riveron, J. T., & Brook, J. D. (2012) · Biochemistry Research International · doi:10.1155/2012/504906 · Cited by 10 · see citing works

Cardiac contraction activates endocardial Notch signaling to modulate chamber maturation in zebrafish

Samsa, L. A., Givens, C., Tzima, E., Stainier, D. Y. R., Li, Q., & Liu, J. (2015) · Development · doi:10.1242/dev.125724 · Cited by 157 · see citing works