The DOI matches its Crossref record; 44 of the 44 references it cites were found in a registry or an index.
Chronic Vagus Nerve Stimulation Improves Autonomic Control and Attenuates Systemic Inflammation and Heart Failure Progression in a Canine High-Rate Pacing Model
Abstract
Background— Autonomic dysfunction, characterized by sympathetic activation and vagal withdrawal, contributes to the progression of heart failure (HF). Although the therapeutic benefits of sympathetic inhibition with β-blockers in HF are clear, the role of increased vagal tone in this setting has been less studied. We have investigated the impact of enhancing vagal tone (achieved through chronic cervical vagus nerve stimulation, [VNS]) on HF development in a canine high-rate ventricular pacing model. Methods and Results— Fifteen dogs were randomized into control (n=7) and VNS (n=8) groups. All dogs underwent 8 weeks of high-rate ventricular pacing (at 220 bpm for the first 4 weeks to develop HF and another 4 weeks at 180 bpm to maintain HF). Concomitant VNS, at an intensity reducing sinus rate ≈20 bpm, was delivered together with the ventricular pacing in the VNS group. At 4 and 8 weeks of ventricular pacing, both left ventricular end-diastolic and -systolic volumes were lower and left ventricular ejection fraction was higher in the VNS group than in the control group. Heart rate variability and baroreflex sensitivity improved in the VNS dogs. Rises in plasma norepinephrine, angiotensin II, and C-reactive protein levels, ordinarily expected in this model, were markedly attenuated with VNS treatment. Conclusions— Chronic VNS improves cardiac autonomic control and significantly attenuates HF development in the canine high-rate ventricular pacing model. The therapeutic benefit of VNS is associated with pronounced anti-inflammatory effects. VNS is a novel and potentially useful therapy for treating HF.
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Cites
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Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin
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Cited by
Role of the Autonomic Nervous System in Modulating Cardiac Arrhythmias
Shen, M. J., & Zipes, D. P. (2014) · Circulation Research · doi:10.1161/circresaha.113.302549 · Cited by 867
The Autonomic Nervous System and Heart Failure
Florea, V. G., & Cohn, J. N. (2014) · Circulation Research · doi:10.1161/circresaha.114.302589 · Cited by 572
A review of vagus nerve stimulation as a therapeutic intervention
Johnson, R. L., & Wilson, C. G. (2018) · Journal of Inflammation Research · doi:10.2147/jir.s163248 · Cited by 562
Chronic vagus nerve stimulation: A new and promising therapeutic approach for chronic heart failure
De Ferrari, G. M., Crijns, H. J. G. M., Borggrefe, M., Milasinovic, G., Smid, J., Zabel, M., Gavazzi, A., Sanzo, A., Dennert, R., Kuschyk, J., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehq391 · Cited by 523
Quintana, D. S., Alvares, G. A., & Heathers, J. A. J. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.73 · Cited by 420
Metadata
- Authors
- Zhang, Y., Popović, Z. B., Bibevski, S., Fakhry, I., Sica, D. A., Van Wagoner, D. R., & Mazgalev, T. N.
- Venue
- Circulation: Heart Failure
- Published
- 2009-11
- Volume
- 2
- Issue
- 6
- Pages
- 692-699
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2103596313
- Cited by
- 375
- References
- 44
- FWCI
- 9.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Zhang, Y., Popović, Z. B., Bibevski, S., Fakhry, I., Sica, D. A., Van Wagoner, D. R., & Mazgalev, T. N. (2009). Chronic Vagus Nerve Stimulation Improves Autonomic Control and Attenuates Systemic Inflammation and Heart Failure Progression in a Canine High-Rate Pacing Model. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.109.873968
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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