The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
The Development of Aortic Insufficiency in Left Ventricular Assist Device-Supported Patients
Open accessAbstract
Background—: Aortic insufficiency (AI) following left ventricular assist device (LVAD) placement can affect device performance. The aim of this study was to examine AI development following LVAD implantation. Methods and Results—: Echocardiograms (n=315) from 78 subjects undergoing HeartMate-XVE (n=25 [32%]) or HeartMate-II (n=53 [68%]) implantations from 2004 to 2008 were reviewed. Studies were obtained preoperatively and at 1, 3, 6, 12, 18, and 24 months after surgery. AI was graded on an interval scale (0=none, 0.5=trivial, 1=mild, 1.5=mild-moderate, 2=moderate, 2.5=moderate-severe, 3=severe), and the change in AI at follow-up was analyzed with significance tests. Kaplan–Meier estimates for freedom from moderate or worse AI at follow-up were generated. Mixed-model linear regression was used to identify correlates of AI progression during LVAD support. The median (25th, 75th percentile) duration of LVAD support was 239 (112, 455) days, and preoperative AI grade was 0.0 (0.0, 0.0). At 6 months, 89±4% of subjects (n=49 at risk) were free from moderate or worse AI, but this was reduced to 74±7% (n=29 at risk) and 49±13% (n=13 at risk) by 12 and 18 months, respectively. Correlates (slope±SE) of AI progression included female sex (0.002±0.001; P =0.01), smaller body surface area (−0.003±0.001 per m 2 ; P =0.0017), and HeartMate-II model type (0.002±0.001; P =0.039). Correlates (β±SE) of progressive AI on postoperative echocardiogram included increasing aortic sinus diameter (0.04±0.01 per mm; P =0.001), an aortic valve that remained closed (0.42±0.06; P <0.001) or only intermittently opened (0.34±0.09; P <0.001), and lower left ventricular diastolic (−0.002±0.0004 per cm 3 ; P <0.001) and systolic (−0.002±0.0004 per cm 3 ; P <0.001) volumes. Conclusions—: AI progresses over time in LVAD-supported patients. As we move toward an era of long-term cardiac support, more studies are needed to determine the clinical significance of these findings.
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Lang, R. M., Bierig, M., Devereux, R. B., Flachskampf, F. A., Foster, E., Pellikka, P. A., Picard, M. H., Roman, M. J., Seward, J., Shanewise, J. S., et al. (2005) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2005.10.005 · Cited by 11,318
What's wrong with Bonferroni adjustments
Perneger, T. V. (1998) · BMJ · doi:10.1136/bmj.316.7139.1236 · Cited by 5,900
Long-Term Use of a Left Ventricular Assist Device for End-Stage Heart Failure
Rose, E. A., Gelijns, A. C., Moskowitz, A. J., Heitjan, D. F., Stevenson, L. W., Dembitsky, W., Long, J. W., Ascheim, D. D., Tierney, A. R., Levitan, R. G., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa012175 · Cited by 3,977
Use of a Continuous-Flow Device in Patients Awaiting Heart Transplantation
Miller, L. W., Pagani, F. D., Russell, S. D., John, R., Boyle, A. J., Aaronson, K. D., Conte, J. V., Naka, Y., Mancini, D., Delgado, R. M., et al. (2007) · New England Journal of Medicine · doi:10.1056/nejmoa067758 · Cited by 1,733
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Feldman, D., Pamboukian, S. V., Teuteberg, J. J., Birks, E., Lietz, K., Moore, S. A., Morgan, J. A., Arabia, F., Bauman, M. E., Buchholz, H. W., et al. (2013) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2012.09.013 · Cited by 1,368
Self-citationStainback, R. F., Estep, J. D., Agler, D. A., Birks, E. J., Bremer, M., Hung, J., Kirkpatrick, J. N., Rogers, J. G., & Shah, N. R. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2015.05.008 · Cited by 323
Metadata
- Authors
- Cowger, J., Pagani, F. D., Haft, J. W., Romano, M. A., Aaronson, K. D., & Kolias, T. J.
- Venue
- Circulation: Heart Failure
- Published
- 2010-11
- Volume
- 3
- Issue
- 6
- Pages
- 668-674
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2151998588
- Cited by
- 361
- References
- 4
- FWCI
- 15.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Cowger, J., Pagani, F. D., Haft, J. W., Romano, M. A., Aaronson, K. D., & Kolias, T. J. (2010). The Development of Aortic Insufficiency in Left Ventricular Assist Device-Supported Patients. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.109.917765
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