Treatment of Obstructive Hypertrophic Cardiomyopathy Symptoms and Gradient Resistant to First-Line Therapy With β-Blockade or Verapamil
Open accessAbstract
BACKGROUND: There is controversy about preferred methods to relieve obstruction in hypertrophic cardiomyopathy patients still symptomatic after β-blockade or verapamil. METHODS AND RESULTS: Of 737 patients prospectively registered at our institution, 299 (41%) required further therapy for obstruction for limiting symptoms, rest gradient 61 ± 45, provoked gradient 115 ± 49 mm Hg, and followed up for 4.8 years. Disopyramide was added in 221 (74%) patients and pharmacological control of symptoms was achieved in 141 (64%) patients. Overall, 138 (46%) patients had surgical relief of obstruction (91% myectomy) and 6 (2%) alcohol septal ablation. At follow-up, resting gradients in the 299 patients had decreased from 61 ± 44 to 10 ± 25 mm Hg (P<0.0001); New York Heart Association class decreased from 2.7 ± 0.7 to 1.8 ± 0.5 (P<0.0001). Kaplan-Meier survival at 10 years in the 299 advanced-care patients was 88% and did not differ from nonobstructed patients (P=0.28). Only 1 patient had sudden death, a low annual rate of 0.06%/y. Kaplan-Meier survival at 10 years in the advanced-care patients did not differ from that expected in a matched cohort of the US population (P=0.90). CONCLUSIONS: Patients with obstruction and symptoms resistant to initial pharmacological therapy with β-blockade or verapamil may realize meaningful symptom relief and low mortality through stepped management, adding disopyramide in appropriately selected patients, and when needed, by surgical myectomy.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Disopyramide reduces left ventricular outflow gradient and improves symptoms in patients with hypertrophic cardiomyopathy.
“has been shown to reduce LV outflow gradient and improve symptoms in patients with hypertrophic cardiomyopathy.[662][663][664]”
From 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (2016) · cites this paper as [664]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy
Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318223e2bd · Cited by 2,105 · see citing works
Hypertensive, Y., & Chin, K. (1982) · Springer eBooks · doi:10.1007/978-3-642-68282-7 · Cited by 1,757 · see citing works
Maron, B. J., McKenna, W. J., Danielson, G. K., KAPPENBERGER, L. J., Kuhn, H. J., Seidman, C. E., Shah, P. M., Spencer, W. H., Spirito, P., ten Cate, F. J., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00941-0 · Cited by 1,572 · see citing works
Maron, M. S., Olivotto, I., Betocchi, S., Casey, S. A., Lesser, J. R., Losi, M. A., Cecchi, F., & Maron, B. J. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa021332 · Cited by 1,468 · see citing works
Hypertrophic Cardiomyopathy Is Predominantly a Disease of Left Ventricular Outflow Tract Obstruction
Maron, M. S., Olivotto, I., Zenovich, A. G., Link, M. S., Pandian, N. G., Kuvin, J. T., Nistri, S., Cecchi, F., Udelson, J. E., & Maron, B. J. (2006) · Circulation · doi:10.1161/circulationaha.106.644682 · Cited by 1,118 · see citing works
Kung, H.-C., Hoyert, D. L., Xu, J., & Murphy, S. L. (2008) · PubMed · Cited by 931 · see citing works
Gersh, B. J., Maron, B. J., Bonow, R. O., Dearani, J. A., Fifer, M. A., Link, M. S., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Rakowski, H., et al. (2011) · Circulation · doi:10.1161/cir.0b013e318223e230 · Cited by 821 · see citing works
Ommen, S. R., Maron, B. J., Olivotto, I., Maron, M. S., Cecchi, F., Betocchi, S., Gersh, B. J., Ackerman, M. J., McCully, R. B., Dearani, J. A., et al. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.090 · Cited by 809 · see citing works
Wigle, E. D., Rakowski, H., Kimball, B. P., & Williams, W. G. (1995) · Circulation · doi:10.1161/01.cir.92.7.1680 · Cited by 775 · see citing works
Maron, B. J., Nishimura, R. A., McKenna, W. J., Rakowski, H., Josephson, M. E., & Kieval, R. S. (1999) · Circulation · doi:10.1161/01.cir.99.22.2927 · Cited by 490 · see citing works
Sherrid, M. V., Barac, I., McKenna, W. J., Elliott, P. M., Dickie, S., Chojnowska, L., Casey, S., & Maron, B. J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.01.012 · Cited by 410 · cited 2× · see citing works
“Nevertheless, we continue the surveillance described above in our disopyramide-treated patients.(3,7) We”
MethodHistorical trends in reported survival rates in patients with hypertrophic cardiomyopathy
Elliot, P. M., Gimeno, J. R., Thaman, R., Shah, J., Ward, D., Dickie, S., Tome, M., & McKenna, W. J. (2005) · Heart · doi:10.1136/hrt.2005.068577 · Cited by 296 · see citing works
Survival After Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy
Sorajja, P., Ommen, S. R., Holmes, D. R., Dearani, J. A., Rihal, C. S., Gersh, B. J., Lennon, R. J., & Nishimura, R. A. (2012) · Circulation · doi:10.1161/circulationaha.111.076257 · Cited by 293 · see citing works
Epstein, S. E., & Rosing, D. R. (1981) · Circulation · doi:10.1161/01.cir.64.3.437 · Cited by 272 · see citing works
ten Cate, F. J., Soliman, O. I. I., Michels, M., Theuns, D. A. M. J., de Jong, P. L., Geleijnse, M. L., & Serruys, P. W. J. C. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.862359 · Cited by 211 · see citing works
Alcohol Septal Ablation for the Treatment of Hypertrophic Obstructive Cardiomyopathy
Nagueh, S. F., Groves, B. Μ., Schwartz, L., Smith, K., Wang, A., Bach, R. G., Nielsen, C. D., Leya, F. S., Buergler, J. M., Rowe, S. K., et al. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.06.073 · Cited by 208 · see citing works
McLeod, C. J., Ommen, S. R., Ackerman, M. J., Weivoda, P. L., Shen, W.-K., Dearani, J. A., Schaff, H. V., Tajik, A. J., & Gersh, B. J. (2007) · European Heart Journal · doi:10.1093/eurheartj/ehm117 · Cited by 203 · see citing works
Sorajja, P., Ommen, S. R., Nishimura, R. A., Gersh, B. J., Berger, P. B., & Tajik, A. J. (2003) · Circulation · doi:10.1161/01.cir.0000097110.55312.bf · Cited by 198 · see citing works
Sherrid, M. V., Chaudhry, F. A., & Swistel, D. G. (2003) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(02)04546-0 · Cited by 179 · see citing works
Long-Term Survival in Patients With Resting Obstructive Hypertrophic Cardiomyopathy
Ball, W., Ivanov, J., Rakowski, H., Wigle, E. D., Linghorne, M., Ralph-Edwards, A. C., Williams, W. G., Schwartz, L., Guttman, A., & Woo, A. (2011) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2011.08.040 · Cited by 170 · see citing works
Mechanism of Benefit of Negative Inotropes in Obstructive Hypertrophic Cardiomyopathy
Sherrid, M. V., Pearle, G., & Gunsburg, D. Z. (1998) · Circulation · doi:10.1161/01.cir.97.1.41 · Cited by 165 · see citing works
Comparing Survival of a Sample to That of a Standard Population
Finkelstein, D. M. (2003) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djg052 · Cited by 158 · see citing works
Surgical Myectomy Versus Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy
Olivotto, I., Ommen, S. R., Maron, M. S., Cecchi, F., & Maron, B. J. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.018 · Cited by 133 · see citing works
A contemporary European experience with surgical septal myectomy in hypertrophic cardiomyopathy
Iacovoni, A., Spirito, P., Simon, C., Iascone, M. R., Dedda, G. D., Filippo, P. D., Pentiricci, S., Boni, L., Senni, M., Gavazzi, A., et al. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehs064 · Cited by 109 · see citing works
Balaram, S. K., Tyrie, L. S., Sherrid, M. V., Afthinos, J. N., Hillel, Z., Winson, G., & Swistel, D. G. (2008) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2008.07.048 · Cited by 68 · see citing works
Alhaj, E. K., Kim, B., Cantales, D., Uretsky, S., Chaudhry, F. A., & Sherrid, M. V. (2013) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2013.02.007 · Cited by 45 · see citing works
Hypertrophic Cardiomyopathy Centers
Maron, B. J. (2009) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2009.05.064 · Cited by 33 · see citing works
Kajimoto, K., Imai, T., Minami, Y., & Kasanuki, H. (2010) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.06.059 · Cited by 33 · see citing works
A Primer of Disopyramide Treatment of Obstructive Hypertrophic Cardiomyopathy
Sherrid, M. V., & Arabadjian, M. E. (2012) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2012.04.003 · Cited by 29 · see citing works
Teichman, S. L., Ferrick, A. M., Kim, S. G., Matos, J. A., Waspe, L. E., & Fisher, J. D. (1987) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(87)80207-3 · Cited by 28 · see citing works
Yancy, C. W., Seidman, C. E., Towbin, J. A., Udelson, J. E., Naidu, S. S., Nishimura, R. A., Ommen, S. R., Gersh, J. K., Maron, B. J., Bonow, R. O., et al. (2012) · Cited by 21 · see citing works
Minami, Y., Kajimoto, K., Kawana, M., Hagiwara, N., & Sherrid, M. V. (2008) · International Journal of Cardiology · doi:10.1016/j.ijcard.2008.11.088 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 33 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Musat D, Joshi R, Obeleniene R, Bangalore S, Winson G, Castaneda V, Musat C, Chaudhry FA, Sherrid MV. Impact of acute response of ob- structive hypertrophic cardiomyopathy to oral disopyramide and corre- lates of response. J Am Coll Cardiol. 2008;51:A61. Abstract.
Cited by
Sorted by citations
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P. F., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castellà, M., Diener, H., Heidbüchel, H., Hendriks, J., et al. (2016) · EP Europace · doi:10.1093/europace/euw295 · Cited by 6,438 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehw210 · Cited by 6,418 · see citing works
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Authors/Task Force members, Elliott, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagege, A. A., Lafont, A., Limongelli, G., et al. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu284 · Cited by 4,332 · see citing works
2023 ESC Guidelines for the management of cardiomyopathies
Arbelo, E., Protonotarios, A., Gimeno, J. R., Arbustini, E., Villa, R. B., Basso, C., Bezzina, C. R., Biagini, E., Blom, N. A., de Boer, R. A., et al. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad194 · Cited by 2,947 · see citing works
2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS
Kirchhof, P., Benussi, S., Kotecha, D., Ahlsson, A., Atar, D., Casadei, B., Castella, M., Diener, H.-C., Heidbuchel, H., Hendriks, J., et al. (2016) · European Journal of Cardio-Thoracic Surgery · doi:10.1093/ejcts/ezw313 · Cited by 1,403 · see citing works
Ommen, S. R., Mital, S. R., Burke, M. A., Day, S. M., Deswal, A. M., Elliot, P. M., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P. F., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.08.044 · Cited by 997 · see citing works
Clinical Course and Management of Hypertrophic Cardiomyopathy
Maron, B. J. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1710575 · Cited by 944 · see citing works
Ommen, S. R., Ho, C. Y., Asif, I. M., Balaji, S., Burke, M. A., Day, S. M., Dearani, J. A., Epps, K., Evanovich, L., Ferrari, V. A., et al. (2024) · Circulation · doi:10.1161/cir.0000000000001250 · Cited by 789 · see citing works
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
Ommen, S. R., Mital, S. R., Burke, M. A., Day, S. M., Deswal, A. M., Elliot, P. M., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P. F., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.08.045 · Cited by 716 · see citing works
2020 AHA/ACC Guideline for the Diagnosis and Treatment of Patients With Hypertrophic Cardiomyopathy
Ommen, S. R., Mital, S. R., Burke, M. A., Day, S. M., Deswal, A. M., Elliot, P. M., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P. F., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000937 · Cited by 628 · see citing works
Management of Hypertrophic Cardiomyopathy
Maron, B. J., Desai, M. Y., Nishimura, R. A., Spirito, P., Rakowski, H., Towbin, J. A., Dearani, J. A., Rowin, E. J., Maron, M. S., & Sherrid, M. V. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.11.021 · Cited by 401 · see citing works
2024 AHA/ACC/AMSSM/HRS/PACES/SCMR Guideline for the Management of Hypertrophic Cardiomyopathy
Ommen, S. R., Ho, C. Y., Asif, I. M., Balaji, S., Burke, M. A., Day, S. M., Dearani, J. A., Epps, K., Evanovich, L., Ferrari, V. A., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.02.014 · Cited by 419 · see citing works
2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy
Elliot, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagège, A. A., Lafont, A. M., Limongelli, G., Mahrholdt, H., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0212 · Cited by 342 · see citing works
Aficamten for Symptomatic Obstructive Hypertrophic Cardiomyopathy
Maron, M. S., Masri, A., Nassif, M. E., Villa, R. B., Arad, M., Cardim, N. M., Choudhury, L., Claggett, B. L., COATS, C. J., Düngen, H., et al. (2024) · New England Journal of Medicine · doi:10.1056/nejmoa2401424 · Cited by 332 · see citing works
Brieger, D. B., Amerena, J. V., Attia, J., Bajorek, B. V., Chan, K. H., Connell, C., Freedman, B., Ferguson, C., Hall, T. L., Haqqani, H. M., et al. (2018) · Heart Lung and Circulation · doi:10.1016/j.hlc.2018.06.1043 · Cited by 328 · see citing works
Ommen, S. R., Mital, S. R., Burke, M. A., Day, S. M., Deswal, A. M., Elliot, P. M., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P. F., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000938 · Cited by 332 · see citing works
Cardim, N. M., Galderisi, M., Edvardsen, T., Plein, S., Popescu, B. A., D’Andrea, A., Bruder, O., Cosyns, B., Davin, L., Donal, E., et al. (2015) · European Heart Journal - Cardiovascular Imaging · doi:10.1093/ehjci/jeu291 · Cited by 283 · see citing works
Hypertrophic obstructive cardiomyopathy
Veselka, J., Anavekar, N. S., & Charron, P. (2016) · The Lancet · doi:10.1016/s0140-6736(16)31321-6 · Cited by 279 · see citing works
The Mitral Valve in Obstructive Hypertrophic Cardiomyopathy
Sherrid, M. V., Balaram, S. K., Kim, B., Axel, L., & Swistel, D. G. (2016) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.01.071 · Cited by 276 · see citing works
How Hypertrophic Cardiomyopathy Became a Contemporary Treatable Genetic Disease With Low Mortality
Maron, B. J., Rowin, E. J., Casey, S. A., & Maron, M. S. (2016) · JAMA Cardiology · doi:10.1001/jamacardio.2015.0354 · Cited by 260 · see citing works
Nagueh, S. F., Phelan, D. M. J., Abraham, T. P., Armour, A. C., Desai, M. Y., Dragulescu, A., Gilliland, Y. E., Lester, S. J., Maldonado, Y., MOHIDDIN, S. A., et al. (2022) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2022.03.012 · Cited by 216 · see citing works
Phase 2 Study of Aficamten in Patients With Obstructive Hypertrophic Cardiomyopathy
Maron, M. S., Masri, A., Choudhury, L., Olivotto, I., Saberi, S., Wang, A., García‐Pavía, P., Lakdawala, N. K., Nagueh, S. F., Rader, F., et al. (2023) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.10.020 · Cited by 207 · see citing works
Hegde, S. M., Lester, S. J., Solomon, S. D., Michels, M., Elliot, P. M., Nagueh, S. F., Choudhury, L., Zemánek, D., Zwas, D. R., Jacoby, D. L., et al. (2021) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2021.09.1381 · Cited by 197 · see citing works
Pharmacological Treatment of Hypertrophic Cardiomyopathy: Current Practice and Novel Perspectives
Ammirati, E., Contri, R., Coppini, R., Cecchi, F., Frigerio, M., & Olivotto, I. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.541 · Cited by 148 · see citing works
Stern, J. A., Markova, S., Ueda, Y., Kim, J. B., Pascoe, P. J., Evanchik, M. J., Green, E. M., & Harris, S. P. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168407 · Cited by 126 · see citing works
JCS/JHFS 2018 Guideline on the Diagnosis and Treatment of Cardiomyopathies
Kitaoka, H., Tsutsui, H., Kubo, T., Ide, T., Chikamori, T., Fukuda, K., Fujino, N., Higo, T., Isobe, M., Kamiya, C., et al. (2021) · Circulation Journal · doi:10.1253/circj.cj-20-0910 · Cited by 118 · see citing works
Cardiomyopathies: Evolution of pathogenesis concepts and potential for new therapies
Sisakian, H. S. (2014) · World Journal of Cardiology · doi:10.4330/wjc.v6.i6.478 · Cited by 108 · see citing works
2020 AHA/ACC guideline for the diagnosis and treatment of patients with hypertrophic cardiomyopathy
Ommen, S. R., Mital, S. R., Burke, M. A., Day, S. M., Deswal, A. M., Elliot, P. M., Evanovich, L. L., Hung, J., Joglar, J. A., Kantor, P. F., et al. (2021) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2021.04.001 · Cited by 92 · see citing works
Surgical Septal Myectomy Versus Alcohol Septal Ablation
Maron, B. J., & Nishimura, R. A. (2014) · Circulation · doi:10.1161/circulationaha.114.011580 · Cited by 88 · see citing works
Safety of Outpatient Initiation of Disopyramide for Obstructive Hypertrophic Cardiomyopathy Patients
Adler, A., Fourey, D., Weissler‐Snir, A., Hindieh, W., Chan, R. H. M., Gollob, M. H., & Rakowski, H. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.116.005152 · Cited by 84 · see citing works
Vriesendorp, P. A., Schinkel, A. F. L., Soliman, O. I. I., Kofflard, M. J. M., de Jong, P. L., van Herwerden, L. A., ten Cate, F. J., & Michels, M. (2014) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2014.12.017 · Cited by 83 · see citing works
Maron, B. J., Dearani, J. A., Smedira, N. G., Schaff, H. V., Wang, S., Rastegar, H., Ralph-Edwards, A. C., Ferrazzi, P., Swistel, D. G., Shemin, R. J., et al. (2022) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2022.06.007 · Cited by 80 · see citing works
Coppini, R., Ferrantini, C., Pioner, J. M., Santini, L., Wang, Z. J., Palandri, C., Scardigli, M., Vitale, G., Sacconi, L., Stefàno, P., et al. (2019) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2019.06.004 · Cited by 79 · see citing works
Maron, M. S., Mahmod, M., Samat, A. H. A., Choudhury, L., Massera, D., Phelan, D. M. J., Cresci, S., Martinez, M. W., Masri, A., Abraham, T. P., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.03.387 · Cited by 67 · see citing works
Halpern, D. G., Swistel, D. G., Po, J. R., Joshi, R., Winson, G., Arabadjian, M. E., Lopresto, C., Kushner, J., Kim, B., Balaram, S. K., et al. (2015) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2015.07.002 · Cited by 61 · see citing works
Hypertrophic Cardiomyopathy: New Concepts and Therapies
Maron, B. J., Rowin, E. J., & Maron, M. S. (2022) · Annual Review of Medicine · doi:10.1146/annurev-med-042220-021539 · Cited by 57 · see citing works
Nampiaparampil, R. G., Swistel, D. G., Schlame, M., Sarić, M., & Sherrid, M. V. (2018) · Journal of the American Society of Echocardiography · doi:10.1016/j.echo.2017.11.016 · Cited by 57 · see citing works
Evolving Contemporary Management of Atrial Fibrillation in Hypertrophic Cardiomyopathy
Rowin, E. J., Link, M. S., Maron, M. S., & Maron, B. J. (2023) · Circulation · doi:10.1161/circulationaha.123.065037 · Cited by 59 · see citing works
Antunes, M. D. O., & Scudeler, T. L. (2020) · IJC Heart & Vasculature · doi:10.1016/j.ijcha.2020.100503 · Cited by 53 · see citing works
Drug Therapy for Hypertrophic Cardiomypathy: Physiology and Practice
Sherrid, M. V. (2016) · Current Cardiology Reviews · doi:10.2174/1573403x1201160126125403 · Cited by 50 · see citing works
Exercise Capacity in Patients With Obstructive Hypertrophic Cardiomyopathy
COATS, C. J., Maron, M. S., Abraham, T. P., Olivotto, I., Lee, M. M. Y., Arad, M., Cardim, N. M., Ma, C., Choudhury, L., Düngen, H., et al. (2023) · JACC Heart Failure · doi:10.1016/j.jchf.2023.10.004 · Cited by 50 · see citing works
Pharmacologic Management for Ventricular Arrhythmias: Overview of Anti-Arrhythmic Drugs
Larson, J. D., Rich, L., Deshmukh, A., Judge, E. C., & Liang, J. J. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11113233 · Cited by 50 · see citing works
2020 Clinical practice guidelines for Hypertrophic cardiomyopathy
Габрусенко, С. А., Gudkova, A. Y., Koziolova, N. A., Alexandrova, S. А., Berseneva, M., Гордеев, М. Л., Sl, D., Zaklyazminskaya, E. V., Irtyuga, O. B., Kaplunova, V. Y., et al. (2021) · Russian Journal of Cardiology · doi:10.15829/1560-4071-2021-4541 · Cited by 53 · see citing works
Hegde, S. M., Claggett, B. L., Wang, X., Jering, K., Prasad, N., Roshanali, F., Masri, A., Nassif, M. E., Villa, R. B., Abraham, T. P., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.08.002 · Cited by 45 · see citing works
Myocardial energy depletion and dynamic systolic dysfunction in hypertrophic cardiomyopathy
Ormerod, J. O. M., Frenneaux, M. P., & Sherrid, M. V. (2016) · Nature Reviews Cardiology · doi:10.1038/nrcardio.2016.98 · Cited by 46 · see citing works
Impact of Aficamten on Disease and Symptom Burden in Obstructive Hypertrophic Cardiomyopathy
Maron, M. S., Masri, A., Nassif, M. E., Villa, R. B., Abraham, T. P., Arad, M., Cardim, N. M., Choudhury, L., Claggett, B. L., COATS, C. J., et al. (2024) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2024.09.003 · Cited by 41 · see citing works
Li, J., Wu, Z., Zheng, D., Sun, Y., Wang, S., & Yan, Y. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10289 · Cited by 35 · see citing works
Misconceptions and Facts About Hypertrophic Cardiomyopathy
Argulian, E., Sherrid, M. V., & Messerli, F. H. (2015) · The American Journal of Medicine · doi:10.1016/j.amjmed.2015.07.035 · Cited by 31 · see citing works
New Developments in Hypertrophic Cardiomyopathy
Cooper, R. M., Raphael, C. E., Liebregts, M., Anavekar, N. S., & Veselka, J. (2017) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2017.07.007 · Cited by 30 · see citing works
Disopyramide for Hypertrophic Cardiomyopathy: A Pragmatic Reappraisal of an Old Drug
Verlinden, N. J., & Coons, J. C. (2015) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.1664 · Cited by 29 · see citing works
Monda, E., Lioncino, M., Palmiero, G., Franco, F., Rubino, M., Cirillo, A., Verrillo, F., Fusco, A., Caiazza, M., Mazzella, M., et al. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.03.013 · Cited by 29 · see citing works
Emerging Medical Treatment for Hypertrophic Cardiomyopathy
Argirò, A., Zampieri, M., Berteotti, M., Marchi, A. G., Tassetti, L., Zocchi, C., Iannone, L., Bacchi, B., Cappelli, F., Stefàno, P., et al. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10050951 · Cited by 29 · see citing works
Advances in the pharmacologic treatment of ventricular arrhythmias
Schleifer, J. W., Sorajja, D., & Shen, W.-K. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2015.1100170 · Cited by 26 · see citing works
Guidelines on the Diagnosis and Treatment of Hypertrophic Cardiomyopathy - 2024
Fernandes, F., Simões, M. V., Correia, E. D. B., Marcondes‐Braga, F. G., Coelho‐Filho, O. R., Mesquita, C. T., Mathias, W., Antunes, M. D. O., Arteaga-Fernández, E., Rochitte, C. E., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240415i · Cited by 26 · see citing works
Maurizi, N., Chiriatti, C., Fumagalli, C., Targetti, M., Passantino, S., Antiochos, P., Skalidis, I., Chiti, C., Biagioni, G., Tomberli, A., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12072725 · Cited by 25 · see citing works
Current management of hypertrophic cardiomyopathy
Sikand, N. V., Stendahl, J. C., Sen, S., Lampert, R. J., & Day, S. M. (2025) · BMJ · doi:10.1136/bmj-2023-077274 · Cited by 24 · see citing works
Surgical Myectomy for Hypertrophic Obstructive Cardiomyopathy
Williams, L. K., & Rakowski, H. (2013) · Circulation · doi:10.1161/circulationaha.113.003953 · Cited by 24 · see citing works
Wolf, C. M., Zenker, M., Burkitt‐Wright, E., Édouard, T., García‐Miñáur, S., Lebl, J., Shaikh, M. G., Tartaglia, M., Verloès, A., & Östman‐Smith, I. (2021) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2021.104372 · Cited by 23 · see citing works
Mathai, S., & Williams, L. K. (2022) · Therapeutic Advances in Chronic Disease · doi:10.1177/20406223221136074 · Cited by 22 · see citing works
Seo, K., Yamamoto, Y., Kirillova, A., Kawana, M., Yadav, S. K., Huang, Y., Wang, Q., Lane, K. V., Pruitt, B. L., Perez, M. V., et al. (2023) · Circulation · doi:10.1161/circulationaha.123.065017 · Cited by 22 · see citing works
Disopyramide use in infants and children with hypertrophic cardiomyopathy
O’Connor, M. J., Miller, K. D., Shaddy, R. E., Lin, K. Y., Hanna, B. D., Ravishankar, C., & Rossano, J. W. (2018) · Cardiology in the Young · doi:10.1017/s1047951117002384 · Cited by 21 · see citing works
The Mitral Valve in Hypertrophic Cardiomyopathy
Sherrid, M. V., & Adams, D. H. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.09.580 · Cited by 19 · see citing works
Management of hypertrophic cardiomyopathy
Zhang, Y., Adamo, M., Zou, C., Porcari, A., Tomasoni, D., Rossi, M., Merlo, M., Liu, H., Wang, J., Zhou, P., et al. (2024) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000001616 · Cited by 20 · see citing works
Mitral Leaflet Shortening as an Ancillary Procedure in Obstructive Hypertrophic Cardiomyopathy
Swistel, D. G., Massera, D., Stepanovic, A., Adlestein, E., Reuter, M., Wu, W., Scheinerman, J. A., Nampi, R. G., Paone, D., Kim, B., et al. (2024) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2024.03.014 · Cited by 18 · see citing works
Medical treatment of hypertrophic cardiomyopathy - What do we know about it today?
Gregor, P., & Čurila, K. (2015) · Cor et Vasa · doi:10.1016/j.crvasa.2015.02.003 · Cited by 18 · see citing works
Yang, Y., Fan, C., Yuan, J., Shui-yun, W., Song, Y., Qiao, S., You, S.-J., Wang, Z., Duan, F., & Li, Y. (2016) · Journal of Interventional Cardiology · doi:10.1111/joic.12331 · Cited by 18 · see citing works
Massera, D., Sherrid, M. V., Adlestein, E., Bokhari, N. A., Alvarez, I. C., Wu, W. Y., Reuter, M. C., Maron, M. S., Maron, B. J., & Rowin, E. J. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.124.037639 · Cited by 17 · see citing works
Revisiting Arrhythmic Risk After Alcohol Septal Ablation
Maron, B. J., & Nishimura, R. A. (2014) · JACC Heart Failure · doi:10.1016/j.jchf.2014.07.008 · Cited by 17 · see citing works
State-of-the-Art Document on Optimal Contemporary Management of Cardiomyopathies
Seferovic, P. M., Polovina, M. M., Rosano, G. M. C., Bozkurt, B., Metra, M., Heymans, S. R. B., Müllens, W., Bauersachs, J. K., Sliwa, K. S., de Boer, R. A., et al. (2023) · European Journal of Heart Failure · doi:10.1002/ejhf.2979 · Cited by 16 · see citing works
Hypertrophic cardiomyopathy: A complex disease
Young, L. D., Smedira, N. G., Tower-Rader, A. F., Lever, H. M., & Desai, M. Y. (2018) · Cleveland Clinic Journal of Medicine · doi:10.3949/ccjm.85a.17076 · Cited by 16 · see citing works
Novel Pharmacotherapy in Hypertrophic Cardiomyopathy
Andries, G., Yandrapalli, S., Naidu, S. S., & Panza, J. A. (2018) · Cardiology in Review · doi:10.1097/crd.0000000000000211 · Cited by 16 · see citing works
The Revolution of Cardiac Myosin Inhibitors in Patients With Hypertrophic Cardiomyopathy
Haraf, R. H., Habib, H., & Masri, A. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2024.01.022 · Cited by 15 · see citing works
Sudden Cardiac Death in Genetic Cardiomyopathies
Atteya, G. A., & Lampert, R. J. (2017) · Cardiac Electrophysiology Clinics · doi:10.1016/j.ccep.2017.07.009 · Cited by 15 · see citing works
Reyes, K. R., Bilgili, G., & Rader, F. (2022) · Heart International · doi:10.17925/hi.2022.16.2.91 · Cited by 15 · see citing works
On the Cardiac Loop and Its Failing: Left Ventricular Outflow Tract Obstruction
Sherrid, M. V., Männer, J., Swistel, D. G., Olivotto, I., & Halpern, D. G. (2020) · Journal of the American Heart Association · doi:10.1161/jaha.119.014857 · Cited by 15 · see citing works
Maron, B. J., Maron, M. S., Sherrid, M. V., & Rowin, E. J. (2022) · Journal of the American Heart Association · doi:10.1161/jaha.121.024566 · Cited by 15 · see citing works
Pysz, P., Rajtar-Salwa, R., Smolka, G. A., Olivotto, I., Wojakowski, W., & Dimitrow, P. P. (2021) · Kardiologia Polska · doi:10.33963/kp.a2021.0064 · Cited by 14 · see citing works
Jensen, M. K., Faber, L., Liebregts, M., Januška, J., Krejčí, J., Bartel, T., Cooper, R. M., Dąbrowski, M., Hansen, P. R., Almaas, V. M., et al. (2018) · European Heart Journal - Quality of Care and Clinical Outcomes · doi:10.1093/ehjqcco/qcy049 · Cited by 14 · see citing works
Maron, M. S., Gimeno, J. R., Veselka, J., Villa, R. B., Claggett, B. L., COATS, C. J., Hegde, S. M., Januzzi, J. L., Kulac, I. J., Masri, A., et al. (2025) · European Heart Journal · doi:10.1093/eurheartj/ehaf364 · Cited by 13 · see citing works
Obstructive Hypertrophic Cardiomyopathy: A Review of New Therapies
Mehra, N. S., Ali, A. H., & Desai, M. Y. (2023) · Future Cardiology · doi:10.2217/fca-2023-0056 · Cited by 12 · see citing works
Amesz, J. H., Langmuur, S. J. J., Zhang, L., Manintveld, O. C., Schinkel, A. F. L., de Jong, P. L., de Groot, N. M. S., & Taverne, Y. J. H. J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116036 · Cited by 12 · see citing works
Crean, A. M., Adler, A., Arbour, L. T., Chan, J., Christian, S., Cooper, R. M., Garceau, P., Giraldeau, G., Heydari, B., Laksman, Z., et al. (2024) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2024.06.007 · Cited by 12 · see citing works
Dicorato, M. M., Citarelli, G., Mangini, F., Alemanni, R., Albanese, M., Cicco, S., Greco, C. A., Forleo, C., Basile, P., Carella, M. C., et al. (2025) · Biomedicines · doi:10.3390/biomedicines13051256 · Cited by 12 · see citing works
Mitral Valve Interventions for Hypertrophic Obstructive Cardiomyopathy
Shuvy, M., Postell, Y. Y., Carasso, S., Marmor, D. B., Strauss, B. H., Maisano, F., & Lapenna, E. (2023) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2023.12.009 · Cited by 10 · see citing works
Elliot, P. M., Anastasakis, A., Borger, M. A., Borggrefe, M., Cecchi, F., Charron, P., Hagège, A. A., Lafont, A. M., Limongelli, G., Mahrholdt, H., et al. (2014) · Revista Española de Cardiología · doi:10.1016/j.recesp.2014.12.001 · Cited by 10 · see citing works
Non-surgical septal reduction therapy in hypertrophic cardiomyopathy
Cooper, R. M., & Stables, R. (2017) · Heart · doi:10.1136/heartjnl-2016-309952 · Cited by 10 · see citing works
Diretriz sobre Diagnóstico e Tratamento da Cardiomiopatia Hipertrófica – 2024
Fernandes, F., Simões, M. V., Correia, E. D. B., Marcondes‐Braga, F. G., Coelho‐Filho, O. R., Mesquita, C. T., Mathias, W., Antunes, M. D. O., Arteaga-Fernández, E., Rochitte, C. E., et al. (2024) · Arquivos Brasileiros de Cardiologia · doi:10.36660/abc.20240415 · Cited by 9 · see citing works
Tian, Z., Li, L., Li, X., Zhang, Q., Peng, D., Ma, W., Yang, P. C., Wang, F., Cheng, X. C., Fu, Y., et al. (2025) · JACC Asia · doi:10.1016/j.jacasi.2025.05.015 · Cited by 9 · see citing works
Medical, Surgical, and Interventional Management of Hypertrophic Cardiomyopathy
Massera, D., Sherrid, M. V., Scheinerman, J. A., Swistel, D. G., & Razzouk, L. (2025) · Circulation Cardiovascular Interventions · doi:10.1161/circinterventions.124.014023 · Cited by 8 · see citing works
Zeng, J., Shu, Q., Lu, C., & Wang, Y. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14291 · Cited by 8 · see citing works
Evolving Strategies for the Management of Obstructive Hypertrophic Cardiomyopathy
Liang, L. W., Lumish, H. S., Sewanan, L. R., Shimada, Y. J., Maurer, M. S., Weiner, S. D., & Clerkin, K. J. (2024) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2024.04.024 · Cited by 8 · see citing works
Hálasz, G., Dei, L., Moroni, F., Ayers, M. P., Ciacci, P., Giacalone, G., Mistrulli, R., Redivo, M., Orellana, S., Gabrielli, D., et al. (2024) · European Journal of Preventive Cardiology · doi:10.1093/eurjpc/zwae198 · Cited by 8 · see citing works
Pinto, G., Chiarito, M., Puscas, T., Bacher, A., Donal, E., Réant, P., Condorelli, G., & Hagège, A. A. (2024) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2024.10.029 · Cited by 8 · see citing works
Markers of responsiveness to disopyramide in patients with hypertrophic cardiomyopathy
Habib, M., Hoss, S., Bruchal-Garbicz, B., Chan, R. H. M., Rakowski, H., Williams, L. K., & Adler, A. (2019) · International Journal of Cardiology · doi:10.1016/j.ijcard.2019.09.066 · Cited by 8 · see citing works
Almanac 2014: cardiomyopathies
Guttmann, O. P., MOHIDDIN, S. A., & Elliot, P. M. (2014) · Heart · doi:10.1136/heartjnl-2013-305420 · Cited by 8 · see citing works
Hypertrophic Cardiomyopathy: The Past, the Present, and the Future
D, E. B. M. (2014) · Springer eBooks · doi:10.1007/978-1-4471-4956-9_1 · Cited by 8 · see citing works
Awad, K., Pereyra, M., Farina, J., Pathangey, G., Abbas, M. T., Scalia, I. G., Couteur, D. G. L., Wilanksy, S., Lester, S. J., Ommen, S. R., et al. (2025) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvaf036 · Cited by 7 · see citing works
Current and emerging medical and surgical therapy in hypertrophic cardiomyopathy
Kim, K. A., & Jung, M. (2025) · Journal of Cardiovascular Imaging · doi:10.1186/s44348-025-00050-9 · Cited by 7 · see citing works
Does Disopyramide Still Have a Place in the Management of Obstructive Hypertrophic Cardiomyopathy?
Corriveau, S., Heydari, B., & Garceau, P. (2024) · CJC Open · doi:10.1016/j.cjco.2024.03.006 · Cited by 7 · see citing works
Rodríguez‐González, M., Castellano‐Martínez, A., Grujic, B., & Prieto-Heredia, M. A. (2017) · Journal of Cardiology Cases · doi:10.1016/j.jccase.2017.03.004 · Cited by 7 · see citing works
- Authors
- Sherrid, M. V., Shetty, A., Winson, G., Kim, B., Musat, D., Alviar, C. L., Homel, P., Balaram, S. K., & Swistel, D. G.
- Affiliations
- St. Luke's-Roosevelt Hospital Center (US)
- ORCID
- Venue
- Circulation Heart Failure
- Published
- 2013-07
- Volume
- 6
- Issue
- 4
- Pages
- 694-702
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2122819292
- Cited by
- 178
- References
- 33
- Citations by year
- 2026: 11 · 2025: 26 · 2024: 26 · 2023: 12 · 2022: 14 · 2021: 13 · 2020: 11 · 2019: 6 · 2018: 13 · 2017: 7 · 2016: 14 · 2015: 10 · 2014: 13 · 2013: 1
- FWCI
- 8.65
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Circulation Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Viral Infections and Immunology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Valve Diseases and Treatments
- Keywords
- hypertrophic obstructive cardiomyopathy, left ventricular outflow tract obstruction, disopyramide, beta-adrenergic blockade, verapamil, myectomy, alcohol septal ablation, symptom relief, survival, sudden death
- MeSH terms
- Adrenergic beta-Antagonists, Aged, Anti-Arrhythmia Agents, Calcium Channel Blockers, Cardiomyopathy, Hypertrophic, Combined Modality Therapy, Disopyramide, Female, Cardiac Surgical Procedures, Humans, Male, Middle Aged, Verapamil, Treatment Failure
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
