Cited by 329Probiotics and Fermented FoodsCardiac Fibrosis and RemodelingCardiac Ischemia and Reperfusion

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Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat

Gan, Xiaohong Tracey, Ettinger, Grace, Huang, Cathy X., Burton, Jeremy P., Haist, James V., Rajapurohitam, Venkatesh, Sidaway, James E., Martin, Glynn, Gloor, Gregory B., Swann, Jonathan R., Reid, Gregor, Karmazyn, Morris·2014·Circulation: Heart Failure

DOI 10.1161/circheartfailure.113.000978

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Abstract

Background—: Probiotics are extensively used to promote gastrointestinal health, and emerging evidence suggests that their beneficial properties can extend beyond the local environment of the gut. Here, we determined whether oral probiotic administration can alter the progression of postinfarction heart failure. Methods and Results—: Rats were subjected to 6 weeks of sustained coronary artery occlusion and administered the probiotic Lactobacillus rhamnosus GR-1 or placebo in the drinking water ad libitum. Culture and 16s rRNA sequencing showed no evidence of GR-1 colonization or a significant shift in the composition of the cecal microbiome. However, animals administered GR-1 exhibited a significant attenuation of left ventricular hypertrophy based on tissue weight assessment and gene expression of atrial natriuretic peptide. Moreover, these animals demonstrated improved hemodynamic parameters reflecting both improved systolic and diastolic left ventricular function. Serial echocardiography revealed significantly improved left ventricular parameters throughout the 6-week follow-up period including a marked preservation of left ventricular ejection fraction and fractional shortening. Beneficial effects of GR-1 were still evident in those animals in which GR-1 was withdrawn at 4 weeks, suggesting persistence of the GR-1 effects after cessation of therapy. Investigation of mechanisms showed a significant increase in the leptin:adiponectin plasma concentration ratio in rats subjected to coronary ligation, which was abrogated by GR-1. Metabonomic analysis showed differences between sham control and coronary artery ligated hearts particularly with respect to preservation of myocardial taurine levels. Conclusions—: The study suggests that probiotics offer promise as a potential therapy for the attenuation of heart failure.

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Authors: Gan, X. T., Ettinger, G., Huang, C. X., Burton, J. P., Haist, J. V., Rajapurohitam, V., Sidaway, J. E., Martin, G., Gloor, G. B., Swann, J. R., Reid, G., & Karmazyn, M.
Affiliations: Western University (CA)
ORCID: Burton, Jeremy P.
Sidaway, James E.
Gloor, Gregory B.
Swann, Jonathan R.
Reid, Gregor
Karmazyn, Morris
Venue: Circulation: Heart Failure
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2014-05
Volume: 7
Issue: 3
Pages: 491-499
ISSN: 1941-3289 (ISSN-L)
1941-3297
DOI: 10.1161/circheartfailure.113.000978
OpenAlex: W2154813987
Cited by: 329
References: 38
Citations by year: 2026: 16 · 2025: 31 · 2024: 34 · 2023: 45 · 2022: 46 · 2021: 44 · 2020: 23 · 2019: 21 · 2018: 17 · 2017: 17 · 2016: 12 · 2015: 14 · 2014: 8
FWCI: 24.33
Type: journal article
Language: en
Open access: closed
Locations: Circulation Heart Failure (publishedVersion)
PubMed (publishedVersion)
ePrints Soton (University of Southampton) (submittedVersion)
Funders: World Health Organization
Canadian Institutes of Health Research (MOP62764)
Topics: Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Fibrosis and Remodeling
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Ischemia and Reperfusion
Keywords: probiotics, Lactobacillus rhamnosus GR-1, myocardial infarction, post-infarction heart failure, left ventricular hypertrophy, atrial natriuretic peptide, leptin/adiponectin ratio, taurine, gut-heart axis, coronary artery occlusion, left ventricular function, cecal microbiota
MeSH terms: Administration, Oral, Animals, Disease Models, Animal, Cardiomegaly, Heart Failure, Heart Ventricles, Hemodynamics, Male, Myocardial Infarction, Rats, Sprague-Dawley, Disease Progression, Probiotics, Rats, Coronary Occlusion

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Probiotic Administration Attenuates Myocardial Hypertrophy and Heart Failure After Myocardial Infarction in the Rat

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