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Effects of Coping Skills Training on Quality of Life, Disease Biomarkers, and Clinical Outcomes in Patients With Heart Failure: A Randomized Clinical Trial

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Sherwood, Andrew, Blumenthal, James A., Koch, Gary G., Hoffman, Benson M., Watkins, Lana L., Smith, Patrick J., O’Connor, Christopher M., Adams, Kirkwood F. +6 more·2017·Circulation: Heart Failure
DOI 10.1161/circheartfailure.116.003410PMC PMC5233412
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Abstract

Background—: Heart failure (HF) is a chronic disease that compromises patients’ quality of life (QoL). Interventions designed to reduce distress and improve disease self-management are needed. We evaluated the efficacy of a telephone-based coping skills training (CST) intervention. Methods and Results—: This randomized clinical trial involved 180 HF outpatients with reduced ejection fraction. Participants ranged in age from 29 to 87 years (mean=58 years); 27% were women, and 47% were nonwhite. Participants were randomized to either a CST intervention or heart failure education, both delivered over 16 weeks. The primary outcomes were (1) postintervention effects on QoL and HF disease biomarkers (both with α=0.01), and (2) a composite measure of time to death or first hospitalization (with α=0.03) over a median follow-up period of 3 years. CST resulted in greater improvements in QoL compared with heart failure education ( P <0.01), including the Kansas City Cardiomyopathy Questionnaire ( P =0.009), depressive symptoms ( P =0.027), and the 6-minute walk test ( P =0.012). However, it did not differentially improve HF disease biomarkers or reduce risk of all-cause hospitalizations or death (hazard ratio=0.84 [95% confidence interval, 0.59–1.12]). Interestingly, exploratory analyses showed that participants randomized to CST experienced a reduction in the composite end point of worsening HF hospitalization or death during the 3-year follow-up period (hazard ratio=0.65 [95% confidence interval, 0.44–0.98]; P =0.040). Conclusions—: CST improved QoL in patients with HF. Monitoring and improving QoL is emerging as an important aspect of the clinical management of HF that can reduce disease burden and may help improve clinical outcomes in this vulnerable patient population. Clinical Trial Registration—: URL: https://www.clinicaltrials.gov . Unique identifier: NCT00873418.

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  • One trial in patients with heart failure observed no postintervention between-group differences (coping skills training versus heart failure education alone) with respect to biomarkers or readmissions/death at the 3-year follow-up.

    “One trial in patients with heart failure observed no postintervention betweengroup differences (coping skills training versus heart failure education alone) with respect to biomarkers or readmissions/death at the 3-year follow-up, 200”

    From Psychological Health, Well-Being, and the Mind-Heart-Body Connection: A Scientific Statement From the American Heart Association (2021) · cites this paper as [200]

    The Results (Primary Outcomes; page unavailable) report no significant post-treatment difference in heart-failure biomarkers, and no significant difference in the primary outcome of all-cause hospitalization or death over a median three-year follow-up. The claim is too broad about readmissions or death: the same section reports an exploratory reduction in worsening-heart-failure hospitalization or death with coping skills training. Biomarkers were assessed after the intervention, not at the three-year follow-up. (LLM, conf=0.85)

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Research works printed but not linked: 30

  1. [1]Mozaffarian D Benjamin EJ Go AS Arnett DK Blaha MJ Cushman M de Ferranti S Despres JP Fullerton HJ Howard VJ Huffman MD Judd SE Kissela BM Lackland DT Lichtman JH Lisabeth LD Liu S Mackey RH Matchar DB McGuire DK Mohler ER 3rd Moy CS Muntner P Mussolino ME Nasir K Neumar RW Nichol G Palaniappan L Pandey DK Reeves MJ Rodriguez CJ Sorlie PD Stein J Towfighi A Turan TN Virani SS Willey JZ Woo D Yeh RW Turner MB American Heart Association Statistics C and Stroke Statistics S Heart disease and stroke statistics--2015 update: a report from the American Heart Association Circulation 2015 131 e29 e322 25520374
  2. [2]Delgado-Passler P McCaffrey R The influences of postdischarge management by nurse practitioners on hospital readmission for heart failure J Am Acad Nurse Pract 2006 18 154 160 16573728
  3. [3]Rutledge T Reis VA Linke SE Greenberg BH Mills PJ Depression in heart failure a meta-analytic review of prevalence, intervention effects, and associations with clinical outcomes J Am Coll Cardiol 2006 48 1527 1537 17045884
  4. [4]Hoekstra T Jaarsma T van Veldhuisen DJ Hillege HL Sanderman R Lesman-Leegte I Quality of life and survival in patients with heart failure Eur J Heart Fail 2013 15 94 102 22989869
  5. [6]Labrunee M Pathak A Loscos M Coudeyre E Casillas JM Gremeaux V Therapeutic education in cardiovascular diseases: state of the art and perspectives Ann Phys Rehabil Med 2012 55 322 341 22784986
  6. [9]Chaudhry SI Phillips CO Stewart SS Riegel B Mattera JA Jerant AF Krumholz HM Telemonitoring for patients with chronic heart failure: a systematic review J Cardiac Fail 2007 13 56 62 PMC1910700 17339004
  7. [10]Grey M Berry D Coping skills training and problem solving in diabetes Curr Diabetes Rep 2004 4 126 131 15035973
  8. [12]Freedland KE Carney RM Rich MW Steinmeyer BC Rubin EH Cognitive Behavior Therapy for Depression and Self-Care in Heart Failure Patients: A Randomized Clinical Trial JAMA Intern Med 2015 175 1773 1782 26414759 PMC4712737
  9. [13]Sherwood A O'Connor CM Routledge FS Hinderliter AL Watkins LL Babyak MA Koch GG Adams KF Jr Dupree CS Chang PP Hoffman BM Johnson J Bowers M Johnson KS Blumenthal JA Coping effectively with heart failure (COPE-HF): design and rationale of a telephone-based coping skills intervention J Card Fail 2011 17 201 207 21362527 PMC3073538
  10. [14]Troughton RW Richards AM BNP for clinical monitoring of heart failure Heart Fail. Clin 2006 2 333 343 17386902
  11. [15]Konstam MA Dracup K Baker DW Bottorff MB Brooks NH Dacey RA Dunbar SB Jackson AB Jessup M Johnson JC Heart failure: evaluation and care of patients with left ventricular systolic dysfunction J Cardiac Fail 1995 1 183 187 9420649
  12. [16]Aronson D Mittleman M Burger AJ Measures of heart period variability as preditors of mortality in hospitalized patients with decompensated congestive heart failure Am J Cardiol 2004 93 59 63 14697467
  13. [17]Meyer B Mortl D Strecker K Hulsmann M Kulemann V Neunteufl T Pacher R Berger R Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide J Am Coll Cardiol 2005 46 1011 1018 16168284
  14. [19]Green CP Porter CB Bresnahan DR Spertus JA Development and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure J Am Coll Cardiol 2000 35 1245 1255 10758967
  15. [22]Turvey CL Klein DM Pies CJ Arndt S Attitudes about impairment and depression in elders suffering from chronic heart failure Int J Psychiatr Med 2003 33 117 132 12968825
  16. [23]Riegel B Carlson B Moser DK Sebern M Hicks FD Roland V Psychometric testing of the self-care of heart failure index J Card Fail 2004 10 350 360 15309704
  17. [24]Blumenthal JA Emery CF Smith PJ Keefe FJ Welty-Wolf K Mabe S Martinu T Johnson JJ Babyak MA O'Hayer VF Diaz PT Durheim M Baucom D Palmer SM The effects of a telehealth coping skills intervention on outcomes in chronic obstructive pulmonary disease: primary results from the INSPIRE-II study Psychosom Med 2014 76 581 592 25251888 PMC4197099
  18. [25]Blumenthal JA Sherwood A Babyak MA Watkins LL Waugh R Georgiades A Bacon SL Hayano J Coleman RE Hinderliter A Effects of exercise and stress management training on markers of cardiovascular risk in patients with ischemic heart disease: a randomized controlled trial JAMA 2005 293 1626 1634 15811982
  19. [26]O'Brien PC Procedures for comparing samples with multiple endpoints Biometrics 1984 40 1079 1087 6534410
  20. [27]Sun H Davison BA Cotter G Pencina MJ Koch GG Evaluating treatment efficacy by multiple end points in phase II acute heart failure clinical trials: analyzing data using a global method Circ Heart Fail 2012 5 742 749 23065036
  21. [28]Felker GM Maisel AS A global rank end point for clinical trials in acute heart failure Circ Heart Fail 2010 3 643 646 20841546
  22. [30]Saville BR Herring AH Koch GG A robust method for comparing two treatments in a confirmatory clinical trial via multivariate time-to-event methods that jointly incorporate information from longitudinal and time-to-event data Stat Med 2010 29 75 85 19830704 PMC3146347
  23. [32]Spertus J Peterson E Conard MW Heidenreich PA Krumholz HM Jones P McCullough PA Pina I Tooley J Weintraub WS Rumsfeld JS Cardiovascular Outcomes Research C Monitoring clinical changes in patients with heart failure: a comparison of methods Am Heart J 2005 150 707 715 [see comment] 16209970
  24. [33]O'Connor CM Whellan DJ Lee KL Keteyian SJ Cooper LS Ellis SJ Leifer ES Kraus WE Kitzman DW Blumenthal JA Rendall DS Miller NH Fleg JL Schulman KA McKelvie RS Zannad F Pina IL Investigators H-A Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial JAMA 2009 301 1439 1450 19351941 PMC2916661
  25. [34]Flynn KE Pina IL Whellan DJ Lin L Blumenthal JA Ellis SJ Fine LJ Howlett JG Keteyian SJ Kitzman DW Kraus WE Miller NH Schulman KA Spertus JA O'Connor CM Weinfurt KP Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial JAMA 2009 301 1451 1459 19351942 PMC2690699
  26. [35]Havranek EP Ware MG Lowes BD Prevalence of depression in congestive heart failure Am J Cardiol 1999 84 348 350 10496452
  27. [37]Spilker B Spilker B Introduction Quality of life assessments in clinical trials 1990 New York Raven Press 3 9
  28. [39]Pais-Ribeiro JL Quality of life is a primary end-point in clinical settings Clin Nutr 2004 23 121 130 14757401
  29. [40]Osoba D Health-related quality of life and cancer clinical trials Ther Adv Med Oncol 2011 3 57 71 21789156 PMC3126042
  30. [41]Molnar-Varga M Molnar MZ Szeifert L Kovacs AZ Kelemen A Becze A Laszlo G Szentkiralyi A Czira ME Mucsi I Novak M Health-related quality of life and clinical outcomes in kidney transplant recipients Am J Kidney Dis 2011 58 444 452 21658828

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Authors
Sherwood, A., Blumenthal, J. A., Koch, G. G., Hoffman, B. M., Watkins, L. L., Smith, P. J., O’Connor, C. M., Adams, K. F., Rogers, J. G., Sueta, C., Chang, P. P., Johnson, K. S., Schwartz, J., & Hinderliter, A. L.
Affiliations
University of North Carolina at Chapel Hill (US)
ORCID
Venue
Circulation: Heart Failure
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2017-01
Volume
10
Issue
1
ISSN
  • 1941-3289 (ISSN-L)
  • 1941-3297
DOI
10.1161/circheartfailure.116.003410
PMC
PMC5233412
OpenAlex
W2588041400
Cited by
55
References
8
Citations by year
2026: 4 · 2025: 3 · 2024: 7 · 2023: 5 · 2022: 11 · 2021: 7 · 2020: 7 · 2019: 3 · 2018: 4 · 2017: 4
FWCI
3.81
Type
journal article
Language
en
Open access
Locations
  • Circulation Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Veterans Affairs
  • National Heart, Lung, and Blood Institute (R01HL091920)
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
  • Health Sciences › Health Professions › Pharmacy › Nursing care and research
Keywords
heart failure, coping skills training, quality of life, telephone-delivered intervention, heart failure education, reduced ejection fraction, disease biomarkers, hospitalization, mortality, depressive symptoms, Kansas City Cardiomyopathy Questionnaire, 6-minute walk test, self-management
MeSH terms
Adaptation, Psychological, Adult, Aged, Aged, 80 and over, Chronic Disease, Female, Heart Failure, Humans, Male, Middle Aged, Quality of Life, Biomarkers, Treatment Outcome

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