The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure
Open accessAbstract
Background—: Inappropriately sustained inflammation is a hallmark of chronic ischemic heart failure (HF); however, the pathophysiological role of T lymphocytes is unclear. Methods and Results—: Permanent coronary ligation was performed in adult C57BL/6 mice. When compared with sham-operated mice, mice with HF (8 weeks after ligation) exhibited the following features: (1) significant ( P <0.05) expansion of circulating CD3 + CD8 + cytotoxic and CD3 + CD4 + helper (Th) T lymphocytes, together with increased Th1, Th2, Th17, and regulatory T-cell (Treg) CD4 + subsets; (2) significant expansion of CD8 + and CD4 + T cells in failing myocardium, with increased Th1, Th2, Th17, and Treg CD4 + subsets, marked reduction of the Th1/Th2 ratio, augmentation of the Th17/Treg ratio, and upregulation of Th2 cytokines; and (3) significantly increased Th1, Th2, Th17 cells, and Tregs, in the spleen and mediastinal lymph nodes, with expansion of splenic antigen-experienced effector and memory CD4 + T cells. Antibody-mediated CD4 + T-cell depletion in HF mice (starting 4 weeks after ligation) reduced cardiac infiltration of CD4 + T cells and prevented progressive left ventricular dilatation and hypertrophy, whereas adoptive transfer of splenic CD4 + T cells (and, to a lesser extent, cardiac CD3 + T cells) from donor mice with HF induced long-term left ventricular dysfunction, fibrosis, and hypertrophy in naive recipient mice. Conclusions—: CD4 + T lymphocytes are globally expanded and activated in chronic ischemic HF, with Th2 (versus Th1) and Th17 (versus Treg) predominance in failing hearts, and with expansion of memory T cells in the spleen. Cardiac and splenic T cells in HF are primed to induce cardiac injury and remodeling, and retain this memory on adoptive transfer.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 1×
“CD44CD69 were further defined as activated effector T cells, CD44CD69 as total memory T cells, and CD44CD62L as central memory T cells.(26,27)”
BackgroundKorn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Structure and function of the spleen
Mebius, R. E., & Kraal, G. (2005) · Nature Reviews Immunology · doi:10.1038/nri1669 · Cited by 2,238
The Biological Basis for Cardiac Repair After Myocardial Infarction: From Inflammation to Fibrosis
Prabhu, S. D., & Frangogiannis, N. G. (2016) · Circulation Research · doi:10.1161/circresaha.116.303577 · Cited by 2,224
Self-citationThe Seattle Heart Failure Model: Prediction of Survival in Heart Failure
Levy, W. C., Mozaffarian, D., Linker, D. T., Sutradhar, S. C., Anker, S. D., Cropp, A. B., Anand, I., Maggioni, A., Burton, P., Sullivan, M. D., et al. (2006) · Circulation · doi:10.1161/circulationaha.105.584102 · Cited by 2,021
Chung, E. S., Packer, M., Lo, K. H., Fasanmade, A. A., & Willerson, J. T. (2003) · Circulation · doi:10.1161/01.cir.0000077913.60364.d2 · Cited by 1,644
Homing and cellular traffic in lymph nodes
von Andrian, U. H., & Mempel, T. R. (2003) · Nature Reviews Immunology · doi:10.1038/nri1222 · Cited by 1,281
Mann, D. L., McMurray, J. J. V., Packer, M., Swedberg, K., Borer, J. S., Colucci, W. S., Djian, J., Drexler, H., Feldman, A., Kober, L., et al. (2004) · Circulation · doi:10.1161/01.cir.0000124490.27666.b2 · Cited by 1,240
The Foxp3+ regulatory T cell: a jack of all trades, master of regulation
Tang, Q., & Bluestone, J. A. (2008) · Nature Immunology · doi:10.1038/ni1572 · Cited by 1,031
Inflammatory Mediators and the Failing Heart: Past, Present, and the Foreseeable Future
Mann, D. L. (2002) · Circulation Research · doi:10.1161/01.res.0000043825.01705.1b · Cited by 988
Cited by
Cardioimmunology: the immune system in cardiac homeostasis and disease
Swirski, F. K., & Nahrendorf, M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0065-8 · Cited by 849
Diffuse myocardial fibrosis: mechanisms, diagnosis and therapeutic approaches
López, B., Ravassa, S., Moreno, M. U., José, G. S., Beaumont, J., González, A., & Díez, J. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00504-1 · Cited by 361
Patel, B., Bansal, S. S., Ismahil, M. A., Hamid, T., Rokosh, G., Mack, M., & Prabhu, S. D. (2018) · JACC: Basic to Translational Science · doi:10.1016/j.jacbts.2017.12.006 · Cited by 297
Self-citationMyocardial Milieu Favors Local Differentiation of Regulatory T Cells
Delgobo, M., Weiß, E., Ashour, D., Richter, L., Popiolkowski, L., Arampatzi, P., Stangl, V., Arias-Loza, P., Mariotti-Ferrandiz, E., Rainer, P. P., et al. (2023) · Circulation Research · doi:10.1161/circresaha.122.322183 · Cited by 57
Verschoor, C. P., Lelic, A., Parsons, R., Evelegh, C., Bramson, J. L., Johnstone, J., Loeb, M. B., & Bowdish, D. M. E. (2017) · The Journal of Infectious Diseases · doi:10.1093/infdis/jix257 · Cited by 31
Metadata
- Authors
- Bansal, S. S., Ismahil, M. A., Goel, M., Patel, B., Hamid, T., Rokosh, G., & Prabhu, S. D.
- Venue
- Circulation: Heart Failure
- Published
- 2017-03
- Volume
- 10
- Issue
- 3
- Pages
- e003688-e003688
- ISSN
- 1941-3289 (ISSN-L)
- 1941-3297
- OpenAlex
- W2593853488
- Cited by
- 323
- References
- 49
- FWCI
- 16.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bansal, S. S., Ismahil, M. A., Goel, M., Patel, B., Hamid, T., Rokosh, G., & Prabhu, S. D. (2017). Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure. Circulation: Heart Failure. https://doi.org/10.1161/circheartfailure.116.003688
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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