Serum C-Reactive Protein and Congestive Heart Failure as Significant Predictors of Herpes Zoster Vaccine Response in Elderly Nursing Home Residents
Open accessAbstract
Background: Elderly long-term care residents often exhibit a myriad of risk factors for immune dysfunction, including chronic inflammation and multiple comorbid conditions, which undoubtedly contribute to their enhanced susceptibility to infection. Hence, understanding the factors required for optimal vaccine responsiveness is critical. Methods: We examined 187 elderly nursing home residents (aged 80-102 years) and 50 community-dwelling seniors (aged 60-75 years) immunized with the live-attenuated varicella-zoster virus (VZV) vaccine. Specifically, we examined whether vaccine responsiveness was associated with serum C-reactive protein (CRP), tumor necrosis factor, interleukin 1β, 6, and 10, leukocyte telomere length, chronic disease status, and frailty. Results: Elderly participants had significantly higher levels of CRP, tumor necrosis factor, and interleukin 6 and shorter leukocyte telomere length. Vaccine responsiveness was inversely related to the CRP level in elderly participants, but not seniors, and those with congestive heart failure were less likely to achieve a 2-fold response (odds ratio, 0.08). The latter relationship is probably due to immunosenescence, because heart failure was associated with increased senescent CD4+ T cells, and reduced naive and effector and central memory CD8+ T cells. Conclusions: In summary, these data improve our understanding of vaccine responsiveness for those in long-term care, suggesting that certain risk factors are associated with a greater likelihood of vaccine failure.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Systemic chronic inflammation can impair normal immune function, increasing susceptibility to infections and tumors and reducing vaccine response.
“SCI can also impair normal immune function, leading to increased susceptibility to infections and tumors and a poor response to vaccines22–25.”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [23]
Certain inflammatory biomarkers, such as CRP, are inversely correlated with older adults' response to herpes zoster vaccine.
“certain inflammatory biomarkers, such as CRP, are inversely correlated with older adults’ response to other vaccines, such as the herpes zoster vaccine23”
From Chronic inflammation in the etiology of disease across the life span (2019) · cites this paper as [23]
Mediators of systemic chronic inflammation are linked to suboptimal vaccine responses in both elderly and younger individuals.
“This may help explain why mediators of systemic chronic inflammation have been linked to suboptimal vaccine responses in not only the elderly26,27 but in younger individuals as well28.”
From SARS-CoV-2, COVID-19 and the aging immune system (2021) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Telomere length measurement by a novel monochrome multiplex quantitative PCR method
Cawthon, R. (2009) · Nucleic Acids Research · doi:10.1093/nar/gkn1027 · Cited by 1,417 · see citing works
Antibody response to influenza vaccination in the elderly: A quantitative review
GOODWIN, K., VIBOUD, C., & SIMONSEN, L. (2006) · Vaccine · doi:10.1016/j.vaccine.2005.08.105 · Cited by 1,064 · see citing works
mTOR inhibition improves immune function in the elderly
Mannick, J. B., Del Giudice, G., Lattanzi, M., Valiante, N. M., Praestgaard, J., Huang, B., Lonetto, M. A., Maecker, H. T., Kovarik, J., Carson, S., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3009892 · Cited by 786 · see citing works
Varicella‐Zoster Virus–Specific Immune Responses in Elderly Recipients of a Herpes Zoster Vaccine
Levin, M. J., Oxman, M. N., Zhang, J. H., Johnson, G. R., Stanley, H., Hayward, A. R., Caulfield, M. J., Irwin, M. R., Smith, J. G., Clair, J. S., et al. (2008) · The Journal of Infectious Diseases · doi:10.1086/528696 · Cited by 355 · see citing works
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure
Bansal, S. S., Ismahil, M. A., Goel, M., Patel, B., Hamid, T., Rokosh, G. D., & Prabhu, S. D. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003688 · Cited by 323 · see citing works
COPLAN, P. M., Schmader, K. E., Nikas, A. A., Chan, I. S. F., Choo, P. W., Levin, M. J., Johnson, G. R., Bauer, M., Williams, H., Kaplan, K. M., et al. (2004) · Journal of Pain · doi:10.1016/j.jpain.2004.06.001 · Cited by 306 · see citing works
Environmental Enteropathy, Oral Vaccine Failure and Growth Faltering in Infants in Bangladesh
Naylor, C., Lu, M., Haque, R., Mondal, D., Buonomo, E. L., Nayak, U., Mychaleckyj, J. C., Kirkpatrick, B. D., Colgate, E. R., Carmolli, M. P., et al. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.09.036 · Cited by 260 · see citing works
Apoptosis and other immune biomarkers predict influenza vaccine responsiveness
Furman, D., Jojic, V., Kidd, B., Shen‐Orr, S., Price, J., Jarrell, J., Tse, T., Huang, H., Lund, P., Maecker, H. T., et al. (2013) · Molecular Systems Biology · doi:10.1038/msb.2013.15 · Cited by 184 · see citing works
Woods, J. A., Keylock, K. T., Lowder, T., Vieira‐Potter, V. J., Zelkovich, W., Dumich, S. A., Colantuano, K., Lyons, K. L., Leifheit, K. A., Cook, M. D., et al. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02563.x · Cited by 179 · see citing works
Bukhari, S. S. I., Phillips, B. E., Wilkinson, D. J., Limb, M. C., Rankin, D., Mitchell, W. K., Kobayashi, H., Greenhaff, P. L., Smith, K., & Atherton, P. J. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00481.2014 · Cited by 162 · see citing works
Wareham David, W., Breuer, J., 郑厚峰, & 张学军 (2007) · doi:10.3760/cma.j.issn.1007-9742.2007.06.122 · Cited by 162 · see citing works
Changes with age in the distribution of a frailty index
Rockwood, K. J. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.05.003 · Cited by 155 · see citing works
Maximizing the retention of antigen specific lymphocyte function after cryopreservation
Disis, M. L., Rosa, C. D., Vivian Goodell, A., Kuan, L.-Y., Chang, J. C. C., Kuus-Reichel, K., Clay, T. M., Lyerly, H. K., Bhatia, S., Ghanekar, S., et al. (2005) · Journal of Immunological Methods · doi:10.1016/j.jim.2005.09.011 · Cited by 153 · see citing works
McElhaney, J. E., Kuchel, G. A., Zhou, X., Swain, S. L., & Haynes, L. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00041 · Cited by 139 · see citing works
Major depressive disorder and immunity to varicella-zoster virus in the elderly
Irwin, M. R., Levin, M. J., Carrillo, C., Olmstead, R., Lucko, A., Lang, N., Caulfield, M. J., Weinberg, A., Chan, I. S. F., Clair, J. B. S., et al. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.02.001 · Cited by 83 · see citing works
Irwin, M. R., Levin, M. J., Laudenslager, M. L., Olmstead, R., Lucko, A., Lang, N., Carrillo, C., Stanley, H. A., Caulfield, M. J., Weinberg, A., et al. (2013) · Clinical Infectious Diseases · doi:10.1093/cid/cis1208 · Cited by 81 · see citing works
Goldman, G. S., & King, P. G. (2012) · Vaccine · doi:10.1016/j.vaccine.2012.05.050 · Cited by 75 · see citing works
Levin, M. J., Schmader, K. E., Pang, L., Williams‐Diaz, A., Zerbe, G. O., Canniff, J. D., Johnson, M. J., Caldas, Y. A., Cho, A., Lang, N., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv480 · Cited by 71 · see citing works
O’Connor, K., & Paauw, D. S. (2013) · Medical Clinics of North America · doi:10.1016/j.mcna.2013.02.002 · Cited by 67 · see citing works
Defective T Memory Cell Differentiation after Varicella Zoster Vaccination in Older Individuals
Qi, Q., Cavanagh, M., Saux, S. L., Wagar, L. E., Mackey, S., Hu, J., Maecker, H. T., Swan, G. E., Davis, M. M., Dekker, C. L., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005892 · Cited by 63 · see citing works
Can Vaccinations Improve Heart Failure Outcomes?
Bhatt, A. S., DeVore, A. D., Hernandez, A. F., & Mentz, R. J. (2017) · JACC Heart Failure · doi:10.1016/j.jchf.2016.12.007 · Cited by 60 · see citing works
Nutritional Formula Improved Immune Profiles of Seniors Living in Nursing Homes
Langkamp‐Henken, B., Wood, S. M., Herrlinger‐Garcia, K. A., Thomas, D. J., Stechmiller, J. K., Bender, B. S., Gardner, E. M., DeMichele, S. J., Schaller, J. P., & Murasko, D. M. (2006) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2006.00982.x · Cited by 57 · see citing works
Immune Biomarkers Predictive of Respiratory Viral Infection in Elderly Nursing Home Residents
Johnstone, J., Parsons, R., Botelho, F. M., Millar, J., McNeil, S., Fülöp, T., McElhaney, J. E., Andrew, M. K., Walter, S. D., Devereaux, P. J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108481 · Cited by 55 · see citing works
Self-citationDecreased Immune Responses to Influenza Vaccination in Patients With Heart Failure
Vardeny, O., Sweitzer, N. K., Detry, M. A., Moran, J. M., Johnson, M. R., & Hayney, M. S. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.11.009 · Cited by 55 · see citing works
T‐Cell Phenotypes Predictive of Frailty and Mortality in Elderly Nursing Home Residents
Johnstone, J., Parsons, R., Botelho, F. M., Millar, J., McNeil, S., Fülöp, T., McElhaney, J. E., Andrew, M. K., Walter, S. D., Devereaux, P. J., et al. (2016) · Journal of the American Geriatrics Society · doi:10.1111/jgs.14507 · Cited by 55 · see citing works
Self-citationClement, M., Marsden, M., Stacey, M. A., Abdul-Karim, J., Brias, S. G., Bento, D. F. C., Scurr, M. J., Ghazal, P., Weaver, C. T., Carlesso, G., et al. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1006050 · Cited by 55 · see citing works
Influenza Vaccine and Survival in Acute Heart Failure
Kopel, E., Klempfner, R., & Goldenberg, I. (2013) · European Journal of Heart Failure · doi:10.1002/ejhf.14 · Cited by 50 · see citing works
Alicino, C., Trucchi, C., Paganino, C., Barberis, I., Boccalini, S., Martinelli, D., Pellizzari, B., Bechini, A., Orsi, A., Bonanni, P., et al. (2016) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2017.1264834 · Cited by 49 · see citing works
Miyagawa, K., Hayashi, Y., Kurihara, S., & Maeda, A. (2008) · Geriatrics & Gerontology International · doi:10.1111/j.1447-0594.2008.00483.x · Cited by 47 · see citing works
Baeyens, A., Saadoun, D., Billiard, F., Rouers, A., Grégoire, S., Zaragoza, B., Grinberg‐Bleyer, Y., Marodon, G., Piaggio, E., & Salomon, B. L. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1400504 · Cited by 45 · see citing works
Beyond adjuvants: Antagonizing inflammation to enhance vaccine immunity
Alter, G., & Sékaly, R. (2015) · Vaccine · doi:10.1016/j.vaccine.2015.03.058 · Cited by 44 · see citing works
Wang, C., Wang, S., Lai, C.-T., Lin, L., Lee, C., & Chou, P. (2004) · Clinical Infectious Diseases · doi:10.1086/425323 · Cited by 37 · see citing works
Xing, Q., Hu, D., Shi, F., & Chen, F. (2013) · Archives of Dermatological Research · doi:10.1007/s00403-013-1367-0 · Cited by 37 · see citing works
Risk factors for poor immune response to influenza vaccination in elderly people
Bellei, N., Carraro, E., Castelo, A. A. M. C., & Granato, C. F. H. (2006) · The Brazilian Journal of Infectious Diseases · doi:10.1590/s1413-86702006000400011 · Cited by 35 · see citing works
Sagawa, M., Kojimahara, N., Otsuka, N., Kimura, M., & Yamaguchi, N. (2010) · Geriatrics and gerontology international/Geriatrics & gerontology international · doi:10.1111/j.1447-0594.2010.00641.x · Cited by 30 · see citing works
Update on herpes zoster vaccination: a family practitioner's guide.
Marla Shapiro, C. M., Kvern, B. L., Watson, P. N. C., Guenther, L., McElhaney, J. E., & McGeer, A. (2011) · Europe PMC (PubMed Central) · Cited by 30 · see citing works
Special Issue: Infectious disease threats.
Paauw, D. S. (2013) · Medical Clinics of North America · Cited by 27 · see citing works
Immunosenescence in the nursing home elderly
Johnstone, J., Millar, J., Lelic, A., Verschoor, C. P., Walter, S. D., Devereaux, P. J., Bramson, J. L., & Loeb, M. B. (2014) · BMC Geriatrics · doi:10.1186/1471-2318-14-50 · Cited by 27 · see citing works
Self-citationMcElhaney, J. E., Herre, J. M., Lawson, M. L., Cole, S. K., Burke, B. L., & Hooton, J. W. L. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.08.032 · Cited by 24 · see citing works
Muszkat, M., Friedman, G., Dannenberg, H., Greenbaum, E., Lipo, M., Heymann, Y., Zakay‐Rones, Z., & Ben‐Yehuda, A. (2003) · Experimental Gerontology · doi:10.1016/j.exger.2003.07.004 · Cited by 23 · see citing works
Lelic, A., Verschoor, C. P., Lau, V. W. C., Parsons, R., Evelegh, C. M., Bowdish, D. M. E., Bramson, J. L., & Loeb, M. B. (2016) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiw462 · Cited by 22 · see citing works
Self-citationLack of Persistence of Influenza Vaccine Antibody Titers in Patients With Heart Failure
Albrecht, C. M., Sweitzer, N. K., Johnson, M. R., & Vardeny, O. (2013) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2013.12.008 · Cited by 21 · see citing works
Seo, Y. B., Choi, W. S., Baek, J. H., Lee, J., Song, J. Y., Lee, J. S., Cheong, H. J., & Kim, W. J. (2013) · Human Vaccines & Immunotherapeutics · doi:10.4161/hv.26858 · Cited by 20 · see citing works
Cools, H. J. M., Gussekloo, J., Remmerswaal, J. E. M., Remarque, E. J., & Kroes, A. C. M. (2009) · Journal of Medical Virology · doi:10.1002/jmv.21456 · Cited by 20 · see citing works
Immunosenescence in patients with chronic systolic heart failure
Xydonas, S., Parissis, J., Lioni, L., Kapsimali, V., Psarra, E., Farmakis, D. T., Kremastinos, D. T., Lekakis, J. P., Sideris, A., Tsirogianni, A., et al. (2016) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000372 · Cited by 19 · see citing works
Hata, A., Inoue, F., Yamasaki, M., Fujikawa, J., Kawasaki, Y., Hamamoto, Y., Honjo, S., Moriishi, E., Mori, Y., & Koshiyama, H. (2013) · Journal of Infection · doi:10.1016/j.jinf.2013.04.010 · Cited by 18 · see citing works
Sato, M., Saito, R., Tanabe, N., Nishikawa, M., Sasaki, A., Gejyo, F., & Suzuki, H. (2005) · Infection Control and Hospital Epidemiology · doi:10.1086/502509 · Cited by 16 · see citing works
Iorio, A., Alatri, A., Camilloni, B., Neri, M., Baglìo, G., & Donatelli, I. (1998) · Gerontology · doi:10.1159/000022052 · Cited by 13 · see citing works
How Should Nursing Homes Use Vaccine to Prevent Zoster?
Drinka, P. J. (2007) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2007.06.001 · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Chronic inflammation in the etiology of disease across the life span
Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915 · see citing works
SARS-CoV-2, COVID-19 and the aging immune system
Bartleson, J. M., Radenkovic, D., Covarrubias, A. J., Furman, D., Winer, D. A., & Verdin, E. (2021) · Nature Aging · doi:10.1038/s43587-021-00114-7 · Cited by 359 · see citing works
Oh, S. J., Lee, J. K., & Shin, O. S. (2019) · Immune Network · doi:10.4110/in.2019.19.e37 · Cited by 261 · see citing works
Rossi, J., Lu, Z. Y., Massart, C., & Levón, K. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.595722 · Cited by 138 · see citing works
Peled, Y., Ram, E., Ii Jacob Lavee, I., Segev, A., Matezky, S., Wieder-Finesod, A., Halperin, R., Mandelboim, M., Indenbaum, V., Levy, I., et al. (2021) · The Journal of Heart and Lung Transplantation · doi:10.1016/j.healun.2021.08.010 · Cited by 99 · see citing works
Acute phase protein response to viral infection and vaccination
Pérez, L. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.07.013 · Cited by 86 · see citing works
Immunosenescence and inflamm-ageing in COVID-19
Zinatizadeh, M. R., Zarandi, P. K., Ghiasi, M., Kooshki, H., Mohammadi, M., Amani, J., & Rezaei, N. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101818 · Cited by 62 · see citing works
Hung, H., Tsai, S., Chou, H., Tsai, M., Hsu, P., & Kuo, Y.-M. (2023) · Scientific Reports · doi:10.1038/s41598-023-32710-5 · Cited by 45 · see citing works
Lee, E. E., Song, K., Hwang, W., Ham, S. Y., Jeong, H., Kim, J. H., Oh, H. S., Kang, Y. M., Lee, E. B., Kim, N. J., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-87668-z · Cited by 45 · see citing works
Transition Metal‐Based Therapies for Inflammatory Diseases
Song, Y., You, Q., & Chen, X. S. (2023) · Advanced Materials · doi:10.1002/adma.202212102 · Cited by 44 · see citing works
Verschoor, C. P., & Kohli, V. (2018) · Cytometry Part A · doi:10.1002/cyto.a.23372 · Cited by 25 · see citing works
Self-citationPicard, E., Armstrong, S., Andrew, M. K., Haynes, L., Loeb, M. B., Pawelec, G., Kuchel, G. A., McElhaney, J. E., & Verschoor, C. P. (2022) · Immunity & Ageing · doi:10.1186/s12979-022-00284-x · Cited by 20 · see citing works
Self-citationHerrero-Fernández, I., Rosado‐Sánchez, I., Álvarez-Ríos, A. I., Galvá, M. I., Luna-Romero, M. D., Sanbonmatsu‐Gámez, S., Pérez-Ruiz, M., Navarro‐Marí, J. M., Carrillo‐Vico, A., Sánchez, B., et al. (2019) · Immunity & Ageing · doi:10.1186/s12979-019-0154-y · Cited by 20 · see citing works
Mehdipour, M., Etienne, J., Liu, C., Mehdipour, T., Kato, C., Conboy, M. J., Conboy, I. M., & KIPROV, D. D. (2021) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2021.103162 · Cited by 20 · see citing works
Zoster Vaccination in Older Adults: Efficacy and Public Health Implications
McElhaney, J. E., Verschoor, C. P., & Pawelec, G. (2019) · The Journals of Gerontology Series A · doi:10.1093/gerona/glz085 · Cited by 15 · see citing works
Self-citationKiecolt‐Glaser, J. K., Renna, M. E., Peng, J., Sheridan, J. F., Lustberg, M. B., Ramaswamy, B., Wesolowski, R., VanDeusen, J. B., Williams, N. O., Sardesai, S. D., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.019 · Cited by 14 · see citing works
Infection in people with heart failure: an overlooked cause of adverse outcomes
Palin, V., Brown, O. I., Hamilton, F., Lillie, P. J., Kearney, M., Cubbon, R. M., & Drozd, M. (2025) · Clinical Medicine · doi:10.1016/j.clinme.2025.100497 · Cited by 10 · see citing works
Huang, R., Quan, J., Su, B., Cai, C., Cai, S., Chen, Y., Mou, Z., Zhou, P., Ma, D., & Cui, X. (2022) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2022.131583 · Cited by 10 · see citing works
Lodge, S., Masuda, R., Nitschke, P., Beilby, J. P., Hui, J., Hunter, M. L., Litton, E., Raby, E., Currie, A. J., Yeap, B. B., et al. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00300 · Cited by 7 · see citing works
Choi, J., Kang, M., Park, K. U., Park, W. B., Kim, K., Kim, E. S., Kim, H. B., Song, K., & Kim, C. (2018) · The Journals of Gerontology Series A · doi:10.1093/gerona/gly287 · Cited by 9 · see citing works
Lodge, S., Masuda, R., Nitschke, P., Beilby, J. P., Hui, J., Hunter, M. L., Yeap, B. B., Millet, Ó., Wist, J., Nicholson, J. K., et al. (2025) · PLoS ONE · doi:10.1371/journal.pone.0311975 · Cited by 8 · see citing works
Kim, J. W., Kwon, K. W., Kim, M., & Cho, J. Y. (2022) · Plants · doi:10.3390/plants11131750 · Cited by 8 · see citing works
Herrero-Fernández, I., Rosado‐Sánchez, I., Genebat, M., Tarancón‐Díez, L., Rodríguez-Méndez, M. M., Pozo‐Balado, M. D. M., Lozano, C., Ruíz-Mateos, E., Leal, M., & Pacheco, Y. M. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1617-1 · Cited by 7 · see citing works
Varicella zoster virus and cardiovascular diseases
Cersosimo, A., Riccardi, M., Amore, L., Cimino, G., Arabia, G., Metra, M., & Vizzardi, E. (2022) · Monaldi Archives for Chest Disease · doi:10.4081/monaldi.2022.2414 · Cited by 6 · see citing works
Mehta, G., Riva, A., Ballester, M. P., Uson, E., Pujadas, M., Carvalho‐Gomes, Â., Sahuco, I., Bono, A., D’Amico, F., Viganò, R., et al. (2023) · Hepatology Communications · doi:10.1097/hc9.0000000000000273 · Cited by 6 · see citing works
Picard, E., Bowdish, D. M. E., McElhaney, J. E., Pawelec, G., Loeb, M. B., & Verschoor, C. P. (2021) · Clinical & Experimental Immunology · doi:10.1111/cei.13593 · Cited by 3 · see citing works
Self-citationYudin, N. S., Belyavskaya, V. A., Maksimov, V. N., Иванощук, Д. Е., Orlov, P. S., & Voevoda, M. I. (2020) · Vavilov Journal of Genetics and Breeding · doi:10.18699/vj19.580 · Cited by 1 · see citing works
Ereshchenko, A., & Gusyakova, O. (2022) · Medical alphabet · doi:10.33667/2078-5631-2022-19-50-54
Outcome prediction of the measles vaccination in healthcare employees
Еreshchenko, A. A., Gusyakova, O. A., Migacheva, N. B., Gilmiyarova, F. N., & Lyamin, A. V. (2023) · Medical Immunology (Russia) · doi:10.15789/10.15789/1563-0625-opo-2546
Picard, E., Armstrong, S., Andrew, M. K., Haynes, L., Loeb, M., Pawelec, G., Kuchel, G. A., McElhaney, J. E., & Verschoor, C. (2022) · Figshare · doi:10.6084/m9.figshare.19905850
Self-citationGenovese, C., Rizzo, C. E., Maisano, D., & Squeri, R. (2026) · The American Journal of Medicine · doi:10.1016/j.amjmed.2026.09.045
- Authors
- Verschoor, C. P., Lelic, A., Parsons, R., Evelegh, C., Bramson, J. L., Johnstone, J., Loeb, M. B., & Bowdish, D. M. E.
- Affiliations
- Canadian Longitudinal Study on Aging (CA)
- Department of Pathology and Molecular Medicine,
- Public Health Ontario (CA)
- McMaster University (CA)
- ORCID
- Venue
- The Journal of Infectious Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-05-31
- Volume
- 216
- Issue
- 2
- Pages
- 191-197
- ISSN
- 0022-1899 (ISSN-L)
- 1537-6613
- PMC
- PMC5853411
- OpenAlex
- W2620183594
- Cited by
- 31
- References
- 49
- Citations by year
- 2026: 1 · 2025: 3 · 2023: 4 · 2022: 8 · 2021: 6 · 2020: 1 · 2019: 5 · 2018: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- The Journal of Infectious Diseases (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research
- Topics
- Health Sciences › Medicine › Epidemiology › Herpesvirus Infections and Treatments
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Health Sciences › Health Professions › General Health Professions › Geriatric Care and Nursing Homes
- Keywords
- C-reactive protein, congestive heart failure, herpes zoster vaccine, vaccine response, elderly nursing home residents, immunosenescence, chronic inflammation, TNF-α, interleukin-6, IL-10, leukocyte telomere length, frailty, varicella-zoster virus, long-term care, vaccine failure
- MeSH terms
- Immunosenescence, Aged, Aged, 80 and over, C-Reactive Protein, Canada, Female, Heart Failure, Herpes Zoster, Homes for the Aged, Humans, Immunity, Cellular, Long-Term Care, Male, Middle Aged, Nursing Homes, T-Lymphocytes, Herpesvirus 3, Human, Linear Models, Logistic Models, Cytokines, Telomere, Herpes Zoster Vaccine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
