The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress in the Ascending Aorta
Abstract
Background—: Hemodynamics may play a role contributing to the progression of bicuspid aortic valve (BAV) aortopathy. This study measured the impact of BAV on the distribution of regional aortic wall shear stress (WSS) compared with control cohorts. Methods and Results—: Local WSS distribution was measured in the thoracic aorta of 60 subjects using 4-dimensional (4D) flow-sensitive magnetic resonance imaging. WSS analysis included 15 BAV patients: 12 with fusion of the right-left coronary cusp (6 stenotic) and 3 with fusion of the right and noncoronary cusp. The right-left BAV cohort was compared with healthy subjects (n=15), age-appropriate subjects (n=15), and age-/aorta size–controlled subjects (n=15). Compared with the age-appropriate and age-/aorta size–matched controls, WSS patterns in the right-left BAV ascending aorta were significantly elevated, independent of stenosis severity (peak WSS=0.9±0.3 N/m 2 compared with 0.4±0.3 N/m 2 in age-/aorta size–controlled subjects; P <0.001). Time-resolved (cine) 2D images of the bicuspid valves were coregistered with 4D flow data, directly linking cusp fusion pattern to a distinct ascending aortic flow jet pattern. The observation of right-anterior ascending aorta wall/jet impingement in right-left BAV patients corresponded to regions with statistically elevated WSS. Alternative jetting patterns were observed in the right and noncoronary cusp fusion patients. Conclusions—: The results of this study demonstrate that bicuspid valves induced significantly altered ascending aorta hemodynamics compared with age- and size-matched controls with tricuspid valves. Specifically, the expression of increased and asymmetric WSS at the aorta wall was related to ascending aortic flow jet patterns, which were influenced by the BAV fusion pattern.
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Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O’Gara, P. T., et al. (2006) · Circulation · doi:10.1161/circulationaha.106.176857 · Cited by 8,495
Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association
Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Adams, R. J., Berry, J. D., Brown, T. M., Carnethon, M. R., Dai, S., de Simone, G., Ford, E. S., et al. (2011) · Circulation · doi:10.1161/cir.0b013e3182009701 · Cited by 6,149
Bonow, R. O., Carabello, B. A., Chatterjee, K., de Leon, A. C., Faxon, D. P., Freed, M. D., Gaasch, W. H., Lytle, B. W., Nishimura, R. A., O'Gara, P. T., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.05.007 · Cited by 2,257
Hiratzka, L. F., Bakris, G. L., Beckman, J. A., Bersin, R. M., Carr, V. F., Casey, D. E., Eagle, K. A., Hermann, L. K., Isselbacher, E. M., Kazerooni, E. A., et al. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.02.015 · Cited by 1,692
Images in Cardiovascular Medicine
(2012) · Wilderness & Environmental Medicine · doi:10.1016/j.wem.2012.05.013 · Cited by 1,519
A classification system for the bicuspid aortic valve from 304 surgical specimens
Sievers, H.-H., & Schmidtke, C. (2007) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2007.01.039 · Cited by 1,222
Erbel, R. (2001) · European Heart Journal · doi:10.1053/euhj.2001.2782 · Cited by 1,217
Siu, S. C., & Silversides, C. K. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.12.068 · Cited by 1,028
Incidence of Aortic Complications in Patients With Bicuspid Aortic Valves
Michelena, H. I., Khanna, A. D., Mahoney, D., Margaryan, E., Topilsky, Y., Suri, R. M., Eidem, B., Edwards, W. D., Sundt, T. M., & Enriquez-Sarano, M. (2011) · JAMA · doi:10.1001/jama.2011.1286 · Cited by 825
Clinical and Pathophysiological Implications of a Bicuspid Aortic Valve
Fedak, P. W. M., Verma, S., David, T. E., Leask, R. L., Weisel, R. D., & Butany, J. (2002) · Circulation · doi:10.1161/01.cir.0000027905.26586.e8 · Cited by 800
Cited by
Erbel (2014) · doi:10.1093/eurheartj/ehu281 · Cited by 4,451
Aortic Dilatation in Patients with Bicuspid Aortic Valve
Verma, S., & Siu, S. C. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1207059 · Cited by 507
2014 ESC Guidelines on the diagnosis and treatment of aortic diseases
Erbel, R., Aboyans, V., Boileau, C., Bossone, E., Di Bartolomeo, R., Eggebrecht, H., Evangelista, A., Falk, V., Frank, H., Gaemperli, O., et al. (2014) · Kardiologia Polska · doi:10.5603/kp.2014.0225 · Cited by 458
Michelena, H. I., Prakash, S. K., Della Corte, A., Bissell, M. M., Anavekar, N., Mathieu, P., Bossé, Y., Limongelli, G., Bossone, E., Benson, D. W., et al. (2014) · Circulation · doi:10.1161/circulationaha.113.007851 · Cited by 442
Borger, M. A., Fedak, P. W. M., Stephens, E. H., Gleason, T. G., Girdauskas, E., Ikonomidis, J. S., Khoynezhad, A., Siu, S. C., Verma, S., Hope, M. D., et al. (2018) · The Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/j.jtcvs.2018.02.115 · Cited by 287
Self-citation
Metadata
- Authors
- Barker, A. J., Markl, M., Bürk, J., Lorenz, R., Bock, J., Bauer, S., Schulz-Menger, J., & von Knobelsdorff-Brenkenhoff, F.
- Venue
- Circulation: Cardiovascular Imaging
- Published
- 2012-07
- Volume
- 5
- Issue
- 4
- Pages
- 457-466
- ISSN
- 1941-9651 (ISSN-L)
- 1942-0080
- OpenAlex
- W2124564923
- Cited by
- 454
- References
- 35
- FWCI
- 26.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Barker, A. J., Markl, M., Bürk, J., Lorenz, R., Bock, J., Bauer, S., Schulz-Menger, J., & von Knobelsdorff-Brenkenhoff, F. (2012). Bicuspid Aortic Valve Is Associated With Altered Wall Shear Stress in the Ascending Aorta. Circulation: Cardiovascular Imaging. https://doi.org/10.1161/circimaging.112.973370
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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