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Cited by 201Fatty Acid Research and HealthNutritional Studies and DietAquaculture Nutrition and Growth

The DOI matches its Crossref record, with a small difference in title or year; 38 of the 38 references it cites were found in a registry or an index.

Omega 3 Fatty Acids and Cardiovascular Outcomes: Systematic Review and Meta-Analysis

Kotwal, Sradha, Jun, Min, Sullivan, David, Perkovic, Vlado, Neal, Bruce·2012·Circulation: Cardiovascular Quality and Outcomes
DOI 10.1161/circoutcomes.112.966168
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Abstract

Background—: Early trials evaluating the effect of omega 3 fatty acids (ω-3 FA) reported benefits for mortality and cardiovascular events but recent larger studies trials have variable findings. We assessed the effects of ω-3 FA on cardiovascular and other important clinical outcomes. Methods and Results—: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for all randomized studies using dietary supplements, dietary interventions, or both. The primary outcome was a composite of cardiovascular events (mostly myocardial infarction, stroke, and cardiovascular death). Secondary outcomes were arrhythmia, cerebrovascular events, hemorrhagic stroke, ischemic stroke, coronary revascularization, heart failure, total mortality, nonvascular mortality, and end-stage kidney disease. Twenty studies including 63030 participants were included. There was no overall effect of ω-3 FA on composite cardiovascular events (relative risk [RR]=0.96; 95% confidence interval [CI], 0.90–1.03; P =0.24) or on total mortality (RR=0.95; 95% CI, 0.86–1.04; P =0.28). ω-3 FA did protect against vascular death (RR=0.86; 95% CI, 0.75–0.99; P =0.03) but not coronary events (RR=0.86; 95% CI, 0.67–1.11; P =0.24). There was no effect on arrhythmia (RR=0.99; 95% CI, 0.85–1.16; P =0.92) or cerebrovascular events (RR=1.03; 95% CI, 0.92–1.16; P =0.59). Adverse events were more common in the treatment group than the placebo group (RR=1.18, 95% CI, 1.02–1.37; P =0.03), predominantly because of an excess of gastrointestinal side effects. Conclusions—: ω-3 FA may protect against vascular disease, but the evidence is not clear-cut, and any benefits are almost certainly not as great as previously believed.

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  1. 10.1001/archinternmed.2012.262 · DOI
  2. Woodward M. Epidemiology: Design and Data Analysis. 2nd ed. Boca Raton, FL: Chapman and Hall/CRC Press; 2005.
  3. 10.1136/bmj.315.7109.629 · DOI · Paper page

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Metadata

Authors
Kotwal, S., Jun, M., Sullivan, D., Perkovic, V., & Neal, B.
Affiliations
The University of Sydney (AU)
ORCID
Venue
Circulation: Cardiovascular Quality and Outcomes
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
2012-11
Volume
5
Issue
6
Pages
808-818
ISSN
  • 1941-7705 (ISSN-L)
  • 1941-7713
DOI
10.1161/circoutcomes.112.966168
OpenAlex
W2038708549
Cited by
201
References
38
Citations by year
2025: 3 · 2024: 7 · 2023: 6 · 2022: 5 · 2021: 8 · 2020: 9 · 2019: 14 · 2018: 21 · 2017: 30 · 2016: 20 · 2015: 29 · 2014: 27 · 2013: 20 · 2012: 1
FWCI
22.93
Type
journal article
Language
en
Open access
closed
Locations
  • Circulation Cardiovascular Quality and Outcomes (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
Keywords
omega-3 fatty acids, cardiovascular outcomes, cardiovascular mortality, myocardial infarction, stroke, vascular death, cardiac arrhythmias, cerebrovascular events, coronary revascularization, heart failure, end-stage renal disease, gastrointestinal adverse effects, dietary supplements, omega-3 supplementation
MeSH terms
Aged, Cardiovascular Agents, Cardiovascular Diseases, Female, Humans, Male, Middle Aged, Fatty Acids, Omega-3, Odds Ratio, Treatment Outcome, Evidence-Based Medicine, Dietary Supplements

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