The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Epigenetic Regulation of Vascular Endothelial Gene Expression
Open accessAbstract
Epigenetics refers to chromatin-based pathways important in the regulation of gene expression and includes 3 distinct, but highly interrelated, mechanisms: DNA methylation, histone density and posttranslational modifications, and RNA-based mechanisms. Together, they offer a newer perspective on transcriptional control paradigms in vascular endothelial cells and provide a molecular basis for how the environment impacts the genome to modify disease susceptibility. This review provides an introduction to epigenetic concepts for vascular biologists. Using endothelial nitric oxide synthase ( NOS3 ) as an example, we examine the growing body of evidence implicating epigenetic pathways in the control of vascular endothelial gene expression in health and disease.
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Citations
Cites
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
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High-Resolution Profiling of Histone Methylations in the Human Genome
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Epigenetic differences arise during the lifetime of monozygotic twins
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Cited by
Transcriptional Control of Endothelial Cell Development
De Val, S., & Black, B. L. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.01.014 · Cited by 346
“…acetylation, will play a major role in opening chromatin and contributing to endothelial specificity, but this hypothesis remains to be tested fully and the role of chromatin modify enzymes in endothelial-specific gene regulation has not been examined in detail (Matouk and Marsden, 2008).”
The western diet and lifestyle and diseases of civilization
Carrera-Bastos, P., Fontes, O'Keefe, Lindeberg, & Cordain (2011) · Research Reports in Clinical Cardiology · doi:10.2147/rrcc.s16919 · Cited by 342
Early environment influences later performance in fishes
Jonsson, B., & Jonsson, N. (2014) · Journal of Fish Biology · doi:10.1111/jfb.12432 · Cited by 311
Activation and Signaling by the AMP-Activated Protein Kinase in Endothelial Cells
Fisslthaler, B., & Fleming, I. (2009) · Circulation Research · doi:10.1161/circresaha.109.201590 · Cited by 295
Metadata
- Authors
- Matouk, C. C., & Marsden, P. A.
- Venue
- Circulation Research
- Published
- 2008-04-25
- Volume
- 102
- Issue
- 8
- Pages
- 873-887
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2137798131
- Cited by
- 227
- References
- 21
- FWCI
- 7.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
