Cited by 145Glycosylation and Glycoproteins ResearchCardiomyopathy and Myosin StudiesRedox biology and oxidative stress

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O -Linked GlcNAc Modification of Cardiac Myofilament Proteins: A Novel Regulator of Myocardial Contractile Function

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Ramirez-Correa, Genaro A., Jin, Wenhai, Wang, Zihao, Zhong, Xin, Gao, Wei Dong, Dias, Wagner B., Vecoli, Cecilia, Hart, Gerald W., Murphy, Anne M.·2008·Circulation Research

DOI 10.1161/circresaha.108.184978PMC PMC2615199

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Abstract

In addition to O -phosphorylation, O -linked modifications of serine and threonine by β- N -acetyl- d -glucosamine (GlcNAc) may regulate muscle contractile function. This study assessed the potential role of O -GlcNAcylation in cardiac muscle contractile activation. To identify specific sites of O -GlcNAcylation in cardiac myofilament proteins, a recently developed methodology based on GalNAz-biotin labeling followed by dithiothreitol replacement and light chromatography/tandem mass spectrometry site mapping was adopted. Thirty-two O -GlcNAcylated peptides from cardiac myofilaments were identified on cardiac myosin heavy chain, actin, myosin light chains, and troponin I. To assess the potential physiological role of the GlcNAc, force–[Ca 2+ ] relationships were studied in skinned rat trabeculae. Exposure to GlcNAc significantly decreased calcium sensitivity (pCa50), whereas maximal force ( F max ) and Hill coefficient ( n ) were not modified. Using a pan-specific O -GlcNAc antibody, it was determined that acute exposure of myofilaments to GlcNAc induced a significant increase in actin O -GlcNAcylation. This study provides the first identification of O -GlcNAcylation sites in cardiac myofilament proteins and demonstrates their potential role in regulating myocardial contractile function.

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Authors: Ramirez-Correa, G. A., Jin, W., Wang, Z., Zhong, X., Gao, W. D., Dias, W. B., Vecoli, C., Hart, G. W., & Murphy, A. M.
Affiliations: From the Departments of Pediatrics (G.A.R.-C., W.J., A.M.M.) and Medicine (C.V.), Division of Cardiology; Departments of Biological Chemistry (Z.W., W.B.D., G.W.H.) and Anesthesia and Critical Care Medicine (X.Z., W.D.G.), Johns Hopkins University School of Medicine, Baltimore, Md; and Department of Pathophysiology (X.Z.), Harbin Medical University, People’s Republic of China.
Johns Hopkins University (US)
ORCID: Wang, Zihao
Zhong, Xin
Gao, Wei Dong
Dias, Wagner B.
Vecoli, Cecilia
Hart, Gerald W.
Murphy, Anne M.
Venue: Circulation Research
Publisher: Ovid Technologies (Wolters Kluwer Health)
Published: 2008-12-05
Volume: 103
Issue: 12
Pages: 1354-1358
ISSN: 0009-7330 (ISSN-L)
1524-4571
DOI: 10.1161/circresaha.108.184978
PMC: PMC2615199
OpenAlex: W2120416709
Cited by: 145
References: 25
Citations by year: 2026: 5 · 2025: 6 · 2024: 12 · 2023: 7 · 2022: 7 · 2021: 8 · 2020: 15 · 2019: 4 · 2018: 12 · 2017: 3 · 2016: 12 · 2015: 7 · 2014: 13 · 2013: 5 · 2012: 14
FWCI: 2.06
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Circulation Research (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health (n01hv28180-13-0-0)
National Heart, Lung, and Blood Institute (N01 HV-28180, R01HL063038, N01 HV028180, R01-HL-63038)
National Institute of Diabetes and Digestive and Kidney Diseases (R01DK061671, R01-DK61671)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiomyopathy and Myosin Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: O-GlcNAcylation, cardiac contractility, calcium sensitivity, myosin heavy chain, myosin light chain, troponin I, Hill coefficient
MeSH terms: Acetylglucosamine, Acylation, Animals, Carbohydrate Conformation, Mice, Inbred C57BL, Actin Cytoskeleton, Myocardial Contraction, Myocardium, Mice, Rats

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O -Linked GlcNAc Modification of Cardiac Myofilament Proteins: A Novel Regulator of Myocardial Contractile Function

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