The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Fate Of Culture-Expanded Mesenchymal Stem Cells in The Microvasculature: In Vivo Observations of Cell Kinetics
Open accessAbstract
Vascular delivery of mesenchymal stem cells (MSCs) following myocardial infarction is under clinical investigation. Little is known about the microvascular fate of MSCs. We used intravital microscopy of rat cremaster muscle microcirculation to track intraarterially delivered MSCs. Rat MSCs (average diameter, 23 μm) were bolused into the ipsilateral common iliac artery. Interrogation of an arteriole–venule pair revealed that 92±7% (n=6) of MSCs arrest and interrupt flow during first pass at the precapillary level, resulting in decreased flow in the feeding arteriole (velocity decreased from 6.3±1.0 to 4.6±1.3 mm/sec; P <0.001). MSC deformability evaluated using filtration through polycarbonate membranes revealed that the cortical tension of MSCs (0.49±0.07 dyne/cm, n=9) was not different from that of circulating mononuclear cells (0.50±0.05 dyne/cm, n=7). When intravital microscopy was performed 3 days following injection, the number of MSCs in the cremaster further decreased to 14% of the initial number, because of cell death in situ. In vivo labeling of the basement membrane revealed that at 1 day, the surviving cells were spread out on the luminal side of the microvessel, whereas at 3 days, they integrated in the microvascular wall. Despite their deformability, intraarterially delivered MSCs entrap at the precapillary level because of their large size, with a small proportion of surviving MSCs integrating in a perivascular niche.
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Cites
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Cited by
Concise review: MSC-derived exosomes for cell-free therapy
Phinney, D. G., & Pittenger, M. F. (2017) · Stem Cells · doi:10.1002/stem.2575 · Cited by 1,834
Mesenchymal stem cells: immune evasive, not immune privileged
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Mesenchymal stem cell secretome: toward cell-free therapeutic strategies in regenerative medicine
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Multipotent mesenchymal stromal cells and the innate immune system
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Shattering barriers toward clinically meaningful MSC therapies
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Metadata
- Authors
- Toma, C., Wagner, W. R., Bowry, S., Schwartz, A., & Villanueva, F.
- Venue
- Circulation Research
- Published
- 2009-02-13
- Volume
- 104
- Issue
- 3
- Pages
- 398-402
- ISSN
- 0009-7330 (ISSN-L)
- 1524-4571
- OpenAlex
- W2166050879
- Cited by
- 366
- References
- 24
- FWCI
- 3.18
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
